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  1. Article ; Online: Neuromorphic functionality of ferroelectric domain walls

    Pankaj Sharma / Jan Seidel

    Neuromorphic Computing and Engineering, Vol 3, Iss 2, p

    2023  Volume 022001

    Abstract: Mimicking and replicating the function of biological synapses with engineered materials is a challenge for the 21st century. The field of neuromorphic computing has recently seen significant developments, and new concepts are being explored. One of these ...

    Abstract Mimicking and replicating the function of biological synapses with engineered materials is a challenge for the 21st century. The field of neuromorphic computing has recently seen significant developments, and new concepts are being explored. One of these approaches uses topological defects, such as domain walls in ferroic materials, especially ferroelectrics, that can naturally be addressed by electric fields to alter and tailor their intrinsic or extrinsic properties and functionality. Here, we review concepts of neuromorphic functionality found in ferroelectric domain walls and give a perspective on future developments and applications in low-energy, agile, brain-inspired electronics and computing.
    Keywords synapses ; topological ; memristor ; solitons ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher IOP Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Time intensity curve in primary solid hepatic lesions

    Vinay Maurya / Pankaj Sharma / Mukul Bhatia

    Medical Journal of Dr. D.Y. Patil Vidyapeeth, Vol 16, Iss 3, Pp 373-

    Does it provide objectivity to otherwise subjective interpretation?

    2023  Volume 380

    Abstract: Aims and Objectives: Magnetic resonance imaging (MRI) is able to characterize the primary solid hepatic lesions well and dynamic contrast enhanced MRI (DCE-MRI) further improves the diagnostic yield. However, the interpretation of enhancement pattern of ... ...

    Abstract Aims and Objectives: Magnetic resonance imaging (MRI) is able to characterize the primary solid hepatic lesions well and dynamic contrast enhanced MRI (DCE-MRI) further improves the diagnostic yield. However, the interpretation of enhancement pattern of a lesion by visual method or eyeballing is quite subjective and is prone to observer error. Time intensity curve (TIC) which plots the signal intensity values in tumor over time provides objectivity in interpretation of DCE-MRI images. Therefore, the aim of this study was to determine the pattern of TIC in primary solid hepatic lesions using DCE-MRI. Method: All cases found to have solid hepatic lesions on ultrasound from January 2017 to December 2018 were included in the study. These cases were subjected to DCE-MRI. Results: Type III-TIC was seen in 30 (93.8%) of cases of hepatocellular carcinoma (HCC), whereas only 2 (6.2%) of cases showed type II curve with χ2 = 43.9848, P < 0.01. Focal Nodular Hyperplasia (FNH) showed type II TIC in 8 (80%) of cases and type III curve in 2 (20%) of cases with χ2 = 34.0052, P < 0.01. Hemangioma showed type I TIC in 14 (93.3%) of cases and type II curve in 1 (6.7%) of cases with χ2 = 44.6185, P < 0.01. Cholangiocarcinoma showed type I TIC, χ2 values could not be determined due to inadequate sample size. Conclusion: TIC provides an objectivity by constructing a time vs signal intensity curve and is less prone to observer error. Therefore, it is recommended that TIC be included in the MRI protocol for evaluating solid hepatic lesions.
    Keywords dynamic cemri ; solid hepatic lesions ; time intensity curve ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Thoracic endovascular aortic repair in stanford Type B* acute aortic dissection

    Manu Gupta / Pankaj Sharma / Chiraag Mandal / Virender Sheorain

    Journal of Medical Evidence, Vol 4, Iss 1, Pp 61-

    2023  Volume 64

    Keywords Medicine ; R
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Markov chain Monte Carlo Gibbs sampler approach for estimating haplotype frequencies among multiple malaria infected human blood samples

    Gie Ken-Dror / Pankaj Sharma

    Malaria Journal, Vol 20, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Abstract Background Malaria patients can have two or more haplotypes in their blood sample making it challenging to identify which haplotypes they carry. In addition, there are challenges in measuring the type and frequency of resistant haplotypes in ... ...

