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Article ; Online: Modulation of Cullin-RING E3 ubiquitin ligase-dependent ubiquitination by small molecule compounds.

Wu, Kenneth / DeVita, Robert J / Pan, Zhen-Qiang

2024 Volume 300, Issue 3, Page(s) 105752

Abstract: Cullin (CUL)-RING (Really Interesting New Gene) E3 ubiquitin (Ub) ligases (CRLs) are the largest E3 family. The E3 CRL core ligase is a subcomplex formed by the CUL C-terminal domain bound with the ROC1/RBX1 RING finger protein, which acts as a hub that ... ...

Abstract	Cullin (CUL)-RING (Really Interesting New Gene) E3 ubiquitin (Ub) ligases (CRLs) are the largest E3 family. The E3 CRL core ligase is a subcomplex formed by the CUL C-terminal domain bound with the ROC1/RBX1 RING finger protein, which acts as a hub that mediates and organizes multiple interactions with E2, Ub, Nedd8, and the ARIH family protein, thereby resulting in Ub transfer to the E3-bound substrate. This report describes the modulation of CRL-dependent ubiquitination by small molecule compounds including KH-4-43, #33, and suramin, which target the CRL core ligases. We show that both KH-4-43 and #33 inhibit the ubiquitination of CK1α by CRL4
MeSH term(s)	Animals ; Humans ; Mice ; beta Catenin/metabolism ; beta-Transducin Repeat-Containing Proteins/metabolism ; Cullin Proteins/metabolism ; Ligands ; Suramin/pharmacology ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination/drug effects ; NEDD8 Protein/metabolism
Chemical Substances	beta Catenin ; beta-Transducin Repeat-Containing Proteins ; BTRC protein, human ; CRBN protein, human ; CSNK1A1 protein, human (EC 2.7.11.1) ; CULL-RING ligase, human (EC 2.3.2.27) ; Cullin Proteins ; Ligands ; NEDD8 protein, human ; Suramin (6032D45BEM) ; Ubiquitin ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; NEDD8 Protein
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2024.105752
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Article ; Online: Monoubiquitination empowers ubiquitin chain elongation.

Wu, Kenneth / DeVita, Robert J / Pan, Zhen-Qiang

The Journal of biological chemistry

2024 Volume 300, Issue 3, Page(s) 105753

Abstract: Ubiquitination often generates lysine 48-linked polyubiquitin chains that signal proteolytic destruction of the protein target. A significant subset of ubiquitination proceeds by a priming/extending mechanism, in which a substrate is first ... ...

Abstract	Ubiquitination often generates lysine 48-linked polyubiquitin chains that signal proteolytic destruction of the protein target. A significant subset of ubiquitination proceeds by a priming/extending mechanism, in which a substrate is first monoubiquitinated with a priming E2-conjugating enzyme or a set of E3 ARIH/E2 enzymes specific for priming. This is then followed by ubiquitin (Ub) chain extension catalyzed by an E2 enzyme capable of elongation. This report provides further insights into the priming/extending mechanism. We employed reconstituted ubiquitination systems of substrates CK1α (casein kinase 1α) and β-catenin by Cullin-RING E3 Ub ligases (CRLs) CRL4
MeSH term(s)	beta Catenin/metabolism ; beta-Transducin Repeat-Containing Proteins/metabolism ; Ubiquitin/metabolism ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Chemical Substances	beta Catenin ; beta-Transducin Repeat-Containing Proteins ; Ubiquitin ; Ubiquitin-Conjugating Enzymes (EC 2.3.2.23) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2024.105753
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Article ; Online: Retrorectal teratoma: A case insight on treatment and outcomes.

Pan, Zhen-Kun / Wu, Meng-Hua / Ye, Jin-Sheng

Asian journal of surgery

2024

Language	English
Publishing date	2024-04-22
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.04.070
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Article: Cullin-RING E3 Ubiquitin Ligase 7 in Growth Control and Cancer.

Pan, Zhen-Qiang

Advances in experimental medicine and biology

2020 Volume 1217, Page(s) 285–296

Abstract: ... ...

Abstract	CRL7
MeSH term(s)	Animals ; Carrier Proteins/metabolism ; Cell Proliferation ; Cullin Proteins/metabolism ; Cytoskeletal Proteins/metabolism ; F-Box Proteins/metabolism ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Proteolysis ; Ubiquitin/metabolism
Chemical Substances	CCDC8 protein, human ; CUL7 protein, human ; Carrier Proteins ; Cullin Proteins ; Cytoskeletal Proteins ; F-Box Proteins ; OBSL1 protein, human ; Ubiquitin
Language	English
Publishing date	2020-04-02
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-981-15-1025-0_17
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Article ; Online: Recent Advances in the Therapeutic Potential of Sinomenine for Cancer Treatment.

