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Article ; Online: Percutaneous Debulking of a Tricuspid Valve Papillary Fibroelastoma: A Rare Presentation and Management Approach.

Zhang, Robert S / Harari, Rafael / Kelly, Sean M / Talmor, Nina / Rhee, Aaron J / Panhwar, Muhammad S / Yee-Chang, Melissa / Nayar, Ambika C / Keller, Norma M / Alviar, Carlos L / Bangalore, Sripal

Circulation. Cardiovascular imaging

2023 Volume 16, Issue 12, Page(s) e015970

MeSH term(s)	Humans ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Cardiac Papillary Fibroelastoma ; Cytoreduction Surgical Procedures ; Echocardiography, Transesophageal ; Fibroma/diagnostic imaging ; Fibroma/surgery
Language	English
Publishing date	2023-12-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2435045-X
ISSN	1942-0080 ; 1941-9651
ISSN (online)	1942-0080
ISSN	1941-9651
DOI	10.1161/CIRCIMAGING.123.015970
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Zs.A 6743: Show issues

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Article ; Online: Waitlist Mortality of Patients With Amyloid Cardiomyopathy who Are Listed for Heart Transplantation and Implications for Organ Allocation.

Panhwar, Muhammad S / Al-Kindi, Sadeer G / Tofovic, David / Oliveira, Guilherme H / Ginwalla, Mahazarin

Journal of cardiac failure

2019 Volume 25, Issue 9, Page(s) 767–771

Abstract: Background: Outcomes of patients with amyloid cardiomyopathy (ACM) undergoing heart transplantation have been reported, but there are scant data concerning the waitlist mortality (WLM) of these patients.: Aim: The aim of this study was to investigate ...

Abstract	Background: Outcomes of patients with amyloid cardiomyopathy (ACM) undergoing heart transplantation have been reported, but there are scant data concerning the waitlist mortality (WLM) of these patients. Aim: The aim of this study was to investigate whether patients with ACM have higher waitlist mortality compared to those with other types of cardiomyopathies. Methods: We queried the United Network for Organ Sharing registry for all patients (age ≥ 18 years) listed for heart transplantation between 2008 and 2015. We compared patients with ACM to those with dilated cardiomyopathy (DCM) or idiopathic restrictive cardiomyopathy (RCM) for WLM and waitlist mortality or delisting for deterioration (WLM/D). We identified 306 patients with ACM, 183 with RCM and 8416 with DCM. Patients with ACM were older (ACM 61 vs RCM 49 vs DCM 51 years, P < .001), were more likely to be male (82% vs 60% vs 73%, P < .001) but less likely to be listed as status 1A (16% vs 18% vs 23%, P< .001). After adjusting for baseline characteristics, ACM was associated with increased risk of mortality and mortality/delisting compared with DCM (HR 2.03 [1.36-3.04], P = .001 for WLM; HR 2.07 [1.55-2.78], P < .001 for WLM/D) but not with other RCMs (HR 1.28 [0.54-3.02], P = .58 for WLM; HR 0.97 [0.56-1.69], P = .91 for WLM/D). Results: Patients with ACM are listed with lower acuity and have higher waitlist mortality compared with those with dilated cardiomyopathies. Further studies are needed to identify whether special prioritization should be considered for patients with ACM listed for heart transplantation.
MeSH term(s)	Amyloidosis/complications ; Cardiomyopathies/complications ; Female ; Heart Failure/etiology ; Heart Failure/mortality ; Heart Failure/physiopathology ; Heart Failure/surgery ; Heart Transplantation/methods ; Humans ; Male ; Middle Aged ; Patient Acuity ; Registries/statistics & numerical data ; Risk Factors ; Tissue and Organ Procurement/methods ; United States ; Waiting Lists/mortality
Language	English
Publishing date	2019-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2019.04.011
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Zs.A 4340: Show issues

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Article ; Online: Successful use of palliative inotrope therapy in end-stage cardiac ATTR amyloidosis.

