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  1. AU="Paola Palestini"
  2. AU=Sahadev Ravindra
  3. AU="Lei, M"
  4. AU="Glasnov, Toma"
  5. AU=Lemieux Jacob E AU=Lemieux Jacob E
  6. AU="Duan, Wen-Yan"
  7. AU="Sybertz, Alexandra"
  8. AU="Jéssica T. Bandeira"
  9. AU="Dieleman, J.A."
  10. AU="Antonio J Giraldez"
  11. AU="Krutenkova A.P."
  12. AU="Hotaling, Jim"
  13. AU="Saywell, Alex"
  14. AU="Ahmad, Nadia N"
  15. AU=Gonzalez-Periz Ana
  16. AU="Gardner, Colin J"
  17. AU="James, Timothy Y"
  18. AU="Giorgadze, Tamar A"
  19. AU="Laudicina, Vito Armando"
  20. AU="M.Cho, "
  21. AU="Balkan, Ayhan"
  22. AU="Akiyoshi Nakakura"
  23. AU="Yusuf, Amman"
  24. AU="Shastri, Jayanthi S."
  25. AU=McMaster Mary L
  26. AU="Ren, Xiaojie"
  27. AU="Grubbs, Griffin L"
  28. AU="Shen, Jianping"
  29. AU="Thuss-Patience, Peter"
  30. AU="Feng, Qingguo"
  31. AU="Mikayla Schowalter"
  32. AU=Milman Evgenia

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  1. Artikel ; Online: Effects of PM2.5 Exposure on the ACE/ACE2 Pathway

    Laura Botto / Elena Lonati / Stefania Russo / Emanuela Cazzaniga / Alessandra Bulbarelli / Paola Palestini

    International Journal of Environmental Research and Public Health, Vol 20, Iss 4393, p

    Possible Implication in COVID-19 Pandemic

    2023  Band 4393

    Abstract: Particulate matter (PM) is a harmful component of urban air pollution and PM2.5, in particular, can settle in the deep airways. The RAS system plays a crucial role in the pathogenesis of pollution-induced inflammatory diseases: the ACE/AngII/AT1 axis ... ...

    Abstract Particulate matter (PM) is a harmful component of urban air pollution and PM2.5, in particular, can settle in the deep airways. The RAS system plays a crucial role in the pathogenesis of pollution-induced inflammatory diseases: the ACE/AngII/AT1 axis activates a pro-inflammatory pathway counteracted by the ACE2/Ang(1-7)/MAS axis, which in turn triggers an anti-inflammatory and protective pathway. However, ACE2 acts also as a receptor through which SARS-CoV-2 penetrates host cells to replicate. COX-2, HO-1, and iNOS are other crucial proteins involved in ultrafine particles (UFP)-induced inflammation and oxidative stress, but closely related to the course of the COVID-19 disease. BALB/c male mice were subjected to PM2.5 sub-acute exposure to study its effects on ACE2 and ACE, COX-2, HO-1 and iNOS proteins levels, in the main organs concerned with the pathogenesis of COVID-19. The results obtained show that sub-acute exposure to PM2.5 induces organ-specific modifications which might predispose to greater susceptibility to severe symptomatology in the case of SARS-CoV-2 infection. The novelty of this work consists in using a molecular study, carried out in the lung but also in the main organs involved in the disease, to analyze the close relationship between exposure to pollution and the pathogenesis of COVID-19.
    Schlagwörter PM2.5 ; mice model ; RAS system ; COVID-19 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Air Pollution and Covid-19

    Silvia Comunian / Dario Dongo / Chiara Milani / Paola Palestini

    International Journal of Environmental Research and Public Health, Vol 17, Iss 4487, p

    The Role of Particulate Matter in the Spread and Increase of Covid-19's Morbidity and Mortality

    2020  Band 4487

    Abstract: Sars-cov-2 virus (Covid-19) is a member of the coronavirus family and is responsible for the pandemic recently declared by the World Health Organization. A positive correlation has been observed between the spread of the virus and air pollution, one of ... ...

