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  1. Article ; Online: Identification of gene classifier and modules associated with SARS-CoV-2 ARI in nasal swab

    Pandikannan Krishnamoorthy / Athira S. Raj / Himanshu Kumar

    Genes and Diseases, Vol 11, Iss 1, Pp 38-

    2024  Volume 41

    Keywords Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Interplay of host and viral factors in inflammatory pathway mediated cytokine storm during RNA virus infection

    Riya Chaudhary / Aparna Meher / Pandikannan Krishnamoorthy / Himanshu Kumar

    Current Research in Immunology, Vol 4, Iss , Pp 100062- (2023)

    2023  

    Abstract: RNA viruses always have been a serious concern for human health by causing several outbreaks, often pandemics. The excessive mortality and deaths associated with the outbreaks caused by these viruses were due to the excessive induction of pro- ... ...

    Abstract RNA viruses always have been a serious concern for human health by causing several outbreaks, often pandemics. The excessive mortality and deaths associated with the outbreaks caused by these viruses were due to the excessive induction of pro-inflammatory cytokines leading to cytokine storm. Cytokines are important for cell-to-cell communication to maintain cell homeostasis. Disturbances of this homeostasis can lead to intricate chain reactions resulting in a massive release of cytokines. This could lead to a severe self-reinforcement of several feedback processes, which could eventually cause systemic harm, multiple organ failure, or death. Multiple inflammation-associated pathways were involved in the cytokine production and its regulation. Different RNA viruses induce these pathways through the interplay with their viral factors and host proteins and miRNAs regulating these pathways. This review will discuss the interplay of host proteins and miRNAs that can play an important role in the regulation of cytokine storm and the possible therapeutic potential of these molecules for the treatment and the challenges associated with the clinical translation.
    Keywords Cytokine storm ; RNA viruses ; Innate immunity ; miRNAs ; Antiviral therapeutics ; Inflammation ; Specialties of internal medicine ; RC581-951
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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