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  1. Article ; Online: Genetic polymorphisms in ABCB1 are correlated with the increased risk of atorvastatin-induced muscle side effects: a cross-sectional study.

    Lalatović, Ninoslava / Ždralević, Maša / Antunović, Tanja / Pantović, Snežana

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 17895

    Abstract: Genetic factors are recognized as risk factors for statin-associated muscle symptoms (SAMS), which are the most common cause of statin intolerance. The aim of this study was to determine whether there is an association between polymorphisms 1236C > T, ... ...

    Abstract Genetic factors are recognized as risk factors for statin-associated muscle symptoms (SAMS), which are the most common cause of statin intolerance. The aim of this study was to determine whether there is an association between polymorphisms 1236C > T, 2677G > T/A, and 3435C > T in the ABCB1 gene, encoding the efflux transporter of statins, and SAMS, as results on this topic are still controversial. A cross-sectional study was conducted on patients with or without SAMS using atorvastatin. The influence of non-genetic variables on SAMS was also evaluated. Our results show that patients with TT genotype in 1236C > T, 2677G > T/A, and 3435C > T polymorphisms had higher risk of developing SAMS, compared to wild type and heterozygous carriers together (OR 4.292 p = 0.0093, OR 5.897 p = 0.0023 and OR 3.547 p = 0.0122, respectively). Furthermore, TTT/TTT diplotype was also associated with a higher risk of SAMS, OR 9.234 (p = 0.0028). Only family history of cardiovascular disease was found to be a risk factor for SAMS, in addition to the known non-genetic variables. We believe that ABCB1 genotyping has great potential to be incorporated into clinical practice to identify high-risk patients in a timely manner.
    MeSH term(s) Humans ; Atorvastatin/adverse effects ; Cross-Sectional Studies ; Genotype ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Polymorphism, Single Nucleotide ; Muscles ; ATP Binding Cassette Transporter, Subfamily B/genetics
    Chemical Substances Atorvastatin (A0JWA85V8F) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44792-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Risk Factors for Potential Drug-Drug Interactions in Outpatients with Dyslipidemia.

    Lalatović, Ninoslava / Pantović, Snežana / Nedović-Vuković, Mirjana / Kostić, Marina

    Iranian journal of public health

    2023  Volume 52, Issue 7, Page(s) 1466–1475

    Abstract: Background: Patients with dyslipidemia are usually multimorbid and require polypharmacy. Therefore, it is important to identify potential drug-drug interactions (pDDIs) in time to prevent their consequences. We aimed to identify and analyze risk factors ...

    Abstract Background: Patients with dyslipidemia are usually multimorbid and require polypharmacy. Therefore, it is important to identify potential drug-drug interactions (pDDIs) in time to prevent their consequences. We aimed to identify and analyze risk factors contributing to their occurrence to guide health professionals.
    Methods: A prospective cross-sectional study of 216 outpatients with dyslipidemia was conducted from May 2021 to April 2022 in Podgorica, the capital of Montenegro. pDDIs were identified using Medscape, Epocrates, and Drugs online interaction checkers. Multivariate regression analysis was performed to evaluate the potential predictors of interactions.
    Results: pDDIs were detected in 212 (98.1%) participants, whereas pDDIs with high clinical significance were detected in 25.46%, 40.74%, and 58.8% of subjects by Drugs, Epocrates, and Medscape, respectively. Polypharmacy emerged as a risk factor for the occurrence of pDDIs in all three checkers in each category of clinical significance. The use of non-steroidal anti-inflammatory drugs and antiplatelet drugs contributes to the incidence of severe pDDIs B=1.014, 95%CI 0.681-1.346,
    Conclusion: Knowledge of the risk factors contributing to the occurrence of pDDIs is important for the development and implementation of strategies for their prevention, and given the high prevalence of dyslipidemia, understanding these factors seems crucial nowadays.
    Language English
    Publishing date 2023-08-07
    Publishing country Iran
    Document type Journal Article
    ISSN 2251-6093 ; 0304-4556
    ISSN (online) 2251-6093
    ISSN 0304-4556
    DOI 10.18502/ijph.v52i7.13248
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  3. Article ; Online: Anti-Tumor Activity vs. Normal Cell Toxicity: Therapeutic Potential of the Bromotyrosines Aerothionin and Homoaerothionin In Vitro.