    Abstract Sars-cov-2 virus (Covid-19) is a member of the coronavirus family and is responsible for the pandemic recently declared by the World Health Organization. A positive correlation has been observed between the spread of the virus and air pollution, one of the greatest challenges of our millennium. Covid-19 could have an air transmission and atmospheric particulate matter (PM) could create a suitable environment for transporting the virus at greater distances than those considered for close contact. Moreover, PM induces inflammation in lung cells and exposure to PM could increase the susceptibility and severity of the Covid-19 patient symptoms. The new coronavirus has been shown to trigger an inflammatory storm that would be sustained in the case of pre-exposure to polluting agents. In this review, we highlight the potential role of PM in the spread of Covid-19, focusing on Italian cities whose PM daily concentrations were found to be higher than the annual average allowed during the months preceding the epidemic. Furthermore, we analyze the positive correlation between the virus spread, PM, and angiotensin-converting enzyme 2 (ACE2), a receptor involved in the entry of the virus into pulmonary cells and inflammation.
    Schlagwörter covid-19 ; particulate matter ; ACE2 ; inflammation ; oxidative stress ; Medicine ; R
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Link between Viral Infections, Immune System, Inflammation and Diet

    Carlotta Suardi / Emanuela Cazzaniga / Stephanie Graci / Dario Dongo / Paola Palestini

    International Journal of Environmental Research and Public Health, Vol 18, Iss 2455, p

    2021  Band 2455

    Abstract: The strong spread of COVID-19 and the significant number of deaths associated with it could be related to improper lifestyles, which lead to a low-grade inflammation (LGI) that not only increases the risk of chronic diseases, but also the risk of facing ... ...

    Abstract The strong spread of COVID-19 and the significant number of deaths associated with it could be related to improper lifestyles, which lead to a low-grade inflammation (LGI) that not only increases the risk of chronic diseases, but also the risk of facing complications relating to infections and a greater susceptibility to infections themselves. Recently, scientific research has widely demonstrated that the microbiota plays a fundamental role in modulating metabolic responses in the immune system. There is, in fact, a two-way interaction between lifestyle, infection, and immunity. The immune response is compromised if nutrition is unbalanced or insufficient, because diet affects the intestinal flora predisposing people to infections and, at the same time, the nutritional state can be aggravated by the immune response itself to the infection. We evaluate the link between balanced diet, the efficiency of the immune system, and microbiota with the aim of providing some practical advice for individuals, with special attention to the elderly. A correct lifestyle that follows the Mediterranean model, which is especially rich in plant-based foods along with the use of extra-virgin olive oil, are the basis of preventing LGI and other chronic pathologies, directly influencing the intestinal microbiota and consequently the immune response.
    Schlagwörter lifestyle ; infection ; immunity ; microbiota ; vitamin ; dietary guidelines ; Medicine ; R
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Digested Cinnamon ( Cinnamomum verum J. Presl) Bark Extract Modulates Claudin-2 Gene Expression and Protein Levels under TNFα/IL-1β Inflammatory Stimulus

    Elena Lonati / Gessica Sala / Paolo Corbetta / Stefania Pagliari / Emanuela Cazzaniga / Laura Botto / Pierangela Rovellini / Ilaria Bruni / Paola Palestini / Alessandra Bulbarelli

    International Journal of Molecular Sciences, Vol 24, Iss 9201, p

    2023  Band 9201

    Abstract: Epigenetic changes, host–gut microbiota interactions, and environmental factors contribute to inflammatory bowel disease (IBD) onset and progression. A healthy lifestyle may help to slow down the chronic or remitting/relapsing intestinal tract ... ...

