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Article ; Online: Cross-Linked Hyaluronan Derivatives in the Delivery of Phycocyanin.

Terracina, Francesca / Saletti, Mario / Paolino, Marco / Venditti, Jacopo / Giuliani, Germano / Bonechi, Claudia / Licciardi, Mariano / Cappelli, Andrea

Gels (Basel, Switzerland)

2024 Volume 10, Issue 2

Abstract: An easy and viable crosslinking technology, based on the "click-chemistry" reaction copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (click-crosslinking), was applied to graft copolymers of medium molecular weight (i.e., 270 kDa) hyaluronic ... ...

Abstract	An easy and viable crosslinking technology, based on the "click-chemistry" reaction copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (click-crosslinking), was applied to graft copolymers of medium molecular weight (i.e., 270 kDa) hyaluronic acid (
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels10020091
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A tri(ethylene glycol)-tethered Morita-Baylis-Hillman dimer in the formation of macrocyclic crown ether-paracyclophane hybrid structures.

Saletti, Mario / Venditti, Jacopo / Paolino, Marco / Zacchei, Arianna / Giuliani, Germano / Giorgi, Gianluca / Bonechi, Claudia / Donati, Alessandro / Cappelli, Andrea

RSC advances

2023 Volume 13, Issue 51, Page(s) 35773–35780

Abstract: A Morita-Baylis-Hillman acetate was dimerized by a click-chemistry Copper(i)-Catalysed Azide-Alkyne Cycloaddition (CuAAC) reaction employing a tri(ethylene glycol) diazide derivative to obtain a dimeric MBHA derivative. The reaction of this dimeric MBHA ... ...

Abstract	A Morita-Baylis-Hillman acetate was dimerized by a click-chemistry Copper(i)-Catalysed Azide-Alkyne Cycloaddition (CuAAC) reaction employing a tri(ethylene glycol) diazide derivative to obtain a dimeric MBHA derivative. The reaction of this dimeric MBHA derivative with
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra06792k
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Article ; Online: A Facile Access to Green Fluorescent Albumin Derivatives.

Saletti, Mario / Paolino, Marco / Venditti, Jacopo / Bonechi, Claudia / Giuliani, Germano / Lamponi, Stefania / Tassone, Giusy / Boccia, Antonella / Botta, Chiara / Blancafort, Lluís / Poggialini, Federica / Vagaggini, Chiara / Cappelli, Andrea

Chembiochem : a European journal of chemical biology

2024 Volume 25, Issue 8, Page(s) e202300862

Abstract: A Morita-Baylis-Hillman Adduct (MBHA) derivative bearing a triphenylamine moiety was found to react with human serum albumin (HSA) shifting its emission from the blue to the green-yellow thus leading to green fluorescent albumin (GFA) derivatives and ... ...

Abstract	A Morita-Baylis-Hillman Adduct (MBHA) derivative bearing a triphenylamine moiety was found to react with human serum albumin (HSA) shifting its emission from the blue to the green-yellow thus leading to green fluorescent albumin (GFA) derivatives and enlarging the platform of probes for aggregation-induced fluorescent-based detection techniques. A possible interaction of MBHA derivative 7 with a lipophilic pocket within the HSA structure was suggested by docking studies. DLS experiments showed that the reaction with HSA induce a conformational change of the protein contributing to the aggregation process of GFA derivatives. The results of investigations on the biological properties suggested that GFA retained the ability of binding drug molecules such as warfarin and diazepam. Finally, cytotoxicity evaluation studies suggested that, although the MBHA derivative 7 at 0.1 μg/mL affected the percentage of cell viability in comparison to the negative control, it cannot be considered cytotoxic, whereas at all the other concentrations≥0.5 μg/mL resulted cytotoxic at different extent.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Protein Binding ; Proteins/metabolism ; Serum Albumin, Human/chemistry ; Spectrometry, Fluorescence
Chemical Substances	Proteins ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2024-03-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202300862
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Article ; Online: Design and photoisomerization dynamics of a new family of synthetic 2-stroke light driven molecular rotary motors.

Filatov, Michael / Paolino, Marco / Min, Seung Kyu / Choi, Cheol Ho

Chemical communications (Cambridge, England)

2019 Volume 55, Issue 36, Page(s) 5247–5250

Abstract: A new family of light driven molecular rotary motors, which can be synthesized from easily available precursor compounds and which are capable of completing a full 360° revolution by two photoisomerization steps only, is proposed. The non-adiabatic ... ...

