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Article ; Online: A longitudinal study of the COVID-19 pandemic impact on mental health in ophthalmic personnel and students.

Pang, Yi / Robbs, Connor / Wang, Jingyun

2024 Volume 19, Issue 3, Page(s) e0300144

Abstract: Background: Our previous study revealed that the COVID-19 pandemic posed mental health challenges to eye care professionals and students. The intent of this study was to identify the longitudinal impact of the COVID-19 pandemic on mental health among ... ...

Abstract	Background: Our previous study revealed that the COVID-19 pandemic posed mental health challenges to eye care professionals and students. The intent of this study was to identify the longitudinal impact of the COVID-19 pandemic on mental health among ophthalmic personnel and students. Additionally, the potential risk factors for mental health problems were investigated. Methods: A two-phase survey among eye care professionals and students in the USA and Canada was conducted. Phase 1 was administrated from June 23 to July 8, 2020, and has been published; Phase 2 was conducted from January 21 to February 2, 2021. A total of 824 eye care professionals and students participated in Phase 2, with a response rate of 44.1%. Symptoms of depression, anxiety, and stress were measured and calculated. Results: Compared with Phase 1, stress scores in Phase 2 were significantly reduced (P<0.001) although they were still higher than the pre-COVID level (P < .001). Scores for depression (P = 0.20) and anxiety (P = 0.40) showed no change, comparing Phase 2 to Phase 1. Reduction of stress scores significantly differed among occupations (P = 0.005); students had less reduction of stress than other eye care professionals (all P<0.05). Vaccination status was significantly associated with a reduction in stress scores (P = 0.04). Conclusions: With the continuing COVID pandemic, although stress level was reduced at 7-month follow-up, the mental health of eye care professionals was still impacted. In this population, COVID-19 vaccination was associated with fewer stress symptoms. These results indicate that the COVID-19 pandemic continues impacting mental health among eye care professionals, especially students. These study results warrant future interventions for eye care personnel and students to prevent or treat mental health disorders.
MeSH term(s)	Humans ; Pandemics ; Mental Health ; Longitudinal Studies ; COVID-19 Vaccines ; COVID-19/epidemiology ; Students ; Anxiety/epidemiology ; Depression/epidemiology
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300144
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Article: Surgical treatment of secondary hyperparathyroidism combined with Sagliker syndrome caused by chronic renal failure: a case report.

Pang, Yi / Meng, Xiangchao

Gland surgery

2022 Volume 11, Issue 9, Page(s) 1568–1573

Abstract: Background: Sagliker syndrome is caused by severe secondary hyperparathyroidism in hemodialysis patients with chronic renal failure. It is mainly manifested by disturbances of calcium and phosphorus metabolism and bone changes, which eventually lead to ... ...

Abstract	Background: Sagliker syndrome is caused by severe secondary hyperparathyroidism in hemodialysis patients with chronic renal failure. It is mainly manifested by disturbances of calcium and phosphorus metabolism and bone changes, which eventually lead to abnormal changes in facial appearance and morphology, seriously affecting the quality of life of patients. With the improvement of management mode and technology for hemodialysis in chronic renal failure, the incidence of severe secondary hyperparathyroidism related to hemodialysis is relatively reduced. Therefore, Sagliker syndrome is more rare. How to early identify and choose the appropriate treatment for Sagliker syndrome is particularly important. Case description: A 34-year-old female patient with uremia, who underwent regular hemodialysis at the Blood Purification Center of Tianjin Third Central Hospital, developed Sagliker syndrome. The general data, clinical symptoms, height changes, biochemical indicators (serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, hemoglobin, and hematocrit), and parathyroid emission computerized tomography (ECT) were collected and analyzed. The patient had a history of hemodialysis with chronic renal failure for 6 years, and presented with bone pain for 2 years. Laboratory tests showed parathyroid hormone was 2,269 pg/mL and ECT showed 3 parathyroid hyperplasia. Finally, total parathyroidectomy and forearm transplantation were performed. The level of parathyroid hormone was significantly lower than that before the operation. On the first postoperative day, the level of parathyroid hormone decreased to 28.3 pg/mL. Four months later, the bone pain symptoms of the patient were significantly improved compared with those before the operation. Conclusions: Sagliker syndrome is a special syndrome in maintenance hemodialysis patients with refractory secondary hyperparathyroidism. Early monitoring and standardized treatment of secondary hyperparathyroidism may prevent the occurrence of Sagliker syndrome. Early identification and diagnosis of Sagliker syndrome and the choice of appropriate treatment will have an important impact for the prognosis.
Language	English
Publishing date	2022-09-21
Publishing country	China (Republic : 1949- )
Document type	Case Reports
ZDB-ID	3016969-0
ISSN	2227-8575 ; 2227-684X
ISSN (online)	2227-8575
ISSN	2227-684X
DOI	10.21037/gs-22-479
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Article ; Online: Native mass spectrometry analysis of conjugated HSA and BSA complexes with various flavonoids.