    Drechsel, Antje / Helm, Jana / Ehrlich, Hermann / Pantovic, Snezana / Bornstein, Stefan R / Bechmann, Nicole

    Marine drugs

    2020  Volume 18, Issue 5

    Abstract: Novel strategies to treat cancer effectively without adverse effects on the surrounding normal tissue are urgently needed. Marine sponges provide a natural and renewable source of promising anti-tumor agents. Here, we investigated the anti-tumor activity ...

    Abstract Novel strategies to treat cancer effectively without adverse effects on the surrounding normal tissue are urgently needed. Marine sponges provide a natural and renewable source of promising anti-tumor agents. Here, we investigated the anti-tumor activity of Aerothionin and Homoaerothionin, two bromotyrosines isolated from the marine demosponge Aplysina cavernicola, on two mouse pheochromocytoma cells, MPC and MTT. To determine the therapeutic window of these metabolites, we furthermore explored their cytotoxicity on cells of the normal tissue. Both metabolites diminished the viability of the pheochromocytoma cell lines significantly from a concentration of 25 µM under normoxic and hypoxic conditions. Treatment of MPC cells leads moreover to a reduction in the number of proliferating cells. To confirm the anti-tumor activity of these bromotyrosines, 3D-pheochromocytoma cell spheroids were treated with 10 µM of either Aerothionin or Homoaerothionin, resulting in a significant reduction or even complete inhibition of the spheroid growth. Both metabolites reduced viability of normal endothelial cells to a comparable extent at higher micromolar concentration, while the viability of fibroblasts was increased. Our in vitro results show promise for the application of Aerothionin and Homoaerothionin as anti-tumor agents against pheochromocytomas and suggest acceptable toxicity on normal tissue cells.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; BALB 3T3 Cells/drug effects ; Cell Line, Tumor/drug effects ; Disease Models, Animal ; Isoxazoles/pharmacology ; Mice ; Porifera/chemistry ; Spiro Compounds/pharmacology ; Tyrosine/analogs & derivatives ; Tyrosine/pharmacology
    Chemical Substances Antineoplastic Agents ; Isoxazoles ; Spiro Compounds ; aerothionin ; bromotyrosine ; Tyrosine (42HK56048U)
    Language English
    Publishing date 2020-05-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18050236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Poverty and other correlates of obesity and underweight among 7-year-olds from Croatia and Montenegro.

    Banjari, I / Martinović, M / Belojević, G / Ašanin, B / Kovačević, N D / Kenjerić, D / Miškulin, M / Pantović, S / Pušeljić, S / Sokolić, D / Buljan, V / Bilić-Kirin, V / Jakšić, M

    Public health

    2020  Volume 182, Page(s) 64–69

    Abstract: Objectives: This study aimed at investigating poverty and other correlates of childhood underweight and obesity in two urban regions with lower (Podgorica, Montenegro) and higher economic development (Osijek, Croatia).: Study design: Comparative ... ...

