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Article: A half life: women caregivers of older disabled relatives.

Paoletti, I

1999 Volume 11, Issue 1, Page(s) 53–67

Abstract: This paper explores the impact of caring on caregivers' life style and health. Interviews were carried out with women caregivers over 50 years old. Transcripts from the interview are analyzed through a detailed discourse analysis within an ... ...

Abstract	This paper explores the impact of caring on caregivers' life style and health. Interviews were carried out with women caregivers over 50 years old. Transcripts from the interview are analyzed through a detailed discourse analysis within an ethnomethodological framework showing how the caring tasks are constructed in the interaction as a women's duty, inscribed in a gendered moral order. A difference is noticeable between family caregivers who describe the caring tasks as the cause of intense stress, physical and psychological problems and voluntary or paid caregivers who see caring as a source of satisfaction and well being.
MeSH term(s)	Adaptation, Psychological ; Aged ; Caregivers/psychology ; Disabled Persons ; Family ; Female ; Humans ; Italy ; Middle Aged ; Surveys and Questionnaires ; Women/psychology ; Women's Health
Language	English
Publishing date	1999
Publishing country	England
Document type	Journal Article
ZDB-ID	1045930-3
ISSN	0895-2841
ISSN	0895-2841
DOI	10.1300/J074v11n01_05
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Zs.A 3067: Show issues

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Article ; Online: Future talk in later life.

Paoletti, Isabella / Gomes, Sandra

Journal of aging studies

2014 Volume 29, Page(s) 131–141

Abstract: This article focuses on the relevance that the dimension of the future has for promoting healthy and active aging. Older people generally have difficulties in talking about the future and when they do they generally express very negative perspectives on ... ...

Abstract	This article focuses on the relevance that the dimension of the future has for promoting healthy and active aging. Older people generally have difficulties in talking about the future and when they do they generally express very negative perspectives on it. The data analyzed in this paper are part of an on-going interdisciplinary research project: "Aging, poverty and social exclusion: an interdisciplinary study on innovative support services" (https://apseclunl.wordpress.com/). The project aims at documenting good practices in social intervention with older people who are at risk of exclusion. This study describes and critically discusses an activity carried out in Portugal among older women in a poor area in the suburb of Lisbon entitled "self-awareness workshop on the future". Through a detailed discourse analysis within an ethnomethodological framework the study shows age membership categorizations in use and categorization processes, examining the workshop interaction. In particular, the article describes how the psychologist works at deconstructing and problematizing the negative connotations related to age membership categories. Taking into consideration the interactionally constructed nature of aging and the material consequences that different attitudes towards aging can imply is very important in particular in relation to the provision of services to older people.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging/psychology ; Attitude ; Europe ; Female ; Forecasting ; Humans ; Life Expectancy ; Longevity ; Middle Aged ; Social Distance
Language	English
Publishing date	2014-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2006012-9
ISSN	1879-193X ; 0890-4065
ISSN (online)	1879-193X
ISSN	0890-4065
DOI	10.1016/j.jaging.2014.01.005
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Article: Communication and gender issues in an Italian medical emergency control room: a case study

Paoletti, Isabella

Gender and communication at work , p. 166-179

2006 , Page(s) 166–179

Author's details	Isabella Paoletti
Language	English
Publisher	Ashgate
Publishing place	Aldershot [u.a.]
Document type	Article
Note	Literaturangaben
ISBN	978-075-463-840-7 ; 075-463-840-5
Database	ECONomics Information System

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Book: Mass innovation

Paoletti, Ingrid / Tardini, Paola

emerging technologies in construction

(Politecnica ; 419)

2011

Author's details	Ingrid Paoletti; Paola Tardini
Series title	Politecnica ; 419
Language	English
Size	151 S., Ill., graph. Darst., 22 cm
Publisher	Maggioli
Publishing place	Santarcangelo di Romagna
Document type	Book
Note	Includes bibliographical references
ISBN	8838760179 ; 9788838760174
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Book ; Online: Practices of Ethics

Paoletti, Isabella / Menendez, Fernanda / Tomas, Maria Isabel

An Empirical Approach to Ethics in Social Sciences Research

2013

Abstract: This book is intended for social sciences researchers, in a variety of disciplines (sociology, sociolinguistics, psychology, gerontology, ethnography, etc.), who, during all the stages of their research, be it quantitative or qualitative, are confronted ... ...