Abstract	A new family of light driven molecular rotary motors, which can be synthesized from easily available precursor compounds and which are capable of completing a full 360° revolution by two photoisomerization steps only, is proposed. The non-adiabatic molecular dynamic simulations show that the photoisomerization steps of the motor's working cycle occur on an ultrafast time scale (ca. 200-300 fs), have a very high quantum yield of isomerization (0.91-0.97), and display high selectivity of torsion in the same direction. It is expected that the new motor should remain operational at lower temperatures than the currently existing motors.
Language	English
Publishing date	2019-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c9cc01955c
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Article ; Online: Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo.

Mugnaini, Claudia / Brizzi, Antonella / Paolino, Marco / Scarselli, Enrico / Castelli, Riccardo / de Candia, Modesto / Gambacorta, Nicola / Nicolotti, Orazio / Kostrzewa, Magdalena / Kumar, Poulami / Mahmoud, Ali Mokhtar / Borgonetti, Vittoria / Iannotta, Monica / Morace, Andrea / Galeotti, Nicoletta / Maione, Sabatino / Altomare, Cosimo D / Ligresti, Alessia / Corelli, Federico

ACS chemical neuroscience

2024 Volume 15, Issue 5, Page(s) 955–971

Abstract: Alzheimer's disease (AD) is a neurodegenerative form of dementia characterized by the loss of synapses and a progressive decline in cognitive abilities. Among current treatments for AD, acetylcholinesterase (AChE) inhibitors have efficacy limited to ... ...

Abstract	Alzheimer's disease (AD) is a neurodegenerative form of dementia characterized by the loss of synapses and a progressive decline in cognitive abilities. Among current treatments for AD, acetylcholinesterase (AChE) inhibitors have efficacy limited to symptom relief, with significant side effects and poor compliance. Pharmacological agents that modulate the activity of type-2 cannabinoid receptors (CB2R) of the endocannabinoid system by activating or blocking them have also been shown to be effective against neuroinflammation. Herein, we describe the design, synthesis, and pharmacological effects in vitro and in vivo of dual-acting compounds that inhibit AChE and butyrylcholinesterase (BChE) and target CB2R. Within the investigated series, compound
MeSH term(s)	Humans ; Butyrylcholinesterase/metabolism ; Acetylcholinesterase/metabolism ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Receptors, Cannabinoid ; Neuroblastoma ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Alzheimer Disease/metabolism ; Cognitive Dysfunction/drug therapy ; Molecular Docking Simulation ; Structure-Activity Relationship
Chemical Substances	Butyrylcholinesterase (EC 3.1.1.8) ; Acetylcholinesterase (EC 3.1.1.7) ; Neuroprotective Agents ; Receptors, Cannabinoid ; Cholinesterase Inhibitors
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.3c00656
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Article ; Online: Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-

Mugnaini, Claudia / Kostrzewa, Magdalena / Casini, Marta / Kumar, Poulami / Catallo, Valeria / Allarà, Marco / Guastaferro, Laura / Brizzi, Antonella / Paolino, Marco / Tafi, Andrea / Kapatais, Christelos / Giorgi, Gianluca / Vacondio, Federica / Mor, Marco / Corelli, Federico / Ligresti, Alessia

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 13

Abstract: Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo[4,3- ...

Abstract	Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo[4,3-
MeSH term(s)	Ligands ; Receptor, Cannabinoid, CB2 ; Drug Inverse Agonism ; Structure-Activity Relationship ; Pyridines ; Receptor, Cannabinoid, CB1 ; Cannabinoids
Chemical Substances	Ligands ; Receptor, Cannabinoid, CB2 ; Pyridines ; Receptor, Cannabinoid, CB1 ; Cannabinoids
Language	English
Publishing date	2023-06-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28134958
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Article ; Online: Investigation on Novel

Paolino, Marco / de Candia, Modesto / Purgatorio, Rosa / Catto, Marco / Saletti, Mario / Tondo, Anna Rita / Nicolotti, Orazio / Cappelli, Andrea / Brizzi, Antonella / Mugnaini, Claudia / Corelli, Federico / Altomare, Cosimo D

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 15

Abstract: The multitarget therapeutic strategy, as opposed to the more traditional 'one disease-one target-one drug', may hold promise in treating multifactorial neurodegenerative syndromes, such as Alzheimer's disease (AD) and related dementias. Recently, ... ...

