LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 15

Search options

  1. Book ; Online ; E-Book: Hygiene

    Sripathi, Shiv Sanjeevi / Pandey, Prerna

    2021  

    Author's details edited by Shiv Sanjeevi Sripathi and Prerna Pandey
    Keywords Hygiene
    Subject code 613
    Language English
    Size 1 online resource (263 pages)
    Publisher Delve Publishing
    Publishing place Burlington, Ontario
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-77407-897-X ; 1-77407-698-5 ; 978-1-77407-897-6 ; 978-1-77407-698-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book ; Online ; E-Book: An insight into the "killers"-viruses that cause epidemics

    Sripathi, Shiv Sanjeevi / Pandey, Prerna

    2021  

    Author's details edited by Shiv Sanjeevi Sripathi and Prerna Pandey
    Keywords Viruses ; Virus diseases ; Epidemics
    Subject code 579.2
    Language English
    Size 1 online resource (286 pages)
    Publisher Delve Publishing
    Publishing place Burlington, ON, Canada
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-77469-006-3 ; 1-77407-805-8 ; 978-1-77469-006-2 ; 978-1-77407-805-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Book: Nature of fish growth hormones

    Megarajan, Sekar / Pandey, Prerna

    2018  

    Author's details edited by: Sekar Megarajan and Prerna Pandey
    Language English
    Size xix, 370 Seiten
    Publisher Delve Publishing
    Publishing place Oakville, ON
    Publishing country Canada
    Document type Book
    HBZ-ID HT019623160
    ISBN 978-1-77361-199-0 ; 1-77361-199-2
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    188/144 available for loan (reading room) Freihandmagazin (U1)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book ; Online ; E-Book: Biocatalysis and agricultural biotechnology

    Priyadarshini, Anjali / Pandey, Prerna

    fundamentals, advances, and practices for a greener future

    2019  

    Author's details Anjali Priyadarshini, Prerna Pandey
    Language English
    Size 1 Online-Ressource (xvi, 348 Seiten), Illustrationen
    Publisher Apple Academic Press
    Publishing place Oakville, ON ; Waretown, NJ
    Publishing country Canada
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019807804
    ISBN 978-1-351-16743-7 ; 978-1-351-16744-4 ; 9781771886895 ; 1-351-16743-X ; 1-351-16744-8 ; 1771886897
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: NGS-based profiling identifies miRNAs and pathways dysregulated in cisplatin-resistant esophageal cancer cells.

    Pandey, Prerna / Suyal, Geetika / Aprajita / Pasbola, Kiran / Sharma, Rinu

    Functional & integrative genomics

    2023  Volume 23, Issue 2, Page(s) 111

    Abstract: Esophageal cancer (EC) incidence remains to be on a global rise supported by an unchanged recurrence and 5-year survival rate owing to the development of chemoresistance. Resistance to cisplatin, one of the majorly used chemotherapeutic drugs in EC, is a ...

    Abstract Esophageal cancer (EC) incidence remains to be on a global rise supported by an unchanged recurrence and 5-year survival rate owing to the development of chemoresistance. Resistance to cisplatin, one of the majorly used chemotherapeutic drugs in EC, is a major nuisance. This study sheds light on miRNA dysregulation and its inverse relation with dysregulated mRNAs to guide pathways into the manifestation of cisplatin resistance in EC. A cisplatin-resistant version of an EC cell line was established and comparative profiling by NGS with the parental cell line was employed to identify dysregulation in miRNA and mRNA levels. Protein-protein interaction network analysis was done using Cytoscape, followed by Funrich pathway analysis. Furthermore, selective significant miRNAs were validated using qRT-PCR. miRNA-mRNA integrated analysis was carried out using the Ingenuity Pathway Analysis (IPA) tool. Expression of various established resistance markers supported the successful establishment of cisplatin-resistant cell line. Whole-cell small RNA sequencing and transcriptome sequencing identified 261 miRNAs and 1892 genes to be significantly differentially expressed (DE), respectively. Pathway analysis indicated enrichment of EMT signaling, supported by NOTCH, mTOR, TNF receptor, and PI3K-mediated AKT signaling pathways, in chemoresistant cells. Validation by qRT-PCR confirmed upregulation of miR-10a-5p, miR-618, miR-99a-5p, and miR-935 and downregulation of miR-335-3p, miR-205-5p, miR-944, miR-130a-3p, and miR-429 in resistant cells. Pathway analysis that followed IPA analysis indicated that the dysregulation of these miRNAs and their target genes may be instrumental in the development and regulation of chemoresistance via p53 signaling, xenobiotic metabolism, and NRF2-mediated oxidative stress. This study concludes the interplay between miRNA and mRNA as an important aspect and occurrence in guiding the regulation, acquisition, and maintenance of chemoresistance in esophageal cancer in vitro.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cisplatin/pharmacology ; Cisplatin/metabolism ; Cisplatin/therapeutic use ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/genetics ; Cell Line ; RNA, Messenger/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic
    Chemical Substances MicroRNAs ; Cisplatin (Q20Q21Q62J) ; RNA, Messenger ; MIRN-944 microRNA, human
    Language English
    Publishing date 2023-03-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2014670-X
    ISSN 1438-7948 ; 1438-793X
    ISSN (online) 1438-7948
    ISSN 1438-793X
    DOI 10.1007/s10142-023-01041-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: NGS-based profiling identifies miRNAs and pathways dysregulated in cisplatin-resistant esophageal cancer cells