Jiang, PanZhen / Zahra, Aqeela / Guo, Xi / Wu, Jianping

Pharmacology

2024 Volume 109, Issue 2, Page(s) 76–85

Abstract: Background: Cancer is a major cause of death worldwide. Although modern medicine has made strides in treatment, a complete cure for cancer remains elusive.: Summary: Utilization of medicinal plants in traditional medicine for the treatment of ... ...

Abstract	Background: Cancer is a major cause of death worldwide. Although modern medicine has made strides in treatment, a complete cure for cancer remains elusive. Summary: Utilization of medicinal plants in traditional medicine for the treatment of multiple diseases, including cancer, is a well-established practice. Sinomenine is an alkaloid extracted from a medicinal plant and has a diverse range of biological properties, including anti-oxidative, anti-inflammatory, and antibacterial effects. Sinomenine exhibits inhibitory effects on various types of tumor cells, including breast, lung, and liver cancers. The anticancer properties of sinomenine are believed to involve stimulation of apoptosis and autophagy as well as suppression of cell proliferation, invasion, and metastasis. Key message: This review summarizes the current research on sinomenine's potential as an anticancer agent, which may contribute to the discovery of more effective cancer treatments.
MeSH term(s)	Anti-Inflammatory Agents ; Morphinans/pharmacology ; Morphinans/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Plants, Medicinal ; Neoplasms/drug therapy
Chemical Substances	sinomenine (63LT81K70N) ; Anti-Inflammatory Agents ; Morphinans ; Antineoplastic Agents
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	206671-3
ISSN	1423-0313 ; 0031-7012
ISSN (online)	1423-0313
ISSN	0031-7012
DOI	10.1159/000536133
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Article ; Online: Dynamical Instability of Self-Gravitating Membranes.

Yang, Huan / Bonga, Béatrice / Pan, Zhen

Physical review letters

2023 Volume 130, Issue 1, Page(s) 11402

Abstract: We show that a generic relativistic membrane with in-plane pressure and surface density having the same sign is unstable with respect to a series of warping mode instabilities with high wave numbers. We also examine the criteria of instability for ... ...

Abstract	We show that a generic relativistic membrane with in-plane pressure and surface density having the same sign is unstable with respect to a series of warping mode instabilities with high wave numbers. We also examine the criteria of instability for commonly studied exotic compact objects with membranes, such as gravastars, anti-de Sitter bubbles, and thin-shell wormholes. For example, a gravastar which satisfies the weak energy condition turns out to be dynamically unstable. A thin-layer black hole mimicker is stable only if it has positive pressure and negative surface density (such as a wormhole), or vice versa.
MeSH term(s)	Membranes ; Molecular Dynamics Simulation
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.011402
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Article ; Online: A Novel Strategy to Track Lysine-48 Ubiquitination by Fluorescence Resonance Energy Transfer.

Wu, Kenneth / Pan, Zhen-Qiang

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2267, Page(s) 91–102

Abstract: Posttranslational modification of protein by lysine-48 (K48) linked ubiquitin (Ub) chains is the major cellular mechanism for selective protein degradation that critically impacts biological processes such as cell cycle checkpoints. In this chapter, we ... ...

Abstract	Posttranslational modification of protein by lysine-48 (K48) linked ubiquitin (Ub) chains is the major cellular mechanism for selective protein degradation that critically impacts biological processes such as cell cycle checkpoints. In this chapter, we describe an in vitro biochemical approach to detect a K48-linked di-Ub chain by fluorescence resonance energy transfer (FRET). To this end, we detail methods for the preparation of the relevant enzymes and substrates, as well as for the execution of the reaction with high efficiency. Tracking K48 polyubiquitination using this sensitive and highly reproducible format provides an opportunity for high-throughput screening that leads to identification of small molecule modulators capable of changing ubiquitination for improving human health.
MeSH term(s)	Animals ; Cell Line ; Fluorescence Resonance Energy Transfer/methods ; Fluorescent Dyes/chemistry ; Humans ; Lysine/chemistry ; Lysine/metabolism ; Ubiquitin/chemistry ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligase Complexes/chemistry ; Ubiquitin-Protein Ligase Complexes/metabolism ; Ubiquitination
Chemical Substances	Fluorescent Dyes ; Ubiquitin ; Ubiquitin-Protein Ligase Complexes (EC 2.3.2.23) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1217-0_7
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Article ; Online: Probiotic-fermented edible herbs as functional foods: A review of current status, challenges, and strategies.

