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Article ; Online: Effect of Unloading Condition on the Healing Process and Effectiveness of Platelet Rich Plasma as a Countermeasure: Study on In Vivo and In Vitro Wound Healing Models.

Cialdai, Francesca / Colciago, Alessandra / Pantalone, Desiré / Rizzo, Angela Maria / Zava, Stefania / Morbidelli, Lucia / Celotti, Fabio / Bani, Daniele / Monici, Monica

International journal of molecular sciences

2020 Volume 21, Issue 2

Abstract: Wound healing is a very complex process that allows organisms to survive injuries. It is strictly regulated by a number of biochemical and physical factors, mechanical forces included. Studying wound healing in space is interesting for two main reasons: ( ...

Abstract	Wound healing is a very complex process that allows organisms to survive injuries. It is strictly regulated by a number of biochemical and physical factors, mechanical forces included. Studying wound healing in space is interesting for two main reasons: (i) defining tools, procedures, and protocols to manage serious wounds and burns eventually occurring in future long-lasting space exploration missions, without the possibility of timely medical evacuation to Earth; (ii) understanding the role of gravity and mechanical factors in the healing process and scarring, thus contributing to unravelling the mechanisms underlying the switching between perfect regeneration and imperfect repair with scarring. In the study presented here, a new in vivo sutured wound healing model in the leech (
MeSH term(s)	Animals ; Cell Count ; Cell Movement/genetics ; Collagen/metabolism ; Elasticity ; Gene Expression Regulation ; Leeches/physiology ; Mice ; Models, Biological ; NIH 3T3 Cells ; Platelet-Rich Plasma/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Weightlessness ; Wound Healing
Chemical Substances	Vascular Endothelial Growth Factor A ; Collagen (9007-34-5)
Language	English
Publishing date	2020-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21020407
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Article ; Online: The role of bed-side laparoscopy in the management of acute mesenteric ischemia of recent onset in post-cardiac surgery patients admitted to ICU.

Bergamini, Carlo / Alemanno, Giovanni / Giordano, Alessio / Pantalone, Desiré / Fontani, Giovanni / Di Bella, Anna Maria / Iacopini, Veronica / Prosperi, Paolo / Martellucci, Jacopo

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2020 Volume 48, Issue 1, Page(s) 87–96

Abstract: Purpose: Acute mesenteric ischemia with non-occlusive mechanism (NOMI) is a possible complication after cardiac surgery in patients admitted to Intensive Care Unit (ICU). Since the diagnosis is often difficult with CT-scan, some authors have evaluated ... ...

Abstract	Purpose: Acute mesenteric ischemia with non-occlusive mechanism (NOMI) is a possible complication after cardiac surgery in patients admitted to Intensive Care Unit (ICU). Since the diagnosis is often difficult with CT-scan, some authors have evaluated the role of bed-side diagnostic laparoscopy (DL). We aimed to contribute to this topic with a personal series. Methods: We retrospectively evaluated patients admitted to ICU after cardiac surgery since 2009 up to 2019, successively operated on for a suspected NOMI of recent onset with non-conclusive CT. They were divided into laparoscopic (Ls) and laparotomic (Lt) group, depending on whether or not they had a DL. They were compared for the CT false-positive (FP) and true-positive (TP) rate and the surgical outcome. Results: Seventy-three patients were enrolled. Lt included 30 patients (41%), Ls 43 (59%). The overall FP were 38 (52%), with a higher incidence in Ls. There was no difference in the mortality rate. The morbidity rate was higher in Lt, and especially in Lt-FP. The TP were 35 (47.9%). The mean operating time (OT) in the Lt-TP group was similar to the sum of the mean OT of the laparotomies plus that of the laparoscopies in the Ls-TP group. Conversely, when considering only laparotomic procedures, the Lt-TP had higher mean OT, such as an increased blood loss CONCLUSIONS: Post-cardiosurgical patients admitted to ICU have a relatively high rate of NOMI, in which CT-scan is often initially non-conclusive. Our data and those from the literature seem to show that in such cases bed-side DL may be an advantageous and safe procedure to avoid needless laparotomy and enables a more tailored open surgery.
MeSH term(s)	Cardiac Surgical Procedures ; Humans ; Intensive Care Units ; Ischemia ; Laparoscopy ; Mesenteric Ischemia/diagnostic imaging ; Mesenteric Ischemia/surgery ; Retrospective Studies
Language	English
Publishing date	2020-09-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-020-01500-3
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Article ; Online: Emergency surgery in the time of Coronavirus: the pandemic effect.

