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  1. Article ; Online: Compartment Syndrome Secondary to Intraosseous Access Abutting Tibial Stem Cement Mantle of a Total Knee Arthroplasty: A Case Report.

    Chughtai, Morad / Pang, Aaron / Khan, Taiba / Cantrell, William A / Mesko, Nathan W / Kamath, Atul F

    JBJS case connector

    2022  Volume 12, Issue 1

    Abstract: Case: A 79-year-old man 6 days status-post left total knee arthroplasty (TKA) presented to our institution from an outside hospital (OSH) after a suspected STEMI and ventricular fibrillation arrest. At the OSH, intraosseous (IO) access was placed in his ...

    Abstract Case: A 79-year-old man 6 days status-post left total knee arthroplasty (TKA) presented to our institution from an outside hospital (OSH) after a suspected STEMI and ventricular fibrillation arrest. At the OSH, intraosseous (IO) access was placed in his right tibia. Orthopaedics was consulted for compartment syndrome at the IO access site. X-rays demonstrated this was secondary to the IO access abutting the cement mantle of a stemmed tibial component of a remote TKA, for which the patient required emergent fasciotomies.
    Conclusions: Healthcare providers should be cognizant of potential orthopaedic hardware that can impede proper introduction of IO access.
    MeSH term(s) Aged ; Arthroplasty, Replacement, Knee/adverse effects ; Bone Cements/adverse effects ; Compartment Syndromes/etiology ; Compartment Syndromes/surgery ; Humans ; Male ; Radiography ; Tibia/surgery
    Chemical Substances Bone Cements
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e21.00655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Management of Tibial Bone Defects: A Multicenter Experience of Hexapod and Ilizarov Frames.

    Sheridan, Gerard A / Pang, Aaron / Page, Brian J / Greenstein, Michael D / Cardoso, Gracielle S / Amorim, Renato / Rozbruch, S Robert / Fragomen, Austin T

    Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

    2023  Volume 7, Issue 8

    Abstract: Introduction: Bone defects may be managed with bone transport or acute shortening and lengthening using circular external fixation devices. We performed a multicenter retrospective cohort study to compare the outcomes between the Ilizarov frames and ... ...

    Abstract Introduction: Bone defects may be managed with bone transport or acute shortening and lengthening using circular external fixation devices. We performed a multicenter retrospective cohort study to compare the outcomes between the Ilizarov frames and hexapod frames for the management of bone defects.
    Methods: Patients treated for bone defects using either Ilizarov or hexapod frames were included for analysis in two specialist institutions. Primary outcomes were time to consolidation, bone healing index (BHI), and external fixator index (EFI). Radiographic parameters included the medial proximal tibial angle, lateral distal tibial angle, posterior proximal tibial angle, and anterior distal tibial angle.
    Results: There were 137 hexapods and 90 Ilizarov frames in total. The mean time to follow-up was 3.7 years in the hexapod group and 4.0 years in the Ilizarov group. Hexapods had a significantly lower time to consolidation (253 days versus 449 days) (P < 0.0001) and BHI (59.1 days/cm versus 87.5 days/cm) (P < 0.0001). Hexapods had a significantly better EFI (72.3 days/cm versus 96.1 days/cm) (P = 0.0009).
    Conclusion: Hexapods may confer a significant advantage over Ilizarov frames in the management of bone defects. Time to consolidation, radiographic parameters, BHI, and EFI are all superior in hexapods.
    MeSH term(s) Humans ; Ilizarov Technique ; Retrospective Studies ; Tibia/diagnostic imaging ; Tibia/surgery ; Bone Lengthening ; External Fixators
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2898328-2
    ISSN 2474-7661 ; 1067-151X
    ISSN (online) 2474-7661
    ISSN 1067-151X
    DOI 10.5435/JAAOSGlobal-D-23-00033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fixation of displaced intra-articular calcaneus fractures is safe using either sinus tarsi or extensile lateral approach.

    Joseph, Noah M / Sinkler, Margaret A / Magister, Steven / Bacharach, Abigail / Pang, Aaron / Boes, Kirsten / Vallier, Heather A / Hirschfeld, Adam G / Ochenjele, George

    Injury

    2023  

    Abstract: Introduction: Management of displaced intra-articular calcaneus fractures continues to challenge surgeons. Use of the extensile lateral surgical approach (ELA) had been standard practice however wound necrosis and infection have become deterrents. The ... ...