Panhwar, Muhammad S / Al-Kindi, Sadeer / Oliveira, Guilherme H / Ginwalla, Mahazarin

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

2017 Volume 24, Issue 4, Page(s) 217–218

MeSH term(s)	Aged ; Amyloid Neuropathies, Familial/complications ; Amyloid Neuropathies, Familial/diagnosis ; Amyloid Neuropathies, Familial/drug therapy ; Amyloid Neuropathies, Familial/genetics ; Cardiotonic Agents/administration & dosage ; Heart Failure/complications ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/genetics ; Humans ; Male ; Palliative Care ; Prealbumin/genetics
Chemical Substances	Cardiotonic Agents ; Prealbumin
Language	English
Publishing date	2017-09-03
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1205246-2
ISSN	1744-2818 ; 1350-6129
ISSN (online)	1744-2818
ISSN	1350-6129
DOI	10.1080/13506129.2017.1372412
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Zs.A 4114: Show issues

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Article ; Online: Impact of malnutrition and frailty on mortality and major amputation in patients with CLTI.

Karim, Adham M / Li, Jun / Panhwar, Muhammad S / Arshad, Samiullah / Shalabi, Shihabaldean / Mena-Hurtado, Carlos / Aronow, Herbert D / Secemsky, Eric A / Shishehbor, Mehdi H

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2022 Volume 99, Issue 4, Page(s) 1300–1309

Abstract: Objectives: To understand the prevalence of malnutrition and its association with chronic limb-threatening ischemia (CLTI) outcomes; to clarify the differential impact of revascularization methods on outcomes; to assess the ability of the CLTI Frailty ... ...

Abstract	Objectives: To understand the prevalence of malnutrition and its association with chronic limb-threatening ischemia (CLTI) outcomes; to clarify the differential impact of revascularization methods on outcomes; to assess the ability of the CLTI Frailty Risk Score (CLTI-FRS) to predict adverse events in patients hospitalized with CLTI. Background: Despite advances in the management of CLTI, a majority still undergo major amputation, and a minority heal within 6 months. There is a lack of validated assessment tools for the identification and management of frailty and malnutrition in these patients. Methods: Using the National Inpatient Sample from January 2012 to September 2015, we identified all patients with CLTI using International Classification of Diseases Ninth Edition Clinical Modification codes. The cohort was divided into three groups according to nutritional status. Multivariable regression analysis was used to analyze the interaction between malnutrition and outcomes of interest. Results: Of 1,414,080 CLTI-related hospitalizations, 163,835 (11.6%) were malnourished, 332,855 (23.5%) patients were frail, 917,390 (64.9%) were well-nourished. In-hospital mortality, major amputation, the average length of stay, and hospital costs were highest among malnourished or frail patients and lowest in well-nourished patients (p < 0.001). Malnourished and frail patients were observed to have lower rates of mortality with endovascular revascularization as compared to surgical (adjusted odds ratios: 0.675 [0.533-0.854; p = 0.001]). Conclusion: Many patients with CLTI are malnourished or frail, and this is associated with mortality and amputation. Both malnourished and frail patients were observed to have a mortality benefit with a less invasive approach to revascularization. Better assessment of nutritional and frailty status of CLTI patients may guide therapy and help prevent amputation and death.
MeSH term(s)	Amputation ; Chronic Disease ; Chronic Limb-Threatening Ischemia ; Endovascular Procedures/adverse effects ; Frailty ; Humans ; Ischemia/diagnosis ; Ischemia/surgery ; Limb Salvage ; Malnutrition/diagnosis ; Malnutrition/etiology ; Malnutrition/surgery ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/surgery ; Risk Factors ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30113
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Zs.A 1226: Show issues

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Article ; Online: Epidemiology of Diverticulitis and Prevalence of First-Ever Colorectal Cancer Postdiverticulitis in Adults in the United States: A Population-Based National Study.

Jin-Dominguez, Fangyuan / Mansoor, Emad / Panhwar, Muhammad S / Abou-Saleh, Mohannad / Isenberg, Gerard / Wong, Richard C K / Cooper, Gregory S

Diseases of the colon and rectum

2020 Volume 64, Issue 2, Page(s) 181–189

Abstract: Background: The incidence of acute diverticulitis is increasing, and previous studies showed a wide range of prevalence of colorectal cancer after diverticulitis. There is a lack of high-quality evidence to support performing colonoscopy after ... ...