    Abstract Epigenetic changes, host–gut microbiota interactions, and environmental factors contribute to inflammatory bowel disease (IBD) onset and progression. A healthy lifestyle may help to slow down the chronic or remitting/relapsing intestinal tract inflammation characteristic of IBD. In this scenario, the employment of a nutritional strategy to prevent the onset or supplement disease therapies included functional food consumption. Its formulation consists of the addition of a phytoextract enriched in bioactive molecules. A good candidate as an ingredient is the Cinnamon verum aqueous extract. Indeed, this extract, subjected to a process of gastrointestinal digestion simulation (INFOGEST), exhibits beneficial antioxidant and anti-inflammatory properties in an in vitro model of the inflamed intestinal barrier. Here, we deepen the study of the mechanisms related to the effect of digested cinnamon extract pre-treatment, showing a correlation between transepithelial electrical resistance (TEER) decrement and alterations in claudin-2 expression under Tumor necrosis factor-α/Interleukin-1β (TNF-α/IL-1) β cytokine administration. Our results show that pre-treatment with cinnamon extract prevents TEER loss by claudin-2 protein level regulation, influencing both gene transcription and autophagy-mediated degradation. Hence, cinnamon polyphenols and their metabolites probably work as mediators in gene regulation and receptor/pathway activation, leading to an adaptive response against renewed insults.
    Schlagwörter inflammation ; IBD ; intestinal barrier ; cinnamon extract ; polyphenols ; in vitro digestion ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Health Status and Nutritional Habits in Maldives Pediatric Population

    Emanuela Cazzaniga / Antonina Orlando / Annalisa Terenzio / Carlotta Suardi / Chiara Mognetti / Francesca Gennaro / Laura Antolini / Paola Palestini

    International Journal of Environmental Research and Public Health, Vol 19, Iss 15728, p

    A Cross-Sectional Study

    2022  Band 15728

    Abstract: Chronic noncommunicable diseases (NCDs) have become the major cause of morbidity and mortality in the Maldives, triggered by the nutrition transition to a “Western diet” that dramatically increases the prevalence of excess weight and hypertension. Our ... ...

    Abstract Chronic noncommunicable diseases (NCDs) have become the major cause of morbidity and mortality in the Maldives, triggered by the nutrition transition to a “Western diet” that dramatically increases the prevalence of excess weight and hypertension. Our study aimed to evaluate dietary habits, blood pressure (BP) and body mass index in Maghoodoo Public School’s students. A sample of 145 students (72 males and 73 females, age 9.37 ± 2.97 years) was enrolled. Factors causing excess weight were investigated through descriptive statistics. The relationship between blood pressure percentiles and possible influencing factors was investigated by a linear regression model. Excess weight was present in 15.07% and 12.5% females and males, respectively. 15.18% of the subjects had elevated BP, with a significant difference according to gender detected only in the PAS z -score. Eating habits were investigated through a parent-filled questionnaire; 70.15% of the students consumed less than two portions of fruit per day, with a significant difference between gender (84.06% and 55.38% for boys and girls, respectively, p < 0.0001) and 71.64% ate less than two servings of vegetables per day. An alarming finding emerged for sweet snacks (30.6% of the students consumed 2–3 servings per day) and sugary drinks (2–3 servings per day for 32.84% of students) consumption. Our findings suggest that excess weight and hypertension in this population could be due to energy-rich, packaged-foods consumption. A nutrition education approach might thus help to reduce cardiovascular risk.
    Schlagwörter excess weight ; food habits ; hypertension ; children ; health status ; Medicine ; R
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Hypertension in Children

    Antonina Orlando / Emanuela Cazzaniga / Marco Giussani / Paola Palestini / Simonetta Genovesi

    Frontiers in Public Health, Vol

    Role of Obesity, Simple Carbohydrates, and Uric Acid

    2018  Band 6

    Abstract: Over the past 60 years there has been a dramatic increase in the prevalence of overweight in children and adolescents, ranging from 4% in 1975 to 18% in 2016. Recent estimates indicate that overweight or obese children and adolescents are more than 340 ... ...

