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Article ; Online: The emerging roles of m

Pan, Xue-Yin / Huang, Cheng / Li, Jun

International journal of biological sciences

2021 Volume 17, Issue 1, Page(s) 271–284

Abstract: The 'epitranscriptome', a collective term for chemical modifications that influence the structure, metabolism, and functions of RNA, has recently emerged as vitally important for the regulation of gene expression. ... ...

Abstract	The 'epitranscriptome', a collective term for chemical modifications that influence the structure, metabolism, and functions of RNA, has recently emerged as vitally important for the regulation of gene expression. N
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/analysis ; Adenosine/metabolism ; Animals ; Carcinogenesis ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/therapy ; Chromosomal Instability ; Hepatitis, Viral, Human/metabolism ; Humans ; Lipid Metabolism ; Liver Neoplasms/etiology ; Liver Neoplasms/metabolism ; Liver Neoplasms/therapy ; Molecular Targeted Therapy ; Neovascularization, Pathologic
Chemical Substances	N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2021-01-01
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.50003
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Article ; Online: Alternative activation of macrophages by prostacyclin synthase ameliorates alcohol induced liver injury.

Pan, Xue-Yin / Wang, Ling / You, Hong-Mei / Cheng, Miao / Yang, Yang / Huang, Cheng / Li, Jun

Laboratory investigation; a journal of technical methods and pathology

2021 Volume 101, Issue 9, Page(s) 1210–1224

Abstract: Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide. Macrophages exhibit different functional states and are classified as classically activated (M1) and alternatively activated (M2) macrophages. However, the mechanisms that ...

Abstract	Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide. Macrophages exhibit different functional states and are classified as classically activated (M1) and alternatively activated (M2) macrophages. However, the mechanisms that govern M1/M2 polarization in chronic ALD remain to be elucidated. Prostacyclin (PGI
MeSH term(s)	Animals ; Cells, Cultured ; Chemical and Drug Induced Liver Injury/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P-450 Enzyme System/pharmacology ; Ethanol/adverse effects ; Intramolecular Oxidoreductases/genetics ; Intramolecular Oxidoreductases/metabolism ; Intramolecular Oxidoreductases/pharmacology ; Liver/drug effects ; Liver/metabolism ; Macrophage Activation/drug effects ; Macrophage Activation/genetics ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; RAW 264.7 Cells ; Signal Transduction/drug effects
Chemical Substances	Ethanol (3K9958V90M) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Intramolecular Oxidoreductases (EC 5.3.-) ; prostacyclin synthetase (EC 5.3.99.4)
Language	English
Publishing date	2021-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80178-1
ISSN	1530-0307 ; 0023-6837
ISSN (online)	1530-0307
ISSN	0023-6837
DOI	10.1038/s41374-021-00531-7
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Ud II Zs.164: Show issues

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Article ; Online: STING-mediated inflammation contributes to Gao binge ethanol feeding model.

Wang, Ling / You, Hong-Mei / Meng, Hong-Wu / Pan, Xue-Yin / Chen, Xin / Bi, Yi-Hui / Zhang, Ya-Fei / Li, Juan-Juan / Yin, Na-Na / Zhang, Zheng-Wei / Huang, Cheng / Li, Jun

Journal of cellular physiology

2021 Volume 237, Issue 2, Page(s) 1471–1485

Abstract: Alcohol metabolism causes hepatocytes to release damage-associated molecular patterns (DAMPs). This includes mitochondrial DNA (mtDNA), which is generated and released from damaged hepatocytes and contributes to liver injury by producing proinflammatory ... ...

Abstract	Alcohol metabolism causes hepatocytes to release damage-associated molecular patterns (DAMPs). This includes mitochondrial DNA (mtDNA), which is generated and released from damaged hepatocytes and contributes to liver injury by producing proinflammatory cytokines. STING is a pattern recognition receptor of DAMPs known to control the induction of innate immunity in various pathological processes. However, the expression profile and functions of STING in the Gao binge ethanol model remain poorly understood. We demonstrated that STING is upregulated in the Gao binge ethanol model. STING functions as an mtDNA sensor in the Kupffer cells of the liver and induces STING-signaling pathway-dependent inflammation and further aggravates hepatocyte apoptosis in the Gao binge ethanol model. This study provides novel insights into predicting disease progression and developing targeted therapies for alcoholic liver injury.
MeSH term(s)	Animals ; DNA, Mitochondrial/genetics ; Ethanol ; Hepatocytes/metabolism ; Inflammation/pathology ; Liver/metabolism ; Mice ; Mice, Inbred C57BL
Chemical Substances	DNA, Mitochondrial ; Ethanol (3K9958V90M)
Language	English
Publishing date	2021-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.30606
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Article ; Online: Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling.

