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Artikel ; Online: HIV RNA/DNA Levels at Diagnosis Can Predict Immune Reconstitution

Dimitrios Basoulis / Nikos Pantazis / Dimitrios Paraskevis / Panos Iliopoulos / Martha Papadopoulou / Karolina Akinosoglou / Angelos Hatzakis / George L. Daikos / Mina Psichogiou

Microorganisms, Vol 11, Iss 1510, p

A Longitudinal Analysis

2023  Band 1510

Abstract: Background: HIV DNA mirrors the number of infected cells and the size of the HIV viral reservoir. The aim of this study was to evaluate the effect of pre-cART HIV DNA levels as a predictive marker of immune reconstitution and on the post-cART CD4 counts ... ...

Abstract Background: HIV DNA mirrors the number of infected cells and the size of the HIV viral reservoir. The aim of this study was to evaluate the effect of pre-cART HIV DNA levels as a predictive marker of immune reconstitution and on the post-cART CD4 counts trends. Methods: HIV DNA was isolated from PBMCs and quantified by real-time PCR. Immune reconstitution was assessed up to four years. Piecewise-linear mixed models were used to describe CD4 count changes. Results: 148 people living with HIV (PLWH) were included. The highest rate of immune reconstitution was observed during the first trimester. There was a trend showing that high HIV RNA level resulted in greater increase in CD4 count, especially during the first trimester of cART (difference above vs. below median 15.1 cells/μL/month; 95% CI −1.4–31.5; p = 0.073). Likewise, higher HIV DNA level would predict greater CD4 increases, especially after the first trimester (difference above vs. below median 1.2 cells/μL/month; 95% CI −0.1–2.6; p = 0.071). Higher DNA and RNA levels combined were significantly associated with greater CD4 increase past the first trimester (difference high/high vs. low/low 2.1 cells/μL/month; 95% CI 0.3–4.0; p = 0.024). In multivariable analysis, lower baseline CD4 counts predicted a greater CD4 rise. Conclusions: In successfully treated PLWH, pre-cART HIV DNA and HIV RNA levels are predictors of immune reconstitution.
Schlagwörter HIV DNA ; immune reconstitution ; viral latency ; Biology (General) ; QH301-705.5
Thema/Rubrik (Code) 570
Sprache Englisch
Erscheinungsdatum 2023-06-01T00:00:00Z
Verlag MDPI AG
Dokumenttyp Artikel ; Online
Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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