Abstract	The multitarget therapeutic strategy, as opposed to the more traditional 'one disease-one target-one drug', may hold promise in treating multifactorial neurodegenerative syndromes, such as Alzheimer's disease (AD) and related dementias. Recently, combining a photopharmacology approach with the multitarget-directed ligand (MTDL) design strategy, we disclosed a novel donepezil-like compound, namely 2-(4-((diethylamino)methyl)benzylidene)-5-methoxy-2,3-dihydro-1
MeSH term(s)	Humans ; Monoamine Oxidase/metabolism ; Acetylcholinesterase/metabolism ; Monoamine Oxidase Inhibitors/pharmacology ; Monoamine Oxidase Inhibitors/therapeutic use ; Molecular Docking Simulation ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Structure-Activity Relationship ; Alzheimer Disease/drug therapy
Chemical Substances	Monoamine Oxidase (EC 1.4.3.4) ; Acetylcholinesterase (EC 3.1.1.7) ; Monoamine Oxidase Inhibitors ; Cholinesterase Inhibitors
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28155857
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Article: Ferulated Poly(vinyl alcohol) based hydrogels.

Pepi, Simone / Paolino, Marco / Saletti, Mario / Venditti, Jacopo / Talarico, Luigi / Andreassi, Marco / Giuliani, Germano / Caselli, Gianfranco / Artusi, Roberto / Cappelli, Andrea / Leone, Gemma / Magnani, Agnese / Rovati, Lucio

Heliyon

2023 Volume 9, Issue 11, Page(s) e22330

Abstract: New graft copolymers were prepared by reaction of poly (vinyl alcohol) (PVA) with mono-imidazolide or bis-imidazolide derivatives of ferulic acid (FA) with the formation of ester bonds. The obtained graft copolymers, thanks to the crosslinking capability ...

Abstract	New graft copolymers were prepared by reaction of poly (vinyl alcohol) (PVA) with mono-imidazolide or bis-imidazolide derivatives of ferulic acid (FA) with the formation of ester bonds. The obtained graft copolymers, thanks to the crosslinking capability of FA, formed in water strong gels as verified by rheological analyses. The resulting hydrogels were characterized to evaluate their applicability as wound dressing. In this perspective, their capability to absorb and retain a large amount of fluid without dissolving was verified by swelling kinetics and Moisture Vapour Transmission Rate measurements. Their stability towards mechanical solicitations was assessed by quantifying elasticity, compliance, stress-relaxation, and adhesivity properties. The analyses pointed out that hydrogel PVA-FA2-3 obtained by feruloylation of PVA with bis-imidazole derivative of ferulic acid using an acylation agent/polymer molar ratio 0.03/1 resulted the best candidate for the foreseen application.
Language	English
Publishing date	2023-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e22330
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Article: Design and photoisomerization dynamics of a new family of synthetic 2-stroke light driven molecular rotary motors

Filatov, Michael / Paolino, Marco / Min, Seung Kyu / Choi, Cheol Ho

Chemical communications. 2019 Apr. 30, v. 55, no. 36

2019

Abstract	A new family of light driven molecular rotary motors, which can be synthesized from easily available precursor compounds and which are capable of completing a full 360° revolution by two photoisomerization steps only, is proposed. The non-adiabatic molecular dynamic simulations show that the photoisomerization steps of the motor's working cycle occur on an ultrafast time scale (ca. 200–300 fs), have a very high quantum yield of isomerization (0.91–0.97), and display high selectivity of torsion in the same direction. It is expected that the new motor should remain operational at lower temperatures than the currently existing motors.
Keywords	chemical compounds ; photoisomerization ; temperature
Language	English
Dates of publication	2019-0430
Size	p. 5247-5250.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c9cc01955c
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Article ; Online: Fulgides as Light-Driven Molecular Rotary Motors: Computational Design of a Prototype Compound.

Filatov, Michael / Paolino, Marco / Min, Seung Kyu / Kim, Kwang S

The journal of physical chemistry letters

2018 Volume 9, Issue 17, Page(s) 4995–5001

Abstract: A new family of light-driven molecular rotary motors utilizing the fulgide motif is proposed and its prototype molecule is studied by quantum chemical calculations and nonadiabatic molecular dynamics simulations. The new motor performs pure ... ...

Abstract	A new family of light-driven molecular rotary motors utilizing the fulgide motif is proposed and its prototype molecule is studied by quantum chemical calculations and nonadiabatic molecular dynamics simulations. The new motor performs pure unidirectional axial rotation of the rotor blade with high quantum efficiency (ϕ ∼ 0.55-0.68) and ultrafast dynamics (⟨ t⟩
Language	English
Publishing date	2018-08-21
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.8b02268
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