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Article ; Online: Altered blood-brain barrier and blood-spinal cord barrier dynamics in amyotrophic lateral sclerosis: Impact on medication efficacy and safety.

Pan, Yijun / Nicolazzo, Joseph A

2022 Volume 179, Issue 11, Page(s) 2577–2588

Abstract: The access of drugs into the central nervous system (CNS) is regulated by the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB). A large body of evidence supports perturbation of these barriers in neurodegenerative diseases, including ... ...

Abstract	The access of drugs into the central nervous system (CNS) is regulated by the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB). A large body of evidence supports perturbation of these barriers in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Modifications to the BBB and BSCB are also reported in amyotrophic lateral sclerosis (ALS), albeit these modifications have received less attention relative to those in other neurodegenerative diseases. Such alterations to the BBB and BSCB have the potential to impact on CNS exposure of drugs in ALS, modulating the effectiveness of drugs intended to reach the brain and the toxicity of drugs that are not intended to reach the brain. Given the clinical importance of these phenomena, this review will summarise reported modifications to the BBB and BSCB in ALS, discuss their impact on CNS drug exposure, and suggest further research directions so as to optimise medicine use in people with ALS.
MeSH term(s)	Amyotrophic Lateral Sclerosis/drug therapy ; Blood-Brain Barrier ; Central Nervous System ; Humans ; Spinal Cord
Language	English
Publishing date	2022-02-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.15802
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Article ; Online: Network Pharmacology Along with Molecular Docking to Explore the Mechanism of Danshen Injection against Anthracycline-induced Cardiotoxicity and Transcriptome Validation.

Dai, Quankai / Pan, Yijun / Zhu, Xiwen / Chen, Mengyao / Xie, Lin / Zhu, Yu / Wan, Guoxing

Current pharmaceutical design

2024

Abstract: Introduction: Although anthracyclines have demonstrated efficacy in cancer therapy, their utilization is constrained by cardiotoxicity. In contrast, Danshen injection (DSI), derived from Salvia miltiorrhiza, has a longstanding tradition of being ... ...

Abstract	Introduction: Although anthracyclines have demonstrated efficacy in cancer therapy, their utilization is constrained by cardiotoxicity. In contrast, Danshen injection (DSI), derived from Salvia miltiorrhiza, has a longstanding tradition of being employed to ameliorate cardiovascular ailments, including anthracycline- induced cardiotoxicity (AIC). Nonetheless, there is a notable dearth of comprehensive systematic investigation into the molecular mechanisms underlying DSI's effects on AIC. Consequently, this study was undertaken to explore the underlying mechanism by which DSI acted against AIC. Methods: Employing network pharmacology approach, the current investigation undertook a comprehensive analysis of the impact of DSI on AIC, which was further validated by transcriptome sequencing with in vitro AIC model. Additionally, molecular docking was conducted to evaluate the binding of active ingredients to core targets. A total of 3,404 AIC-related targets and 12 active ingredients in DSI, including chrysophanol, luteolin, tanshinone IIA, isoimperatorin, among others, were collected by differentially expressed analysis and database search, respectively. Results: The network pharmacology and enrichment analysis suggested 102 potential targets and 29 signaling pathways associated with the protective effect of DSI on AIC. Three core targets (CA12, NOS3, and POLH) and calcium signaling pathways were further validated by transcriptomic analysis of the in-vitro model. The high affinity of the active ingredients binding to corresponding targets was confirmed by molecular docking. Conclusion: The present study suggested that DSI might exert a cardioprotective effect on AIC via the inhibition of CA12, NOS3, and POLH, as well as the modulation of calcium signaling. Further experiments are warranted to verify the findings.
Language	English
Publishing date	2024-03-13
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/0113816128289845240305070522
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Article: Structure, assembly and application of novel peanut oil body protein extracts nanoparticles

Pan, Yijun / Jin, Weiping / Huang, Qingrong

Food chemistry. 2022 Jan. 15, v. 367

2022

Abstract: Oil bodies (OBs), which are found mainly in the seeds or nuts of oleaginous plants, are spherical droplets with a triacylglycerol core covered by phospholipid-protein layer. Oil body protein extracts (OBPEs), mainly oleosins, contribute to the unique ... ...