Pan, Xue-Yin / You, Hong-Mei / Wang, Ling / Bi, Yi-Hui / Yang, Yang / Meng, Hong-Wu / Meng, Xiao-Ming / Ma, Tao-Tao / Huang, Cheng / Li, Jun

Theranostics

2019 Volume 9, Issue 15, Page(s) 4308–4323

Abstract: ... ...

Abstract	Background
MeSH term(s)	Animals ; Apoptosis ; Calcineurin/metabolism ; Calcium-Binding Proteins/metabolism ; Carbon Tetrachloride ; Cell Nucleus/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; Dependovirus/metabolism ; Down-Regulation/genetics ; Gene Silencing ; Hepatic Stellate Cells/metabolism ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Methylation ; Mice, Inbred C57BL ; Muscle Proteins/metabolism ; NFATC Transcription Factors/metabolism ; Organ Specificity ; Protein Transport ; Signal Transduction ; DNA Methyltransferase 3B
Chemical Substances	Calcium-Binding Proteins ; DSCR1 protein, mouse ; Muscle Proteins ; NFATC Transcription Factors ; Carbon Tetrachloride (CL2T97X0V0) ; DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; Calcineurin (EC 3.1.3.16)
Language	English
Publishing date	2019-06-09
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.32710
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Article ; Online: Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells.

Yu, Hai-Xia / Yao, Yao / Bu, Fang-Tian / Chen, Yu / Wu, Yu-Ting / Yang, Yang / Chen, Xin / Zhu, Yan / Wang, Qin / Pan, Xue-Yin / Meng, Xiao-Ming / Huang, Cheng / Li, Jun

Molecular immunology

2019 Volume 107, Page(s) 29–40

Abstract: Yes-associated protein (YAP) is a significant downstream protein in the Hippo signaling pathway with important functions in cell proliferation, apoptosis, invasion and migration. YAP also plays a role in the progression and development of various liver ... ...

Abstract	Yes-associated protein (YAP) is a significant downstream protein in the Hippo signaling pathway with important functions in cell proliferation, apoptosis, invasion and migration. YAP also plays a role in the progression and development of various liver diseases. In hepatic fibrosis development and reversion, the proliferation and apoptosis of activated hepatic stellate cells (HSCs) play a critical role. However, the contribution of YAP to hepatic fibrosis progression and reversion and the underlying mechanism have not been investigated. Here we investigated the expression and function of YAP in the proliferation and apoptosis of activated HSCs. We found that YAP expression was increased in liver fibrosis tissues from CCl
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Apoptosis/drug effects ; Carbon Tetrachloride ; Cell Cycle Proteins ; Cell Line ; Cell Proliferation/drug effects ; Disease Models, Animal ; Gene Silencing/drug effects ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Mice, Inbred C57BL ; Models, Biological ; Phosphoproteins/metabolism ; Transforming Growth Factor beta1/metabolism ; Verteporfin/pharmacology ; Wnt Signaling Pathway/drug effects
Chemical Substances	Adaptor Proteins, Signal Transducing ; Cell Cycle Proteins ; Phosphoproteins ; Transforming Growth Factor beta1 ; Yap1 protein, mouse ; Verteporfin (0X9PA28K43) ; Carbon Tetrachloride (CL2T97X0V0)
Language	English
Publishing date	2019-01-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2019.01.004
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Zs.A 166: Show issues

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Article ; Online: Hesperetin derivative attenuates CCl

Chen, Xin / Li, Xiao-Feng / Chen, Yu / Zhu, Sai / Li, Hai-Di / Chen, Si-Yu / Wang, Jia-Nan / Pan, Xue-Yin / Bu, Fang-Tian / Huang, Cheng / Li, Jun

International immunopharmacology

2019 Volume 76, Page(s) 105838

Abstract: Hepatic fibrosis, a common pathological feature and leading cause of various chronic liver diseases, still lacks effective therapy. Hesperetin derivative (HD) is a derivative of Traditional Chinese Medicine monomer isolated from the fruit peel of ... ...

