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Article ; Online: Advancing nanotechnology for neoantigen-based cancer theranostics.

Zou, Jianhua / Zhang, Yu / Pan, Yuanbo / Mao, Zhengwei / Chen, Xiaoyuan

2024 Volume 53, Issue 7, Page(s) 3224–3252

Abstract: Neoantigens play a pivotal role in the field of tumour therapy, encompassing the stimulation of anti-tumour immune response and the enhancement of tumour targeting capability. Nonetheless, numerous factors directly influence the effectiveness of ... ...

Abstract	Neoantigens play a pivotal role in the field of tumour therapy, encompassing the stimulation of anti-tumour immune response and the enhancement of tumour targeting capability. Nonetheless, numerous factors directly influence the effectiveness of neoantigens in bolstering anti-tumour immune responses, including neoantigen quantity and specificity, uptake rates by antigen-presenting cells (APCs), residence duration within the tumour microenvironment (TME), and their ability to facilitate the maturation of APCs for immune response activation. Nanotechnology assumes a significant role in several aspects, including facilitating neoantigen release, promoting neoantigen delivery to antigen-presenting cells, augmenting neoantigen uptake by dendritic cells, shielding neoantigens from protease degradation, and optimizing interactions between neoantigens and the immune system. Consequently, the development of nanotechnology synergistically enhances the efficacy of neoantigens in cancer theranostics. In this review, we provide an overview of neoantigen sources, the mechanisms of neoantigen-induced immune responses, and the evolution of precision neoantigen-based nanomedicine. This encompasses various therapeutic modalities, such as neoantigen-based immunotherapy, phototherapy, radiotherapy, chemotherapy, chemodynamic therapy, and other strategies tailored to augment precision in cancer therapeutics. We also discuss the current challenges and prospects in the application of neoantigen-based precision nanomedicine, aiming to expedite its clinical translation.
MeSH term(s)	Humans ; Antigens, Neoplasm ; Precision Medicine ; Neoplasms/diagnosis ; Neoplasms/therapy ; Immunotherapy ; Nanotechnology ; Cancer Vaccines ; Tumor Microenvironment
Chemical Substances	Antigens, Neoplasm ; Cancer Vaccines
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472875-8
ISSN	1460-4744 ; 0306-0012
ISSN (online)	1460-4744
ISSN	0306-0012
DOI	10.1039/d3cs00162h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection.

Pan, Yuanbo / Tang, Wei / Fan, Wenpei / Zhang, Jianmin / Chen, Xiaoyuan

Chemical Society reviews

2022 Volume 51, Issue 23, Page(s) 9759–9830

Abstract: Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages the surrounding normal tissues. Therefore, it is imperative to develop ... ...

Abstract	Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages the surrounding normal tissues. Therefore, it is imperative to develop precision RT for improving the treatment outcome and reducing the adverse effects. Recent breakthroughs in nanotechnology have provided a variety of strategies by which RT can precisely and efficiently eradicate local tumors. In this review, we would like to summarize a series of nanotechnology-mediated strategies to achieve precision RT, including tumor-targeted delivery, image-guided precision radiotherapy, and exo/endogenous stimuli-responsive nanomedicines for enhanced tumor accumulation/penetration. In addition, this review will also discuss two representative featured applications of precision RT: RT-induced immunotherapy against cancer metastasis and radioprotection of the surrounding healthy tissues. Since RT is usually thought to be only effective for treating local tumors, this review will interpret the unusual mechanisms of RT-mediated systemic antitumor immunity for eliminating distant cancer metastasis as well as the abscopal effects of RT in combination with other treatments (
MeSH term(s)	Humans ; Nanotechnology ; Neoplasms/drug therapy ; Neoplasms/radiotherapy ; Immunotherapy ; Nanomedicine
Language	English
Publishing date	2022-11-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472875-8
ISSN	1460-4744 ; 0306-0012
ISSN (online)	1460-4744
ISSN	0306-0012
DOI	10.1039/d1cs01145f
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Article ; Online: Engineering Single-Atom Nanozymes for Catalytic Biomedical Applications.