Abstract	Oil bodies (OBs), which are found mainly in the seeds or nuts of oleaginous plants, are spherical droplets with a triacylglycerol core covered by phospholipid-protein layer. Oil body protein extracts (OBPEs), mainly oleosins, contribute to the unique physicochemical stability of OBs. The application of OBPEs in aqueous environment has been greatly limited by their highly hydrophobic structures. In this study, OBPEs were successfully extracted from peanut seeds and their profiles were characterized by LC-MS/MS. OBPEs nanoparticles were successfully assembled in aqueous environment for the first time using the antisolvent precipitation method. The mean diameter of OBPEs nanoparticles was 215.6 ± 1.8 nm with a polydispersity index of 0.238 ± 0.005. The morphology of these colloidal particles was found to be roughly spherical shape as confirmed by transmission electron microscopy (TEM). Oil-in-water (O/W) Pickering emulsions with good stability against coalescence could be formed at protein concentration as low as 0.1 mg/mL. Cryo-scanning electron microscopy (cryo-SEM) confirmed that spherical nanoparticles were packed at the oil–water interface. This research will greatly expand the applications of OBPEs in structuring the interfaces and developing novel formulations in the food and pharmaceutical fields.
Keywords	body protein ; food chemistry ; hydrophobicity ; lipid bodies ; oil-water interface ; peanut oil ; peanuts ; transmission electron microscopy ; triacylglycerols
Language	English
Dates of publication	2022-0115
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.130678
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Article ; Online: Intra- and Peri-tumoral Radiomics Based on Dynamic Contrast Enhanced-MRI to Identify Lymph Node Metastasis and Prognosis in Intrahepatic Cholangiocarcinoma.

Pan, Yi-Jun / Wu, Sun-Jie / Zeng, Yan / Cao, Zi-Rui / Shan, Yan / Lin, Jiang / Xu, Peng-Ju

Journal of magnetic resonance imaging : JMRI

2024

Abstract: Background: Lymph node metastasis (LNM) in patients with intrahepatic cholangiocarcinoma (iCCA) affects treatment strategies and prognosis. However, preoperative imaging is not reliable enough for identifying LNM.: Purpose: To develop and validate a ... ...

Abstract	Background: Lymph node metastasis (LNM) in patients with intrahepatic cholangiocarcinoma (iCCA) affects treatment strategies and prognosis. However, preoperative imaging is not reliable enough for identifying LNM. Purpose: To develop and validate a radiomics nomogram based on dynamic contrast enhanced (DCE)-MR images for identifying LNM and prognosis in iCCA. Study type: Retrospective. Subjects: Two hundred four patients with pathologically proven iCCA who underwent curative-intent resection and lymphadenectomy (training cohort: N = 107, internal test cohort: N = 46, and external test cohort: N = 51). Field strength/sequence: T1- and T2-weighted imaging, diffusion-weighted imaging and DCE imaging at 1.5 T or 3.0 T. Assessment: Radiomics features were extracted from intra- and peri-tumoral regions on preoperative DCE-MR images. Imaging features were evaluated by three radiologists, and significant variables in univariable and multivariable regression analysis were included in clinical model. The best-performing radiomics signature and clinical characteristics (intrahepatic duct dilatation, MRI-reported LNM) were combined to build a nomogram. Patients were divided into high-risk and low-risk groups based on their nomogram scores (cutoff = 0.341). Patients were followed up for 1-102 months (median 12) after surgery, the overall survival (OS) and recurrence-free survival (RFS) were calculated. Statistical tests: Receiver operating characteristic (ROC) curve, calibration, decision curve, Delong test, Kaplan-Meier curves, log rank test. Two tailed P < 0.05 was considered statistically significant. Results: The nomogram incorporating intra- and peri-tumoral radiomics features, intrahepatic duct dilatation and MRI-reported LNM obtained the best discrimination for LNM, with areas under the ROC curves of 0.946, 0.913, and 0.859 in the training, internal, and external test cohorts. In the entire cohort, high-risk patients had significantly lower RFS and OS than low-risk patients. High-risk of LNM was an independent factor of unfavorable OS and RFS. Data conclusion: The nomogram integrating intra- and peri-tumoral radiomics signatures has potential to identify LNM and prognosis in iCCA. Evidence level: 3 TECHNICAL EFFICACY: Stage 2.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.29390
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Article ; Online: Structure, assembly and application of novel peanut oil body protein extracts nanoparticles.

