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  1. Article ; Online: Exploring Koch's postulate for SARS-CoV-2-induced acute pancreatitis: is it all about the ACE?

    Pandanaboyana, S

    The British journal of surgery

    2021  Volume 108, Issue 8, Page(s) 879–881

    MeSH term(s) COVID-19/complications ; Humans ; Islets of Langerhans/virology ; Neuropilin-1/metabolism ; Pancreas/metabolism ; Pancreatitis/virology ; Receptor, Angiotensin, Type 2/metabolism ; SARS-CoV-2 ; Serine Endopeptidases/metabolism
    Chemical Substances Receptor, Angiotensin, Type 2 ; Neuropilin-1 (144713-63-3) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Language English
    Publishing date 2021-06-08
    Publishing country England
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znab178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Redefining resectability in pancreatic cancer after neoadjuvant therapy: are we any closer?

    Robertson, Francis P / Pandanaboyana, Sanjay

    Hepatobiliary surgery and nutrition

    2023  Volume 12, Issue 1, Page(s) 131–134

    Language English
    Publishing date 2023-01-16
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-22-638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Optimal Timing of Cholecystectomy for Severe Acute Pancreatitis and Understanding Complications and Comorbidities.

    Robertson, Francis P / Dennison, Ashley R / Pandanaboyana, Sanjay

    JAMA surgery

    2024  Volume 159, Issue 4, Page(s) 465

    MeSH term(s) Humans ; Pancreatitis/surgery ; Pancreatitis/etiology ; Acute Disease ; Cholecystectomy/adverse effects ; Cholecystectomy, Laparoscopic/adverse effects ; Comorbidity ; Retrospective Studies
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.6926
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  4. Article ; Online: Complexity of trials on pain management in acute pancreatitis: an ongoing challenge.

    Kamarajah, Sivesh K / MacLennan, Graeme / Pandanaboyana, Sanjay

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2024  

    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Letter
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2024.03.031
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  5. Article ; Online: Lymphangioma of the gallbladder.

    Hawkyard, Jake / Pandanaboyana, Sanjay

    Surgery

    2022  Volume 172, Issue 3, Page(s) e33–e34

    MeSH term(s) Abdomen ; Gallbladder Neoplasms/diagnostic imaging ; Gallbladder Neoplasms/surgery ; Humans ; Lymphangioma/diagnostic imaging ; Lymphangioma/surgery
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2022.03.029
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  6. Article ; Online: Author's Reply: Analgesia in the Initial Management of Acute Pancreatitis-A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    Thavanesan, Navamayooran / Pandanaboyana, Sanjay

    World journal of surgery

    2022  Volume 46, Issue 8, Page(s) 2014–2015

    MeSH term(s) Acute Disease ; Analgesia ; Humans ; Pain ; Pain Management ; Pancreatitis/therapy ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2022-06-04
    Publishing country United States
    Document type Letter ; Meta-Analysis ; Systematic Review ; Comment
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-022-06611-z
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  7. Article ; Online: Upfront surgery vs. neoadjuvant therapy for resectable pancreatic cancer: a narrative review of available evidence.

    Ratnayake, Chathura B B / Roberts, Keith J / Pandanaboyana, Sanjay

    Chinese clinical oncology

    2022  Volume 11, Issue 1, Page(s) 2

    Abstract: Background and objective: Though the use of neoadjuvant therapy (NAT) is increasing in the setting of borderline resectable (BRPC) and locally advance pancreatic cancer (LAPC), the role of NAT in resectable pancreatic cancer (RPC) remains uncertain.: ... ...

    Abstract Background and objective: Though the use of neoadjuvant therapy (NAT) is increasing in the setting of borderline resectable (BRPC) and locally advance pancreatic cancer (LAPC), the role of NAT in resectable pancreatic cancer (RPC) remains uncertain.
    Methods: This is a narrative review, summarising the contemporary evidence and emerging studies comparing neoadjuvant therapy to upfront resection and adjuvant therapy in RPC.
    Key and content and findings: Upfront resection followed by adjuvant chemotherapy is currently the standard of care for RPC. Though BRPC and LAPC have reported significant overall survival benefits with NAT, those results have yet to be translated to RPC. Downstaging is only reported in a small proportion of patients who receive NAT; most have stable disease and a small number have progression. Preliminary trial data have largely been consistent with that observed in the past whereby a modest improvement in R0 resection rates and pathological findings is observed with NAT, however rates of distant recurrence and overall survival remain similar to upfront resection. A significant proportion further fail to achieve resection due to the side effects, deconditioning and delays to surgery. Most international recommendations have been guided by non-randomised data sets and long-term data from emerging phase III trials are yet to be published.
    Conclusions: Although we have observed improved R0 resection rates with NAT, this has yet to translate to a robust improvement in overall survival. Concerns regarding delays to resection, and limited response to NAT remain a topic of ongoing investigation.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Humans ; Neoadjuvant Therapy ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/surgery
    Language English
    Publishing date 2022-02-17
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2828547-5
    ISSN 2304-3873 ; 2304-3873
    ISSN (online) 2304-3873
    ISSN 2304-3873
    DOI 10.21037/cco-21-161
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  8. Article: Quality of life after surgical and endoscopic management of severe acute pancreatitis: A systematic review.

