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  1. Book: Diabetes and Ccrdiovascular disease

    Paneni, Francesco / Cosentino, Francesco

    a guide to clinical management

    2015  

    Author's details Francesco Paneni ; Francesco Cosentino
    Keywords Management of diabetes and cardiovascular disease ; Cardiovascular risk factors ; Myocardial revascularization strategies ; Multifactorial treatment ; Drug therapies
    Language English
    Size XIII, 214 S. : Ill., graph. Darst., 33 farb. Ill., 21 schw.-w. Tab., 190 mm x 127 mm
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018700205
    ISBN 978-3-319-17761-8 ; 3-319-17761-3 ; 9783319177625 ; 3319177621
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: The ESC Textbook of Vascular Biology.

    Paneni, Francesco

    European heart journal

    2019  Volume 38, Issue 38, Page(s) 2868

    Language English
    Publishing date 2019-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehx574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Homocysteine: A futile comeback or a promising tool for the risk assessment of hypertensive patients?

    Bernardi, Marco / Paneni, Francesco / Sabouret, Pierre

    European journal of preventive cardiology

    2024  

    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwae053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Why epigenetics is (not) a biosocial science and why that matters.

    Chiapperino, Luca / Paneni, Francesco

    Clinical epigenetics

    2022  Volume 14, Issue 1, Page(s) 144

    Abstract: Epigenetic modifications offer compelling evidence of the environmental etiology of complex diseases. Social and biographical conditions, as well as material exposures, all modulate our biology with consequences for risk predispositions and health ... ...

    Abstract Epigenetic modifications offer compelling evidence of the environmental etiology of complex diseases. Social and biographical conditions, as well as material exposures, all modulate our biology with consequences for risk predispositions and health conditions. Elucidating these complex biosocial loops is one of the main challenges animating epigenetics. Yet, research on the development of epigenetic biomarkers often pulls in a direction that departs from a view of biological determinants of health embedded in their social and material environment. Taking the example of the epigenetics of cardiovascular diseases, this paper illustrates how common understandings of epigenetic biomarkers strongly lean toward considering them as mere targets for molecular intervention, rather than as correlates of a complex biological and social patterning of disease. This reductionism about biosocial dynamics of disease, we argue, hampers the pursuit of the goals epigenetics has given itself (in cardiology and beyond). If epigenetic mechanisms point to the deep socio-environmental embeddedness of our health, we conclude, future designs and methods of this research may require an improved methodological consideration of a biosocial perspective.
    MeSH term(s) Humans ; DNA Methylation ; Epigenomics ; Epigenesis, Genetic
    Language English
    Publishing date 2022-11-11
    Publishing country Germany
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-022-01366-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diabetes and heart failure: from disease mechanisms to personalized care.

    DE Sensi, Francesco / Paneni, Francesco

    Minerva cardiology and angiology

    2022  Volume 70, Issue 3, Page(s) 341–343

    MeSH term(s) Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Heart Failure/epidemiology ; Heart Failure/therapy ; Humans
    Language English
    Publishing date 2022-05-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3059238-0
    ISSN 2724-5772
    ISSN (online) 2724-5772
    DOI 10.23736/S2724-5683.22.06078-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Increased risk of incident diabetes in patients with long COVID.

    Paneni, Francesco / Patrono, Carlo

    European heart journal

    2022  Volume 43, Issue 22, Page(s) 2094–2095

    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Incidence ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Empagliflozin across the stages of diabetic heart disease.

    Paneni, Francesco

    European heart journal

    2017  Volume 39, Issue 5, Page(s) 371–373

    MeSH term(s) Benzhydryl Compounds ; Diabetes Mellitus, Type 2 ; Glucosides ; Heart Failure ; Hospitalization ; Humans
    Chemical Substances Benzhydryl Compounds ; Glucosides ; empagliflozin (HDC1R2M35U)
    Language English
    Publishing date 2017-10-07
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehx519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Epigenome in Atherosclerosis.

    Costantino, Sarah / Paneni, Francesco

    Handbook of experimental pharmacology

    2021  Volume 270, Page(s) 511–535

    Abstract: Emerging evidence suggests the growing importance of "nongenetic factors" in the pathogenesis of atherosclerotic vascular disease. Indeed, the inherited genome determines only part of the risk profile as genomic approaches do not take into account ... ...

    Abstract Emerging evidence suggests the growing importance of "nongenetic factors" in the pathogenesis of atherosclerotic vascular disease. Indeed, the inherited genome determines only part of the risk profile as genomic approaches do not take into account additional layers of biological regulation by "epi"-genetic changes. Epigenetic modifications are defined as plastic chemical changes of DNA/histone complexes which critically affect gene activity without altering the DNA sequence. These modifications include DNA methylation, histone posttranslational modifications, and non-coding RNAs and have the ability to modulate gene expression at both transcriptional and posttranscriptional level. Notably, epigenetic signals are mainly induced by environmental factors (i.e., pollution, smoking, noise) and, once acquired, may be transmitted to the offspring. The inheritance of adverse epigenetic changes may lead to premature deregulation of pathways involved in vascular damage and endothelial dysfunction. Here, we describe the emerging role of epigenetic modifications as fine-tuners of gene transcription in atherosclerosis. Specifically, the following aspects are described in detail: (1) discovery and impact of the epigenome in cardiovascular disease, (2) the epigenetic landscape in atherosclerosis; (3) inheritance of epigenetic signals and premature vascular disease; (4) epigenetic control of lipid metabolism, vascular oxidative stress, inflammation, autophagy, and apoptosis; (5) epigenetic biomarkers in patients with atherosclerosis; (6) novel therapeutic strategies to modulate epigenetic marks. Understanding the individual epigenetic profile may pave the way for new approaches to determine cardiovascular risk and to develop personalized therapies to treat atherosclerosis and its complications.
    MeSH term(s) Atherosclerosis/genetics ; DNA Methylation ; Epigenesis, Genetic ; Epigenome ; Genome ; Humans
    Language English
    Publishing date 2021-01-21
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2020_422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A 'Once-and-Done' Approach to the Lifelong Reduction of Elevated Cholesterol.

    Paneni, Francesco / Volpe, Massimo

    European heart journal

    2021  Volume 42, Issue 37, Page(s) 3820–3821

    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Is tirzepatide in the surpass lane over GLP-1 receptor agonists for the treatment of diabetes?

    Paneni, Francesco / Patrono, Carlo

    European heart journal

    2021  Volume 42, Issue 41, Page(s) 4211–4212

    MeSH term(s) Diabetes Mellitus ; Gastric Inhibitory Polypeptide ; Glucagon-Like Peptide-1 Receptor ; Humans ; Hypoglycemic Agents
    Chemical Substances Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Gastric Inhibitory Polypeptide (59392-49-3) ; tirzepatide (OYN3CCI6QE)
    Language English
    Publishing date 2021-11-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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