Zhu, Yang / Liao, Yaxin / Zou, Jianhua / Cheng, Junjie / Pan, Yuanbo / Lin, Lisen / Chen, Xiaoyuan

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 30, Page(s) e2300750

Abstract: Nanomaterials with enzyme-mimicking properties, coined as nanozymes, are a promising alternative to natural enzymes owing to their remarkable advantages, such as high stability, easy preparation, and favorable catalytic performance. Recently, with the ... ...

Abstract	Nanomaterials with enzyme-mimicking properties, coined as nanozymes, are a promising alternative to natural enzymes owing to their remarkable advantages, such as high stability, easy preparation, and favorable catalytic performance. Recently, with the rapid development of nanotechnology and characterization techniques, single atom nanozymes (SAzymes) with atomically dispersed active sites, well-defined electronic and geometric structures, tunable coordination environment, and maximum metal atom utilization are developed and exploited. With superior catalytic performance and selectivity, SAzymes have made impressive progress in biomedical applications and are expected to bridge the gap between artificial nanozymes and natural enzymes. Herein, the recent advances in SAzyme preparation methods, catalytic mechanisms, and biomedical applications are systematically summarized. Their biomedical applications in cancer therapy, oxidative stress cytoprotection, antibacterial therapy, and biosensing are discussed in depth. Furthermore, to appreciate these advances, the main challenges, and prospects for the future development of SAzymes are also outlined and highlighted in this review.
MeSH term(s)	Nanostructures/chemistry ; Catalysis ; Nanotechnology
Language	English
Publishing date	2023-04-14
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202300750
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Article ; Online: Corrigendum to "Endo/exo-genous dual-stimuli responsive gold nanotetrapod-based nanoprobe for magnetic resonance imaging and enhanced multimodal therapeutics by amplifying ·OH generation" [Acta Biomaterialia 154 (2022) 549-558].

Shi, Yu / Zeng, Leyong / Pan, Yuanbo / Zhang, Hao / Wang, Zhaoyang / Shi, Yuehua / Wu, Aiguo

Acta biomaterialia

2023 Volume 161, Page(s) 327

Language	English
Publishing date	2023-02-14
Publishing country	England
Document type	Published Erratum
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2023.02.008
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Article ; Online: Comparative metabarcoding analysis of phytoplankton community composition and diversity in aquaculture water and the stomach contents of Tegillarca granosa during months of growth

Huang, Hailong / Chen, Sentao / Xu, Zhihui / Wu, Yanhua / Mei, Limin / Pan, Yuanbo / Yan, Xiaojun / Zhou, Chengxu

Marine Pollution Bulletin. 2023 Feb., v. 187 p.114556-

2023

Abstract: Filter-feeder bivalves and phytoplankton are interdependent. Their interaction plays important role in estuarine and coastal ecosystem. The correlation between bivalve feeding and phytoplankton is highly species specificity and environment dependent. In ... ...

Abstract	Filter-feeder bivalves and phytoplankton are interdependent. Their interaction plays important role in estuarine and coastal ecosystem. The correlation between bivalve feeding and phytoplankton is highly species specificity and environment dependent. In the background of miniature and nondiatom trend of phytoplankton in coastal seawaters, how bivalve respond and how the response play roles in the phytoplankton community are poorly known. In the present study, by applying DNA metabarcoding approach based on plastid 23S rDNA, this question was addressed by comparing the phytoplankton composition in the seston and the stomach content of blood clam Tegillarca granosa sampled during the growth period from March to November 2020 in an experimental farm on tidal flat in Xiangshan Bay, East China Sea. The result showed that, a total of seven phyla, 55 genera and 73 species of phytoplankton were identified for all samples. Chlorophyta, Bacillariophyta, and Cyanobacteria were found to be three dominant phyla both in the stomach contents and seston. High diversity of pico-sized phytoplankton, which was easy overlooked by microscopy, was revealed both in seston and stomach contents. This result indicated that the clam was able to feed on the pico-sized algae. At the genus level, the most abundant genera were the pico-sized green alga Ostreococcus (6.12 %–67.88 %) in seston and Picochlorum (4.07 %–35.33 %) in the stomach contents. In addition, microalgae of high nutritional value showed trend of higher proportion in stomach contents than that in seston, especially in July and September when significant growth of T. granosa was observed during this period (the body size increased 155 %). Biodiversity of phytoplankton in the seston was totally higher than that in stomach content, however, the changes among the months showed respective trend. Especially in July when the biodiversity was the lowest in seston, that in the stomach content showed the highest. The results indicated that blood clam farming might influence the phytoplankton composition, including those of pico-sized level, although the particular species in seston were mainly correlating with the dominant environmental factors such as temperature, salinity, pH respectively. These results extend the understanding of roles that bivalve aquaculture may play in the changing of coastal phytoplankton community.
Keywords	Bacillariophyta ; Chlorophyta ; Cyanobacteria ; DNA barcoding ; Tegillarca granosa ; biodiversity ; body size ; clams ; coastal ecosystems ; coastal water ; community structure ; demonstration farms ; estuaries ; marine pollution ; microalgae ; microscopy ; mollusc culture ; nutritive value ; pH ; phytoplankton ; salinity ; seston ; stomach ; temperature ; East China Sea ; Phytoplankton community ; Metabarcoding approach ; Food selective ; Miniature trend
Language	English
Dates of publication	2023-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2022.114556
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Changes in biochemical metabolites in manila clam after a temporary culture with high-quality microalgal feed mixed with the dinoflagellate species Karlodinium veneficum and K. zhouanum

