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  1. Article ; Online: Plasmonic Gold Nanostar-Based Probes with Distance-Dependent Plasmon-Enhanced Fluorescence for Ultrasensitive DNA Methyltransferase Assay.

    Zhao, Tingting / Pang, Xiaozhe / Wang, Congkai / Wang, Lei / Yang, Yifan / Wang, Junqi / Jia, Jiangfei / Liu, Xinxue / Xu, Shenghao / Luo, Xiliang

    Analytical chemistry

    2024  Volume 96, Issue 11, Page(s) 4402–4409

    Abstract: The ultrasensitive DNA methyltransferase (Dam MTase) assay is of high significance for biomedical research and clinical diagnosis because of its profound effect on gene regulation. However, detection sensitivity is still limited by shortcomings, ... ...

    Abstract The ultrasensitive DNA methyltransferase (Dam MTase) assay is of high significance for biomedical research and clinical diagnosis because of its profound effect on gene regulation. However, detection sensitivity is still limited by shortcomings, including photobleaching and weak signal intensities of conventional fluorophores at low concentrations. Plasmonic nanostructures with ultrastrong electromagnetic fields and fluorescence enhancement capability that can overcome these intrinsic defects hold great potential for ultrasensitive bioanalysis. Herein, a silica-coated gold nanostars (Au NSTs@SiO
    MeSH term(s) Site-Specific DNA-Methyltransferase (Adenine-Specific)/analysis ; Silicon Dioxide ; Gold/chemistry ; Biosensing Techniques ; DNA Modification Methylases ; Escherichia coli ; Fluorescent Dyes/chemistry ; DNA ; DNA Probes/chemistry
    Chemical Substances Site-Specific DNA-Methyltransferase (Adenine-Specific) (EC 2.1.1.72) ; Silicon Dioxide (7631-86-9) ; Gold (7440-57-5) ; DNA Modification Methylases (EC 2.1.1.-) ; Fluorescent Dyes ; DNA (9007-49-2) ; DNA Probes
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c04122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Light and endogenous enzyme triggered plasmonic antennas for accurate subcellular molecular imaging with enhanced spatial resolution.

    Chen, Shuwei / Yin, Yue / Pang, Xiaozhe / Wang, Congkai / Wang, Lei / Wang, Junqi / Jia, Jiangfei / Liu, Xinxue / Xu, Shenghao / Luo, Xiliang

    Chemical science

    2023  Volume 15, Issue 2, Page(s) 566–572

    Abstract: Developing accurate tumor-specific molecular imaging approaches holds great potential for evaluating cancer progression. However, traditional molecular imaging approaches still suffer from restricted tumor specificity due to the "off-tumor" signal ... ...

    Abstract Developing accurate tumor-specific molecular imaging approaches holds great potential for evaluating cancer progression. However, traditional molecular imaging approaches still suffer from restricted tumor specificity due to the "off-tumor" signal leakage. In this work, we proposed light and endogenous APE1-triggered plasmonic antennas for accurate tumor-specific subcellular molecular imaging with enhanced spatial resolution. Light activation ensures subcellular molecular imaging and endogenous enzyme activation ensures tumor-specific molecular imaging. In addition, combined with the introduction of plasmon enhanced fluorescence (PEF), off-tumor signal leakage at the subcellular level was effectively reduced, resulting in the significantly enhanced discrimination ratio of tumor/normal cells (∼11.57-fold) which is better than in previous reports, demonstrating great prospects of these plasmonic antennas triggered by light and endogenous enzymes for tumor-specific molecular imaging at the subcellular level.
    Language English
    Publishing date 2023-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc05728c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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