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  1. Article ; Online: A commentary on 'Indications for surgical resection of complicated infantile hemangiomas in the β-blocker's era: a single-institution experience from a retrospective cohort study'.

    Chen, Tingting / Ye, Binbin / Xu, Yangxia / Pang, Fuzhen

    International journal of surgery (London, England)

    2023  Volume 109, Issue 12, Page(s) 4389–4390

    MeSH term(s) Humans ; Infant ; Retrospective Studies ; Hemangioma/drug therapy ; Hemangioma/surgery ; Treatment Outcome ; Adrenergic beta-Antagonists/therapeutic use
    Chemical Substances Adrenergic beta-Antagonists
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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  2. Article ; Online: LncRNA FGD5-AS1 Alleviates Inflammation in Allergic Rhinitis through the miR-223-3p/COX11 Axis.

    Li, Binbin / Yu, Xiaoping / Pang, Fuzhen

    International archives of allergy and immunology

    2023  Volume 185, Issue 3, Page(s) 201–211

    Abstract: Introduction: Long noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of allergic rhinitis (AR). The current investigation is focused on elucidating the functional impact of a specific lncRNA, FGD5 antisense RNA 1 (FGD5-AS1), on the ... ...

    Abstract Introduction: Long noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of allergic rhinitis (AR). The current investigation is focused on elucidating the functional impact of a specific lncRNA, FGD5 antisense RNA 1 (FGD5-AS1), on the development and progression of AR through its interaction with miR-223-3p.
    Methods: An experimental framework for AR was constructed in both cellular and animal models. Quantitative assessment of FGD5-AS1, miR-223-3p, and COX11 mRNA expression was conducted using real-time quantitative reverse transcription PCR. The expression of inflammatory factors, immunoglobulin E, LTC4, and ECP, was examined using ELISA. Apoptosis in human nasal epithelial cells was assessed by the flow cytometry method. The protein expression of COX11 was examined using Western blotting. Nasal mucosal function was further evaluated by hematoxylin and eosin staining. Furthermore, bioinformatics evaluations, dual-luciferase reporter assays, and a series of experimental procedures unveiled a putative competitive endogenous RNA regulatory mechanism.
    Results: We found the expression of lncRNA FGD5-AS1 was decreased in AR. In vitro lncRNA FGD5-AS1 attenuated the production of inflammatory cytokines in nasal epithelial cells. Furthermore, elevated FGD5-AS1 expression significantly alleviated AR symptoms by reducing nasal epithelial apoptosis and inflammation. MiR-223-3p was identified as a direct target of FGD5-AS1. Moreover, miRNA-223-3p directly downregulated the expression of COX11 mRNA. Subsequent experiments confirmed that FGD5-AS1 regulated AR through the miR-223-3p/COX11 axis, thereby inhibiting inflammation.
    Conclusion: The FGD5-AS1/miR-223-3p/COX11 axis plays a pivotal role in the pathogenesis of AR, suggesting that FGD5-AS1 could serve as a potential diagnostic biomarker and therapeutic target for AR.
    MeSH term(s) Animals ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Inflammation/genetics ; Rhinitis, Allergic/genetics ; RNA, Messenger ; Cell Proliferation ; Copper Transport Proteins/genetics ; Copper Transport Proteins/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Electron Transport Chain Complex Proteins/genetics ; Electron Transport Chain Complex Proteins/metabolism ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism
    Chemical Substances MicroRNAs ; RNA, Long Noncoding ; RNA, Messenger ; COX11 protein, human ; Copper Transport Proteins ; Mitochondrial Proteins ; Electron Transport Chain Complex Proteins ; FGD5 protein, human ; Guanine Nucleotide Exchange Factors ; MIRN223 microRNA, human
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000534985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: MicroRNA-30a Targets ATG5 and Attenuates Airway Fibrosis in Asthma by Suppressing Autophagy.

    Li, Bin Bin / Chen, Yun Long / Pang, Fuzhen

    Inflammation

    2019  Volume 43, Issue 1, Page(s) 44–53

    Abstract: Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway ... ...

    Abstract Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this study was to examine whether the antifibrotic effect of epithelial microRNAs (miRNAs) relies on regulating autophagy-mediated airway remodeling and to identify the factors involved and the underlying mechanisms. Our results showed miR-30a were downregulated in children with asthma and ovalbumin (OVA) mouse model in parallel with the upregulation of autophagy-related proteins; moreover, we observed miR-30a inhibited the autophagy by downregulated autophagy-related 5 (ATG5). Then, we observed that overexpression of miR-30a suppressed the fibrogenesis and autophagic flux which was stimulated by interleukin-33 (IL-33) in bronchial epithelial cells. In vivo experiments showed that miR-30a overexpression decreased airway remodeling by decreased autophagy. This study uncovered a previously unrecognized antifibrotic role of miR-30a in asthma, in IL-33-induced lung epithelial cells in vitro, and in a murine model of OVA-induced airway inflammation in vivo and explored the underlying mechanisms.
    MeSH term(s) Adolescent ; Airway Remodeling ; Animals ; Asthma/genetics ; Asthma/metabolism ; Asthma/pathology ; Asthma/physiopathology ; Autophagy ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Case-Control Studies ; Cell Line ; Child ; Disease Models, Animal ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Fibrosis ; Humans ; Lung/metabolism ; Lung/pathology ; Lung/physiopathology ; Male ; Mice, Inbred C57BL ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Signal Transduction
    Chemical Substances ATG5 protein, human ; Atg5 protein, mouse ; Autophagy-Related Protein 5 ; MIRN30b microRNA, human ; MicroRNAs ; Mirn30d microRNA, mouse
    Language English
    Publishing date 2019-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 434408-x
    ISSN 1573-2576 ; 0360-3997
    ISSN (online) 1573-2576
    ISSN 0360-3997
    DOI 10.1007/s10753-019-01076-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1401: Show issues Location:
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  4. Article ; Online: Analysis of functionally graded carbon nanotube-reinforced composite structures