    Abstract Objectives: This study aimed at investigating poverty and other correlates of childhood underweight and obesity in two urban regions with lower (Podgorica, Montenegro) and higher economic development (Osijek, Croatia).
    Study design: Comparative study.
    Methods: A comparative study was conducted on 693 children (52% boys), aged 7 years old (224 from Podgorica and 469 from Osijek). Parents completed the study-specific questionnaire on relevant factors for children's nutritional status. We measured children's height and weight and calculated their body mass index (BMI). International Obesity Task Force cut-off values of BMI were used to assess children's nutritional status. Subjective social position was assessed by the Mac Arthur scale.
    Results: There were more underweight children in Osijek compared with Podgorica, both among boys (5.5% vs. 1.6%) and girls (6.9% vs. 1.0%). Obesity was more frequent in Podgorica than Osijek, both among boys (11.3% vs. 5.9%) and girls (10.0% vs. 4.3%). However, poverty in two cities diminished observed differences in children's nutritional status. The odds for child underweight decreased by 12.2%, while the odds for obesity increased by 3.6% per each paternal BMI unit. The frequency of child obesity was lowered per each step higher on the Mac Arthur scale and with breastfeeding by 23.2% and 68.0%, respectively.
    Conclusions: We show that a higher economic development is related to less obese children but more underweight children. However, poverty seems to impact nutritionally all children equally, regardless of the regional economic development. Paternal and not maternal BMI is relevant for both extremes in children's nutritional status. Breastfeeding and higher social position independently protect from child obesity.
    MeSH term(s) Body Mass Index ; Body Weight ; Child ; Croatia/epidemiology ; Female ; Humans ; Male ; Montenegro/epidemiology ; Nutritional Status ; Pediatric Obesity/epidemiology ; Poverty/statistics & numerical data ; Sex Factors ; Socioeconomic Factors ; Surveys and Questionnaires ; Thinness/epidemiology ; Urban Population
    Language English
    Publishing date 2020-03-12
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 427333-3
    ISSN 1476-5616 ; 0033-3506
    ISSN (online) 1476-5616
    ISSN 0033-3506
    DOI 10.1016/j.puhe.2020.01.017
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  5. Article: Spindle-cell epithelioma of the vagina diagnosed during pregnancy--a case report.

    Pantovic, S / Stefanovic, A / Stojnic, J / Jeremic, K / Sparic, R / Kadija, S / Milenkovic, S

    European journal of gynaecological oncology

    2015  Volume 36, Issue 2, Page(s) 223–225

    Abstract: Spindle-cell epithelioma or "mixed tumor" of the vagina is an unusual and intriguing vaginal tumor consisting of both epithelial and mesenchymal components. A case of spindle-cell epithelioma of the vagina diagnosed at delivery of a 31-year-old ... ...

    Abstract Spindle-cell epithelioma or "mixed tumor" of the vagina is an unusual and intriguing vaginal tumor consisting of both epithelial and mesenchymal components. A case of spindle-cell epithelioma of the vagina diagnosed at delivery of a 31-year-old primiparous woman is described. The excision of the mass was performed immediately after the delivery, which was uneventful. The patient was regularly followed up and no evidence of local recurrence or dissemination was found 40 months after surgery. The presentation and the diagnosis of this kind of tumor in pregnancy, and its effect on the pregnancy and delivery are still largely unknown. Since it is unlikely that any institution will have a large number of patients with this rare disease, case reports add further information to this entity. As the number of cases studied is small, close follow-up is recommended although there has been no report in the literature of metastasis so far.
    MeSH term(s) Adult ; Carcinoma/diagnosis ; Carcinoma/pathology ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Neoplastic/diagnosis ; Pregnancy Complications, Neoplastic/pathology ; Vaginal Neoplasms/diagnosis ; Vaginal Neoplasms/pathology
    Language English
    Publishing date 2015-04-23
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 604589-3
    ISSN 0392-2936
    ISSN 0392-2936
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  6. Article: Treatment of pregnant patient with disseminated intravascular coagulation (DIC) due to placental abruption--a case report.

    Pantovic, S / Kadija, S / Dotlic, J / Stojnic, J / Jeremic, K / Sparic, R / Stefanovic, A

    Clinical and experimental obstetrics & gynecology

    2015  Volume 42, Issue 5, Page(s) 692–695

    Abstract: A primigravid woman at 29th gestational week with placental abruption causing fetal death, that underwent instant cesarean section, developed a disseminated intravascular coagulation (DIC), revealed by hemoperitoneum and hematoma of the abdominal wall. ... ...