Pan, Yijun / Jin, Weiping / Huang, Qingrong

Food chemistry

2021 Volume 367, Page(s) 130678

Abstract	Oil bodies (OBs), which are found mainly in the seeds or nuts of oleaginous plants, are spherical droplets with a triacylglycerol core covered by phospholipid-protein layer. Oil body protein extracts (OBPEs), mainly oleosins, contribute to the unique physicochemical stability of OBs. The application of OBPEs in aqueous environment has been greatly limited by their highly hydrophobic structures. In this study, OBPEs were successfully extracted from peanut seeds and their profiles were characterized by LC-MS/MS. OBPEs nanoparticles were successfully assembled in aqueous environment for the first time using the antisolvent precipitation method. The mean diameter of OBPEs nanoparticles was 215.6 ± 1.8 nm with a polydispersity index of 0.238 ± 0.005. The morphology of these colloidal particles was found to be roughly spherical shape as confirmed by transmission electron microscopy (TEM). Oil-in-water (O/W) Pickering emulsions with good stability against coalescence could be formed at protein concentration as low as 0.1 mg/mL. Cryo-scanning electron microscopy (cryo-SEM) confirmed that spherical nanoparticles were packed at the oil-water interface. This research will greatly expand the applications of OBPEs in structuring the interfaces and developing novel formulations in the food and pharmaceutical fields.
MeSH term(s)	Arachis ; Chromatography, Liquid ; Emulsions ; Lipid Droplets ; Nanoparticles ; Particle Size ; Peanut Oil ; Tandem Mass Spectrometry
Chemical Substances	Emulsions ; Peanut Oil
Language	English
Publishing date	2021-07-23
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2021.130678
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Article ; Online: Flaxseed Gum/Arabic Gum/Tween 80-Based Oleogel as a Fat Substitute Applied in Emulsified Sausage: Physicochemical Properties, Sensory Attributes and Nutritional Quality.

Zhu, Qiaomei / Chen, Fu / Li, Peiyang / Wu, Tao / Pan, Yijun / Zhang, Min

Gels (Basel, Switzerland)

2023 Volume 9, Issue 9

Abstract: In the present study, flaxseed gum (FG), Arabic gum (GA) and Tween 80 were used to prepare oleogels through an emulsion-templated method, and the obtained oleogels were designed for the partial substitution of pork fat in emulsified sausage. An increment ...

Abstract	In the present study, flaxseed gum (FG), Arabic gum (GA) and Tween 80 were used to prepare oleogels through an emulsion-templated method, and the obtained oleogels were designed for the partial substitution of pork fat in emulsified sausage. An increment in FG concentrations enhanced the viscoelasticity of emulsions, which resulted in the improved stability of emulsion systems, with smaller droplet sizes. In addition, increased FG concentrations contributed to higher mechanical strength, denser network structure and lower oil loss of oleogels. As a fat substitute, the prepared oleogels improved the textural properties and nutritional quality of emulsified sausages. With the increase in the substitution level of oleogels, the hardness and chewiness of the emulsified sausage increased, and the cooking loss decreased. Meanwhile, the reformulation with oleogels decreased the saturated fat from 57.04 g/100 g lipid to 12.05 g/100 g lipid, while increasing the ratio of omega-6 to omega-3 essential fatty acids from 0.10 to 0.39. The obtained results demonstrated that the flaxseed gum/Arabic gum/Tween 80-based oleogels had huge potential to successfully replace pork fat in emulsified sausage products.
Language	English
Publishing date	2023-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels9090759
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Article ; Online: Voxel-based morphometric magnetic resonance imaging evaluation of small head fetus: A comparative study with normal developmental fetus.