Martellucci, Jacopo / Damigella, Andrea / Bergamini, Carlo / Alemanno, Giovanni / Pantalone, Desirè / Coratti, Andrea / Muiesan, Paolo / Cianchi, Fabio / Prosperi, Paolo

Minerva surgery

2020 Volume 76, Issue 4, Page(s) 382–387

Abstract: Background: The COVID-19 epidemic became a challenge for Emergency Departments (ED) and a remarkable reduction in surgical emergencies has been widely noticed. The aim of the present study was to evaluate the impact of the pandemic period in the need of ...

Abstract	Background: The COVID-19 epidemic became a challenge for Emergency Departments (ED) and a remarkable reduction in surgical emergencies has been widely noticed. The aim of the present study was to evaluate the impact of the pandemic period in the need of surgical emergencies. Methods: Between January 1, and May 31, 2020 all the consecutive general surgery emergencies performed by the Unit Hospital Emergency Surgery of the Careggi University (Florence, Italy) were prospectively recorded and compared to the same period of 2019. Demographic and clinical data were recorded and analyzed. Results: The number of surgical procedures decreased only in the month of March 2020 (compared to 2019), while in April the total numer of emergency surgical procedures was similar. Only appendectomy, complicated hernia repair and colonic resection were significantly reduced (40%, 48% and 33% respectively). The number of small intestine excision, cholecystectomy and lysis of peritoneal adhesions remained stable throughout the entire period. No statistically significant differences were found considering age, sex, Emergency Surgery Score, mortality, ICU postoperative admission and time between admission and surgery, even when analyzed with multivariate analysis for every single surgical procedure, suggesting a comparable disease severity and comorbility patterns. Mortality in COVID patients was 25%, compared to 7% of no-covid patients. Conclusions: The COVID-19 pandemic has caused major changes in daily clinical practice, especially in areas such as Emergency. This has led to a temporary reduction and changes in the flow of patients to the emergency room, with implications also for emergency surgical activities.
MeSH term(s)	COVID-19 ; Emergencies ; Emergency Service, Hospital ; Humans ; Pandemics ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-11
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3067899-7
ISSN	2724-5438
ISSN (online)	2724-5438
DOI	10.23736/S2724-5691.20.08545-4
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Article: Robot-assisted surgery in space: pros and cons. A review from the surgeon's point of view.

Pantalone, Desirè / Faini, Giulia Satu / Cialdai, Francesca / Sereni, Elettra / Bacci, Stefano / Bani, Daniele / Bernini, Marco / Pratesi, Carlo / Stefàno, PierLuigi / Orzalesi, Lorenzo / Balsamo, Michele / Zolesi, Valfredo / Monici, Monica

NPJ microgravity

2021 Volume 7, Issue 1, Page(s) 56

Abstract: The target of human flight in space has changed from permanence on the International Space Station to missions beyond low earth orbit and the Lunar Gateway for deep space exploration and Missions to Mars. Several conditions affecting space missions had ... ...