Abstract	Background: The incidence of acute diverticulitis is increasing, and previous studies showed a wide range of prevalence of colorectal cancer after diverticulitis. There is a lack of high-quality evidence to support performing colonoscopy after diverticulitis. Objective: We aimed to describe the incidence of first-ever diverticulitis and prevalence of first-ever colorectal cancer postdiverticulitis in the United States. Design: This is a retrospective cohort study. Settings: We queried a national database that contains data from 26 major integrated healthcare systems in the United States. Patients: We identified an aggregated patient cohort aged ≥18 years with a diagnosis of first-ever diverticulitis from February 2015 to February 2020, followed by first-ever colorectal cancer diagnosis, at least 1 day after and within 1 year of diverticulitis. Main outcome measures: The incidence of first-ever diverticulitis was calculated. The prevalence and OR of first-ever colorectal cancer after diverticulitis were analyzed. Results: Among 31,778,290 individuals, we found the incidence of first-ever acute diverticulitis to be 2.9%. The prevalence of colorectal cancer within 1 year of first-ever acute diverticulitis was 0.57%, whereas the prevalence of colorectal cancer without a history of diverticulitis was 0.31% (OR = 1.8 (95% CI, 1.76-1.86)). The majority (92.3%) of the postdiverticulitis colorectal cancer were diagnosed within the first 6 months. The risk of colorectal cancer postdiverticulitis was higher in women (OR = 1.9), African Americans (OR = 2.0), and adults aged 18 to 65 years (OR = 2.3). Limitations: We are unable to validate the diagnostic code because patient information in our database is deidentified. Conclusions: Individuals are twice as likely to be diagnosed with colorectal cancer within 1 year of their first episode of acute diverticulitis compared with individuals without diverticulitis. We advocate for colonoscopy after the first occurrence of acute diverticulitis to screen for colorectal cancer, particularly for patients without a recent colonoscopy. See Video Abstract at http://links.lww.com/DCR/B412.
MeSH term(s)	Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Colonoscopy ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Databases, Factual ; Diverticulitis, Colonic/complications ; Diverticulitis, Colonic/epidemiology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Logistic Models ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Risk Factors ; United States/epidemiology ; Young Adult
Language	English
Publishing date	2020-10-07
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	212581-x
ISSN	1530-0358 ; 0012-3706
ISSN (online)	1530-0358
ISSN	0012-3706
DOI	10.1097/DCR.0000000000001837
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Article ; Online: Association of Acute Venous Thromboembolism With In-Hospital Outcomes of Coronary Artery Bypass Graft Surgery.

Panhwar, Muhammad S / Ginwalla, Mahazarin / Kalra, Ankur / Gupta, Tanush / Kolte, Dhaval / Khera, Sahil / Bhatt, Deepak L / Sabik, Joseph F

Journal of the American Heart Association

2019 Volume 8, Issue 19, Page(s) e013246

Abstract: Background While venous thromboembolism (VTE) prophylaxis is a strong recommendation after most surgeries, it is controversial in cardiac surgeries such as coronary artery bypass grafting (CABG), because of perceived low VTE incidence and increased ... ...

Abstract	Background While venous thromboembolism (VTE) prophylaxis is a strong recommendation after most surgeries, it is controversial in cardiac surgeries such as coronary artery bypass grafting (CABG), because of perceived low VTE incidence and increased bleeding risk. Prior studies may not have been adequately powered to study outcomes of VTE in this population. We sought to investigate the postoperative incidence and outcomes of CABG patients using a large national inpatient database. Methods and Results We utilized the 2013 to 2014 National Inpatient Sample to identify all patients >18 years of age who underwent CABG (without concomitant valvular procedures), and had VTE during the hospital stay. We then compared clinically relevant outcomes in patients with and without VTE. We identified 331 950 CABG procedures. Of these, 1.3% (n=4205) had VTE. Patients with VTE were more likely to be older (mean 67.2±10.4 years versus 65.2±10.4 years,
MeSH term(s)	Aged ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/mortality ; Databases, Factual ; Female ; Hospital Costs ; Hospital Mortality ; Humans ; Incidence ; Inpatients ; Length of Stay ; Male ; Middle Aged ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; United States/epidemiology ; Venous Thromboembolism/economics ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/mortality ; Venous Thromboembolism/therapy
Language	English
Publishing date	2019-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.119.013246
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Article ; Online: Effect of Influenza on Outcomes in Patients With Heart Failure.