Pan, Yuanbo / Meng, Ran / Li, Yanrong / Yang, Ling / Mei, Limin / Wu, Yanhua / Xu, Jilin / Zhou, Chengxu / Yan, Xiaojun

Harmful Algae. 2023 June, v. 125 p.102422-

2023

Abstract: Phytoplankton composition is an important factor affecting the growth and physiological biochemical characteristics of filter-feeding bivalves. With the increasing trend in dinoflagellate biomass and blooms in mariculture areas, how the physio- ... ...

Abstract	Phytoplankton composition is an important factor affecting the growth and physiological biochemical characteristics of filter-feeding bivalves. With the increasing trend in dinoflagellate biomass and blooms in mariculture areas, how the physio-biochemical traits and seafood quality of the mariculture organism are affected by the dinoflagellates, especially those at nonfatal levels, is not well understood. Different densities of two Karlodinium species, namely K. veneficum (KV) and K. zhouanum (KZ), mixed with high quality microalgal food Isochrysis galbana was applied in feeding manila clam Ruditapes philippinarum in a 14-day temporary culture, to comparatively study how the critical biochemical metabolites such as glycogen, free amino acids (FAAs), fatty acids (FAs), volatile organic compounds (VOCs) in the clam were affected. The survival rate of the clam showed dinoflagellate density and species specificity. The high-density KV group inhibited survival to 32% lower than that of the pure I. galbana control, respectively, while KZ at low concentrations did not significantly affect the survival compared with the control. In the high-density KV group, the glycogen and FAA contents decreased (p < 0.05), indicating that energy and protein metabolism were significantly affected. Amount of carnosine (49.91 ± 14.64 to 84.74 ± 8.59 μg/g of muscle wet weight) was detected in all the dinoflagellate-mixed groups, while it was not present in the field samples or in the pure I. galbana control, showing that carnosine participated in the anti-stress activities when the clam was exposed to the dinoflagellates. The global composition of FAs did not significantly vary among the groups. However, contents of the endogenous C₁₈ PUFA precursors linoleic acid and α-linolenic acid significantly decreased in the high-density KV group compared to all the other groups, indicating that high density of KV affected the metabolisms of fatty acids. From the results of the changed VOC composition, oxidation of fatty acids and degradation of free amino acids might occur in the clams exposed to dinoflagellates. The increased VOCs, such as aldehydes, and decreased 1-octen-3-ol probably produced a more fishy taste and reduced food flavor quality when the clam was exposed to the dinoflagellates. This present study demonstrated that the biochemical metabolism and seafood qulity of the clam were affected. However, KZ with moderate density in the feed seemed to be beneficial in aquaculture for increasing the content of carnosine, a high-valued substance with multiple bioactivities.
Keywords	Isochrysis galbana ; Miozoa ; Ruditapes philippinarum ; biomass ; carnosine ; clams ; energy ; flavor ; glycogen ; linoleic acid ; mariculture ; metabolites ; microalgae ; muscles ; octenol ; oxidation ; phytoplankton ; protein metabolism ; seafoods ; survival rate ; taste ; volatile organic compounds ; Karlodinium ; FAAs ; Fatty acids
Language	English
Dates of publication	2023-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	2091119-1
ISSN	1878-1470 ; 1568-9883
ISSN (online)	1878-1470
ISSN	1568-9883
DOI	10.1016/j.hal.2023.102422
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Letter by Zhou et al Regarding Article, "Brain Cleanup as a Potential Target for Poststroke Recovery: The Role of RXR (Retinoic X Receptor) in Phagocytes".