Abstract	The target of human flight in space has changed from permanence on the International Space Station to missions beyond low earth orbit and the Lunar Gateway for deep space exploration and Missions to Mars. Several conditions affecting space missions had to be considered: for example the effect of weightlessness and radiations on the human body, behavioral health decrements or communication latency, and consumable resupply. Telemedicine and telerobotic applications, robot-assisted surgery with some hints on experimental surgical procedures carried out in previous missions, had to be considered as well. The need for greater crew autonomy in health issues is related to the increasing severity of medical and surgical interventions that could occur in these missions, and the presence of a highly trained surgeon on board would be recommended. A surgical robot could be a valuable aid but only inasfar as it is provided with multiple functions, including the capability to perform certain procedures autonomously. Space missions in deep space or on other planets present new challenges for crew health. Providing a multi-function surgical robot is the new frontier. Research in this field shall be paving the way for the development of new structured plans for human health in space, as well as providing new suggestions for clinical applications on Earth.
Language	English
Publishing date	2021-12-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2823626-9
ISSN	2373-8065
ISSN	2373-8065
DOI	10.1038/s41526-021-00183-3
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Article: Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity.

Riwaldt, Stefan / Corydon, Thomas J / Pantalone, Desiré / Sahana, Jayashree / Wise, Petra / Wehland, Markus / Krüger, Marcus / Melnik, Daniela / Kopp, Sascha / Infanger, Manfred / Grimm, Daniela

Frontiers in bioengineering and biotechnology

2021 Volume 9, Page(s) 679650

Abstract: Functioning as the outermost self-renewing protective layer of the human organism, skin protects against a multitude of harmful biological and physical stimuli. Consisting of ectodermal, mesenchymal, and neural crest-derived cell lineages, tissue ... ...

Abstract	Functioning as the outermost self-renewing protective layer of the human organism, skin protects against a multitude of harmful biological and physical stimuli. Consisting of ectodermal, mesenchymal, and neural crest-derived cell lineages, tissue homeostasis, and signal transduction are finely tuned through the interplay of various pathways. A health problem of astronauts in space is skin deterioration. Until today, wound healing has not been considered as a severe health concern for crew members. This can change with deep space exploration missions and commercial spaceflights together with space tourism. Albeit the molecular process of wound healing is not fully elucidated yet, there have been established significant conceptual gains and new scientific methods. Apoptosis, e.g., programmed cell death, enables orchestrated development and cell removal in wounded or infected tissue. Experimental designs utilizing microgravity allow new insights into the role of apoptosis in wound healing. Furthermore, impaired wound healing in unloading conditions would depict a significant challenge in human-crewed exploration space missions. In this review, we provide an overview of alterations in the behavior of cutaneous cell lineages under microgravity in regard to the impact of apoptosis in wound healing. We discuss the current knowledge about wound healing in space and simulated microgravity with respect to apoptosis and available therapeutic strategies.
Language	English
Publishing date	2021-06-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2021.679650
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Article ; Online: The Role of DAMPS in Burns and Hemorrhagic Shock Immune Response: Pathophysiology and Clinical Issues. Review.

Pantalone, Desirè / Bergamini, Carlo / Martellucci, Jacopo / Alemanno, Giovanni / Bruscino, Alessandro / Maltinti, Gherardo / Sheiterle, Maximilian / Viligiardi, Riccardo / Panconesi, Roberto / Guagni, Tommaso / Prosperi, Paolo

International journal of molecular sciences

2021 Volume 22, Issue 13

Abstract: Severe or major burns induce a pathophysiological, immune, and inflammatory response that can persist for a long time and affect morbidity and mortality. Severe burns are followed by a "hypermetabolic response", an inflammatory process that can be ... ...

Abstract	Severe or major burns induce a pathophysiological, immune, and inflammatory response that can persist for a long time and affect morbidity and mortality. Severe burns are followed by a "hypermetabolic response", an inflammatory process that can be extensive and become uncontrolled, leading to a generalized catabolic state and delayed healing. Catabolism causes the upregulation of inflammatory cells and innate immune markers in various organs, which may lead to multiorgan failure and death. Burns activate immune cells and cytokine production regulated by damage-associated molecular patterns (DAMPs). Trauma has similar injury-related immune responses, whereby DAMPs are massively released in musculoskeletal injuries and elicit widespread systemic inflammation. Hemorrhagic shock is the main cause of death in trauma. It is hypovolemic, and the consequence of volume loss and the speed of blood loss manifest immediately after injury. In burns, the shock becomes evident within the first 24 h and is hypovolemic-distributive due to the severely compromised regulation of tissue perfusion and oxygen delivery caused by capillary leakage, whereby fluids shift from the intravascular to the interstitial space. In this review, we compare the pathophysiological responses to burns and trauma including their associated clinical patterns.
MeSH term(s)	Alarmins/metabolism ; Burns/immunology ; Cytokines/metabolism ; Gene Expression Regulation ; Humans ; Mitochondria/metabolism ; Shock, Hemorrhagic/immunology
Chemical Substances	Alarmins ; Cytokines
Language	English
Publishing date	2021-06-29
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22137020
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Article: Emergency surgery in the time of Coronavirus: the pandemic effect