Panhwar, Muhammad S / Kalra, Ankur / Gupta, Tanush / Kolte, Dhaval / Khera, Sahil / Bhatt, Deepak L / Ginwalla, Mahazarin

JACC. Heart failure

2019 Volume 7, Issue 2, Page(s) 112–117

Abstract: Objectives: This study sought to determine whether influenza infection increases morbidity and mortality in patients hospitalized with heart failure (HF).: Background: Patients with HF may be at increased risk of morbidity and mortality from ... ...

Abstract	Objectives: This study sought to determine whether influenza infection increases morbidity and mortality in patients hospitalized with heart failure (HF). Background: Patients with HF may be at increased risk of morbidity and mortality from influenza infection. However, there are limited data for the associated hazards of influenza infection in patients with HF. Methods: We queried the 2013 to 2014 National Inpatient Sample database for all adult patients (18 years of age or older) admitted with HF with and without concomitant influenza infection. Propensity score matching was used to match patients across age, race, sex, and comorbidities. Outcomes included in-hospital mortality, in-hospital complications, length of stay, and average hospital costs. Results: Of 8,189,119 all-cause hospitalizations in patients with HF, 54,590 (0.67%) had concomitant influenza infection. Patients with concomitant influenza had higher incidence of in-hospital mortality (6.2% vs. 5.4%, respectively; odds ratio [OR]: 1.15 [95% confidence interval [CI]: 1.03 to 1.30]; p = 0.02), acute respiratory failure (36.9% vs. 23.1%, respectively; OR: 1.95 [95% CI: 1.83 to 2.07]; p < 0.001), acute respiratory failure requiring mechanical ventilation (18.2% vs. 11.3%, respectively; OR: 1.75 [95% CI: 1.62 to 1.89]; p < 0.001), acute kidney injury (AKI) (30.3% vs. 28.7%, respectively; OR: 1.08 [95% CI: 1.02 to 1.15]; p = 0.01), and AKI requiring dialysis (2.4% vs. 1.8%, respectively; OR: 1.37 [95% CI: 1.14 to 1.65]; p = 0.001). Patients with influenza had longer mean lengths of stay (5.9 days vs. 5.2 days, respectively; p <0.001) but similar average hospital costs ($12,137 vs. $12,003, respectively; p = 0.40). Conclusions: Influenza infection is associated with increased in-hospital morbidity and mortality in patients with HF. Our results emphasize the need for efforts to mitigate the incidence of influenza, specifically in this high-risk patient cohort.
MeSH term(s)	Aged ; Female ; Follow-Up Studies ; Heart Failure/complications ; Heart Failure/epidemiology ; Hospital Mortality/trends ; Hospitalization/trends ; Humans ; Incidence ; Influenza, Human/complications ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Inpatients ; Male ; Morbidity/trends ; Propensity Score ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; Survival Rate/trends ; United States/epidemiology ; Vaccination/methods
Language	English
Publishing date	2019-01-02
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2018.10.011
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Article ; Online: Influence of Influenza Infection on In-Hospital Acute Myocardial Infarction Outcomes.

Tripathi, Byomesh / Kumar, Varun / Kalra, Ankur / Gupta, Tanush / Sawant, Abhishek C / Sharma, Purnima / Arora, Shilpkumar / Panhwar, Muhammad S / Gopalan, Radha / Deshmukh, Abhishek / Pershad, Ashish / Gulati, Martha / Bhatt, Deepak L

The American journal of cardiology

2020 Volume 130, Page(s) 7–14

Abstract: Influenza is associated with significant morbidity in the United States but its influence on in-hospital outcomes in patients with AMI has not been well studied. The Nationwide Readmission Database (NRD) from 2010 to 2014 was queried using the ... ...