    Abstract Over the past 60 years there has been a dramatic increase in the prevalence of overweight in children and adolescents, ranging from 4% in 1975 to 18% in 2016. Recent estimates indicate that overweight or obese children and adolescents are more than 340 million. Obesity is often associated with hypertension, which is an important cardiovascular risk factor. Recent studies show that the presence of hypertension is a frequent finding in the pediatric age. Hypertensive children easily become hypertensive adults. This phenomenon contributes to increasing cardiovascular risk in adulthood. Primary hypertension is a growing problem especially in children and adolescents of western countries, largely because of its association with the ongoing obesity epidemic. Recently, it has been hypothesized that a dietary link between obesity and elevated blood pressure (BP) values could be simple carbohydrate consumption, particularly fructose, both in adults and in children. Excessive intake of fructose leads to increased serum uric acid (SUA) and high SUA values are independently associated with the presence of hypertension and weaken the efficacy of lifestyle modifications in children. The present review intends to provide an update of existing data regarding the relationship between BP, simple carbohydrates (particularly fructose), and uric acid in pediatric age. In addition, we analyze the national policies that have been carried out over the last few years, in order to identify the best practices to limit the socio-economic impact of the effects of excessive sugar consumption in children.
    Schlagwörter obesity ; cardiovascular disease ; hypertension ; fructose ; uric acid ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2018-05-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: The Impact of a Nutritional Intervention Program on Eating Behaviors in Italian Athletes

    Annalisa Terenzio / Alice Cassera / Adriano Gervasoni / Alessandra Pozzi / Antonina Orlando / Andrea Greco / Paola Palestini / Emanuela Cazzaniga

    International Journal of Environmental Research and Public Health, Vol 18, Iss 7313, p

    2021  Band 7313

    Abstract: A balanced diet is a fundamental component of athletes’ health, training, and performance. The majority of athletes choose adequate quantities of macronutrients but, at the same time, do not respect World Health Organization dietary guidelines, eating a ... ...

    Abstract A balanced diet is a fundamental component of athletes’ health, training, and performance. The majority of athletes choose adequate quantities of macronutrients but, at the same time, do not respect World Health Organization dietary guidelines, eating a lot of discretionary food and not drinking enough water. Athletes need more nutritional education to improve the quality of their food choice. By modifying their eating habits, they could also enhance their performance. Our study aimed to evaluate the impact of nutritional intervention on eating habits in a group of Northern Italian athletes. A sample of 87 athletes (41 males and 46 females) aged 16.5 ± 2.9 was enrolled. We organized meetings and detected eating habits (before and after the meetings) using a food frequencies questionnaire. We found that nutritional intervention positively affected participants consumption of vegetables ( p < 0.05), nuts ( p < 0.001), legumes ( p < 0.001), and fish ( p < 0.05). Other aspects of the athletes’ eating habits were not significantly improved. Some gender differences were found; males increased their consumption of vegetables ( p < 0.05) and nuts ( p < 0.001), while females increased their intake of legumes ( p < 0.001). Our finding suggested that nutritional intervention could promote healthy eating habits among athletes. If sports nutrition experts, coaches, personal trainers, sports medicine experts, and athletes cooperated, they could guarantee athletes’ health status.
    Schlagwörter nutritional intervention ; athletes ; lifestyle ; nutrition ; health ; Medicine ; R
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Coffee-Derived Phenolic Compounds Activate Nrf2 Antioxidant Pathway in I/R Injury In Vitro Model

    Elena Lonati / Tatiana Carrozzini / Ilaria Bruni / Pedro Mena / Laura Botto / Emanuela Cazzaniga / Daniele Del Rio / Massimo Labra / Paola Palestini / Alessandra Bulbarelli

    Molecules, Vol 27, Iss 1049, p

    A Nutritional Approach Preventing Age Related-Damages

    2022  Band 1049

    Abstract: Age-related injuries are often connected to alterations in redox homeostasis. The imbalance between free radical oxygen species and endogenous antioxidants defenses could be associated with a growing risk of transient ischemic attack and stroke. In this ... ...