Zhou, Yunxiang / Pan, Yuanbo / Shao, Anwen

Stroke

2020 Volume 51, Issue 5, Page(s) e89

MeSH term(s)	Brain ; Phagocytes ; Transcription Factors
Chemical Substances	Transcription Factors
Language	English
Publishing date	2020-04-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.120.029270
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Article: Transcriptome Analyses Reveal Systematic Molecular Pathology After Optic Nerve Crush.

Pan, Yuan-Bo / Sun, Yiyu / Li, Hong-Jiang / Zhou, Lai-Yang / Zhang, Jianmin / Feng, Dong-Fu

Frontiers in cellular neuroscience

2022 Volume 15, Page(s) 800154

Abstract: The function of glial cells in axonal regeneration after injury has been the subject of controversy in recent years. Thus, deeper insight into glial cells is urgently needed. Many studies on glial cells have elucidated the mechanisms of a certain gene or ...

Abstract	The function of glial cells in axonal regeneration after injury has been the subject of controversy in recent years. Thus, deeper insight into glial cells is urgently needed. Many studies on glial cells have elucidated the mechanisms of a certain gene or cell type in axon regeneration. However, studies that manipulate a single variable may overlook other changes. Here, we performed a series of comprehensive transcriptome analyses of the optic nerve head over a period of 90 days after optic nerve crush (ONC), showing systematic molecular changes in the optic nerve head (ONH). Furthermore, using weighted gene coexpression network analysis (WGCNA), we established gene module programs corresponding to various pathological events at different times post-ONC and found hub genes that may be potential therapeutic targets. In addition, we analyzed the changes in different glial cells based on their subtype markers. We revealed that the transition trend of different glial cells depended on the time course, which provides clues for modulating glial function in further research.
Language	English
Publishing date	2022-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2021.800154
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Article ; Online: Correction to: Construction of a lncRNA-associated competing endogenous RNA regulatory network after traumatic brain injury in mouse.

Wang, Siqi / Sun, Yiyu / Hu, Shaobo / Lou, Cen / Pan, Yuan-Bo

Molecular brain

2022 Volume 15, Issue 1, Page(s) 60

Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Published Erratum
ZDB-ID	2436057-0
ISSN	1756-6606 ; 1756-6606
ISSN (online)	1756-6606
ISSN	1756-6606
DOI	10.1186/s13041-022-00950-7
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Article ; Online: Endo/exo-genous dual-stimuli responsive gold nanotetrapod-based nanoprobe for magnetic resonance imaging and enhanced multimodal therapeutics by amplifying·OH generation.

Shi, Yu / Zeng, Leyong / Pan, Yuanbo / Zhang, Hao / Wang, Zhaoyang / Shi, Yuehua / Wu, Aiguo

Acta biomaterialia

2022 Volume 154, Page(s) 549–558

Abstract: Tumor microenvironment (TME) responsive chemodynamic therapy (CDT) can produce high-toxic hydroxyl radicals (·OH) to kill cancer cells, but the limited concentration of endogenous hydrogen peroxide ( ... ...

Abstract	Tumor microenvironment (TME) responsive chemodynamic therapy (CDT) can produce high-toxic hydroxyl radicals (·OH) to kill cancer cells, but the limited concentration of endogenous hydrogen peroxide (H
MeSH term(s)	Humans ; Manganese Compounds/pharmacology ; Manganese Compounds/chemistry ; Gold/chemistry ; Oxides/pharmacology ; Oxides/chemistry ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/chemistry ; Tumor Microenvironment ; Glutathione/pharmacology ; Magnetic Resonance Imaging ; Neoplasms/pathology ; Cell Line, Tumor
Chemical Substances	Manganese Compounds ; Gold (7440-57-5) ; Oxides ; Hydrogen Peroxide (BBX060AN9V) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2022-10-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2022.10.014
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