Abstract	Influenza is associated with significant morbidity in the United States but its influence on in-hospital outcomes in patients with AMI has not been well studied. The Nationwide Readmission Database (NRD) from 2010 to 2014 was queried using the International Classification of Diseases-Ninth edition, Clinical Modification (ICD-9-CM) codes to identify all patients ≥18 years who were admitted for AMI with and without concurrent influenza. Propensity score matching was used to adjust patients' baseline characteristics and co-morbidities. In-hospital mortality, 30-day readmission rates, in-hospital complications, and resource utilization were analyzed. We identified a total of 2,428,361 patients admitted with AMI, of whom 3,006 (0.12%) had coexisting influenza. We noted significantly higher in-hospital mortality (7.7% vs 5.6%, p <0.01) and 30-day readmission rates (15.8% vs 14.1%, p <0.01) in patients with influenza compared with those without it. After propensity matching, the differences in in-hospital mortality and 30-day readmission were no longer statistically significant between the groups. Patients with influenza had a higher incidence of acute kidney injury (30.9% vs 24.6%, p <0.01), acute respiratory failure (50.2% vs 32.2%, p <0.01), need for mechanical ventilation (13.9% vs 9.2%, p <0.01), and sepsis (10% vs 3.8%, p <0.01) in the matched cohort. Patients with influenza had longer hospital stays (8.4 days vs 6.4 days, p <0.01) and mean costs of care (26,200USD vs 23,400USD, p <0.01). In conclusion, AMI patients with concomitant influenza infection had higher in-hospital mortality, 30-day readmission, in-hospital complications, and higher resource utilization compared with those without influenza.
MeSH term(s)	Adolescent ; Adult ; Cohort Studies ; Female ; Hospital Mortality ; Humans ; Influenza, Human/complications ; Male ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/mortality ; Patient Readmission/statistics & numerical data ; Young Adult
Language	English
Publishing date	2020-06-07
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2020.05.045
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Article ; Online: Outcomes Among Patients With Heart Failure With Reduced Ejection Fraction Undergoing Transcatheter Aortic Valve Replacement: Minimally Invasive Strategy Versus Conventional Strategy.

Panhwar, Muhammad S / Li, Jun / Zidar, David A / Clevenger, Joshua / Lipinski, Jerry / Patel, Toral R / Karim, Adham / Saric, Petar / Patel, Sandeep M / Kalra, Ankur / Attizzani, Guilherme

The Journal of invasive cardiology

2018 Volume 31, Issue 3, Page(s) 15–20

Abstract: Objectives: To investigate the effect of TAVR technique on in-hospital and 30-day outcomes in patients with aortic stenosis (AS) and reduced ejection fraction (EF).: Background: Patients with AS and concomitant low EF may be at risk for adverse ... ...

