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  1. Article ; Online: Obituary: neostigmine, the consequences of a premature loss.

    Skurzak, Stefano / Stratta, Chiara / Marzullo, Antonella / Clara, Maria E / Gallo, Mauro / Panio, Angelo

    Minerva anestesiologica

    2022  Volume 88, Issue 3, Page(s) 203–205

    MeSH term(s) Humans ; Neostigmine/therapeutic use
    Chemical Substances Neostigmine (3982TWQ96G)
    Language English
    Publishing date 2022-03-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.21.16288-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 192: Show issues

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  2. Article ; Online: Effects of liver ischemia-reperfusion injury on respiratory mechanics and driving pressure during orthotopic liver transplantation.

    Fanelli, Vito / Costamagna, Andrea / Carosso, Fabio / Rotondo, Giuseppe / Pivetta, Emanuele E / Panio, Angelo / Cappello, Paola / Mazzeo, Anna T / Del Sorbo, Lorenzo / Grasso, Salvatore / Mascia, Luciana / Brazzi, Luca / Romagnoli, Renato / Salizzoni, Mauro / Ranieri, Marco V

    Minerva anestesiologica

    2018  Volume 85, Issue 5, Page(s) 494–504

    Abstract: Background: During orthotopic liver transplantation (OLT), liver graft ischemia-reperfusion injury (IRI) triggers a cytokine-mediated systemic inflammatory response, which impairs graft function and disrupts distal organ homeostasis. The objective of ... ...

    Abstract Background: During orthotopic liver transplantation (OLT), liver graft ischemia-reperfusion injury (IRI) triggers a cytokine-mediated systemic inflammatory response, which impairs graft function and disrupts distal organ homeostasis. The objective of this prospective, observational trial was to assess the effects of IRI on lung and chest wall mechanics in the intraoperative period of patients undergoing OLT.
    Methods: In 26 patients undergoing OLT, we measured elastance of the respiratory system (ERS), partitioned into lung (EL) and chest wall (ECW), hemodynamics, and fluid and blood product intake before laparotomy (T1), after portal/caval surgical clamp (T2), and immediately (T3) and, at 90 and 180 minutes post-reperfusion (T4 and T5, respectively). Interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1), IL-1β and tumor necrosis factor-α plasma concentrations were assessed at T1, T4 and T5.
    Results: EL significantly decreased from T1 to T2 (13.5±4.4 vs 9.7±4.8 cmH2O/L, P<0.05), remained stable at T3, while at T4 (12.3±4.4 cmH2O/L, P<0.05) was well above levels recorded at T2, reaching its highest value at T5 (15±3.9 cmH2O/L, P<0.05). Variations in ERS, EL, driving pressure (∆P) and trans-pulmonary pressure (∆PL) significantly correlated with changes in IL-6 and MCP-1 plasma concentrations, but not with changes in wedge pressure, fluid amounts, and red blood cells and platelets administered. No correlation was found between changes in cytokine concentrations and ECW.
    Conclusions: We found that EL, ECW, ∆P and ∆PL underwent significant variations during the OLT procedure. Further, we documented a significant association between the respiratory mechanics changes and the inflammatory response following liver graft reperfusion.
    MeSH term(s) Cytokines/blood ; Female ; Hemodynamics ; Humans ; Intraoperative Complications/physiopathology ; Laparotomy ; Liver Circulation ; Liver Transplantation ; Lung/physiopathology ; Male ; Middle Aged ; Prospective Studies ; Pulmonary Wedge Pressure ; Reperfusion Injury/physiopathology ; Respiratory Mechanics ; Systemic Inflammatory Response Syndrome/physiopathology ; Thoracic Wall/physiopathology
    Chemical Substances Cytokines
    Language English
    Publishing date 2018-10-30
    Publishing country Italy
    Document type Journal Article ; Observational Study
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.18.12890-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 192: Show issues

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  3. Article: Bacterial- and fungal-positive cultures in organ donors: clinical impact in liver transplantation.

    Cerutti, Elisabetta / Stratta, Chiara / Romagnoli, Renato / Serra, Roberto / Lepore, Mirella / Fop, Fabrizio / Mascia, Luciana / Lupo, Francesco / Franchello, Alessandro / Panio, Angelo / Salizzoni, Mauro

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2006  Volume 12, Issue 8, Page(s) 1253–1259

    Abstract: Infection transmission from donor to recipient is a dreadful complication in transplantation. Although bacteremia was previously detected in 5% of donors without negative impact on recipient outcome, the current expansion of graft pool requires ... ...

    Abstract Infection transmission from donor to recipient is a dreadful complication in transplantation. Although bacteremia was previously detected in 5% of donors without negative impact on recipient outcome, the current expansion of graft pool requires consideration of the infectious risk associated with suboptimal donors. This study aims to evaluate the incidence and risk factors of infection in unselected cadaveric liver donors, the occurrence of microorganism transmission to recipient and its influence on patient survival. Results of microbiologic cultures obtained before harvesting in intensive care unit (ICU) and routinely at harvesting from 610 consecutive liver donors were retrospectively analyzed. Evidence for bacterial and fungal transmission to the recipient was searched for in each culture-positive donor. One or more cultures were positive in 293 donors (48%), while bacteremia was present in 128 (21%). Culture-positive and bacteremic donors were of significantly older age and had longer ICU stays. At multivariate analysis, an ICU stay of 3 or more days was the only significant predictor of donor infection. Although 1-year patient/graft survival rates were not influenced by donor culture positivity, pathogen transmission occurred in 11 cases with high recipient 1-year mortality (45%). In those 11 cases, median donor age was 74 years, significantly much older than that of the other culture-positive donors. In conclusion, donors with a prolonged ICU stay are at increased risk of infection, while older donor age is associated with pathogen transmission to the recipient. Adequate donor maintenance and careful microbiologic surveillance and treatment, especially of elderly donors, may limit transmission of donor infection.
    MeSH term(s) Adolescent ; Adult ; Aged ; Bacterial Infections/transmission ; Body Fluids/microbiology ; Cadaver ; Child ; Child, Preschool ; Communicable Diseases/transmission ; Female ; Humans ; Infant ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Mycoses/transmission ; Organ Preservation Solutions ; Postoperative Complications/microbiology ; Retrospective Studies ; Risk Factors ; Tissue Donors
    Chemical Substances Organ Preservation Solutions
    Language English
    Publishing date 2006-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.20811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4702: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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