Abstract	This book is intended for social sciences researchers, in a variety of disciplines (sociology, sociolinguistics, psychology, gerontology, ethnography, etc.), who, during all the stages of their research, be it quantitative or qualitative, are confronted with ethical dilemmas. As such, the chapters in this book attempt to provide the reader with examples of ethical reflection within the research process. The selection does not cover all the possible ethical issues they may face, but all of the
Language	English
Size	Online-Ressource (223 p)
Publisher	Cambridge Scholars Publishing
Publishing place	Newcastle upon Tyne
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9781443847452 ; 1443847453
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Upregulation of Ca

La Barbera, Livia / Nobili, Annalisa / Cauzzi, Emma / Paoletti, Ilaria / Federici, Mauro / Saba, Luana / Giacomet, Cecilia / Marino, Ramona / Krashia, Paraskevi / Melone, Marcello / Keller, Flavio / Mercuri, Nicola Biagio / Viscomi, Maria Teresa / Conti, Fiorenzo / D'Amelio, Marcello

Molecular neurodegeneration

2022 Volume 17, Issue 1, Page(s) 76

Abstract: Background: Recent clinical and experimental studies have highlighted the involvement of Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of Alzheimer's Disease (AD). We have previously described a progressive and selective ... ...

Abstract	Background: Recent clinical and experimental studies have highlighted the involvement of Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of Alzheimer's Disease (AD). We have previously described a progressive and selective degeneration of these neurons in the Tg2576 mouse model of AD, long before amyloid-beta plaque formation. The degenerative process in DA neurons is associated with an autophagy flux impairment, whose rescue can prevent neuronal loss. Impairments in autophagy can be the basis for accumulation of damaged mitochondria, leading to disturbance in calcium (Ca Methods: In Tg2576 mice, we performed amperometric recordings of DA levels and analysis of dopaminergic fibers in the Nucleus Accumbens - a major component of the ventral striatum precociously affected in AD patients - together with retrograde tracing, to identify the most vulnerable DA neuron subpopulations in the VTA. Then, we focused on these neurons to analyze mitochondrial integrity and Apoptosis-inducing factor (AIF) localization by electron and confocal microscopy, respectively. Stereological cell count was also used to evaluate degeneration of DA neuron subpopulations containing the Ca Results: We found a progressive degeneration of mesolimbic DA neurons projecting to the ventral striatum, located in the paranigral nucleus and parabrachial pigmented subnucleus of the VTA. At the onset of degeneration (3 months of age), the vulnerable DA neurons in the Tg2576 accumulate damaged mitochondria, while AIF translocates from the mitochondria to the nucleus. Although we describe an age-dependent loss of the DA neurons expressing Calbindin-D28K or Calretinin, we observed that the remaining cells upregulate the levels of Ca Conclusion: Overall, our results suggest that the overexpression of Ca
MeSH term(s)	Mice ; Animals ; Ventral Tegmental Area/metabolism ; Ventral Tegmental Area/pathology ; Dopaminergic Neurons/metabolism ; Dopamine/metabolism ; Calbindin 2/metabolism ; Alzheimer Disease/metabolism ; Up-Regulation ; Carrier Proteins/metabolism ; Calbindin 1/metabolism
Chemical Substances	Dopamine (VTD58H1Z2X) ; Calbindin 2 ; Carrier Proteins ; Calbindin 1
Language	English
Publishing date	2022-11-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2244557-2
ISSN	1750-1326 ; 1750-1326
ISSN (online)	1750-1326
ISSN	1750-1326
DOI	10.1186/s13024-022-00580-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Healthcare for all in emerging countries: a preliminary investigation of facilities in Kolkata, India.

Rebecchi, Andrea / Gola, Marco / Kulkarni, Mrudula / Lettieri, Emanuele / Paoletti, Ingrid / Capolongo, Stefano

Annali dell'Istituto superiore di sanita

2016 Volume 52, Issue 1, Page(s) 88–97

Abstract: Introduction: India is one of the five countries with the lowest public health spending levels: the private medical services are one of the most developed fields, meanwhile public health ones are totally inadequate with the most number of health ... ...