    Abstract Introduction: Management of displaced intra-articular calcaneus fractures continues to challenge surgeons. Use of the extensile lateral surgical approach (ELA) had been standard practice however wound necrosis and infection have become deterrents. The sinus tarsi approach (STA) has gained popularity as a less invasive technique to optimize articular reduction while minimizing soft tissue injury. Our aim was to compare wound complications and infections following calcaneus fractures treated using ELA versus STA.
    Methods: Retrospective review of 139 displaced intra-articular calcaneus fractures (AO/OTA 82C; Sanders II-IV injuries) treated operatively at 2 level-I trauma centers using STA (n = 84) or ELA (n = 55) over a 3-year period with minimum 1-year follow up was performed. Demographic, injury, and treatment-related characteristics were collected. Primary outcomes of interest included wound complications, infection, reoperation, and American Orthopaedic Foot and Ankle Society ankle and hindfoot scores. Univariate comparisons between groups were conducted using Chi-Square, Mann-Whitney, and independent sample t-tests at the p < 0.05 significance level, where appropriate. Multivariable regression analysis was performed to identify risk factors for poor outcomes.
    Results: Demographic characteristics were homogenous between cohorts. Most sustained falls from height (77%). Sanders III fractures were most common (42%). Patients treated with STA went to surgery earlier (6.0 days STA vs 13.2 ELA, p < 0.001). No differences were seen in restoration of Bohler's angle, varus/valgus angle, or calcaneal height, yet the ELA significantly improved calcaneal width (-2 mm STA vs -13.3 mm ELA, p < 0.001). There were no significant differences in wound necrosis or deep infection based on surgical approach (12% STA vs 22% ELA, p = 0.15). Seven patients underwent subtalar arthrodesis for arthrosis (4% STA vs 7% ELA). No differences in AOFAS scores were seen. Risk factors for reoperation included Sanders type IV patterns (OR = 6.6, p = 0.001), increasing BMI (OR = 1.2, p = 0.021), and advanced age (OR = 1.1, p = 0.005), not surgical approach.
    Conclusion: Despite prior concerns, use of ELA versus STA for fixation of displaced intra-articular calcaneus fractures was not associated with more complication risk, illustrating both are safe when indicated and executed appropriately.
    Language English
    Publishing date 2023-02-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2023.02.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Skull base osteomyelitis originating in the middle ear or mastoid: a review of 3 cases.

    Pang, Aaron / Chong, Kevin

    Ear, nose, & throat journal

    2007  Volume 90, Issue 3, Page(s) 121–124

    Abstract: Skull base osteomyelitis is a life-threatening condition that sometimes arises as a sequela of otitis media and mastoiditis. We present a retrospective analysis of the clinical course of 3 patients with skull base osteomyelitis that originated in the ... ...

    Abstract Skull base osteomyelitis is a life-threatening condition that sometimes arises as a sequela of otitis media and mastoiditis. We present a retrospective analysis of the clinical course of 3 patients with skull base osteomyelitis that originated in the middle ear or mastoid. All 3 patients were elderly diabetic men who presented with headache. We review the clinical features, radiologic findings, and culture results in all 3 cases, and we describe the treatment regimens that led to a successful response in all 3 patients.
    MeSH term(s) Aged ; Humans ; Male ; Mastoiditis/complications ; Mastoiditis/diagnosis ; Mastoiditis/therapy ; Osteomyelitis/diagnosis ; Osteomyelitis/etiology ; Osteomyelitis/therapy ; Otitis Media/complications ; Otitis Media/diagnosis ; Otitis Media/therapy ; Skull Base
    Language English
    Publishing date 2007-08-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/014556131109000310
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  5. Article ; Online: Maspin differential expression patterns as a potential marker for targeted screening of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma.

    Dzinic, Sijana H / Mahdi, Zaid / Bernardo, M Margarida / Vranic, Semir / Beydoun, Haya / Nahra, Nadine / Alijagic, Amra / Harajli, Deanna / Pang, Aaron / Saliganan, Dan M / Rahman, Abid M / Skenderi, Faruk / Hasanbegovic, Berisa / Dyson, Gregory / Beydoun, Rafic / Sheng, Shijie

    PloS one

    2019  Volume 14, Issue 4, Page(s) e0215089

    Abstract: Aim: Barrett's esophagus (BE) is a predisposing factor of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma (ECA/GEJ Aca). BE patients are stratified and subsequently monitored according to the risk of malignant progression by the ... ...