Martellucci, Jacopo / Damigella, Andrea / Bergamini, Carlo / Alemanno, Giovanni / Pantalone, Desiré / Coratti, Andrea / Muiesan, Paolo / Cianchi, Fabio / Prosperi, Paolo

Minerva chir

Abstract: BACKGROUND: The COVID-19 epidemic became a challenge for Emergency Departments (ED) and a remarkable reduction in surgical emergencies has been widely noticed. Aim of the present study was to evaluate the impact of the pandemic period in the need of ... ...

Abstract	BACKGROUND: The COVID-19 epidemic became a challenge for Emergency Departments (ED) and a remarkable reduction in surgical emergencies has been widely noticed. Aim of the present study was to evaluate the impact of the pandemic period in the need of surgical emergencies. METHODS: Between January 1st and May 31st 2020 all the consecutive general surgery emergencies performed by the Careggi University hospital emergency surgery unit were prospectively recorded and compared to the same period of 2019. Demographic and clinical data were recorded and analyzed. RESULTS: The number of surgical procedures decreased only in the month of March 2020 (compared to 2019), while in April the total numer of emergency surgical procedures was similar. Only appendectomy, complicated hernia repair and colonic resection were significantly reduced (40%, 48% and 33% respectively). The number of small intestine excision, cholecystectomy and lysis of peritoneal adhesions remained stable throughout the entire period. No statistically significant differences were found considering age, sex, Emergency Surgery Score, mortality, ICU postoperative admission and time between admission and surgery, even when analyzed with multivariate analysis for every single surgical procedure, suggesting a comparable disease severity and comorbility patterns. Mortality in COVID patients was 25%, compared to 7% of no-covid patients. CONCLUSIONS: The COVID pandemic has caused major changes in daily clinical practice, especially in areas such as Emergency. This has led to a temporary reduction and changes in the flow of patients to the emergency room, with implications also for emergency surgical activities.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #921335
Database	COVID19

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Article: Upper G.I. hemorrhage from glass fragments' ingestion in a patient with jejunal diverticula - Case report.

Gattai, Riccardo / Pantalone, Desire' / Migliaccio, Maria Luisa / Bonizzoli, Manuela / Peris, Adriano / Bechi, Paolo

International journal of surgery case reports

2014 Volume 6C, Page(s) 191–193

Abstract: Introduction: Acute upper gastrointestinal bleeding is a common emergency. The ingestion of foreign bodies represents a less frequent cause of bleeding, but it is equally life-threatening, especially if the patient does not report the incident.: ... ...

Abstract	Introduction: Acute upper gastrointestinal bleeding is a common emergency. The ingestion of foreign bodies represents a less frequent cause of bleeding, but it is equally life-threatening, especially if the patient does not report the incident. Presentation of case: We are reporting the case of a 77-year-old patient with a bleeding caused by ingestion of glass fragments with co-existing jejunal diverticula. Discussion: The ingestion of foreign bodies is a rare, mostly accidental event. Another possible source of upper G.I. bleeding is jejunal diverticula; in this case, the examination of the specimens showed evidence of glass ingestion fragments as the likely cause of bleeding. Conclusion: Surgeons should be aware that patients may fail to report correctly on the possible causes of bleeding, misleading the diagnosis, and delaying the diagnostic routes.
Language	English
Publishing date	2014-11-29
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2014.11.069
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Article ; Online: Preparation of A Spaceflight: Apoptosis Search in Sutured Wound Healing Models.