Abstract	Objectives: To investigate the effect of TAVR technique on in-hospital and 30-day outcomes in patients with aortic stenosis (AS) and reduced ejection fraction (EF). Background: Patients with AS and concomitant low EF may be at risk for adverse hemodynamic effects from general anesthesia utilized in transcatheter aortic valve replacement (TAVR) via the conventional strategy (CS). These patients may be better suited for the minimally invasive strategy (MIS), which employs conscious sedation. However, data are lacking that compare MIS to CS in patients with AS and concomitant low EF. Methods: In this retrospective study, we identified all patients with low EF (<50%) undergoing transfemoral MIS-TAVR vs CS-TAVR between March 2011 and May 2018. Our primary endpoint was defined as the composite of in-hospital mortality and major periprocedural bleeding or vascular complications. Results: Two hundred and seventy patients had EF <50%, while 154 patients had EF ≤35%. Overall, a total of 236 patients were in the MIS group and 34 were in the CS group. Baseline characteristics between the two groups were similar except for Society of Thoracic Surgeons (STS) score (MIS 8.4 ± 5.1 vs CS 11.7 ± 6.8; P<.01). There were no differences between the two groups in incidence of the primary endpoint (MIS 5.5% vs CS 8.8%; odds ratio for MIS, 0.60; 95% confidence interval, 0.16-2.23; P=.45). Conclusions: In patients with severe AS and reduced EF, MIS was not associated with adverse in-hospital or 30-day clinical outcomes compared with CS. In these patients, MIS may be a suitable alternative to CS without compromising clinical outcomes.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/epidemiology ; Aortic Valve Stenosis/therapy ; Cardiac Catheterization/methods ; Cardiac Output, Low/diagnostic imaging ; Cohort Studies ; Conscious Sedation/methods ; Echocardiography, Transesophageal/methods ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/therapy ; Hospital Mortality ; Humans ; Length of Stay ; Logistic Models ; Male ; Minimally Invasive Surgical Procedures/methods ; Multivariate Analysis ; Prognosis ; Reference Values ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Surgery, Computer-Assisted/methods ; Survival Rate ; Transcatheter Aortic Valve Replacement/methods ; Transcatheter Aortic Valve Replacement/mortality ; Treatment Outcome
Language	English
Publishing date	2018-12-15
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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Zs.A 3701: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism.

Sha, Haibo / Sun, Shengyi / Francisco, Adam B / Ehrhardt, Nicole / Xue, Zhen / Liu, Lei / Lawrence, Peter / Mattijssen, Frits / Guber, Robert D / Panhwar, Muhammad S / Brenna, J Thomas / Shi, Hang / Xue, Bingzhong / Kersten, Sander / Bensadoun, André / Péterfy, Miklós / Long, Qiaoming / Qi, Ling

Cell metabolism

2014 Volume 20, Issue 3, Page(s) 458–470

Abstract: Sel1L is an essential adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum (ER)-associated degradation (ERAD), a universal quality-control system in the cell; but its physiological role remains unclear. Here we show that mice with ... ...

Abstract	Sel1L is an essential adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum (ER)-associated degradation (ERAD), a universal quality-control system in the cell; but its physiological role remains unclear. Here we show that mice with adipocyte-specific Sel1L deficiency are resistant to diet-induced obesity and exhibit postprandial hypertriglyceridemia. Further analyses reveal that Sel1L is indispensable for the secretion of lipoprotein lipase (LPL), independent of its role in Hrd1-mediated ERAD and ER homeostasis. Sel1L physically interacts with and stabilizes the LPL maturation complex consisting of LPL and lipase maturation factor 1 (LMF1). In the absence of Sel1L, LPL is retained in the ER and forms protein aggregates, which are degraded primarily by autophagy. The Sel1L-mediated control of LPL secretion is also seen in other LPL-expressing cell types including cardiac myocytes and macrophages. Thus, our study reports a role of Sel1L in LPL secretion and systemic lipid metabolism.
MeSH term(s)	Adipocytes/metabolism ; Animals ; Cells, Cultured ; Diet, High-Fat/adverse effects ; Endoplasmic Reticulum-Associated Degradation ; Female ; Gene Deletion ; Hyperglycemia/genetics ; Hyperglycemia/metabolism ; Intracellular Signaling Peptides and Proteins ; Lipid Metabolism ; Lipoprotein Lipase/chemistry ; Lipoprotein Lipase/metabolism ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Obesity/etiology ; Obesity/genetics ; Obesity/metabolism ; Protein Aggregates ; Protein Multimerization ; Proteins/genetics ; Proteins/metabolism
Chemical Substances	Intracellular Signaling Peptides and Proteins ; LMF1 protein, mouse ; Membrane Proteins ; Protein Aggregates ; Proteins ; Sel1h protein, mouse ; Lipoprotein Lipase (EC 3.1.1.34)
Language	English
Publishing date	2014-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2014.06.015
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Order via subito

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Order via subito

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In stock of ZB MED Cologne/Königswinter

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito