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  1. Article ; Online: Bacterial histones unveiled.

    Pani, Bibhusita / Nudler, Evgeny

    Nature microbiology

    2023  Volume 8, Issue 11, Page(s) 1939–1941

    MeSH term(s) Histones ; Bacteria ; Immunity, Innate
    Chemical Substances Histones
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01509-5
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  2. Article: Editorial: Novel drug-designing approaches to combat antimicrobial resistance.

    Muteeb, Ghazala / Rehman, Md Tabish / Pani, Bibhusita / Khan, Rizwan Hasan

    Frontiers in molecular biosciences

    2024  Volume 10, Page(s) 1342702

    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1342702
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  3. Article ; Online: Mechanistic insights into transcription coupled DNA repair.

    Pani, Bibhusita / Nudler, Evgeny

    DNA repair

    2017  Volume 56, Page(s) 42–50

    Abstract: Transcription-coupled DNA repair (TCR) acts on lesions in the transcribed strand of active genes. Helix distorting adducts and other forms of DNA damage often interfere with the progression of the transcription apparatus. Prolonged stalling of RNA ... ...

    Abstract Transcription-coupled DNA repair (TCR) acts on lesions in the transcribed strand of active genes. Helix distorting adducts and other forms of DNA damage often interfere with the progression of the transcription apparatus. Prolonged stalling of RNA polymerase can promote genome instability and also induce cell cycle arrest and apoptosis. These generally unfavorable events are counteracted by RNA polymerase-mediated recruitment of specific proteins to the sites of DNA damage to perform TCR and eventually restore transcription. In this perspective we discuss the decision-making process to employ TCR and we elucidate the intricate biochemical pathways leading to TCR in E. coli and human cells.
    MeSH term(s) DNA Repair ; Escherichia coli/genetics ; Humans ; Transcription, Genetic
    Language English
    Publishing date 2017
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2017.06.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5555: Show issues Location:
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  4. Article: Zn-dependent β-amyloid Aggregation and its Reversal by the Tetrapeptide HAEE.

    Mitkevich, Vladimir A / Barykin, Evgeny P / Eremina, Svetlana / Pani, Bibhusita / Katkova-Zhukotskaya, Olga / Polshakov, Vladimir I / Adzhubei, Alexei A / Kozin, Sergey A / Mironov, Alexander S / Makarov, Alexander A / Nudler, Evgeny

    Aging and disease

    2023  Volume 14, Issue 2, Page(s) 309–318

    Abstract: The pathogenesis of Alzheimer's disease (AD) is associated with the formation of cerebral amyloid plaques, the main components of which are the modified Aβ molecules as well as the metal ions. Aβ isomerized at Asp7 residue (isoD7-Aβ) is the most abundant ...

    Abstract The pathogenesis of Alzheimer's disease (AD) is associated with the formation of cerebral amyloid plaques, the main components of which are the modified Aβ molecules as well as the metal ions. Aβ isomerized at Asp7 residue (isoD7-Aβ) is the most abundant isoform in amyloid plaques. We hypothesized that the pathogenic effect of isoD7-Aβ is due to the formation of zinc-dependent oligomers, and that this interaction can be disrupted by the rationally designed tetrapeptide (HAEE). Here, we utilized surface plasmon resonance, nuclear magnetic resonance, and molecular dynamics simulation to demonstrate Zn
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2022.0827
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  5. Article: A Magic Spot in Genome Maintenance.

    Rasouly, Aviram / Pani, Bibhusita / Nudler, Evgeny

    Trends in genetics : TIG

    2017  Volume 33, Issue 1, Page(s) 58–67

    Abstract: Nucleotide excision repair (NER) is the key DNA repair system that eliminates the majority of DNA helix-distorting lesions. RNA polymerase (RNAP) expedites the recognition of DNA damage by NER components via transcription-coupled DNA repair (TCR). In ... ...

