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  1. Book ; Online: Zur vergleichenden Anatomie und Physiologie des Gleichgewichts- und Gehörorganes

    Panse, Rudolf

    (Bibliothek niederrheinischer Verein - Gesundheitspflege)

    2020  

    Author's details von Dr. Rudolf Panse, Ohrenarzt in Dresden-Neustadt, Oberarzt am Diakonissenhaus
    Series title Bibliothek niederrheinischer Verein - Gesundheitspflege
    Language German
    Size 1 Online-Ressource (Seite [185]- 236), Illustrationen
    Publisher ZB MED - Informationszentrum Lebenswissenschaften
    Publishing place Köln
    Publishing country XA-DXDE
    Document type Book ; Online
    HBZ-ID CT002017697
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book ; Online: Die sogenannte Sklerose des Mittelohres

    Panse, Rudolf

    (Bibliothek niederrheinischer Verein - Gesundheitspflege)

    2020  

    Author's details von Dr. Rudolf Panse, Ohrenarzt in Dresden-Neustadt
    Series title Bibliothek niederrheinischer Verein - Gesundheitspflege
    Language German
    Size 1 Online-Ressource (Seite [407]-432)
    Publisher ZB MED - Informationszentrum Lebenswissenschaften
    Publishing place Köln
    Publishing country XA-DXDE
    Document type Book ; Online
    HBZ-ID CT002017691
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Das Cholesteatom des Ohres

    Panse, Rudolf

    (Bibliothek niederrheinischer Verein - Gesundheitspflege)

    2020  

    Author's details von Dr. Rudolf Panse, Ohrenarzt in Dresden-Neustadt
    Series title Bibliothek niederrheinischer Verein - Gesundheitspflege
    Language German
    Size 1 Online-Ressource (Seite [75]-94)
    Publisher ZB MED - Informationszentrum Lebenswissenschaften
    Publishing place Köln
    Publishing country XA-DXDE
    Document type Book ; Online
    HBZ-ID CT002017683
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Book ; Online: Advances in Autoimmune Myasthenia Gravis

    Le Panse, Rozen / Kusner, Linda L. / Berrih-Aknin, Sonia / Rostedt Punga, Anna

    2020  

    Keywords Medicine ; Immunology ; autoantibodies ; CD4 T cells ; thymus ; therapy ; miRNA
    Size 1 electronic resource (205 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230922
    ISBN 9782889661077 ; 2889661075
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Comment on "Detecting Key Genes Regulated by miRNAs in Dysfunctional Crosstalk Pathway of Myasthenia Gravis".

    Le Panse, Rozen

    BioMed research international

    2017  Volume 2017, Page(s) 6950308

    MeSH term(s) Cell Physiological Phenomena ; Humans ; MicroRNAs/genetics ; Myasthenia Gravis
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2017-02-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2017/6950308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: New Pathways and Therapeutic Targets in Autoimmune Myasthenia Gravis.

    Behin, Anthony / Le Panse, Rozen

    Journal of neuromuscular diseases

    2018  Volume 5, Issue 3, Page(s) 265–277

    Abstract: Acquired Myasthenia Gravis (MG) is a neuromuscular disease caused by autoantibodies against components of the neuromuscular junction. It is a prototype organ-specific autoimmune disease with well-defined antigenic targets mainly the nicotinic ... ...

    Abstract Acquired Myasthenia Gravis (MG) is a neuromuscular disease caused by autoantibodies against components of the neuromuscular junction. It is a prototype organ-specific autoimmune disease with well-defined antigenic targets mainly the nicotinic acetylcholine receptor (AChR). Patients suffer from fluctuating, fatigable muscle weakness that worsens with activity and improves with rest.Various therapeutic strategies have been used over the years to alleviate MG symptoms. These strategies aim at improving the transmission of the nerve impulse to muscle or at lowering the immune system with steroids or immunosuppressant drugs. Nevertheless, MG remains a chronic disease and symptoms tend to persist in many patients, some being or becoming refractory over time. In this review, based on recent experimental data on MG or based on results from clinical trials for other autoimmune diseases, we explore new potential therapeutic approaches for MG patients, going from non-specific approaches with the use of stem cells with their anti-inflammatory and immunosuppressive properties to targeted therapies using monoclonal antibodies specific for cell-surface antigens or circulating molecules.
    MeSH term(s) Animals ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/physiopathology ; Autoimmune Diseases/therapy ; Humans ; Myasthenia Gravis/drug therapy ; Myasthenia Gravis/physiopathology ; Myasthenia Gravis/therapy ; Receptors, Nicotinic/drug effects ; Synaptic Transmission
    Chemical Substances Receptors, Nicotinic
    Language English
    Publishing date 2018-07-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2214-3599
    ISSN 2214-3599
    DOI 10.3233/JND-170294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders.

    Huijbers, Maartje G / Marx, Alexander / Plomp, Jaap J / Le Panse, Rozen / Phillips, William D

    The Lancet. Neurology

    2022  Volume 21, Issue 2, Page(s) 163–175

    Abstract: Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction disorders. Although a plethora of immunosuppressive treatments exist, no cure is available to date and many patients are left with debilitating muscle weakness. Recent ... ...