Riwaldt, Stefan / Monici, Monica / Graver Petersen, Asbjørn / Birk Jensen, Uffe / Evert, Katja / Pantalone, Desiré / Utpatel, Kirsten / Evert, Matthias / Wehland, Markus / Krüger, Marcus / Kopp, Sascha / Frandsen, Sofie / Corydon, Thomas / Sahana, Jayashree / Bauer, Johann / Lützenberg, Ronald / Infanger, Manfred / Grimm, Daniela

International journal of molecular sciences

2017 Volume 18, Issue 12

Abstract: To prepare the ESA (European Space Agency) spaceflight project "Wound healing and Sutures in Unloading Conditions", we studied mechanisms of apoptosis in wound healing models based on ex vivo skin tissue cultures, kept for 10 days alive in serum-free ... ...

Abstract	To prepare the ESA (European Space Agency) spaceflight project "Wound healing and Sutures in Unloading Conditions", we studied mechanisms of apoptosis in wound healing models based on ex vivo skin tissue cultures, kept for 10 days alive in serum-free DMEM/F12 medium supplemented with bovine serum albumin, hydrocortisone, insulin, ascorbic acid and antibiotics at 32 °C. The overall goal is to test: (i) the viability of tissue specimens; (ii) the gene expression of activators and inhibitors of apoptosis and extracellular matrix components in wound and suture models; and (iii) to design analytical protocols for future tissue specimens after post-spaceflight download. Hematoxylin-Eosin and Elastica-van-Gieson staining showed a normal skin histology with no signs of necrosis in controls and showed a normal wound suture. TdT-mediated dUTP-biotin nick end labeling for detecting DNA fragmentation revealed no significant apoptosis. No activation of caspase-3 protein was detectable.
MeSH term(s)	Animals ; Apoptosis/genetics ; Apoptosis/physiology ; Caspase 3/metabolism ; Dermis/metabolism ; Epidermis/metabolism ; Extracellular Matrix/metabolism ; Humans ; In Situ Nick-End Labeling ; In Vitro Techniques ; Skin/metabolism ; Wound Healing/genetics ; Wound Healing/physiology
Chemical Substances	CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2017-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms18122604
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Article: Ernioplastica "senza tensione" con protesi: due tecniche a confronto.

Taruffi, Francesco / Bernini, Marco / Pantalone, Desire / Paolucci, Roberto / Panichi, Sergio / Andreoli, Francesco

Chirurgia italiana

2002 Volume 54, Issue 6, Page(s) 819–827

Abstract: The paper evaluates the results of the surgical therapy of primary inguinal hernia in adult subjects performed in our Institution from 1994 to 2000. The Trabucco and Lichtenstein procedures were compared. Two hundred and fifteen patients--123 Trabucco ... ...

Title translation	"Tension-free" hernioplasty with prosthesis: comparison of 2 techniques.
Abstract	The paper evaluates the results of the surgical therapy of primary inguinal hernia in adult subjects performed in our Institution from 1994 to 2000. The Trabucco and Lichtenstein procedures were compared. Two hundred and fifteen patients--123 Trabucco and 92 Lichtenstein--were enrolled in the study. A file was created for each patient with details of personal data, procedures, anaesthesia and postoperative course. A form regarding the present state of each patient was filled in, mainly by phone, but sometimes by physical examination, if patients complained of problems. The results were evaluated statistically using the Fisher f and X2 tests. Only four parameters showed significant differences: wound swelling, constipation and days off work were less frequent with the Trabucco procedure, while there was less loss of the foreign body sensation in the Lichtenstein patients (6.7% vs. 18.3%). No recurrences were detected. The results of the two procedures can be considered comparable.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Hernia, Inguinal/surgery ; Humans ; Male ; Middle Aged ; Prostheses and Implants ; Retrospective Studies ; Surgical Procedures, Operative/methods
Language	Italian
Publishing date	2002-11
Publishing country	Italy
Document type	Comparative Study ; English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603591-7
ISSN	0009-4773
ISSN	0009-4773
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