    Abstract Abstract Background Malaria patients can have two or more haplotypes in their blood sample making it challenging to identify which haplotypes they carry. In addition, there are challenges in measuring the type and frequency of resistant haplotypes in populations. This study presents a novel statistical method Gibbs sampler algorithm to investigate this issue. Results The performance of the algorithm is evaluated on simulated datasets consisting of patient blood samples characterized by their multiplicity of infection (MOI) and malaria genotype. The simulation used different resistance allele frequencies (RAF) at each Single Nucleotide Polymorphisms (SNPs) and different limit of detection (LoD) of the SNPs and the MOI. The Gibbs sampler algorithm presents higher accuracy among high LoD of the SNPs or the MOI, validated, and deals with missing MOI compared to previous related statistical approaches. Conclusions The Gibbs sampler algorithm provided robust results when faced with genotyping errors caused by LoDs and functioned well even in the absence of MOI data on individual patients.
    Keywords Haplotype reconstruction ; Multiplicity of infection ; Single nucleotide polymorphisms ; Markov chain Monte Carlo ; Gibbs sampler algorithm ; Malaria ; Arctic medicine. Tropical medicine ; RC955-962 ; Infectious and parasitic diseases ; RC109-216
    Subject code 616
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Percutaneous inferior vena caval filter placement

    Sachin Madaan / Udit Chauhan / Pankaj Sharma

    Journal of Medical Evidence, Vol 3, Iss 3, Pp 288-

    2022  Volume 291

    Keywords Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Innovative Method to Retrieve Misplaced Guidewires Using Guidewires and Balloons

    Udit Chauhan / Pankaj Sharma / Saransh Ahlawat / Mohit Tayal

    Indian Journal of Radiology and Imaging, Vol 32, Iss 01, Pp 124-

    2022  Volume 126

    Abstract: Central venous catheters (CVC) are placed commonly for long-term access in critically ill patients for injecting medicines, including chemotherapy in oncology patients, and for total parenteral nutrition. We herein describe innovative method of snaring ... ...

    Abstract Central venous catheters (CVC) are placed commonly for long-term access in critically ill patients for injecting medicines, including chemotherapy in oncology patients, and for total parenteral nutrition. We herein describe innovative method of snaring two misplaced guidewires using balloons and guidewires.
    Keywords central venous catheters ; guidewires ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: COVID myocardial involvement presenting as left ventricular aneurysm and clot associated with normal coronary anatomy, deep vein thrombosis, and abnormal brachial artery flow-mediated dilatation

    Mohit Tayal / Vandana Dhingra / Pankaj Sharma / Rohit Walia

    Journal of Family Medicine and Primary Care, Vol 11, Iss 5, Pp 2217-

    2022  Volume 2219

    Abstract: A 40-year-old non-diabetic, non-hypertensive male patient presented with complaints of dyspnea of a few days duration and coronavirus -19 disease (COVID) pneumonia. The electrocardiography (ECG) revealed sinus tachycardia with T inversion in V1 only. The ...

    Abstract A 40-year-old non-diabetic, non-hypertensive male patient presented with complaints of dyspnea of a few days duration and coronavirus -19 disease (COVID) pneumonia. The electrocardiography (ECG) revealed sinus tachycardia with T inversion in V1 only. The ECG revealed a left ventricular aneurysm with a clot and severe left ventricular dysfunction. He had deep vein thrombosis involving the left lower leg. The cardiac magnetic resonance imaging revealed a left ventricular posterodorsal aneurysm with a large clot. Computed tomography angiography revealed normal coronaries and no evidence of pulmonary embolism or aortitis. The d-dimer was raised. A brachial artery Doppler revealed severe impairment of flow-mediated dilatation, suggesting endothelial dysfunction. He was stabilized with anti-platelets and anticoagulants, and diuretics.
    Keywords covid-19 ; deep vein thrombosis ; hypercoagulable state ; left ventricular aneurysm ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Therapy-Acquired Clonal Mutations in Thiopurine Drug-Response Genes Drive Majority of Early Relapses in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

    Rozy Thakur / Prateek Bhatia / Minu Singh / Sreejesh Sreedharanunni / Pankaj Sharma / Aditya Singh / Amita Trehan

    Diagnostics, Vol 13, Iss 884, p

    2023  Volume 884

    Abstract: Methods: Forty pediatric (0–12 years) B-ALL DNA samples (20 paired Diagnosis-Relapse) and an additional six B-ALL DNA samples (without relapse at 3 years post treatment), as the non-relapse arm, were retrieved from the biobank for advanced genomic ... ...

