Article ; Online: Circulating cell-free DNA release in vitro: kinetics, size profiling, and cancer-related gene methylation.
Journal of cellular physiology
2019 Volume 234, Issue 8, Page(s) 14079–14089
Abstract: Circulating cell-free DNA (ccfDNA) is a biological entity of great interest due to its potential as liquid biopsy biomaterial carrying clinically valuable information. To better understand its nature, we studied ccfDNA in vitro in two human cancer cell ... ...
| Abstract | Circulating cell-free DNA (ccfDNA) is a biological entity of great interest due to its potential as liquid biopsy biomaterial carrying clinically valuable information. To better understand its nature, we studied ccfDNA in vitro in two human cancer cell lines MCF-7 and HeLa. Normalized indexes of ccfDNA per cell population decreased over time of culture but were significantly elevated after exposure to IC |
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| MeSH term(s) | Azacitidine/pharmacology ; Biomarkers, Tumor/genetics ; Cell-Free Nucleic Acids/drug effects ; Cell-Free Nucleic Acids/genetics ; DNA Methylation/genetics ; HeLa Cells ; Humans ; Kinetics ; MCF-7 Cells ; Neoplasms/genetics ; Neoplasms/pathology | |||||
| Chemical Substances | Biomarkers, Tumor ; Cell-Free Nucleic Acids ; Azacitidine (M801H13NRU) | |||||
| Language | English | |||||
| Publishing date | 2019-01-07 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 3116-1 | |||||
| ISSN | 1097-4652 ; 0021-9541 | |||||
| ISSN (online) | 1097-4652 | |||||
| ISSN | 0021-9541 | |||||
| DOI | 10.1002/jcp.28097 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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