Alexander, Nicolas / McDonald, Lucas / Wesdemiotis, Chrys / Pang, Yi

The Analyst

2024 Volume 149, Issue 6, Page(s) 1929–1938

Abstract: Mass spectrometry was used to study the binding interaction between serum albumin proteins (BSA and HSA) and flavone dyes, which is known to induce large fluorescence signals for protein detection. By electrospray ionization mass spectrometry (ESI-MS), ... ...

Abstract	Mass spectrometry was used to study the binding interaction between serum albumin proteins (BSA and HSA) and flavone dyes, which is known to induce large fluorescence signals for protein detection. By electrospray ionization mass spectrometry (ESI-MS), multiple charged species/states could be produced in ammonium acetate buffer, while preserving the native structures of the proteins. Subsequent introduction of a flavone dye into the buffered solution resulted in an immediate interaction, forming the respective protein-dye conjugates associated by non-covalent interactions. Formation of protein-dye conjugates induced a notable response in the ESI-MS spectra, including changes in both the charge states and molecular mass of the protein species. The resulting data pointed out that the protein-flavone dye maintained a 1 : 1 ratio in the conjugate, although multiple binding sites for drug molecules are present in albumin proteins.
MeSH term(s)	Flavonoids ; Spectrometry, Mass, Electrospray Ionization/methods ; Proteins ; Binding Sites ; Flavones
Chemical Substances	Flavonoids ; Proteins ; Flavones
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d3an02070c
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Article ; Online: An NIR-emitting cyanine dye with pyridinium groups: the impact of regio-bond connection on the photophysical properties.

Li, Yonghao / Tuttle, Matthew A / Liu, Qin / Pang, Yi

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 16, Page(s) 2208–2211

Abstract: Two ESIPT-based isomeric cyanines were synthesized with significant bathochromic shift in the optical ... ...

Abstract	Two ESIPT-based isomeric cyanines were synthesized with significant bathochromic shift in the optical absorption
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc06189b
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Article ; Online: Impact of climate change on vegetation patterns in Altay Prefecture, China.

Li, Li / Pang, Yi-Zhi / Sun, Gui-Quan / Ruan, Shigui

Mathematical medicine and biology : a journal of the IMA

2024 Volume 41, Issue 1, Page(s) 53–80

Abstract: Altay Prefecture, a typical arid region in northwestern China, has experienced the climate transition from warming-drying to warming-wetting since 1980s and has attracted widespread attention. Nonetheless, it is still unclear how climate change has ... ...

Abstract	Altay Prefecture, a typical arid region in northwestern China, has experienced the climate transition from warming-drying to warming-wetting since 1980s and has attracted widespread attention. Nonetheless, it is still unclear how climate change has influenced the distribution of vegetation in this region. In this paper, a reaction-diffusion model of the climate-vegetation system is proposed to study the impact of climate change (precipitation, temperature and carbon dioxide concentration) on vegetation patterns in Altay Prefecture. Our results indicate that the tendency of vegetation growth in Altay Prefecture improved gradually from 1985 to 2010. Under the current climate conditions, the increase of precipitation results in the change of vegetation pattern structures, and eventually vegetation coverage tends to be uniform. Moreover, we found that there exists an optimal temperature where the spot vegetation pattern structure remains stable. Furthermore, the increase in carbon dioxide concentration induces vegetation pattern transition. Based on four climate change scenarios of the Coupled Model Intercomparison Project Phase 6 (CMIP6), we used the power law range (PLR) to predict the optimal scenario for the sustainable development of the vegetation ecosystem in Altay Prefecture.
MeSH term(s)	Ecosystem ; Climate Change ; Carbon Dioxide ; China ; Temperature
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2119786-6
ISSN	1477-8602 ; 0265-0746 ; 1477-8599
ISSN (online)	1477-8602
ISSN	0265-0746 ; 1477-8599
DOI	10.1093/imammb/dqae002
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Article ; Online: Convergence insufficiency symptom survey: A tool to evaluate convergence excess in young adults.

