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  1. Article: First study on

    Triratapiban, Chanittha / Lueangaramkul, Varanya / Phecharat, Nantawan / Pantanam, Achiraya / Lekcharoensuk, Porntippa / Theerawatanasirikul, Sirin

    Veterinary world

    2023  Volume 16, Issue 3, Page(s) 618–630

    Abstract: Background and aim: Feline infectious peritonitis (FIP), one of the most important infectious diseases in cats is caused by FIP virus (FIPV), a mutated variant of feline coronavirus. Feline infectious peritonitis has a negative impact on feline health, ... ...

    Abstract Background and aim: Feline infectious peritonitis (FIP), one of the most important infectious diseases in cats is caused by FIP virus (FIPV), a mutated variant of feline coronavirus. Feline infectious peritonitis has a negative impact on feline health, with extremely high mortality in clinical FIP-infected cats, particularly young cats. There are no approved drugs for FIP treatment, and therapeutic possibilities for FIP treatment are limited. This study aimed to utilize nature-derived bioactive flavonoids with antiviral properties to inhibit FIPV infection in Crandell-Rees feline kidney (CRFK) cells.
    Materials and methods: The cytotoxicity of 16 flavonoids was evaluated on CRFK cells using a colorimetric method (MTS) assay. Viral kinetics of FIPV at 50 tissue culture infectious dose (TCID
    Results: Two flavonoids, namely, isoginkgetin and luteolin, inhibited FIPV replication during post-viral entry in a dose-dependent manner, with 50% maximal effective concentrations = 4.77 ± 0.09 and 36.28 ± 0.03 μM, respectively. Based on viral kinetics, both flavonoids could inhibit FIPV replication at the early stage of infection at 0-6-HPI for isoginkgetin and 2-6-HPI for luteolin using a time-of-addition assay. Isoginkgetin exerted a direct virucidal effect that reduced the viral titers by 2 and 1.89 log
    Conclusion: Isoginkgetin interfered with FIPV replication during both post-viral infection and virucidal experiments on CRFK cells, whereas luteolin inhibited the virus after infection. These results demonstrate the potential of herbal medicine for treating FIP.
    Language English
    Publishing date 2023-03-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2456277-4
    ISSN 2231-0916 ; 0972-8988
    ISSN (online) 2231-0916
    ISSN 0972-8988
    DOI 10.14202/vetworld.2023.618-630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Small Molecules Targeting 3C Protease Inhibit FMDV Replication and Exhibit Virucidal Effect in Cell-Based Assays.

    Theerawatanasirikul, Sirin / Lueangaramkul, Varanya / Pantanam, Achiraya / Mana, Natjira / Semkum, Ploypailin / Lekcharoensuk, Porntippa

    Viruses

    2023  Volume 15, Issue 9

    Abstract: Foot-and-mouth disease (FMD) is a highly contagious disease in cloven-hoofed animals, caused by the foot-and-mouth disease virus (FMDV). It is endemic in Asia and Africa but spreads sporadically throughout the world, resulting in significant losses in ... ...

    Abstract Foot-and-mouth disease (FMD) is a highly contagious disease in cloven-hoofed animals, caused by the foot-and-mouth disease virus (FMDV). It is endemic in Asia and Africa but spreads sporadically throughout the world, resulting in significant losses in the livestock industry. Effective anti-FMDV therapeutics could be a supportive control strategy. Herein, we utilized computer-aided, structure-based virtual screening to filter lead compounds from the National Cancer Institute (NCI) diversity and mechanical libraries using FMDV 3C protease (3C
    MeSH term(s) Animals ; Peptide Hydrolases ; Foot-and-Mouth Disease Virus ; Molecular Docking Simulation ; Endopeptidases ; Antiviral Agents/pharmacology ; 3C Viral Proteases
    Chemical Substances Peptide Hydrolases (EC 3.4.-) ; Endopeptidases (EC 3.4.-) ; Antiviral Agents
    Language English
    Publishing date 2023-09-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15091887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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