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  1. Article ; Online: Comparison of the Alinity M STI with the GeneXpert CT/NG for the detection of sexually transmitted microorganisms.

    Farfour, Eric / Kitous, Cyril / Zucman, David / Touche, Pauline / Panel, Kewin / Fourn, Erwan / Vasse, Marc

    Diagnostic microbiology and infectious disease

    2024  Volume 108, Issue 3, Page(s) 116179

    Abstract: We assess the performances of the Alinity M STI assay (Abbott Molecular) in comparison to the Xpert CT/NG assay (Cepheid). We first retrospectively used a collection of 70 frozen samples of which 33, 31, and 6 were positives for Chlamydia trachomatis (CT) ...

    Abstract We assess the performances of the Alinity M STI assay (Abbott Molecular) in comparison to the Xpert CT/NG assay (Cepheid). We first retrospectively used a collection of 70 frozen samples of which 33, 31, and 6 were positives for Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), and both micro-organisms respectively. The Alinity M STI and the Xpert CT/NG results were in accordance for all. The mean difference in cycle threshold values between the Xpert CT/NG and the Alinity M STI were -1.6 and 0.0 for CT and NG respectively. Then 214 fresh samples collected from 121 patients were prospectively tested with both instruments. Anal swabs, throat swabs, vaginal swabs, and urines accounted each for about 25%. Seven (3.2%) samples of which 5 anal swabs, provided inconclusive results with the Alinity M STI. In conclusion, the Alinity M STI is an accurate device for the microbiological diagnosis of NG and CT infections.
    MeSH term(s) Female ; Humans ; Chlamydia trachomatis/genetics ; Gonorrhea/diagnosis ; Gonorrhea/microbiology ; Retrospective Studies ; Neisseria gonorrhoeae/genetics ; Chlamydia Infections/diagnosis ; Tomography, X-Ray Computed ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/microbiology ; Trichomonas vaginalis ; Prevalence
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2024.116179
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  2. Article ; Online: Recurrent cardiac arrest due to eosinophilia-related coronary vasospasm successfully treated by benralizumab.

    Groh, Matthieu / Pineton de Chambrun, Marc / Georges, Jean-Louis / Panel, Kewin / Lefèvre, Guillaume / Kahn, Jean-Emmanuel / Tcherakian, Colas / Convers-Domart, Raphaèle

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 9, Page(s) 3497–3499.e1

    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Coronary Vasospasm/diagnosis ; Coronary Vasospasm/drug therapy ; Eosinophilia/drug therapy ; Female ; Heart Arrest ; Humans ; Young Adult
    Chemical Substances Antibodies, Monoclonal, Humanized ; benralizumab (71492GE1FX)
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.04.067
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  3. Article ; Online: Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit.

    Gaillet, Antoine / Bay, Pierre / Péju, Edwige / Ait-Oufella, Hafid / Azoulay, Elie / Benchabane, Nacime / Cerf, Charles / Cohen, Yves / de Prost, Nicolas / Faguer, Stanislas / Geri, Guillaume / Grangé, Steven / Kahn, Jean-Emmanuel / Kreitmann, Louis / Larcher, Romaric / Lefèvre, Guillaume / Mabrouki, Asma / Mekonsto-Dessap, Armand / Panel, Kewin /
    Pène, Frédéric / Pineton de Chambrun, Marc / Quenot, Jean-Pierre / Tandjaoui-Lambiotte, Yacine / Timsit, Jean-Francois / Vieillard-Baron, Antoine / Dargent, Auguste / Herault, Antoine / Groh, Matthieu

    Intensive care medicine

    2023  Volume 49, Issue 3, Page(s) 291–301

    Abstract: Purpose: Although eosinophil-induced manifestations can be life-threatening, studies focusing on the epidemiology and clinical manifestations of eosinophilia in the intensive care unit (ICU) are lacking.: Methods: A retrospective, national, ... ...