    Abstract A primigravid woman at 29th gestational week with placental abruption causing fetal death, that underwent instant cesarean section, developed a disseminated intravascular coagulation (DIC), revealed by hemoperitoneum and hematoma of the abdominal wall. After re-laparotomy and transfusion of blood, fresh plasma, and platelets, the patient was discharged from hospital on the 14th postoperative day completely recovered. To conclude, conservative surgical approach for DIC treatment is possible and safe. Novel antifibrinolitic drugs are recommended for obstetrical patients with DIC to enable a healthy subsequent pregnancy.
    MeSH term(s) Abruptio Placentae/diagnosis ; Abruptio Placentae/surgery ; Adult ; Antifibrinolytic Agents/administration & dosage ; Cesarean Section ; Diagnosis, Differential ; Disseminated Intravascular Coagulation/diagnosis ; Disseminated Intravascular Coagulation/therapy ; Female ; Fetal Death ; Hematoma/diagnosis ; Hematoma/therapy ; Humans ; Laparotomy ; Pregnancy ; Pregnancy Complications, Hematologic/diagnosis ; Pregnancy Complications, Hematologic/therapy
    Chemical Substances Antifibrinolytic Agents
    Language English
    Publishing date 2015-10-22
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 754459-5
    ISSN 0390-6663
    ISSN 0390-6663
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  7. Article ; Online: Hypertension and correlates among Montenegrin schoolchildren-a cross-sectional study.

    Martinovic, M / Belojevic, G / Evans, G W / Kavaric, N / Asanin, B / Pantovic, S / Jaksic, M / Boljevic, J

    Public health

    2017  Volume 147, Page(s) 15–19

    Abstract: Objectives: In one of the few national studies of children in a former Eastern bloc country emerging as a Western democracy and the first such study ever in Montenegro, this study establishes the prevalence and correlates of childhood hypertension (CH).! ...

    Abstract Objectives: In one of the few national studies of children in a former Eastern bloc country emerging as a Western democracy and the first such study ever in Montenegro, this study establishes the prevalence and correlates of childhood hypertension (CH).
    Study design: A cross-sectional national study.
    Methods: The study was conducted with 3254 children aged 7-13 years (50.3% male) from 39 elementary schools. We used a structured questionnaire to gather sociodemographic information as well as data on factors potentially related to CH. Children's nutritional status was assessed using the criteria of the International Obesity Task Force. Waist circumference was also measured. Blood pressure was measured in schools using an oscillometric monitor. CH was defined as an average systolic blood pressure and/or diastolic blood pressure greater than or equal to the 95th percentile for sex, age, and height.
    Results: The prevalence of CH was 10.4% with no differences between boys and girls. Multiple regression revealed that the odds for child hypertension were lowered by 10% for each year of age. On the other hand, rural environment and child obesity raised the odds of hypertension by 38% and 68%, respectively.
    Conclusions: We found hypertension in one out of ten Montenegrin schoolchildren, with no gender differences. Obesity and rural areas may be unfriendly to children's blood pressure.
    MeSH term(s) Adolescent ; Child ; Cross-Sectional Studies ; Female ; Humans ; Hypertension/epidemiology ; Male ; Montenegro/epidemiology ; Pediatric Obesity/epidemiology ; Prevalence ; Risk Factors ; Rural Health/statistics & numerical data ; Students/statistics & numerical data ; Surveys and Questionnaires
    Language English
    Publishing date 2017-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 427333-3
    ISSN 1476-5616 ; 0033-3506
    ISSN (online) 1476-5616
    ISSN 0033-3506
    DOI 10.1016/j.puhe.2017.02.007
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  8. Article ; Online: High Fat Diet Exaggerate Metabolic and Reproductive PCOS Features by Promoting Oxidative Stress: An Improved EV Model in Rats.

    Rakic, Dejana / Joksimovic Jovic, Jovana / Jakovljevic, Vladimir / Zivkovic, Vladimir / Nikolic, Maja / Sretenovic, Jasmina / Nikolic, Marina / Jovic, Nikola / Bicanin Ilic, Marija / Arsenijevic, Petar / Dimitrijevic, Aleksandra / Vulovic, Tatjana / Ristic, Natasa / Bulatovic, Kristina / Bolevich, Sergej / Stijak, Lazar / Pantovic, Suzana

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 6

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Rats ; Female ; Animals ; Humans ; Polycystic Ovary Syndrome/metabolism ; Diet, High-Fat/adverse effects ; Estradiol/adverse effects ; Reproduction ; Oxidative Stress ; Valerates/adverse effects
    Chemical Substances Estradiol (4TI98Z838E) ; Valerates
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59061104
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  9. Article: Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart.