Chen, Changan / Zhang, He / Pan, Yijun / Wang, Yingfang / Tian, Xiaomei / Gu, Qianyu / Zhang, Guofu

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

2023 Volume 83, Issue 3, Page(s) 257–266

Abstract: Purpose: To explore the application value of voxel-based morphometric (VBM) in prenatal diagnosis of microcephaly.: Methods: A retrospective study of magnetic resonance imaging of fetuses with microcephaly was performed using a single-shot fast spin ... ...

Abstract	Purpose: To explore the application value of voxel-based morphometric (VBM) in prenatal diagnosis of microcephaly. Methods: A retrospective study of magnetic resonance imaging of fetuses with microcephaly was performed using a single-shot fast spin echo sequence; semiautomatic segmentation of grey matter (GM), white matter (WM), and cerebrospinal fluid (CSF); calculation of their volumes; and VBM analysis of their GM. Two independent samples t-test was used to statistically analyse the fetal GM volume in the microcephaly and normal control groups. Total intracranial volume (TIV), GM volume, WM volume, and CSF volume were linearly regressed against gestational age and compared between the two groups. Results: In the fetus with microcephaly, GM volume of frontal lobe, temporal lobe, cuneus, anterior central gyrus, and posterior central gyrus decreased significantly (P < 0.001, corrected by family-wise error at mass level). The GM volume of microcephaly was significantly lower than that of the control group (except for 28 weeks of gestation) (P < 0.05). TIV, GM volume, WM volume, and CSF volume were all positively correlated with gestational age, and the curves in the microcephaly group were all lower than those in the control group. Conclusion: Compared with the normal control group, the GM volume of microcephaly fetuses decreased, and there were significant differences in many brain regions through VBM analysis.
MeSH term(s)	Humans ; Pregnancy ; Female ; Microcephaly/diagnostic imaging ; Retrospective Studies ; Brain/diagnostic imaging ; Brain/pathology ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Nervous System Malformations ; Magnetic Resonance Imaging/methods ; Fetus/diagnostic imaging
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	605533-3
ISSN	1873-474X ; 0736-5748
ISSN (online)	1873-474X
ISSN	0736-5748
DOI	10.1002/jdn.10253
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Article: Modulating interfacial structure and lipid digestion of natural Camellia oil body by roasting and boiling processes

Chen, Chunling / Pan, Yijun / Niu, Yifei / Peng, Dengfeng / Huang, Wenjing / Shen, Wangyang / Jin, Weiping / Huang, Qingrong

Food chemistry. 2023 Feb. 15, v. 402

2023

Abstract: Oil body (OB) is the lipid-storage organelle in oilseed, and its stability is crucial for oilseed processing. Herein, effects of roasting and boiling on the structure, stability, and in vitro lipid digestion of Camellia OB were studied. The interfacial ... ...

Abstract	Oil body (OB) is the lipid-storage organelle in oilseed, and its stability is crucial for oilseed processing. Herein, effects of roasting and boiling on the structure, stability, and in vitro lipid digestion of Camellia OB were studied. The interfacial structure and physical stability of the extracted OB were investigated by electrophoresis, confocal-Raman spectroscopy, zeta-potential, and surface hydrophobicity, etc. Boiling caused protein loss on the OB surfaces, forming a stable phospholipid interface, which resulted in coalescence of the droplets (d > 100 μm) and negative ζ-potential (-3 ∼ -8 mV) values at a pH of 2.0. However, roasting partially denatured the proteins in the seeds, which were adsorbed on the OB surfaces. The random coil structure of interfacial protein increased to ∼20 % after thermal treatment. Besides, heating decreased the surface hydrophobicity of OB and improved lipid digestion. After boiling 60 min, the extent of lipolysis increased from 41.7 % (raw) to 57.4 %.
Keywords	Camellia ; electrophoresis ; food chemistry ; heat treatment ; hydrophobicity ; lipid bodies ; lipolysis ; oilseeds ; pH ; phospholipids ; protein depletion ; spectroscopy ; zeta potential
Language	English
Dates of publication	2023-0215
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2022.134198
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Article: Tunable self-assemblies of whey protein isolate fibrils for pickering emulsions structure regulation