    Abstract Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction disorders. Although a plethora of immunosuppressive treatments exist, no cure is available to date and many patients are left with debilitating muscle weakness. Recent advances in the understanding of the structure and function of the neuromuscular junction, and the development of novel in vitro and in vivo models, have been instrumental in unravelling the pathophysiology of these autoimmune diseases. These advances are providing the rationale for the development of new therapeutic strategies. Restoration of the immune imbalance in these diseases, in parallel with symptomatic therapeutic approaches at the neuromuscular junction, will be crucial to obtain long-term remission or even cure.
    MeSH term(s) Humans ; Neuromuscular Junction ; Neuromuscular Junction Diseases
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(21)00357-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5955: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Thymectomy in myasthenia gravis: when, why, and how?

    Berrih-Aknin, Sonia / Le Panse, Rozen

    The Lancet. Neurology

    2019  Volume 18, Issue 3, Page(s) 225–226

    MeSH term(s) Humans ; Myasthenia Gravis ; Prednisone ; Scorpion Venoms ; Thymectomy
    Chemical Substances Scorpion Venoms ; margatoxin (6197NL836C) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2019-01-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(18)30467-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Role of miRNAs in Normal and Myasthenia Gravis Thymus.

    Cron, Mélanie A / Guillochon, Émilie / Kusner, Linda / Le Panse, Rozen

    Frontiers in immunology

    2020  Volume 11, Page(s) 1074

    Abstract: The thymus, a primary lymphoid organ, provides a complex environment essential for the generation of the T-cell repertoire. Thymic alterations occur during life either in the context of thymic involution upon aging or the pathophysiological context of ... ...

    Abstract The thymus, a primary lymphoid organ, provides a complex environment essential for the generation of the T-cell repertoire. Thymic alterations occur during life either in the context of thymic involution upon aging or the pathophysiological context of Myasthenia Gravis (MG). These changes involve complicated regulatory networks, in which microRNAs (miRNAs) are key players. Here, we analyzed the role of miRNAs in thymocyte maturation and differentiation sustained by thymic epithelial cells. We compared data from the literature regarding the role of mouse thymic miRNAs and original data obtained from a human thymic miRnome study. We identified a set of highly expressed miRNAs defined as ThymiRs and investigated miRNA expression in infants as compared to adults to determine those associated with human thymic involution. Thymic changes are also frequently observed in MG, an autoimmune disease which results in the production of anti-acetylcholine receptor (AChR) antibodies that lead to muscle weaknesses. Alterations such as thymoma in late-onset MG patients and hyperplasia with ectopic germinal centers (GCs) in early-onset (EOMG) patients are found. Thymic miRNA expression has been studied in AChR-MG patients both in thymoma-associated MG (TAMG) and EOMG, and their function through their mRNA targets investigated. Most of the dysregulated thymic miRNAs in EOMG are associated with GC development, such as miR-7, miR-24, miR-139, miR-143, miR-145, miR-146, miR-150, miR-452, miR-548 or thymic inflammation, such as miR-125b, miR-146, or miR-29. Understanding these pathways may provide therapeutic targets or biomarkers of disease manifestations.
    MeSH term(s) Aging/genetics ; Aging/immunology ; Animals ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Gene Expression Profiling ; Humans ; Mice ; MicroRNAs/genetics ; MicroRNAs/immunology ; Myasthenia Gravis/genetics ; Myasthenia Gravis/immunology ; Myasthenia Gravis/pathology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Thymoma/genetics ; Thymoma/immunology ; Thymoma/pathology ; Thymus Gland/immunology ; Thymus Gland/metabolism ; Thymus Gland/pathology ; Thymus Neoplasms/genetics ; Thymus Neoplasms/immunology ; Thymus Neoplasms/pathology
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2020-06-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Comparative Bio-efficacy of Various Insecticides against Thrips tabaci (Lindeman) on Onion

    Panse, Raju

    Pesticide research journal. 2012 Dec., v. 24, no. 2

    2012  

    Abstract: Onion thrips (Thrips tabaci L.) is a serious pest of onion crop, which causes economical loss if the crop is infested at an early stage. The field experiments were conducted during 2009–10 and 2010–11 at Vegetable Research Farm, JNKVV, Jabalpur, MP to ... ...

    Abstract Onion thrips (Thrips tabaci L.) is a serious pest of onion crop, which causes economical loss if the crop is infested at an early stage. The field experiments were conducted during 2009–10 and 2010–11 at Vegetable Research Farm, JNKVV, Jabalpur, MP to evaluate the bio-efficacy of six insecticides viz., Profenofos, Dimethoate, Quinolphos, Carbaryl, Deltamethrin, and Phosphomidan against onion thrips. Deltamethrin 2.8 EC, 0.01% (8.46 thrips/plant) was found to be the superior treatment in reducing the incidence of Thrips tabaci followed by Profenofos 50 EC, 0.2% (10.58 thrips/plant). The highest marketable yield (289.92 q/ha) was obtained in the plot treated with Deltamethrin followed by Profenofos (278.75 q/ha). The highest cost benefit ratio (1:42.44) and yield increase over control (67.53%) was obtained from Deltamethrin treated plot followed by Profenofos (1:33.64 and 61.08%).
    Keywords Thrips tabaci ; carbaryl ; cost benefit analysis ; deltamethrin ; dimethoate ; farms ; field experimentation ; incidence ; onions ; pests ; profenofos ; research ; yields
    Language English
    Dates of publication 2012-12
    Size p. 227-230.
    Publishing place Society of Pesticide Science India
    Document type Article
    Note NAL-light
    ISSN 2249-524X
    Database NAL-Catalogue (AGRICOLA)

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