    Abstract Aim: Barrett's esophagus (BE) is a predisposing factor of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma (ECA/GEJ Aca). BE patients are stratified and subsequently monitored according to the risk of malignant progression by the combination of endoscopy and biopsy. This study is to evaluate the maspin expression patterns as early diagnostic markers of malignancy in BE patients.
    Materials and methods: Immunohistochemistry (IHC) staining was performed on 62 archival core biopsies from 35 patients, including BE without dysplasia (intestinal metaplasia, IM), BE with low grade dysplasia, BE with high grade dysplasia, carcinoma in situ, and well to poorly differentiated ECA/GEJ Aca (PD-ECA/GEJ Aca). The intensity and the subcellular distribution of immunoreactivity were evaluated microscopically. Statistical analysis was performed using the χ2 and Fisher exact tests.
    Results: The level of epithelial-specific tumor suppressor maspin protein inversely correlated with the progression from IM to PD-ECA/GEJ Aca. Lesions of each pathological grade could be divided into subtypes that exhibited distinct maspin subcellular distribution patterns, including nuclear only (Nuc), combined nuclear and cytoplasmic (Nuc+Cyt), cytoplasmic only (Cyt) and overall negligible (Neg). The Cyt subtype, which was minor in both IM and dysplasia (approximately 10%), was predominant in ECA/GEJ Aca as early as well-differentiated lesions (more than 50%: p = 0.0092). In comparison, nuclear staining of the tumor suppressor TP53 was heterogeneous in dysplasia, and did not correlate with the differentiation grades of ECA/GEJ Aca.
    Conclusion: The Cyt subtype of maspin expression pattern in core biopsies of BE patients may serve as a molecular marker for early diagnosis of ECA/GEJ Aca.
    MeSH term(s) Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Barrett Esophagus/metabolism ; Barrett Esophagus/pathology ; Biomarkers, Tumor/metabolism ; Case-Control Studies ; Disease Progression ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophagogastric Junction/metabolism ; Esophagogastric Junction/pathology ; Esophagus/metabolism ; Esophagus/pathology ; Humans ; Metaplasia/metabolism ; Metaplasia/pathology ; Precancerous Conditions/metabolism ; Precancerous Conditions/pathology ; Serpins/metabolism
    Chemical Substances Biomarkers, Tumor ; SERPIN-B5 ; Serpins
    Language English
    Publishing date 2019-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0215089
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  6. Article ; Online: An Essential Role of

    Dzinic, Sijana H / Bernardo, M Margarida / Li, Xiaohua / Fernandez-Valdivia, Rodrigo / Ho, Ye-Shih / Mi, Qing-Sheng / Bandyopadhyay, Sudeshna / Lonardo, Fulvio / Vranic, Semir / Oliveira, Daniel S M / Bonfil, R Daniel / Dyson, Gregory / Chen, Kang / Omerovic, Almasa / Sheng, Xiujie / Han, Xiang / Wu, Dinghong / Bi, Xinling / Cabaravdic, Dzenana /
    Jakupovic, Una / Wahba, Marian / Pang, Aaron / Harajli, Deanna / Sakr, Wael A / Sheng, Shijie

    Cancer research

    2017  Volume 77, Issue 4, Page(s) 886–896

    Abstract: Maspin (SerpinB5) is an epithelial-specific tumor suppressor gene product that displays context-dependent cellular functions. Maspin-deficient mouse models created to date have not definitively established maspin functions critical for cancer suppression. ...

    Abstract Maspin (SerpinB5) is an epithelial-specific tumor suppressor gene product that displays context-dependent cellular functions. Maspin-deficient mouse models created to date have not definitively established maspin functions critical for cancer suppression. In this study, we generated a mouse strain in which exon 4 of the
    MeSH term(s) Alopecia Areata/etiology ; Animals ; Embryonic Development ; Female ; Histone Deacetylase 1/physiology ; Male ; Mammary Glands, Animal/pathology ; Mice ; Mice, Inbred C57BL ; Organ Specificity ; Prostate/pathology ; Serpins/genetics ; Serpins/physiology ; Tumor Suppressor Proteins/physiology
    Chemical Substances SERPIN-B5 ; Serpins ; Tumor Suppressor Proteins ; Hdac1 protein, mouse (EC 3.5.1.98) ; Histone Deacetylase 1 (EC 3.5.1.98)
    Language English
    Publishing date 2017-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-16-2219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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