    Abstract Methods: Forty pediatric (0–12 years) B-ALL DNA samples (20 paired Diagnosis-Relapse) and an additional six B-ALL DNA samples (without relapse at 3 years post treatment), as the non-relapse arm, were retrieved from the biobank for advanced genomic analysis. Deep sequencing (1050–5000X; mean 1600X) was performed using a custom NGS panel of 74 genes incorporating unique molecular barcodes. Results: A total 47 major clones (>25% VAF) and 188 minor clones were noted in 40 cases after bioinformatic data filtering. Of the forty-seven major clones, eight (17%) were diagnosis-specific, seventeen (36%) were relapse-specific and 11 (23%) were shared. In the control arm, no pathogenic major clone was noted in any of the six samples. The most common clonal evolution pattern observed was therapy-acquired (TA), with 9/20 (45%), followed by M-M, with 5/20 (25%), m-M, with 4/20 (20%) and unclassified (UNC) 2/20 (10%). The TA clonal pattern was predominant in early relapses 7/12 (58%), with 71% (5/7) having major clonal mutations in the NT5C2 or PMS2 gene related to thiopurine-dose response. In addition, 60% (3/5) of these cases were preceded by an initial hit in the epigenetic regulator, KMT2D . Mutations in common relapse-enriched genes comprised 33% of the very early relapses, 50% of the early and 40% of the late relapses. Overall, 14/46 (30%) of the samples showed the hypermutation phenotype, of which the majority (50%) had a TA pattern of relapse. Conclusions: Our study highlights the high frequency of early relapses driven by TA clones, demonstrating the need to identify their early rise during chemotherapy by digital PCR.
    Keywords B-ALL ; deep sequencing ; therapy-acquired ; relapse ; Medicine (General) ; R5-920
    Subject code 572
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Evolution of Mobile Wireless Communication Networks-1G to 5G as well as Future Prospective of Next Generation Communication Network

    Pankaj Sharma

    International Journal of Computer Science and Mobile Computing, Vol 2, Iss 8, Pp 47-

    2013  Volume 53

    Abstract: Mobile communication systems revolutionized the way people communicate. Evolution of wirelessaccess technologies is about to reach its fourth generation (4G) and the 5G mobile networks will focus on thedevelopment of the user terminals where the ... ...

    Abstract Mobile communication systems revolutionized the way people communicate. Evolution of wirelessaccess technologies is about to reach its fourth generation (4G) and the 5G mobile networks will focus on thedevelopment of the user terminals where the terminals will have access to different wireless technologies atthe same time and will combine different flows from different technologies. Looking past, wireless accesstechnologies have followed different evolutionary paths aimed at unified target related to performance andefficiency in high mobile environment. The first generation (1G) has fulfilled the basic mobile voice, whilethe second generation (2G) has introduced capacity and coverage. This is followed by the third generation(3G), which has quest for data at higher speeds to open the gates for truly “mobile broadband” experience,which was further realized by the fourth generation (4G).The Fourth generation (4G) provides access to widerange of telecommunication services, including advanced mobile services, supported by mobile and fixednetworks, which are increasingly packet based, along with a support for low to high mobility applications andwide range of data rates, in accordance with service demands in multiuser environment. Fifth generationshould be more intelligent technology that interconnects the entire world. This article provides a high leveloverview of the Long Term Evolution (LTE) and Worldwide Interoperability for Microwave Access(WiMAX)-the leading technologies for next-generation mobile broadband.
    Keywords Wireless Communication ; ITU ; Networks ; Mobile Broadband ; Generation ; Technology ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Computer Science ; DOAJ:Technology and Engineering
    Subject code 303
    Language English
    Publishing date 2013-08-01T00:00:00Z
    Publisher International Journal of Computer Science and Mobile Computing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Herniation of ureter

    Preeti Gupta / Pankaj Sharma / Vinay Maurya / Mukul Bhatia

    The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

    a rare cause of hydroureteronephrosis

    2021  Volume 4

    Abstract: Abstract Background Omentum and bowel loops are commonly seen in inguinal hernia. An unusual case of extraperitoneal herniation of ureter was detected in hernial sac with other contents, on computed tomography (CT) urography. Case presentation A 54-year- ... ...

    Abstract Abstract Background Omentum and bowel loops are commonly seen in inguinal hernia. An unusual case of extraperitoneal herniation of ureter was detected in hernial sac with other contents, on computed tomography (CT) urography. Case presentation A 54-year-old male presented with inguinal hernia, with no previous history of surgery or trauma. Pre-operative screening showed a unilateral hydroureteronephrosis involving the pelvicalyceal system and entire ureter. No calculus was visualized in the ureter on ultrasound. On non-contrast CT (NCCT) followed by CT urography, the ureter was seen descending into the hernia sac causing hydroureteronephrosis. The patient subsequently underwent mesh repair surgery of the inguinal hernia with meticulous reduction of the herniated contents including the ureter, resulting in complete resolution of the hydroureteronephrosis. Conclusion An isolated extraperitoneal inguinal herniation of the ureter without concomitant urinary bladder involvement is extremely rare, especially with no prior history of trauma or surgery, as seen in our case. The case also exemplifies the role of pre-operative imaging as a protocol in cases of inguinal hernia to prevent per-operative complications.
    Keywords Ureter ; Inguinal ; Hernia ; CT urography ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 616
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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