    Abstract Purpose: Although eosinophil-induced manifestations can be life-threatening, studies focusing on the epidemiology and clinical manifestations of eosinophilia in the intensive care unit (ICU) are lacking.
    Methods: A retrospective, national, multicenter (14 centers) cohort study over 6 years of adult patients who presented with eosinophilia ≥ 1 × 10
    Results: 620 patients (0.9% of all ICU hospitalizations) were included: 40% with early eosinophilia (within the first 24 h of ICU admission, ICU-Eo1 group) and 56% with delayed (> 24 h after ICU admission, ICU-Eo2 group) eosinophilia. In ICU-Eo1, eosinophilia was mostly due to respiratory (14.9%) and hematological (25.8%) conditions, frequently symptomatic (58.1%, mainly respiratory and cardiovascular manifestations) requiring systemic corticosteroids in 32.2% of cases. In ICU-Eo2, eosinophil-related organ involvement was rare (25%), and eosinophilia was mostly drug-induced (46.8%). Survival rates at day 60 (D60) after ICU admission were 21.4% and 17.2% (p = 0.219) in ICU-Eo1 and ICU-Eo2 patients, respectively. For ICU-Eo1 patients, in multivariate analysis, risk factors for death at D60 were current immunosuppressant therapy at ICU admission, eosinophilia of onco-hematological origin and the use of vasopressors at ICU admission, whereas older age and the use of vasopressors or mechanical ventilation at the onset of eosinophilia were associated with a poorer prognosis for ICU-Eo2 patients.
    Conclusion: Eosinophilia ≥ 1 × 10
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Cohort Studies ; Intensive Care Units ; Eosinophilia/epidemiology ; Hospitalization
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06967-9
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  4. Article ; Online: Correction: Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit.

    Gaillet, Antoine / Bay, Pierre / Péju, Edwige / Ait-Oufella, Hafid / Azoulay, Elie / Benchabane, Nacime / Cerf, Charles / Cohen, Yves / de Prost, Nicolas / Faguer, Stanislas / Geri, Guillaume / Grangé, Steven / Kahn, Jean-Emmanuel / Kreitmann, Louis / Larcher, Romaric / Lefèvre, Guillaume / Mabrouki, Asma / Mekonsto-Dessap, Armand / Panel, Kewin /
    Pène, Frédéric / Pineton de Chambrun, Marc / Quenot, Jean-Pierre / Tandjaoui-Lambiotte, Yacine / Timsit, Jean-Francois / Vieillard-Baron, Antoine / Dargent, Auguste / Herault, Antoine / Groh, Matthieu

    Intensive care medicine

    2023  Volume 49, Issue 5, Page(s) 611

    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07059-y
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  5. Article ; Online: Cutaneous manifestations of lymphoid-variant hypereosinophilic syndrome.

    Laurent, Claire / Lefèvre, Guillaume / Kahn, Jean-Emmanuel / Staumont-Salle, Delphine / Felten, Renaud / Puget, Marie / Moulinet, Thomas / Machelart, Irène / Launay, David / Charvet, Estelle / Bouaziz, Jean David / Jachiet, Marie / Espitia, Alexandra / Mahr, Alfred / Le Clech, Christian / Malphettes, Marion / Morice, Cécile / Mourah, Samia / Moins-Teisserenc, Hélène /
    Lifermann, François / Soulier-Guérin, Karine / Villate, Alban / Baillou, Chloé / Grados, Aurélie / Robbins, Ailsa / Abisror, Noemie / Bagot, Martine / Boutboul, David / Panel, Kewin / Vignon-Pennamen, Marie-Dominique / Rivet, Jacqueline / Battistella, Maxime / Groh, Matthieu / de Masson, Adèle

    The British journal of dermatology

    2022  Volume 187, Issue 6, Page(s) 1011–1013

    MeSH term(s) Humans ; Hypereosinophilic Syndrome ; Collagen Diseases ; Skin Diseases
    Language English
    Publishing date 2022-08-12
    Publishing country England
    Document type Letter
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21782
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  6. Article ; Online: Venous thrombosis and predictors of relapse in eosinophil-related diseases.