    Abstract Nucleotide excision repair (NER) is the key DNA repair system that eliminates the majority of DNA helix-distorting lesions. RNA polymerase (RNAP) expedites the recognition of DNA damage by NER components via transcription-coupled DNA repair (TCR). In bacteria, a modified nucleotide ppGpp ('magic spot') is a pleiotropic second messenger that mediates the response to nutrient deficiencies by altering the initiation properties of RNAP. In this review, we discuss newly elucidated roles of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in transcription elongation that couple this alarmone to DNA damage repair and maintenance.
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2016.11.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2272: Show issues Location:
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  6. Article ; Online: Inhibitors of bacterial H

    Shatalin, Konstantin / Nuthanakanti, Ashok / Kaushik, Abhishek / Shishov, Dmitry / Peselis, Alla / Shamovsky, Ilya / Pani, Bibhusita / Lechpammer, Mirna / Vasilyev, Nikita / Shatalina, Elena / Rebatchouk, Dmitri / Mironov, Alexander / Fedichev, Peter / Serganov, Alexander / Nudler, Evgeny

    Science (New York, N.Y.)

    2023  Volume 372, Issue 6547, Page(s) 1169–1175

    Abstract: Emergent resistance to all clinical antibiotics calls for the next generation of therapeutics. Here we report an effective antimicrobial strategy targeting the bacterial hydrogen sulfide ( ... ...

    Abstract Emergent resistance to all clinical antibiotics calls for the next generation of therapeutics. Here we report an effective antimicrobial strategy targeting the bacterial hydrogen sulfide (H
    MeSH term(s) Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/pharmacology ; Biofilms ; Crystallography, X-Ray ; Cystathionine gamma-Lyase/antagonists & inhibitors ; Cystathionine gamma-Lyase/chemistry ; Cystathionine gamma-Lyase/genetics ; Cystathionine gamma-Lyase/metabolism ; Drug Discovery ; Drug Resistance, Bacterial ; Drug Synergism ; Drug Tolerance ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Hydrogen Sulfide/metabolism ; Mice ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/enzymology ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/growth & development ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/pharmacology ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/enzymology ; Staphylococcus aureus/genetics ; Staphylococcus aureus/growth & development
    Chemical Substances Anti-Bacterial Agents ; Enzyme Inhibitors ; Small Molecule Libraries ; Cystathionine gamma-Lyase (EC 4.4.1.1) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abd8377
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    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 77: Show issues

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  7. Article ; Online: Publisher Correction: Dietary thiols accelerate aging of C. elegans.

    Gusarov, Ivan / Shamovsky, Ilya / Pani, Bibhusita / Gautier, Laurent / Eremina, Svetlana / Katkova-Zhukotskaya, Olga / Mironov, Alexander / Makarov, Alexander А / Nudler, Evgeny

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 7220

    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-27126-6
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  8. Article ; Online: Dietary thiols accelerate aging of C. elegans.

    Gusarov, Ivan / Shamovsky, Ilya / Pani, Bibhusita / Gautier, Laurent / Eremina, Svetlana / Katkova-Zhukotskaya, Olga / Mironov, Alexander / Makarov, Alexander А / Nudler, Evgeny

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 4336

    Abstract: Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species (ROS) are widely believed to promote aging and age-related diseases, and antioxidants can neutralize ROS, it follows that GSH and its precursor, N-acetyl cysteine ( ... ...