    Psaltis, Emmanouil / Varghese, Chris / Pandanaboyana, Sanjay / Nayar, Manu

    World journal of gastrointestinal endoscopy

    2022  Volume 14, Issue 7, Page(s) 443–454

    Abstract: Background: Treatment for severe acute severe pancreatitis (SAP) can significantly affect Health-related quality of life (HR-QoL). The effects of different treatment strategies such as endoscopic and surgical necrosectomy on HR-QoL in patients with SAP ... ...

    Abstract Background: Treatment for severe acute severe pancreatitis (SAP) can significantly affect Health-related quality of life (HR-QoL). The effects of different treatment strategies such as endoscopic and surgical necrosectomy on HR-QoL in patients with SAP remain poorly investigated.
    Aim: To critically appraise the available evidence on HR-QoL following surgical or endoscopic necrosectomy in patient with SAP.
    Methods: A literature search was performed on PubMed, Google™ Scholar, the Cochrane Library, MEDLINE and Reference Citation Analysis databases for studies that investigated HR-QoL following surgical or endoscopic necrosectomy in patients with SAP. Data collected included patient characteristics, outcomes of interventions and HR-QoL-related details.
    Results: Eleven studies were found to have evaluated HR-QoL following treatment for severe acute pancreatitis including 756 patients. Three studies were randomized trials, four were prospective cohort studies and four were retrospective cohort studies with prospective follow-up. Four studies compared HR-QoL following surgical and endoscopic necrosectomy. Several metrics of HR-QoL were used including Short Form (SF)-36 and EuroQol. One randomized trial and one cohort study demonstrated significantly improved physical scores at three months in patients who underwent endoscopic necrosectomy compared to surgical necrosectomy. One prospective study that examined HR-QoL following surgical necrosectomy reported some deterioration in the functional status of the patients. On the other hand, a cohort study that assessed the long-term HR-QoL following sequential surgical necrosectomy stated that all patients had SF-36 > 60%. In the only study that examined patients following endoscopic necrosectomy, the HR-QoL was also very good. Three studies investigated the quality adjusted life years suggesting that endoscopic and surgical approaches to management of pancreatic necrosis were comparable in cost effectiveness. Finally, regarding HR-QoL between open necrosectomy and minimally invasive approaches, patients who underwent the later had a significantly better overall quality of life, vitality and mental health.
    Conclusion: This review would suggest that the endoscopic approach might offer better HR-QoL compared to surgical necrosectomy. However, the available comparative literature was very limited. More randomized trials powered to detect differences in HR-QoL are required.
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573698-X
    ISSN 1948-5190
    ISSN 1948-5190
    DOI 10.4253/wjge.v14.i7.443
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  9. Article ; Online: Systematic review of sarcopenia in chronic pancreatitis: prevalence, impact on surgical outcomes, and survival.

    Bundred, James / Thakkar, Rohan G / Pandanaboyana, Sanjay

    Expert review of gastroenterology & hepatology

    2022  Volume 16, Issue 7, Page(s) 665–672

    Abstract: Introduction: Chronic pancreatitis (CP) is characterized by progressive inflammatory changes to the pancreas, leading to loss of endocrine and exocrine function. Emerging literature suggests sarcopenia may adversely affect outcomes for chronic ... ...

    Abstract Introduction: Chronic pancreatitis (CP) is characterized by progressive inflammatory changes to the pancreas, leading to loss of endocrine and exocrine function. Emerging literature suggests sarcopenia may adversely affect outcomes for chronic pancreatitis patients. This systematic review examines the evidence surrounding the impact of sarcopenia on patients with CP.
    Areas covered: A systematic literature search of MEDLINE (via PUBMED), Cochrane and EMBASE databases was undertaken to identify articles describing body composition assessment in patients with CP. Data collected included definitions of sarcopenia, sarcopenia assessment methodology, baseline demographics, surgical outcomes, and short- and long-term outcomes.
    Expert opinion: In total, nine studies reported on 977 patients with a sarcopenia prevalence of 32.3% (95% CI 22.9-42.6%). CT remains the primary modality to assess for sarcopenia, due to ease of access. None of the studies reporting on post-operative outcomes for patients with chronic pancreatitis found a significant increase in complications among those with sarcopenia. Mortality within 1 year in the outpatient setting from one study of patients with CP was 16% in sarcopenic patients versus 3% (HR: 6.69 (95% CI: 1.79-24.9), p < 0.001) in those with no sarcopenia.Sarcopenia is prevalent in patients with CP occurring in approximately a third of patients. Sarcopenia is associated with an adverse impact on long-term survival.
    MeSH term(s) Body Composition ; Humans ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/epidemiology ; Pancreatitis, Chronic/surgery ; Prevalence ; Sarcopenia/complications ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology ; Treatment Outcome
    Language English
    Publishing date 2022-06-27
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2022.2091544
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  10. Article ; Online: SARS-CoV-2 pandemic has impacted on patterns of aetiology for acute pancreatitis and management of gallstone pancreatitis in the UK.

    Varghese, Chris / Nayar, Manu / Pandanaboyana, Sanjay

    Gut

    2022  Volume 71, Issue 12, Page(s) 2602–2605

    MeSH term(s) Humans ; SARS-CoV-2 ; Pandemics ; Pancreatitis/diagnosis ; Pancreatitis/epidemiology ; Pancreatitis/etiology ; Gallstones/complications ; Gallstones/diagnostic imaging ; Acute Disease ; COVID-19 ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-01-17
    Publishing country England
    Document type Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2021-326845
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