    Pandey, Prerna / Suyal, Geetika / Aprajita / Pasbola, Kiran / Sharma, Rinu

    Funct Integr Genomics. 2023 June, v. 23, no. 2 p.111-111

    2023  

    Abstract: Esophageal cancer (EC) incidence remains to be on a global rise supported by an unchanged recurrence and 5-year survival rate owing to the development of chemoresistance. Resistance to cisplatin, one of the majorly used chemotherapeutic drugs in EC, is a ...

    Abstract Esophageal cancer (EC) incidence remains to be on a global rise supported by an unchanged recurrence and 5-year survival rate owing to the development of chemoresistance. Resistance to cisplatin, one of the majorly used chemotherapeutic drugs in EC, is a major nuisance. This study sheds light on miRNA dysregulation and its inverse relation with dysregulated mRNAs to guide pathways into the manifestation of cisplatin resistance in EC. A cisplatin-resistant version of an EC cell line was established and comparative profiling by NGS with the parental cell line was employed to identify dysregulation in miRNA and mRNA levels. Protein-protein interaction network analysis was done using Cytoscape, followed by Funrich pathway analysis. Furthermore, selective significant miRNAs were validated using qRT-PCR. miRNA-mRNA integrated analysis was carried out using the Ingenuity Pathway Analysis (IPA) tool. Expression of various established resistance markers supported the successful establishment of cisplatin-resistant cell line. Whole-cell small RNA sequencing and transcriptome sequencing identified 261 miRNAs and 1892 genes to be significantly differentially expressed (DE), respectively. Pathway analysis indicated enrichment of EMT signaling, supported by NOTCH, mTOR, TNF receptor, and PI3K-mediated AKT signaling pathways, in chemoresistant cells. Validation by qRT-PCR confirmed upregulation of miR-10a-5p, miR-618, miR-99a-5p, and miR-935 and downregulation of miR-335-3p, miR-205-5p, miR-944, miR-130a-3p, and miR-429 in resistant cells. Pathway analysis that followed IPA analysis indicated that the dysregulation of these miRNAs and their target genes may be instrumental in the development and regulation of chemoresistance via p53 signaling, xenobiotic metabolism, and NRF2-mediated oxidative stress. This study concludes the interplay between miRNA and mRNA as an important aspect and occurrence in guiding the regulation, acquisition, and maintenance of chemoresistance in esophageal cancer in vitro.
    Keywords cell lines ; cisplatin ; drug therapy ; esophageal neoplasms ; genomics ; metabolism ; microRNA ; oxidative stress ; protein-protein interactions ; survival rate ; transcriptome ; tumor necrosis factor receptors ; xenobiotics
    Language English
    Dates of publication 2023-06
    Size p. 111.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 2014670-X
    ISSN 1438-7948 ; 1438-793X
    ISSN (online) 1438-7948
    ISSN 1438-793X
    DOI 10.1007/s10142-023-01041-z
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: A Probabilistic Digital Twin for Leak Localization in Water Distribution Networks Using Generative Deep Learning.

    Mücke, Nikolaj T / Pandey, Prerna / Jain, Shashi / Bohté, Sander M / Oosterlee, Cornelis W

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 13

    Abstract: Localizing leakages in large water distribution systems is an important and ever-present problem. Due to the complexity originating from water pipeline networks, too few sensors, and noisy measurements, this is a highly challenging problem to solve. In ... ...