    Abstract Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species (ROS) are widely believed to promote aging and age-related diseases, and antioxidants can neutralize ROS, it follows that GSH and its precursor, N-acetyl cysteine (NAC), are among the most popular dietary supplements. However, the long- term effects of GSH or NAC on healthy animals have not been thoroughly investigated. We employed C. elegans to demonstrate that chronic administration of GSH or NAC to young or aged animals perturbs global gene expression, inhibits skn-1-mediated transcription, and accelerates aging. In contrast, limiting the consumption of dietary thiols, including those naturally derived from the microbiota, extended lifespan. Pharmacological GSH restriction activates the unfolded protein response and increases proteotoxic stress resistance in worms and human cells. It is thus advantageous for healthy individuals to avoid excessive dietary antioxidants and, instead, rely on intrinsic GSH biosynthesis, which is fine-tuned to match the cellular redox status and to promote homeostatic ROS signaling.
    MeSH term(s) Acetylcysteine/pharmacology ; Aging/drug effects ; Aging/genetics ; Aging/physiology ; Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/physiology ; Caenorhabditis elegans Proteins/genetics ; DNA-Binding Proteins/genetics ; Dietary Supplements ; Escherichia coli ; Female ; Fibroblasts/metabolism ; Gene Expression Regulation/drug effects ; Glutathione/metabolism ; Glutathione/pharmacology ; Humans ; Male ; Paraquat/pharmacology ; Reactive Oxygen Species/metabolism ; Sulfhydryl Compounds/metabolism ; Transcription Factors/genetics ; Unfolded Protein Response/physiology
    Chemical Substances Caenorhabditis elegans Proteins ; DNA-Binding Proteins ; Reactive Oxygen Species ; Sulfhydryl Compounds ; Transcription Factors ; skn-1 protein, C elegans (148733-36-2) ; Glutathione (GAN16C9B8O) ; Paraquat (PLG39H7695) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2021-07-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-24634-3
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  9. Article: The moonlighting function of bacteriophage P4 capsid protein, Psu, as a transcription antiterminator.

    Ranjan, Amitabh / Banerjee, Ramanuj / Pani, Bibhusita / Sen, Udayditya / Sen, Ranjan

    Bacteriophage

    2013  Volume 3, Issue 2, Page(s) e25657

    Abstract: Psu, a 20-kD bacteriophage P4 capsid decorating protein moonlights as a transcription antiterminator of the Rho-dependent termination. Psu forms specific complex ... ...

    Abstract Psu, a 20-kD bacteriophage P4 capsid decorating protein moonlights as a transcription antiterminator of the Rho-dependent termination. Psu forms specific complex with
    Language English
    Publishing date 2013-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2682433-4
    ISSN 2159-7081 ; 2159-7073
    ISSN (online) 2159-7081
    ISSN 2159-7073
    DOI 10.4161/bact.25657
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  10. Article ; Online: Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials.

    Rasouly, Aviram / Shamovsky, Yosef / Epshtein, Vitaly / Tam, Kayan / Vasilyev, Nikita / Hao, Zhitai / Quarta, Giulio / Pani, Bibhusita / Li, Lingting / Vallin, Carmen / Shamovsky, Ilya / Krishnamurthy, Shankarling / Shtilerman, Aaron / Vantine, Samantha / Torres, Victor J / Nudler, Evgeny

    Nature microbiology

    2021  Volume 6, Issue 11, Page(s) 1410–1423

    Abstract: Mutations in the rifampicin (Rif)-binding site of RNA polymerase (RNAP) confer antibiotic resistance and often have global effects on transcription that compromise fitness and stress tolerance of resistant mutants. We suggested that the non-essential ... ...

    Abstract Mutations in the rifampicin (Rif)-binding site of RNA polymerase (RNAP) confer antibiotic resistance and often have global effects on transcription that compromise fitness and stress tolerance of resistant mutants. We suggested that the non-essential genome, through its impact on the bacterial transcription cycle, may represent an untapped source of targets for combination antimicrobial therapies. Using transposon sequencing, we carried out a genome-wide analysis of fitness cost in a clinically common rpoB H526Y mutant. We find that genes whose products enable increased transcription elongation rates compound the fitness costs of resistance whereas genes whose products function in cell wall synthesis and division mitigate it. We validate our findings by showing that the cell wall synthesis and division defects of rpoB H526Y result from an increased transcription elongation rate that is further exacerbated by the activity of the uracil salvage pathway and unresponsiveness of the mutant RNAP to the alarmone ppGpp. We applied our findings to identify drugs that inhibit more readily rpoB H526Y and other Rif
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/enzymology ; Bacteria/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; DNA-Directed RNA Polymerases/genetics ; DNA-Directed RNA Polymerases/metabolism ; Drug Resistance, Bacterial ; Genome, Bacterial ; Mutation ; Rifampin/pharmacology ; Transcription, Genetic
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; DNA-Directed RNA Polymerases (EC 2.7.7.6) ; Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2021-10-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-021-00973-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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