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  1. Article ; Online: Novel strategies for the characterization of cancellous bone morphology: Virtual isolation and analysis.

    Veneziano, Alessio / Cazenave, Marine / Alfieri, Fabio / Panetta, Daniele / Marchi, Damiano

    American journal of physical anthropology

    2021  Volume 175, Issue 4, Page(s) 920–930

    Abstract: Objectives: The advent of micro-computed tomography (μCT) made cancellous bone more accessible than ever before. Nevertheless, the characterization of cancellous bone is made difficult by its inherent complexity and the difficulties in defining homology ...

    Abstract Objectives: The advent of micro-computed tomography (μCT) made cancellous bone more accessible than ever before. Nevertheless, the characterization of cancellous bone is made difficult by its inherent complexity and the difficulties in defining homology across datasets. Here we propose novel virtual methodological approaches to overcome those issues and complement existing methods.
    Materials and methods: We present a protocol for the isolation of the whole cancellous region within a μCT scanned bone. This method overcomes the subsampling issues and allows studying cancellous bone as a single unit. We test the protocol on a set of primate bones. In addition, we describe a set of morphological indices calculated on the topological skeleton of the cancellous bone: node density, node connectivity, trabecular angle, trabecular tortuosity, and fractal dimension. The usage of the indices is shown on a small comparative sample of primate femoral heads.
    Results: The isolation protocol proves reliable in isolating cancellous structures from several different bones, regardless of their shape. The indices seem to detect some functional differences, although further testing on comparative samples is needed to clarify their potential for the study of cancellous architecture.
    Conclusions: The approaches presented overcome some of the difficulties of trabecular bone studies. The methods presented here represent an alternative or supporting method to the existing tools available to address the biomechanics of cancellous bone.
    MeSH term(s) Animals ; Biomechanical Phenomena ; Bone Density ; Cancellous Bone/diagnostic imaging ; Femur Head ; Primates ; X-Ray Microtomography
    Language English
    Publishing date 2021-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219376-0
    ISSN 1096-8644 ; 0002-9483
    ISSN (online) 1096-8644
    ISSN 0002-9483
    DOI 10.1002/ajpa.24272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: X-ray and ultrasound imaging

    Brahme, Anders / Panetta, Daniele

    (Comprehensive biomedical physics ; / ed.-in-chief: Anders Brahme ; Vol. 2)

    2014  

    Author's details vol. ed.: Daniele Panetta
    Series title Comprehensive biomedical physics
    / ed.-in-chief: Anders Brahme ; Vol. 2
    Language English
    Size XVI, 517 S.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Document type Book
    ISBN 9780444633361 ; 0444633367
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: Lip Reconstruction by Double Layer and Double Flap New Combination Technique: A Case Series.

    Cortese, Antonio / Catalano, Salvatore / Giunta, Antonio Alberto Maria / Borri, Antonio / Panetta, Daniele / Claudio, Pier Paolo

    Dentistry journal

    2022  Volume 10, Issue 2

    Abstract: In the past, lip reconstruction after ablative surgery has been performed by primary closure and more recently by free flap transfer technique. Cheek's skin flap has been used to reconstruct the lower lip cutaneous portion. This study presents a ... ...

    Abstract In the past, lip reconstruction after ablative surgery has been performed by primary closure and more recently by free flap transfer technique. Cheek's skin flap has been used to reconstruct the lower lip cutaneous portion. This study presents a reconstructive method for the vermillion and the lip's cutaneous portion using the Goldstein-Robotti techniques (for the vermillion) and the buccinator flap to reconstruct the cutaneous lip portion and the perioral muscles. This procedure allows a complete reconstruction with a double layer technique for defects of more than one-third of both lips, together or alone, including modiolus, showing satisfactory functionality and aesthetics. The procedure was carried out by splitting the buccinator muscle and elongating the upper and lower buccinator bundles, together or alone. Soft tissue blunt dissection prevented most facial nerves and vessels injuries, ensuring blood supply and an amount of lip sensitivity. Even in the case of facial vessel ligatures after neck dissection, the technique was possible basing the flap pedicle on the internal maxillary artery branches (buccinator) and contralateral facial vessels (orbicularis). We present a case series of six reconstructions of various defects of the upper and lower lips, including the commissure after ablative surgery for squamous cell carcinoma and polymorphous adenocarcinoma. The results showed satisfactory functional and aesthetic outcomes, with similar tissue texture, static and dynamic symmetry achieved for all the patients.
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681351-8
    ISSN 2304-6767 ; 2304-6767
    ISSN (online) 2304-6767
    ISSN 2304-6767
    DOI 10.3390/dj10020019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Alveolar Bone Remodeling with or without Collagen Filling of the Extraction Socket: A High-Resolution X-ray Tomography Animal Study.

    Covani, Ugo / Giammarinaro, Enrica / Panetta, Daniele / Salvadori, Piero A / Cosola, Saverio / Marconcini, Simone

    Journal of clinical medicine

    2022  Volume 11, Issue 9

    Abstract: The healing process of the tooth extraction socket often leads to significant resorption of the alveolar bone, eventually causing clinical difficulties for future implant-supported rehabilitations. The aim of the present animal study was to evaluate ... ...

    Abstract The healing process of the tooth extraction socket often leads to significant resorption of the alveolar bone, eventually causing clinical difficulties for future implant-supported rehabilitations. The aim of the present animal study was to evaluate alveolar bone remodeling after tooth extraction in a rabbit model, either with or without the use of a plain collagen plug inside the socket, by means of micro-computed tomography. The study included the micro-tomography analysis of 36 rabbits' incisor extraction sockets, either left empty or filled with a collagen plug. All animals were euthanized in a staggered manner, in order to address molecular, histologic, and radiographic analyses at different time-points, up to 90 days after surgery. The three-dimensional evaluation was carried out using micro-computed tomography technology on excised bone blocks including the alveolus and the contralateral bone. Both linear and volumetric measures were recorded: the percentage of bone volume change (ΔBV) within the region of interest was considered the primary endpoint of the study. The micro-CT analysis revealed mean volumetric changes of -58.1% ± from baseline to 3 months for the control group, and almost no bone loss for the test group, -4.6%. The sockets treated with the collagen plug showed significantly less dimensional resorption, while the natural-healing group showed an evident collapse of the alveolar bone three months after extraction surgery.
    Language English
    Publishing date 2022-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11092493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Maternal High-Fat Diet Programs White and Brown Adipose Tissues In Vivo in Mice, with Different Metabolic and Microbiota Patterns in Obesity-Susceptible or Obesity-Resistant Offspring.

    Guzzardi, Maria Angela / Collado, Maria Carmen / Panetta, Daniele / Tripodi, Maria / Iozzo, Patricia

    Metabolites

    2022  Volume 12, Issue 9

    Abstract: Maternal obesity causes metabolic dysfunction in the offspring, including dysbiosis, overeating, obesity, and type 2 diabetes. Early-life phases are fundamental for developing subcutaneous (SAT) and brown adipose tissues (BAT), handling energy excesses. ... ...

    Abstract Maternal obesity causes metabolic dysfunction in the offspring, including dysbiosis, overeating, obesity, and type 2 diabetes. Early-life phases are fundamental for developing subcutaneous (SAT) and brown adipose tissues (BAT), handling energy excesses. Imaging of
    Language English
    Publishing date 2022-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12090828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Computer tomography and magnetic resonance for multimodal imaging of fossils and mummies.

    Giovannetti, Giulio / Guerrini, Andrea / Minozzi, Simona / Panetta, Daniele / Salvadori, Piero A

    Magnetic resonance imaging

    2022  Volume 94, Page(s) 7–17

    Abstract: The study of fossils and mummies has largely benefited from the use of modern noninvasive and nondestructive imaging technologies and represents a fast developing area. In this review, we describe the emerging role of imaging based on Magnetic Resonance ( ...

    Abstract The study of fossils and mummies has largely benefited from the use of modern noninvasive and nondestructive imaging technologies and represents a fast developing area. In this review, we describe the emerging role of imaging based on Magnetic Resonance (MR) and Computer Tomography (CT) employed for the study of ancient remains and mummies. For each methodology, the state of the art in paleoradiology applications is described, by emphasizing new technologies developed in the field of both CT, such as micro- and nano-CT, dual-energy and multi-energy CT, and MR, with the description of novel dedicated sequences, radiofrequency coils and gradients. The complementarity of CT and MR in paleoradiology is also discussed, by pointing out what MR provides in addition to CT, with an overview on the state of the art of emerging strategies in the use of CT/MR combination for the study of a sample following a multimodal integrated approach.
    MeSH term(s) Mummies/diagnostic imaging ; Fossils ; Magnetic Resonance Spectroscopy/methods ; Magnetic Resonance Imaging/methods ; Computers ; Multimodal Imaging
    Language English
    Publishing date 2022-09-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 604885-7
    ISSN 1873-5894 ; 0730-725X
    ISSN (online) 1873-5894
    ISSN 0730-725X
    DOI 10.1016/j.mri.2022.08.019
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  7. Article: Photon-Counting Computed Tomography (PCCT): Technical Background and Cardio-Vascular Applications.

    Meloni, Antonella / Frijia, Francesca / Panetta, Daniele / Degiorgi, Giulia / De Gori, Carmelo / Maffei, Erica / Clemente, Alberto / Positano, Vincenzo / Cademartiri, Filippo

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Photon-counting computed tomography (PCCT) is a new advanced imaging technique that is going to transform the standard clinical use of computed tomography (CT) imaging. Photon-counting detectors resolve the number of photons and the incident X-ray energy ...

    Abstract Photon-counting computed tomography (PCCT) is a new advanced imaging technique that is going to transform the standard clinical use of computed tomography (CT) imaging. Photon-counting detectors resolve the number of photons and the incident X-ray energy spectrum into multiple energy bins. Compared with conventional CT technology, PCCT offers the advantages of improved spatial and contrast resolution, reduction of image noise and artifacts, reduced radiation exposure, and multi-energy/multi-parametric imaging based on the atomic properties of tissues, with the consequent possibility to use different contrast agents and improve quantitative imaging. This narrative review first briefly describes the technical principles and the benefits of photon-counting CT and then provides a synthetic outline of the current literature on its use for vascular imaging.
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13040645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: In Vivo Imaging of Biodegradable Implants and Related Tissue Biomarkers.

    Riehakainen, Leon / Cavallini, Chiara / Armanetti, Paolo / Panetta, Daniele / Caramella, Davide / Menichetti, Luca

    Polymers

    2021  Volume 13, Issue 14

    Abstract: Non-invasive longitudinal imaging of osseointegration of bone implants is essential to ensure a comprehensive, physical and biochemical understanding of the processes related to a successful implant integration and its long-term clinical outcome. This ... ...

    Abstract Non-invasive longitudinal imaging of osseointegration of bone implants is essential to ensure a comprehensive, physical and biochemical understanding of the processes related to a successful implant integration and its long-term clinical outcome. This study critically reviews the present imaging techniques that may play a role to assess the initial stability, bone quality and quantity, associated tissue remodelling dependent on implanted material, implantation site (surrounding tissues and placement depth), and biomarkers that may be targeted. An updated list of biodegradable implant materials that have been reported in the literature, from metal, polymer and ceramic categories, is provided with reference to the use of specific imaging modalities (computed tomography, positron emission tomography, ultrasound, photoacoustic and magnetic resonance imaging) suitable for longitudinal and non-invasive imaging in humans. The advantages and disadvantages of the single imaging modality are discussed with a special focus on preclinical imaging for biodegradable implant research. Indeed, the investigation of a new implant commonly requires histological examination, which is invasive and does not allow longitudinal studies, thus requiring a large number of animals for preclinical testing. For this reason, an update of the multimodal and multi-parametric imaging capabilities will be here presented with a specific focus on modern biomaterial research.
    Language English
    Publishing date 2021-07-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13142348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography.