    Abstract Localizing leakages in large water distribution systems is an important and ever-present problem. Due to the complexity originating from water pipeline networks, too few sensors, and noisy measurements, this is a highly challenging problem to solve. In this work, we present a methodology based on generative deep learning and Bayesian inference for leak localization with uncertainty quantification. A generative model, utilizing deep neural networks, serves as a probabilistic surrogate model that replaces the full equations, while at the same time also incorporating the uncertainty inherent in such models. By embedding this surrogate model into a Bayesian inference scheme, leaks are located by combining sensor observations with a model output approximating the true posterior distribution for possible leak locations. We show that our methodology enables producing fast, accurate, and trustworthy results. It showed a convincing performance on three problems with increasing complexity. For a simple test case, the Hanoi network, the average topological distance (ATD) between the predicted and true leak location ranged from 0.3 to 3 with a varying number of sensors and level of measurement noise. For two more complex test cases, the ATD ranged from 0.75 to 4 and from 1.5 to 10, respectively. Furthermore, accuracies upwards of 83%, 72%, and 42% were achieved for the three test cases, respectively. The computation times ranged from 0.1 to 13 s, depending on the size of the neural network employed. This work serves as an example of a digital twin for a sophisticated application of advanced mathematical and deep learning techniques in the area of leak detection.
    MeSH term(s) Deep Learning ; Bayes Theorem ; Neural Networks, Computer ; Models, Statistical ; Water Supply
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23136179
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Tumour suppressor role of microRNA-335-5p in esophageal squamous cell carcinoma by targeting TTK (Mps1).

    Suyal, Geetika / Pandey, Prerna / Saraya, Anoop / Sharma, Rinu

    Experimental and molecular pathology

    2021  Volume 124, Page(s) 104738

    Abstract: Background: Esophageal cancer is an aggressive malignancy. miR-335-5p is reported to possess both tumour suppressor and tumour promoter activities in different cancers.: Objectives: We investigated the role of miR-335-5p in esophageal cancer by ... ...

    Abstract Background: Esophageal cancer is an aggressive malignancy. miR-335-5p is reported to possess both tumour suppressor and tumour promoter activities in different cancers.
    Objectives: We investigated the role of miR-335-5p in esophageal cancer by expression and functional studies.
    Materials and methods: The role of miR-335-5p in ESCC was evaluated using MTT assay, cell cycle analysis, colony formation assay, scratch assay, matrigel invasion, and migration assay.
    Results: Our expression studies showed a significantly decreased expression of tissue and circulating miR-335-5p in esophageal cancer. Our results herein report a key tumour suppressive role of miR-335-5p in esophageal carcinogenesis by inhibiting proliferation, migration, and invasion in ESCC cells. Using RNA-seq and Insilico analysis we found TTK to be a newly identified direct target and confirmed it by using luciferase assay.
    Conclusion: Overall, our expression and functional analysis results demonstrated herein point towards the potential role of miR-335-5p in esophageal tumorigenesis. Moreover, this is the first report showing TTK as a downstream target of miR-335-5p.
    MeSH term(s) Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/genetics ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophageal Squamous Cell Carcinoma/pathology ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism
    Chemical Substances Cell Cycle Proteins ; MIRN335 microRNA, human ; MicroRNAs ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; TTK protein, human (EC 2.7.12.1)
    Language English
    Publishing date 2021-12-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207655-x
    ISSN 1096-0945 ; 0014-4800
    ISSN (online) 1096-0945
    ISSN 0014-4800
    DOI 10.1016/j.yexmp.2021.104738
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book: Biocatalysis and agricultural biotechnology

    Priyadarshini, Anjali / Pandey, Prerna

    fundamentals, advances, and practices for a greener future

    2019  

    Author's details Anjali Priyadarshini, PhD, Prerna Pandey, PhD
    Keywords Agricultural biotechnology. ; Biocatalysis. ; Enzymes/Biotechnology.
    Language English
    Dates of publication 2019-2019
    Size xvi, 348 pages :, illustrations (some color) ;, 24 cm
    Document type Book
    ISBN 9781771886895 ; 1771886897
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Nano-modified screen-printed electrode-based electrochemical immunosensors for oral cancer biomarker detection in undiluted human serum and saliva samples.

    Gulati, Payal / Singh, Avinash Kumar / Yadav, Amit K / Pasbola, Kiran / Pandey, Prerna / Sharma, Rinu / Thakar, Alok / Solanki, Pratima R

    Nanoscale advances

    2023  Volume 6, Issue 2, Page(s) 705–721

    Abstract: This proposed work reports the development of in-house made conductive ink-based screen-printed electrodes (SPEs) for label-free detection of oral cancer biomarkers. Carbon ink synthesis includes graphite powder, gum arabic, and water. The selectivity ... ...

    Abstract This proposed work reports the development of in-house made conductive ink-based screen-printed electrodes (SPEs) for label-free detection of oral cancer biomarkers. Carbon ink synthesis includes graphite powder, gum arabic, and water. The selectivity test of the fabricated SPE involves immobilizing antibodies specific to biomarkers and challenges with redox-active interference, other serum molecules, and non-target biomarkers. Three different biomarkers, cytokeratin-19 fragment (CYFRA 21-1), interleukin 8 (IL-8), and tumor protein p53 (TP-53), act as target entities for the detection of oral cancer in patients' samples (serum,
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d3na00682d
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top