Abstract	Introduction: India is one of the five countries with the lowest public health spending levels: the private medical services are one of the most developed fields, meanwhile public health ones are totally inadequate with the most number of health facilities concentrated in cities, where only the 25% of the population lives. Public facilities are mainly made up of primary level and not well distributed on the territories, so they do not guarantee accessibility to a wide sample of population, who live in rural areas of India. Methodology: Starting from the analysis of three different health care levels in the Indian context, the research team developed a meta-project that considers all the current criticisms and the Indian customs through a flexible layout that responds to the healthcare needs of population. Result and discussion: The research work is aimed to develop a meta-project that considers all the current criticisms and the Indian customs through flexible layouts that responds to the healthcare needs of population. Conclusion: The innovation of the research work is to develop the hygienic aspects, the layout and the distribution, the sub-division of the medical functions through the Indian culture and the needs of the country. The choice of lowly technologies permits to promote the usage of local materials, their maintenance and skills for creating a virtuous economic system.
MeSH term(s)	Delivery of Health Care ; Developing Countries ; Facility Design and Construction ; Health Facilities ; Humans ; India ; Needs Assessment ; Public Health
Language	English
Publishing date	2016
Publishing country	Italy
Document type	Journal Article
ZDB-ID	950344-4
ISSN	0021-2571
ISSN	0021-2571
DOI	10.4415/ANN_16_01_15
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Article: Effect of temperature on the shift of Pseudomonas fluorescens from an environmental microorganism to a potential human pathogen.

Donnarumma, G / Buommino, E / Fusco, A / Paoletti, I / Auricchio, L / Tufano, M A

International journal of immunopathology and pharmacology

2010 Volume 23, Issue 1, Page(s) 227–234

Abstract: Pseudomonas fluorescens is a Gram-negative bacterium generally considered of scarce clinical significance. However, in the last few years, the isolation of P. fluorescens as the causative agent of nosocomial infections has rapidly increased. P. ... ...

Abstract	Pseudomonas fluorescens is a Gram-negative bacterium generally considered of scarce clinical significance. However, in the last few years, the isolation of P. fluorescens as the causative agent of nosocomial infections has rapidly increased. P. fluorescens is a psychrophile microorganism which grows at an optimal temperature of 25-30 degrees Celcius. In spite of this constraint, it has recently been reported that the human physiological temperature does not appear to be a barrier for this microorganism. In this study we examined the ability of P. fluorescens, grown at 28 degrees C or at 37 degrees C, to adhere to cultured human A549 pulmonary cells and to form biofilm. The ability of P. fluorescens to induce expression of proinflammatory cytokines, beta-defensin 2 and the intercellular adhesion molecule-1 was also investigated. Our results clearly indicate that inflammatory mediators are induced when the microorganism is grown at a lower temperature, while biofilm is formed only at 37 degrees C. The results presented are consistent with previous reports indicating P. fluorescens as an opportunistic pathogen and underscore the urgent need for further studies to better characterize the virulence of this microorganism.
MeSH term(s)	Bacterial Adhesion ; Biofilms ; Cell Line ; Cytokines/biosynthesis ; Humans ; Intercellular Adhesion Molecule-1/biosynthesis ; Pseudomonas fluorescens/pathogenicity ; Pseudomonas fluorescens/physiology ; Temperature ; beta-Defensins/biosynthesis
Chemical Substances	Cytokines ; DEFB4A protein, human ; beta-Defensins ; Intercellular Adhesion Molecule-1 (126547-89-5)
Language	English
Publishing date	2010-01
Publishing country	England
Document type	Journal Article
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/039463201002300120
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Article: Anti-Inflammatory, Immunomodulatory, and Tissue Repair Activity on Human Keratinocytes by Green Innovative Nanocomposites.

Morganti, Pierfrancesco / Fusco, Alessandra / Paoletti, Iole / Perfetto, Brunella / Del Ciotto, Paola / Palombo, Marco / Chianese, Angelo / Baroni, Adone / Donnarumma, Giovanna

Materials (Basel, Switzerland)

2017 Volume 10, Issue 7

Abstract: The use of raw materials obtained by waste and processed through innovative industrial methodologies has generated an industry of about a trillion dollars in a short time, and in the near future will provide resources and services for the conservation ... ...