Abstract	Hepatic fibrosis, a common pathological feature and leading cause of various chronic liver diseases, still lacks effective therapy. Hesperetin derivative (HD) is a derivative of Traditional Chinese Medicine monomer isolated from the fruit peel of Citrusaurantium L. (Rutaceae). In the present study, we revealed the anti-fibrotic effects of HD in CCl
MeSH term(s)	Animals ; Apoptosis/drug effects ; Carbon Tetrachloride ; Cells, Cultured ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/genetics ; Chemical and Drug Induced Liver Injury/metabolism ; Cytokines/genetics ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Hesperidin/pharmacology ; Hesperidin/therapeutic use ; Humans ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice, Inbred C57BL ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Transforming Growth Factor beta1/pharmacology ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein GLI1/metabolism
Chemical Substances	Cytokines ; Gli1 protein, mouse ; Protective Agents ; Transforming Growth Factor beta1 ; Zinc Finger Protein GLI1 ; Carbon Tetrachloride (CL2T97X0V0) ; Hesperidin (E750O06Y6O) ; hesperetin (Q9Q3D557F1)
Language	English
Publishing date	2019-08-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2019.105838
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Zs.A 5408: Show issues

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Article ; Online: Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis.

Chen, Xin / Li, Hai-Di / Bu, Fang-Tian / Li, Xiao-Feng / Chen, Yu / Zhu, Sai / Wang, Jia-Nan / Chen, Si-Yu / Sun, Ying-Yin / Pan, Xue-Yin / Yin, Na-Na / Xu, Jie-Jie / Huang, Cheng / Li, Jun

Theranostics

2020 Volume 10, Issue 11, Page(s) 4851–4870

Abstract: ... ...

Abstract	Rationale
MeSH term(s)	Animals ; Cell Line, Tumor ; Cell Proliferation ; Disease Models, Animal ; Down-Regulation ; F-Box-WD Repeat-Containing Protein 7/genetics ; F-Box-WD Repeat-Containing Protein 7/metabolism ; Hepatic Stellate Cells/metabolism ; Humans ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; Liver Cirrhosis/prevention & control ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; RNA, Circular/genetics ; Signal Transduction
Chemical Substances	F-Box-WD Repeat-Containing Protein 7 ; FBXW7 protein, human ; MIRN18 microRNA, human ; MicroRNAs ; RNA, Circular
Language	English
Publishing date	2020-03-26
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.42423
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Article ; Online: Transmembrane protein 88 attenuates liver fibrosis by promoting apoptosis and reversion of activated hepatic stellate cells.

Cai, Shuang-Peng / Cheng, Xiao-Yu / Chen, Pei-Jie / Pan, Xue-Yin / Xu, Tao / Huang, Cheng / Meng, Xiao-Ming / Li, Jun

Molecular immunology

2016 Volume 80, Page(s) 58–67

Abstract: Transmembrane protein 88 (Tmem88) is a crucial inhibitor for Wnt/β-catenin pathway in the development of myocardial cells. Due to the important role of β-catenin in the activation and proliferation of hepatic stellate cells (HSCs), it is necessary to ... ...