    Panetta, Daniele / Tollapi, Lara / Paolicchi, Adriana / Marri, Elisa / Aringhieri, Giacomo / Caramella, Davide

    SAGE open medicine

    2021  Volume 9, Page(s) 20503121211059949

    Abstract: Objectives: To investigate microstructural alterations of explanted long-term central venous catheters of totally implantable venous access devices, using micro-computed tomography.: Methods: A total of 16 catheters (9 made of silicone and 7 made of ... ...

    Abstract Objectives: To investigate microstructural alterations of explanted long-term central venous catheters of totally implantable venous access devices, using micro-computed tomography.
    Methods: A total of 16 catheters (9 made of silicone and 7 made of polyurethane), all non-fractured, have been analyzed in this study. Eight catheters were implanted for an average duration of 994 days (min-max: 98-2731 days), while the remaining eight catheters (four for each material, forming the SIref and PUref control groups) were analyzed before implant and used as a reference. X-ray micro-computed tomography was used to reconstruct the three-dimensional geometry of selected segments of each catheter (ca. 10 cm per sample).
    Results: Morphometric analysis of the catheters revealed increases wall thickness and section area in the polyurethane group as compared with the reference central venous catheters of the same materials (wall thickness: 403 ± 12 μm in the polyurethane (PU) group vs 382 ± 4 μm in PUref, p = 0.014; wall cross-section area: 2.04 ± 0.09 mm
    Conclusion: Morphological change and local structural alteration can occur in both silicone and polyurethane catheters. This evidence suggests the need for further studies connecting those morphological changes with modification of mechanical robustness, which ultimately can play a role for patient safety.
    Language English
    Publishing date 2021-12-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/20503121211059949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: FLASH ultra-high dose rates in radiotherapy: preclinical and radiobiological evidence.

    Borghini, Andrea / Vecoli, Cecilia / Labate, Luca / Panetta, Daniele / Andreassi, Maria Grazia / Gizzi, Leonida A

    International journal of radiation biology

    2021  Volume 98, Issue 2, Page(s) 127–135

    Abstract: Purpose: Flash radiotherapy (FLASH-RT) is currently being regarded as the next breakthrough in radiation treatment of cancer, delivering ultrahigh radiation doses in a very short time, and sparing normal tissues from detrimental injury. Here we review ... ...

    Abstract Purpose: Flash radiotherapy (FLASH-RT) is currently being regarded as the next breakthrough in radiation treatment of cancer, delivering ultrahigh radiation doses in a very short time, and sparing normal tissues from detrimental injury. Here we review the current evidence on the preclinical findings as well as the radiobiological mechanisms underlying the FLASH effect. We also briefly examine the scenario of available technologies for delivering FLASH dose-rates for research and their implications for future clinical use.
    Conclusions: Preclinical studies report that the FLASH-RT reduces radiation-induced toxicity whilst maintaining an equivalent tumor response across different animal models. However, the molecular radiobiology underlying FLASH effect is not fully understood and further experiments are necessary to understand the biological response. Future studies also includes the design of a FLASH delivery system able to produce beams appropriate for treatment of tumors with ultra-high dose rates. All these research activities will greatly benefit from a multidisciplinary collaboration across biology, physics and clinical oncology, increasing the potential of a rapid clinical translation of FLASH-RT.
    MeSH term(s) Animals ; Clinical Protocols ; Neoplasms/radiotherapy ; Radiation Oncology ; Radiobiology ; Radiotherapy ; Radiotherapy Dosage
    Language English
    Publishing date 2021-12-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.1080/09553002.2022.2009143
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