    Abstract Age-related injuries are often connected to alterations in redox homeostasis. The imbalance between free radical oxygen species and endogenous antioxidants defenses could be associated with a growing risk of transient ischemic attack and stroke. In this context, a daily supply of dietary antioxidants could counteract oxidative stress occurring during ischemia/reperfusion injury (I/R), preventing brain damage. Here we investigated the potential antioxidant properties of coffee-derived circulating metabolites and a coffee pulp phytoextract, testing their efficacy as ROS scavengers in an in vitro model of ischemia. Indeed, the coffee fruit is an important source of phenolic compounds, such as chlorogenic acids, present both in the brewed seed and in the discarded pulp. Therefore, rat brain endothelial cells, subjected to oxygen and glucose deprivation (OGD) and recovery (ogR) to mimic reperfusion, were pretreated or not with coffee by-products. The results indicate that, under OGD/ogR, the ROS accumulation was reduced by coffee by-product. Additionally, the coffee extract activated the Nrf2 antioxidant pathway via Erk and Akt kinases phosphorylation, as shown by increased Nrf2 and HO-1 protein levels. The data indicate that the daily intake of coffee by-products as a dietary food supplement represents a potential nutritional strategy to counteract aging.
    Schlagwörter coffee phytoextract ; coffee metabolites ; phenolic compounds ; oxidative stress ; Nrf2/ARE antioxidant pathway ; oxygen and glucose deprivation ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: LSEA Evaluation of Lipid Mediators of Inflammation in Lung and Cortex of Mice Exposed to Diesel Air Pollution

    Luca Massimino / Alessandra Bulbarelli / Paola Antonia Corsetto / Chiara Milani / Laura Botto / Francesca Farina / Luigi Antonio Lamparelli / Elena Lonati / Federica Ungaro / Krishna Rao Maddipati / Paola Palestini / Angela Maria Rizzo

    Biomedicines, Vol 10, Iss 3, p

    2022  Band 712

    Abstract: Airborne ultrafine particle (UFP) exposure is a great concern as they have been correlated to increased cardiovascular mortality, neurodegenerative diseases and morbidity in occupational and environmental settings. The ultrafine components of diesel ... ...

    Abstract Airborne ultrafine particle (UFP) exposure is a great concern as they have been correlated to increased cardiovascular mortality, neurodegenerative diseases and morbidity in occupational and environmental settings. The ultrafine components of diesel exhaust particles (DEPs) represent about 25% of the emission mass; these particles have a great surface area and consequently high capacity to adsorb toxic molecules, then transported throughout the body. Previous in-vivo studies indicated that DEP exposure increases pro- and antioxidant protein levels and activates inflammatory response both in respiratory and cardiovascular systems. In cells, DEPs can cause additional reactive oxygen species (ROS) production, which attacks surrounding molecules, such as lipids. The cell membrane provides lipid mediators (LMs) that modulate cell-cell communication, inflammation, and resolution processes, suggesting the importance of understanding lipid modifications induced by DEPs. In this study, with a lipidomic approach, we evaluated in the mouse lung and cortex how DEP acute and subacute treatments impact polyunsaturated fatty acid-derived LMs. To analyze the data, we designed an ad hoc bioinformatic pipeline to evaluate the functional enrichment of lipid sets belonging to the specific biological processes (Lipid Set Enrichment Analysis-LSEA). Moreover, the data obtained correlate tissue LMs and proteins associated with inflammatory process (COX-2, MPO), oxidative stress (HO-1, iNOS, and Hsp70), involved in the activation of many xenobiotics as well as PAH metabolism (Cyp1B1), suggesting a crucial role of lipids in the process of DEP-induced tissue damage.
    Schlagwörter LSEA ; lipid mediators ; air pollution ; inflammation ; diesel exhaust particles ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Remodelling of Membrane Rafts Expression in Lung Cells as an Early Sign of Mechanotransduction-Signalling in Pulmonary Edema

    Paola Palestini / Laura Botto / Ilaria Rivolta / Giuseppe Miserocchi

    Journal of Lipids, Vol

    2011  Band 2011

    Schlagwörter Physiology ; QP1-981 ; Science ; Q ; DOAJ:Physiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences ; Biochemistry ; QD415-436 ; Organic chemistry ; QD241-441 ; Chemistry ; QD1-999 ; DOAJ:Biochemistry ; DOAJ:Life Sciences
    Sprache Englisch
    Erscheinungsdatum 2011-01-01T00:00:00Z
    Verlag Hindawi Publishing Corporation
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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