Abstract	Transmembrane protein 88 (Tmem88) is a crucial inhibitor for Wnt/β-catenin pathway in the development of myocardial cells. Due to the important role of β-catenin in the activation and proliferation of hepatic stellate cells (HSCs), it is necessary to investigate the function of Tmem88 in HSCs. In this study, we found that Tmem88 expression was decreased in the human liver fibrotic tissues, primary HSCs from fibrotic mice and activated HSC-T6 cells. Functionally, Tmem88 could inhibit HSCs activation and proliferation by blocking Wnt/β-catenin pathway, and promoted the apoptosis of activated HSCs by initiating Bcl-2/Bax/Caspase3 pathway. Moreover, the level of DNA metyltransferase 3a (Dnmt3a) was upregulated in activated HSCs, and siRNA-mediated Dnmt3a silencing led to Tmem88 restoration. These results indicated that Tmem88 played an important role in HSCs activation, proliferation and apoptosis, and Tmem88 expression might be modulated by Dnmt3a.
MeSH term(s)	Animals ; Apoptosis/physiology ; Blotting, Western ; Cell Line ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; Female ; Flow Cytometry ; Gene Expression Regulation/physiology ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Humans ; Immunohistochemistry ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Rats ; Real-Time Polymerase Chain Reaction ; Wnt Signaling Pathway/physiology
Chemical Substances	Membrane Proteins ; TMEM88 protein, human ; TMEM88 protein, mouse ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; DNA methyltransferase 3A (EC 2.1.1.37)
Language	English
Publishing date	2016-12
Publishing country	England
Document type	Journal Article
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2016.11.002
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Zs.A 166: Show issues

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Article: DNA Methylation of

Pan, Xue-Yin / Yang, Yang / Meng, Hong-Wu / Li, Hai-di / Chen, Xin / Huang, Hui-Min / Bu, Fang-Tian / Yu, Hai-Xia / Wang, Qin / Huang, Cheng / Meng, Xiao-Ming / Li, Jun

Frontiers in pharmacology

2018 Volume 9, Page(s) 553

Abstract: The activation of hepatic stellate cells (HSCs) is a central event in the progression of liver fibrosis. Multiple studies proved that DNA methylation might accelerate HSCs activation. However, the specific pathogenesis of liver fibrosis remains not fully ...

Abstract	The activation of hepatic stellate cells (HSCs) is a central event in the progression of liver fibrosis. Multiple studies proved that DNA methylation might accelerate HSCs activation. However, the specific pathogenesis of liver fibrosis remains not fully addressed. Our laboratory performed Genome methylation screening to find out the methylated gene in mice with liver fibrosis. The pilot experiments showed that the promoter of
Language	English
Publishing date	2018-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.00553
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Article: SUN2: A potential therapeutic target in cancer.

Chen, Xin / Chen, Yu / Huang, Hui-Min / Li, Hai-Di / Bu, Fang-Tian / Pan, Xue-Yin / Yang, Yang / Li, Wan-Xia / Li, Xiao-Feng / Huang, Cheng / Meng, Xiao-Ming / Li, Jun

Oncology letters

2018 Volume 17, Issue 2, Page(s) 1401–1408

Abstract: The incidence of cancer is increasing at an alarming rate despite recent advances in prevention strategies, diagnostics and therapeutics for various types of cancer. The identification of novel biomarkers to aid in prognosis and treatment for cancer is ... ...

Abstract	The incidence of cancer is increasing at an alarming rate despite recent advances in prevention strategies, diagnostics and therapeutics for various types of cancer. The identification of novel biomarkers to aid in prognosis and treatment for cancer is urgently required. Uncontrolled proliferation and dysregulated apoptosis are characteristics exhibited by cancer cells in the initiation of various types of cancer. Notably, aberrant expression of crucial oncogenes or cancer suppressors is a defining event in cancer occurrence. Research has demonstrated that SAD1/UNC84 domain protein-2 (SUN2) serves a suppressive role in breast cancer, atypical teratoid/rhabdoid tumors and lung cancer progression. Furthermore, SUN2 inhibits cancer cell proliferation, migration and promotes apoptosis. Recent reports have also shown that SUN2 serves prominent roles in resistance to the excessive DNA damage that destabilizes the genome and promotes cancer development, and these functions of SUN2 are critical for evading initiation of cancer. Additionally, increasing evidence has demonstrated that SUN2 is involved in maintaining cell nuclear structure and appears to be a central component for organizing the natural nuclear architecture in cancer cells. The focus of the present review is to provide an overview on the pharmacological functions of SUN2 in cancers. These findings suggest that SUN2 may serve as a promising therapeutic target and novel predictive marker in various types of cancer.
Language	English
Publishing date	2018-11-27
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2018.9764
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