    Réau, Valériane / Vallée, Alexandre / Terrier, Benjamin / Plessier, Aurélie / Abisror, Noémie / Ackermann, Félix / Benainous, Ruben / Bohelay, Gérôme / Chabi-Charvillat, Marie-Laure / Cornec, Divi / Desbois, Anne-Claire / Faguer, Stanislas / Freymond, Nathalie / Gaillet, Antoine / Hamidou, Mohamed / Killian, Martin / Le Jeune, Sylvain / Marchetti, Anne / Meyer, Guy /
    Osorio-Perez, Francisco / Panel, Kewin / Rautou, Pierre-Emmanuel / Rohmer, Julien / Simon, Nicolas / Tcherakian, Colas / Vasse, Marc / Zuelgaray, Elina / Lefevre, Guillaume / Kahn, Jean-Emmanuel / Groh, Matthieu

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 6388

    Abstract: Eosinophils have widespread procoagulant effects. Eosinophilic cardiovascular toxicity mostly consists of endomyocardial damage or eosinophilic vasculitis, while reported cases of venous thrombosis (VT) are scarce. We aimed to report on the clinical ... ...

    Abstract Eosinophils have widespread procoagulant effects. Eosinophilic cardiovascular toxicity mostly consists of endomyocardial damage or eosinophilic vasculitis, while reported cases of venous thrombosis (VT) are scarce. We aimed to report on the clinical features and treatment outcomes of patients with unexplained VT and eosinophilia, and to identify predictors of relapse. This retrospective, multicenter, observational study included patients aged over 15 years with VT, concomitant blood eosinophilia ≥ 1G/L and without any other moderate-to-strong contributing factors for VT. Fifty-four patients were included. VT was the initial manifestation of eosinophil-related disease in 29 (54%) patients and included pulmonary embolism (52%), deep venous thrombosis (37%), hepatic (11%) and portal vein (9%) thromboses. The median [IQR] absolute eosinophil count at VT onset was 3.3G/L [1.6-7.4]. Underlying eosinophil-related diseases included FIP1L1-PDGFRA-associated chronic myeloid neoplasm (n = 4), Eosinophilic Granulomatosis with Polyangiitis (n = 9), lymphocytic (n = 1) and idiopathic (n = 29) variants of hypereosinophilic syndrome. After a median [IQR] follow-up of 24 [10-62] months, 7 (13%) patients had a recurrence of VT. In multivariate analysis, persistent eosinophilia was the sole variable associated with a shorter time to VT relapse (HR 7.48; CI95% [1.94-29.47]; p = 0.015). Long-term normalization of eosinophil count could prevent the recurrence of VT in a subset of patients with unexplained VT and eosinophilia ≥ 1G/L.
    MeSH term(s) Adult ; Aged ; Churg-Strauss Syndrome/epidemiology ; Churg-Strauss Syndrome/pathology ; Churg-Strauss Syndrome/therapy ; Eosinophilia/complications ; Eosinophilia/epidemiology ; Eosinophilia/pathology ; Eosinophilia/therapy ; Eosinophils/pathology ; Female ; Humans ; Hypereosinophilic Syndrome/epidemiology ; Hypereosinophilic Syndrome/genetics ; Hypereosinophilic Syndrome/pathology ; Hypereosinophilic Syndrome/therapy ; Leukemia/epidemiology ; Leukemia/genetics ; Leukemia/pathology ; Leukemia/therapy ; Male ; Middle Aged ; Portal Vein/pathology ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/pathology ; Pulmonary Embolism/therapy ; Recurrence ; Retrospective Studies ; Treatment Outcome ; Venous Thrombosis/epidemiology ; Venous Thrombosis/genetics ; Venous Thrombosis/pathology ; Venous Thrombosis/therapy ; mRNA Cleavage and Polyadenylation Factors/genetics
    Chemical Substances FIP1L1 protein, human ; mRNA Cleavage and Polyadenylation Factors
    Language English
    Publishing date 2021-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-85852-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Epidemiology, clinical picture and long-term outcomes of FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia: Data from 151 patients.

