Article ; Online: Network Pharmacology and Molecular Docking Analysis on Molecular Targets and Mechanisms of Fei Jin Sheng Formula in the Treatment of Lung Cancer.
2023 Volume 29, Issue 14, Page(s) 1121–1134
Abstract: Background: Fei Jin Sheng Formula (FJSF) is widely used in clinical treatment of lung cancer. But the underlying active ingredients and mechanisms are unclear.: Objective: To investigate the active components and functional mechanisms of FJSF in ... ...
| Abstract | Background: Fei Jin Sheng Formula (FJSF) is widely used in clinical treatment of lung cancer. But the underlying active ingredients and mechanisms are unclear. Objective: To investigate the active components and functional mechanisms of FJSF in treating lung cancer using a network pharmacology approach and molecular docking combined with Results: FJSF contained 272 active ingredients and 52 potential targets for lung cancer. GO enrichment analysis is mainly related to cell migration and movement, lipid metabolism, and protein kinase activity. KEGG pathway enrichment analysis mainly involves PI3K-Akt, TNF, HIF-1, and other pathways. Molecular docking shows that the compound Xambioona, quercetin and methyl palmitate in FJSF has a strong binding ability with NTRK1, APC, and DVL2. Analysis of the data in UCSC to analyze the expression of DVL2 in lung cancer shows that DVL2 was overexpressed in lung adenocarcinoma tissues. Kaplan-Meier analysis shows that the higher DVL2 expression in lung cancer patients was associated with poorer overall survival and poorer survival in stage I patients. It was negatively correlated with the infiltration of various immune cells in the lung cancer microenvironment. Conclusion: FJSF may play a role in inhibiting the occurrence and development of lung cancer by downregulating the expression of DVL2 in A549 cells through its active ingredient Methyl Palmitate. These results provide scientific evidence for further investigations into the role of FJSF and Methyl Palmitate in the treatment of lung cancer. |
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| MeSH term(s) | Humans ; Molecular Docking Simulation ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Lung Neoplasms/drug therapy ; A549 Cells ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Tumor Microenvironment | |||||
| Chemical Substances | Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Drugs, Chinese Herbal | |||||
| Language | English | |||||
| Publishing date | 2023-05-04 | |||||
| Publishing country | United Arab Emirates | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1304236-1 | |||||
| ISSN | 1873-4286 ; 1381-6128 | |||||
| ISSN (online) | 1873-4286 | |||||
| ISSN | 1381-6128 | |||||
| DOI | 10.2174/1381612829666230503164755 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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