Cui, Rui / Zhang, Cong / Pan, Zhen-Hui / Hu, Teng-Gen / Wu, Hong

Comprehensive reviews in food science and food safety

2024 Volume 23, Issue 2, Page(s) e13305

Abstract: Recently, consumers have become increasingly interested in natural, health-promoting, and chronic disease-preventing medicine and food homology (MFH). There has been accumulating evidence that many herbal medicines, including MFH, are biologically active ...

Abstract	Recently, consumers have become increasingly interested in natural, health-promoting, and chronic disease-preventing medicine and food homology (MFH). There has been accumulating evidence that many herbal medicines, including MFH, are biologically active due to their biotransformation through the intestinal microbiota. The emphasis of scientific investigation has moved from the functionally active role of MFH to the more subtle role of biotransformation of the active ingredients in probiotic-fermented MFH and their health benefits. This review provides an overview of the current status of research on probiotic-fermented MFH. Probiotics degrade toxins and anti-nutritional factors in MFH, improve the flavor of MFH, and increase its bioactive components through their transformative effects. Moreover, MFH can provide a material base for the growth of probiotics and promote the production of their metabolites. In addition, the health benefits of probiotic-fermented MFH in recent years, including antimicrobial, antioxidant, anti-inflammatory, anti-neurodegenerative, skin-protective, and gut microbiome-modulating effects, are summarized, and the health risks associated with them are also described. Finally, the future development of probiotic-fermented MFH is prospected in combination with modern development technologies, such as high-throughput screening technology, synthetic biology technology, and database construction technology. Overall, probiotic-fermented MFH has the potential to be used in functional food for preventing and improving people's health. In the future, personalized functional foods can be expected based on synthetic biology technology and a database on the functional role of probiotic-fermented MFH.
MeSH term(s)	Humans ; Functional Food ; Probiotics ; Fermented Foods ; Antioxidants ; Anti-Infective Agents
Chemical Substances	Antioxidants ; Anti-Infective Agents
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2185829-9
ISSN	1541-4337 ; 1541-4337
ISSN (online)	1541-4337
ISSN	1541-4337
DOI	10.1111/1541-4337.13305
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Article ; Online: Transabdominal minimal invasive surgery for ultralow anterior resection-intersphincteric dissection with total hiatal ligament excision and rectal pull-through and eversion for direct access to the distal resection margin - a video vignette.

Li, Shoufeng / Pan, Zhen / Wang, Ye / Chen, Jackie / Liu, Xing / Zhuang, Jinfu / Guan, Guoxian

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2024

Language	English
Publishing date	2024-04-14
Publishing country	England
Document type	Letter
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16992
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Zs.A 5799: Show issues

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Article ; Online: Antibiotics resistance removal from piggery wastewater by an integrated anaerobic-aerobic biofilm reactor: Efficiency and mechanism.

Tang, Lianggang / Pan, Zhen / Li, Xuan / Li, Jianzheng / Meng, Jia

The Science of the total environment

2023 Volume 905, Page(s) 167031

Abstract: Antibiotic resistance residual in piggery wastewater poses serious threat to environment and human health. Biological treatment process is commonly installed to remove nutrient from piggery wastewater and also effective in removing antibiotics to varying ...

Abstract	Antibiotic resistance residual in piggery wastewater poses serious threat to environment and human health. Biological treatment process is commonly installed to remove nutrient from piggery wastewater and also effective in removing antibiotics to varying degrees. But the specific pathways and mechanisms involved in the removal of antibiotic resistance are not yet well-understood. An integrated anaerobic-aerobic biofilm reactor (IAOBR) has been demonstrated efficient in removing conventional nutrients. It is here shown that the IAOBR effectively removed 79.0% of Sulfonamides, 55.7% of Tetracyclines and 53.6% of Quinones. Antibiotic resistance bacteria (ARB) were simultaneously inactivated by ~0.5 logs. Antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) were decreased by 0.51 logs and 0.42 logs, respectively. The antibiotics were mainly removed through aerobic compartments of the IAOBR. The mass loss of antibiotics in the reactor was achieved by biodegradation and adsorption, accounting for 52.1% and 47.9%, respectively. An obvious accumulation of ARGs was observed in the activated sludge. The potential host of ARGs was analyzed via microbial community and network. Partial least squares-structural equation model and correlation analysis revealed that the enrichment of ARGs was positively affected by MGEs, followed by bacterial community and ARBs, but the effect of antibiotics on ARGs was negative. Outcomes of this study provide valuable insights into the mechanisms of antibiotic resistance removal in biological treatment processes.
MeSH term(s)	Humans ; Wastewater ; Angiotensin Receptor Antagonists/pharmacology ; Genes, Bacterial ; Anaerobiosis ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Drug Resistance, Microbial/genetics ; Bacteria/genetics ; Sewage ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Wastewater ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Sewage ; Anti-Bacterial Agents
Language	English
Publishing date	2023-09-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.167031
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