    Sretenovic, Jasmina / Zivkovic, Vladimir / Srejovic, Ivan / Pantovic, Suzana / Jovic, Jovana Joksimovic / Nikolic, Maja / Turnic, Tamara Nikolic / Savic, Maja / Jevdjevic, Maja / Milosavljevic, Zoran / Bolevich, Sergej / Jakovljevic, Vladimir

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 8

    Abstract: 1) Background: The aim of this study was to show the effects of swimming and nandrolone administration on cardiodynamic and morphometric parameters of the isolated rat heart. (2) The study included 72 Wistar rats, divided into three groups, scheduled to ...

    Abstract (1) Background: The aim of this study was to show the effects of swimming and nandrolone administration on cardiodynamic and morphometric parameters of the isolated rat heart. (2) The study included 72 Wistar rats, divided into three groups, scheduled to be sacrificed after the second, third, and fourth week. Each group was divided into four subgroups: control (T-N-), nandrolone (T-N+), swimming training (T+N-), and swimming training plus nandrolone (T+N+) group. The rats from T+N- and T+N+ swam 1 h/day, 5 days/week while ones from T-N+ and T+N+ received weekly nandrolone decanoate (20 mg/kg). The isolated hearts were perfused according to the Langendorff technique and measured parameters: dp/dt max/min, SLVP, DLVP, heart rate, and coronary flow. Hearts were fixed and stained with H/E and Masson trichrome dyes. (3) dp/dt max and dp/dt min were increased in the T-N+ group at higher perfusion pressure compared to the T-N- group. SLVP and DLVP were increased in all groups after the 4th week. Collagen content was increased in T-N+ by 403% and in T+N+ by 357% groups, while it was decreased in T+N- compared to the control after 4th week. (4) Conclusions: Nandrolone alone or combined with swimming had a deleterious effect on myocardial function and perfusion.
    Language English
    Publishing date 2022-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12081242
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  10. Article: The mathematical analysis of the heart rate and blood lactate curves during incremental exercise testing.

    Rosic, Mirko / Ilic, V / Obradovic, Z / Pantovic, S / Rosic, G

    Acta physiologica Hungarica

    2011  Volume 98, Issue 4, Page(s) 456–464

    Abstract: This paper describes a new mathematical approach for the analysis of HR (heart rate) and BL (blood lactate) curves during incremental exercise testing using a HR/BL curve and its derivatives, taking into account the native shape of all curves, without ... ...

    Abstract This paper describes a new mathematical approach for the analysis of HR (heart rate) and BL (blood lactate) curves during incremental exercise testing using a HR/BL curve and its derivatives, taking into account the native shape of all curves, without any linear approximation. Using this approach the results indicate the appearance of three characteristic points (A, B and C) on the HR/BL curve. The point A on the HR/BL curve which is the value that corresponds to the load (12.73 ± 0.46 km h-1) at which BL starts to increase above the resting levels (0.9 ± 0.06 mM), and is analogous to Lactate Turn Point 1 (LTP1). The point C on the HR/BL curve which corresponds to a BL of approximately 4mM, and is analogous to LTP2. The point B on the HR/BL curve, which corresponds to the load (16.32 ± 0.49 km h-1) at which the moderate increase turns into a more pronounced increase in BL. This point has not been previously recognized in literature. We speculate this point represents attenuation of left ventricular ejection fraction (LVEF) increase, accompanied by the decrease in diastolic time duration during incremental exercise testing. Proposed mathematical approach allows precise determination of lactate turnpoints during incremental exercise testing.
    MeSH term(s) Adult ; Anaerobic Threshold/physiology ; Exercise/physiology ; Exercise Test/methods ; Heart Rate/physiology ; Humans ; Lactic Acid/blood ; Male ; Models, Cardiovascular ; Physiology/methods ; Young Adult
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2011-12
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 802801-1
    ISSN 1588-2683 ; 0231-424X ; 0001-6756
    ISSN (online) 1588-2683
    ISSN 0231-424X ; 0001-6756
    DOI 10.1556/APhysiol.98.2011.4.9
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