    Zhang Hang / Gao Cong / Li Haichao / Pang Fuzhen / Zou Tongda / Wang Hongfu / Wang Na

    Nanotechnology Reviews, Vol 9, Iss 1, Pp 1408-

    A review

    2020  Volume 1426

    Abstract: Functionally graded carbon nanotube-reinforced composite (FG-CNTRC) is a novel nanomaterial; the mechanical behavior of FG-CNRC has become a hot topic in the Materials Science and Engineering Science recently, thanks to its excellent mechanical and ... ...

    Abstract Functionally graded carbon nanotube-reinforced composite (FG-CNTRC) is a novel nanomaterial; the mechanical behavior of FG-CNRC has become a hot topic in the Materials Science and Engineering Science recently, thanks to its excellent mechanical and electrical properties after its fusion with matrix. In this paper, the review efforts for research progress on the modeling and analysis of FG-CNTRC structures are carried out. Firstly, the development background of FG-CNRC is presented, as well as some basic theories and main equations for mechanical analysis of FG-CNTRC structure. Then, the mechanical behaviors of FG-CNTRC beams, plates, and shells under loading conditions are comprehensively reviewed, with the emphasis on discussing the bending, buckling, and vibration behaviors of the structures. Finally, the future research orientation of the field is considered and prospected.
    Keywords carbon nanotubes ; functionally graded ; nanostructures ; composite ; mechanical behaviors ; Technology ; T ; Chemical technology ; TP1-1185 ; Physical and theoretical chemistry ; QD450-801
    Subject code 690
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Application of First-Order Shear Deformation Theory on Vibration Analysis of Stepped Functionally Graded Paraboloidal Shell with General Edge Constraints.

    Pang, Fuzhen / Li, Haichao / Jing, Fengmei / Du, Yuan

    Materials (Basel, Switzerland)

    2018  Volume 12, Issue 1

    Abstract: The paper introduces a semi-analytical approach to analyze free vibration characteristics of stepped functionally graded (FG) paraboloidal shell with general edge conditions. The analytical model is established based on multi-segment partitioning ... ...

    Abstract The paper introduces a semi-analytical approach to analyze free vibration characteristics of stepped functionally graded (FG) paraboloidal shell with general edge conditions. The analytical model is established based on multi-segment partitioning strategy and first-order shear deformation theory. The displacement components along axial direction are represented by Jacobi polynomials, and the Fourier series are utilized to express displacement components in circumferential direction. Based on penalty method about spring stiffness technique, the general edge conditions of doubly curved paraboloidal shell can be easily simulated. The solutions about doubly curved paraboloidal shell were solved by approach of Rayleigh⁻Ritz. Convergence study about boundary parameters, Jacobi parameters et al. are carried out, respectively. The comparison with published literatures, FEM and experiment results show that the present method has good convergence ability and excellent accuracy.
    Language English
    Publishing date 2018-12-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma12010069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: An exact solution for the free-vibration analysis of functionally graded carbon-nanotube-reinforced composite beams with arbitrary boundary conditions.

    Shi, Zeyu / Yao, Xiongliang / Pang, Fuzhen / Wang, Qingshan

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 12909

    Abstract: We present an exact method to model the free vibration of functionally graded carbon-nanotube-reinforced composite (FG-CNTRC) beams with arbitrary boundary conditions based on first-order shear deformation elasticity theory. Five types of carbon nanotube ...

    Abstract We present an exact method to model the free vibration of functionally graded carbon-nanotube-reinforced composite (FG-CNTRC) beams with arbitrary boundary conditions based on first-order shear deformation elasticity theory. Five types of carbon nanotube (CNT) distributions are considered. The distributions are either uniform or functionally graded and are assumed to be continuous through the thickness of the beams. The displacements and rotational components of the beams are expressed as a linear combination of the standard Fourier series and several supplementary functions. The formulation is derived using the modified Fourier series and solved using the strong-form solution and the weak-form solution (i.e., the Rayleigh-Ritz method). Both solutions are applicable to various combinations of boundary constraints, including classical boundary conditions and elastic-supported boundary conditions. The accuracy, efficiency and validity of the two solutions presented are demonstrated via comparison with published results. A parametric study is conducted on the influence of several key parameters, namely, the L/h ratio, CNT volume fraction, CNT distribution, boundary spring stiffness and shear correction factor, on the free vibration of FG-CNTRC beams.
    Language English
    Publishing date 2017-10-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-12596-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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