Pang, Yi / Gabriel, Helen / Tan, Qing-Qing

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

2023 Volume 43, Issue 4, Page(s) 615–622

Abstract: Purpose: To determine the effectiveness of the Convergence Insufficiency Symptom Survey (CISS) in evaluating visual symptoms in young adults with convergence excess (CE).: Methods: A cross-sectional study was performed based on a population of ... ...

Abstract	Purpose: To determine the effectiveness of the Convergence Insufficiency Symptom Survey (CISS) in evaluating visual symptoms in young adults with convergence excess (CE). Methods: A cross-sectional study was performed based on a population of optometry students. Comprehensive binocular vision tests including cover test, near point of convergence, fusional vergence and accommodative amplitude, were performed. Participants were categorised into three groups: normal binocular vision (NBV), CE and CE + accommodative insufficiency (AI) (i.e., CE + AI). The CISS was administered to each participant. An analysis of variance with Bonferroni correction was performed to compare clinical measures among the three groups. A receiver-operating characteristic (ROC) curve was constructed to evaluate the ability of CISS to differentiate CE from the NBV population. Results: A total of 181 participants were enrolled, including 96 in the NBV group, 66 in the CE group and 19 in the CE + AI group. A significant difference in CISS score was detected between the three groups (p < 0.001). Post-hoc tests showed significantly higher CISS scores in the CE group (16.7 ± 10.8) and the CE + AI group (19.7 ± 10.9) compared with the NBV group (12.2 ± 7.8) (p = 0.01 and p = 0.005, respectively), with no difference between the CE and the CE + AI groups (p = 0.52). The ROC curve showed the CISS poorly (but significantly) differentiated CE from NBV (area under the curve = 0.62, p = 0.01). The optimal cutoff value for a CISS score to differentiate CE was 16, with sensitivity and specificity of 52% and 72%, respectively. Conclusions: Young adults with CE had significantly higher CISS scores than those with NBV. Although using the CISS solely for diagnosing CE is not recommended, it can be used to provide a measure of symptoms in individuals identified as having CE based on clinical measurements.
MeSH term(s)	Humans ; Young Adult ; Cross-Sectional Studies ; Ocular Motility Disorders/diagnosis ; Sensitivity and Specificity ; Surveys and Questionnaires ; ROC Curve ; Vision, Binocular ; Convergence, Ocular ; Accommodation, Ocular
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604564-9
ISSN	1475-1313 ; 0275-5408
ISSN (online)	1475-1313
ISSN	0275-5408
DOI	10.1111/opo.13106
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Article ; Online: Comparison of Cirrus spectral domain OCT with disc-macula distance to disc diameter ratio in diagnosing congenital optic nerve hypoplasia.

Pang, Yi / Frantz, Kelly A / Yin, Huizi Kelly

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

2023 Volume 43, Issue 4, Page(s) 916–921

Abstract: Purpose: Diagnosis of congenital optic nerve hypoplasia (CONH) can be challenging in children or uncooperative individuals. Misdiagnosis can lead to inappropriate treatment; thus, it is important to identify an objective and reliable measurement. The ... ...

Abstract	Purpose: Diagnosis of congenital optic nerve hypoplasia (CONH) can be challenging in children or uncooperative individuals. Misdiagnosis can lead to inappropriate treatment; thus, it is important to identify an objective and reliable measurement. The purpose of this study was to evaluate whether Cirrus spectral domain optical coherence tomography (SD-OCT) is a valid test for diagnosing CONH by comparing it to the disc-macula distance to disc diameter (DM:DD) ratio. Methods: A total of 93 participants (64 controls and 29 CONH) underwent comprehensive eye examinations, fundus photography and Cirrus SD-OCT. Receiver operating characteristic (ROC) curves for the DM:DD ratio and OCT disc area were constructed for CONH and control eyes. Results: Mean (±SD) OCT disc area was 1.46 (±0.42) mm Conclusions: Although the DM:DD ratio is superior to OCT in diagnosing CONH with a higher sensitivity and specificity, the ratio is subject to inter-examiner variability and can be challenging to obtain. We found the Cirrus SD-OCT to be a valid objective test for diagnosing CONH. Caution is advised when using SD-OCT in segmental CONH or in an eye with NLP. We suggest 1.66 mm
MeSH term(s)	Child ; Humans ; Tomography, Optical Coherence/methods ; Optic Nerve Hypoplasia ; Optic Disk ; Macula Lutea ; Diagnostic Techniques, Ophthalmological
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604564-9
ISSN	1475-1313 ; 0275-5408
ISSN (online)	1475-1313
ISSN	0275-5408
DOI	10.1111/opo.13138
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Article ; Online: An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke.