Jiang, Fangcheng / Pan, Yijun / Peng, Dengfeng / Huang, Wenjing / Shen, Wangyang / Jin, Weiping / Huang, Qingrong

Food hydrocolloids. 2022 Mar., v. 124

2022

Abstract: Protein fibrils are potential emulsifiers with a highly pH-dependent structure. Therefore, the influence of pH on the self-assemblies of whey protein isolate (WPI) fibrils was investigated through turbidity, transmission electron microscopy, and small- ... ...

Abstract	Protein fibrils are potential emulsifiers with a highly pH-dependent structure. Therefore, the influence of pH on the self-assemblies of whey protein isolate (WPI) fibrils was investigated through turbidity, transmission electron microscopy, and small-angle X-ray scattering tests. Next, the effects of fibril structure on the interfacial profiles and physical properties of stabilized Pickering emulsions were studied. With an increase in pH from 2.0 to 5.0, the cross-sectional radius of WPI fibrils increased from 1.87 ± 0.12 nm to 7.75 ± 0.33 nm, while with a further increase in pH to 7.0, the fibrils decreased to single strand. For all pH conditions, the WPI fibrils effectively absorbed at the oil-water interface. At pH 5.0, the contact angle of fibrils was the maximum (50.6°), and the diffusion rate was the fastest. The d₄,₃ values of the WPI fibril-stabilized Pickering emulsions were around 70–80 μm with no significant differences. Moreover, the Pickering emulsions stabilized by fibrils assembled at pH 5.0 showed a predominantly elastic gel-like behavior and high stability. This work clarifies the relationship between the structure of assembled WPI fibrils and their emulsifying properties, and it provides a theoretical basis for developing emulsion-based delivery systems.
Keywords	contact angle ; hydrocolloids ; oil-water interface ; pH ; small-angle X-ray scattering ; transmission electron microscopy ; turbidity ; whey protein isolate
Language	English
Dates of publication	2022-03
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	742742-6
ISSN	1873-7137 ; 0268-005X
ISSN (online)	1873-7137
ISSN	0268-005X
DOI	10.1016/j.foodhyd.2021.107264
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Article ; Online: Impact of aging, Alzheimer's disease and Parkinson's disease on the blood-brain barrier transport of therapeutics.

Pan, Yijun / Nicolazzo, Joseph A

Advanced drug delivery reviews

2018 Volume 135, Page(s) 62–74

Abstract: Older people are at a greater risk of medicine-induced toxicity resulting from either increased drug sensitivity or age-related pharmacokinetic changes. The scenario is further complicated with the two most prevalent age-related neurodegenerative ... ...

Abstract	Older people are at a greater risk of medicine-induced toxicity resulting from either increased drug sensitivity or age-related pharmacokinetic changes. The scenario is further complicated with the two most prevalent age-related neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD). With aging, AD and PD, there is growing evidence of altered structure and function of the blood-brain barrier (BBB), including modifications to tight junctions and efflux transporters, such as P-glycoprotein. The subsequent impact on CNS drug exposure and risk of neurotoxicity from systemically-acting medicines is less well characterized. The purpose of this review, therefore, is to provide an overview of the multiple changes that occur to the BBB as a result of aging, AD and PD, and the impact that such changes have on CNS exposure of drugs, based on studies conducted in aged rodents or rodent models of disease, and in elderly people with and without AD or PD.
MeSH term(s)	Aging/metabolism ; Alzheimer Disease/drug therapy ; Blood-Brain Barrier/metabolism ; Humans ; Parkinson Disease/drug therapy ; Pharmaceutical Preparations/administration & dosage ; Pharmaceutical Preparations/metabolism
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2018-04-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	639113-8
ISSN	1872-8294 ; 0169-409X
ISSN (online)	1872-8294
ISSN	0169-409X
DOI	10.1016/j.addr.2018.04.009
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