    Rohmer, Julien / Couteau-Chardon, Amélie / Trichereau, Julie / Panel, Kewin / Gesquiere, Cyrielle / Ben Abdelali, Raouf / Bidet, Audrey / Bladé, Jean-Sébastien / Cayuela, Jean-Michel / Cony-Makhoul, Pascale / Cottin, Vincent / Delabesse, Eric / Ebbo, Mikaël / Fain, Olivier / Flandrin, Pascale / Galicier, Lionel / Godon, Catherine / Grardel, Nathalie / Guffroy, Aurélien /
    Hamidou, Mohamed / Hunault, Mathilde / Lengline, Etienne / Lhomme, Faustine / Lhermitte, Ludovic / Machelart, Irène / Mauvieux, Laurent / Mohr, Catherine / Mozicconacci, Marie-Joelle / Naguib, Dina / Nicolini, Franck E / Rey, Jerome / Rousselot, Philippe / Tavitian, Suzanne / Terriou, Louis / Lefèvre, Guillaume / Preudhomme, Claude / Kahn, Jean-Emmanuel / Groh, Matthieu

    American journal of hematology

    2020  Volume 95, Issue 11, Page(s) 1314–1323

    Abstract: FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare disease: robust epidemiological data are lacking and reported issues are scarce, of low sample-size and limited follow-up. Imatinib mesylate (IM) is highly efficient but no ... ...

    Abstract FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare disease: robust epidemiological data are lacking and reported issues are scarce, of low sample-size and limited follow-up. Imatinib mesylate (IM) is highly efficient but no predictive factor of relapse after discontinuation has yet been identified. One hundred and fifty-one patients with F/P+ MN-eo (143 males; mean age at diagnosis 49 years; mean annual incidence: 0.18 case per million population) were included in this retrospective nationwide study involving all French laboratories who perform the search of F/P fusion gene (study period: 2003-2019). The main organs involved included the spleen (44%), skin (32%), lungs (30%), heart (19%) and central nervous system (9%). Serum vitamin B12 and tryptase levels were elevated in 74/79 (94%) and 45/57 (79%) patients, respectively, and none of the 31 patients initially treated with corticosteroids achieved complete hematologic remission. All 148 (98%) IM-treated patients achieved complete hematologic and molecular (when tested, n = 84) responses. Forty-six patients eventually discontinued IM, among whom 20 (57%) relapsed. In multivariate analysis, time to IM initiation (continuous HR: 1,01 [0.99-1,03]; P = .05) and duration of IM treatment (continuous HR: 0,97 [0,95-0,99]; P = .004) were independent factors of relapse after discontinuation of IM. After a mean follow-up of 80 (56) months, the 1, 5- and 10-year overall survival rates in IM-treated patients were 99%, 95% and 84% respectively. In F/P+ MN-eo, prompt initiation of IM and longer treatment durations may prevent relapses after discontinuation of IM.
    MeSH term(s) Adrenal Cortex Hormones/administration & dosage ; Adult ; Disease-Free Survival ; Eosinophilia/blood ; Eosinophilia/drug therapy ; Eosinophilia/genetics ; Eosinophilia/mortality ; Female ; France/epidemiology ; Hematologic Neoplasms/blood ; Hematologic Neoplasms/drug therapy ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/mortality ; Humans ; Incidence ; Male ; Middle Aged ; Myeloproliferative Disorders/blood ; Myeloproliferative Disorders/drug therapy ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/mortality ; Oncogene Proteins, Fusion/blood ; Oncogene Proteins, Fusion/genetics ; Receptor, Platelet-Derived Growth Factor alpha/blood ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Retrospective Studies ; Survival Rate ; Tryptases/blood ; Vitamin B 12/blood ; mRNA Cleavage and Polyadenylation Factors/blood ; mRNA Cleavage and Polyadenylation Factors/genetics
    Chemical Substances Adrenal Cortex Hormones ; Oncogene Proteins, Fusion ; mRNA Cleavage and Polyadenylation Factors ; FIP1L1-PDGFRA fusion protein, human (EC 2.7.10.1) ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1) ; Tryptases (EC 3.4.21.59) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2020-09-19
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Multicenter Study
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.25945
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