Wang, Junfeng / Liu, Qibing / Li, Yingbo / Pang, Yi

Journal of pharmaceutical analysis

2023 Volume 14, Issue 4, Page(s) 100903

Abstract: A two-photon near infrared (NIR) fluorescence turn-on sensor with high selectivity and sensitivity for ... ...

Abstract	A two-photon near infrared (NIR) fluorescence turn-on sensor with high selectivity and sensitivity for Zn
Language	English
Publishing date	2023-11-29
Publishing country	China
Document type	Journal Article
ZDB-ID	2630174-X
ISSN	2214-0883 ; 2095-1779
ISSN (online)	2214-0883
ISSN	2095-1779
DOI	10.1016/j.jpha.2023.11.010
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Article ; Online: All Gauged Curvature-Squared Supergravities in Five Dimensions.

Gold, Gregory / Hutomo, Jessica / Khandelwal, Saurish / Ozkan, Mehmet / Pang, Yi / Tartaglino-Mazzucchelli, Gabriele

Physical review letters

2024 Volume 131, Issue 25, Page(s) 251603

Abstract: We present a complete basis to study gauged curvature-squared supergravity in five dimensions. We replace the conventional ungauged Riemann-squared action with a new log invariant, offering a comprehensive framework for all gauged curvature-squared ... ...

Abstract	We present a complete basis to study gauged curvature-squared supergravity in five dimensions. We replace the conventional ungauged Riemann-squared action with a new log invariant, offering a comprehensive framework for all gauged curvature-squared supergravities. Our findings address long-standing challenges and have implications for precision tests in the AdS/CFT correspondence.
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.251603
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Article ; Online: Safety and Efficacy of the Modified Vaccinia Ankara-Bavaria Nordic Vaccine Against Mpox in the Real World: Systematic Review and Meta-Analysis.

Pang, Yi / Cao, Demin / Zhu, Xiaoying / Long, Qinqin / Tian, Fengqin / Long, Xidai / Li, Yulei

Viral immunology

2024 Volume 37, Issue 4, Page(s) 216–219

Abstract: In May 2022, mpox began to spread worldwide, posing a serious threat to human public health. Modified Vaccinia Ankara-Bavaria Nordic (MVA-BN) is a live attenuated orthopoxvirus vaccine that has been authorized by the U.S. Food and Drug Administration as ... ...

Abstract	In May 2022, mpox began to spread worldwide, posing a serious threat to human public health. Modified Vaccinia Ankara-Bavaria Nordic (MVA-BN) is a live attenuated orthopoxvirus vaccine that has been authorized by the U.S. Food and Drug Administration as the vaccine of choice for the prevention of mpox. In this study, we conducted a meta-analysis of all currently published literature on the efficacy and safety of the MVA-BN vaccine in the real world, showing that the MVA-BN vaccine is effective and safe, with efficacy of up to 75% with a single dose and up to 80% with a two-dose vaccine. Meanwhile, we found that subcutaneous injection has lower local and systemic adverse events than intradermal injection, regardless of single- or two-dose vaccination, and subcutaneous injection is better tolerated in children, the elderly, or people with underlying medical conditions. These results have important reference value for clinical practice.
MeSH term(s)	Humans ; Vaccine Efficacy ; Vaccines, Attenuated/immunology ; Vaccines, Attenuated/administration & dosage ; Vaccines, Attenuated/adverse effects ; Poxviridae Infections/prevention & control ; Poxviridae Infections/immunology ; Vaccinia virus/immunology ; Vaccinia virus/genetics ; Vaccination ; Injections, Subcutaneous ; Injections, Intradermal ; Viral Vaccines/adverse effects ; Viral Vaccines/immunology ; Viral Vaccines/administration & dosage ; Orthopoxvirus/immunology ; Orthopoxvirus/genetics ; Child
Chemical Substances	Vaccines, Attenuated ; Viral Vaccines
Language	English
Publishing date	2024-05-08
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	639075-4
ISSN	1557-8976 ; 0882-8245
ISSN (online)	1557-8976
ISSN	0882-8245
DOI	10.1089/vim.2023.0147
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