Abstract	The use of raw materials obtained by waste and processed through innovative industrial methodologies has generated an industry of about a trillion dollars in a short time, and in the near future will provide resources and services for the conservation and sustainable use of natural resources in order to ensure a better and fairer welfare for the human race. The production of nano-fiber chitin non-woven tissue is in accordance with the Organization for Economic Co-operation and Development (OECD) and European Union (EU) bio-economic programs: 100% biodegradable, ecological, and therefore useful in decreasing dependence on fossil fuel resources. The aim of our study is the evaluation of different formulations of a non-woven tissue obtained from electrospinning of a mixture of nanochitin fibrils, lignin, and poly (ethylene) oxide (PEO) on the restoration of damaged tissues. Wound repair is a complex process that involves epithelial and immune cells and includes the induction of metalloproteinases, inflammatory mediators, and angiogenic factors. Our in vitro results have shown that all of the realized chitin nanofibrils-bio-lignin non-woven tissues tested as nontoxic for human keratinocytes (HaCat) cells. Furthermore, the bio-composites that included bio-lignin at 0.1% have been able to modulate the expression of pro-inflammatory cytokines (Tumor Necrosis Factor-α, IL-1α, and IL8), lipopolysaccharide (LPS)-induced, and matrix metalloproteinases (MMPs) and human beta-defensin 2 (HBD-2) expression in HaCat cells, suggesting an anti-inflammatory and immunomodulatory role. Taken together, our results suggest that our chitin nanofibrils-bio-lignin non-woven tissue represents a skin-friendly tool that is able to favor a correct and fast wound repair.
Language	English
Publishing date	2017-07-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma10070843
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Article ; Online: Tacrolimus does not alter the production of several cytokines and antimicrobial peptide in Malassezia furfur-infected-keratinocytes.

Balato, Anna / Paoletti, Iole / De Gregorio, Vincenza / Cantelli, Mariateresa / Ayala, Fabio / Donnarumma, Giovanna

Mycoses

2014 Volume 57, Issue 3, Page(s) 176–183

Abstract: Topical immunosuppressant therapy is widely used in the treatment of inflammatory skin diseases, such as atopic dermatitis and psoriasis. Besides its beneficial therapeutic effects, application of topical anti-inflammatory drugs may render the epidermis ... ...

Abstract	Topical immunosuppressant therapy is widely used in the treatment of inflammatory skin diseases, such as atopic dermatitis and psoriasis. Besides its beneficial therapeutic effects, application of topical anti-inflammatory drugs may render the epidermis more vulnerable to invading pathogens by suppressing innate immune responses in keratinocytes (KCs). Cytokines, chemokines and antimicrobial peptides (AMPs) produced by epithelial cells enable them to participate in innate and acquired immune responses. The aim of the present work was to study the influence of tacrolimus (FK506) on KCs infected with Malassezia furfur (M. furfur), evaluating the expression of pro-inflammatory cytokines IL-1α and IL-6, chemokine IL-8, anti-inflammatory cytokines transforming growth factor beta1 (TGF-β1) and IL-10 and AMP β-defensin-2. Human KCs were obtained from surgical specimens of normal adult skin. The expression of mRNAs in KCs: FK506-treated, FK506-treated and M. furfur-infected as well as only M. furfur-infected was quantified by real-time quantitative polymerase chain reaction. Next, the production of the AMP β-defensin-2 and of the above-mentioned pro-inflammatory and anti-inflammatory cytokines was evaluated using enzyme-linked immunosorbent assay. In this study, FK506 did not alter cytokine and AMP production by KCs; this led us to hypothesise that it may not enhance the risk of mycotic skin infections.
MeSH term(s)	Antimicrobial Cationic Peptides/metabolism ; Cell Survival/drug effects ; Cytokines/metabolism ; Enzyme-Linked Immunosorbent Assay ; Humans ; Interleukin-10/metabolism ; Interleukin-1alpha/metabolism ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Keratinocytes/drug effects ; Keratinocytes/microbiology ; Malassezia/growth & development ; Malassezia/isolation & purification ; Psoriasis/metabolism ; RNA, Messenger/metabolism ; Skin/microbiology ; Tacrolimus/pharmacology ; Transforming Growth Factor beta1/metabolism ; beta-Defensins/metabolism
Chemical Substances	Antimicrobial Cationic Peptides ; Cytokines ; Interleukin-1alpha ; Interleukin-6 ; Interleukin-8 ; RNA, Messenger ; Transforming Growth Factor beta1 ; beta-Defensins ; Interleukin-10 (130068-27-8) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2014-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392487-7
ISSN	1439-0507 ; 0933-7407
ISSN (online)	1439-0507
ISSN	0933-7407
DOI	10.1111/myc.12140
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