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  1. Book ; Online: Malaria

    Paolo Piccaluga, Pier

    Recent Advances and New Perspectives

    (Infectious Diseases ; 20)

    2023  

    Series title Infectious Diseases ; 20
    Keywords Infectious & contagious diseases ; plasmodium falciparum ; oxidative stress ; pathogenesis ; mortality ; antioxidant activity ; pcr
    Language English
    Size 1 electronic resource (256 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030381049
    ISBN 9781803567938 ; 1803567937
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Acute Leukemias

    Paolo Piccaluga, Pier

    2021  

    Keywords Oncology
    Size 1 electronic resource (322 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021049001
    ISBN 9781838811730 ; 1838811737
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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  3. Book ; Online: Peripheral T-cell Lymphomas

    Paolo Piccaluga, Pier

    2019  

    Keywords Oncology ; epigenetics, genomics, targeted therapy, precision medicine, transcriptomics, tyrosine kinase inhibitors
    Language English
    Size 1 electronic resource (132 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030645025
    ISBN 9781838812270 ; 183881227X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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    Inter-library loan at ZB MED

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  4. Article ; Online: Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases.

    Mundo, Lucia / Ambrosio, Maria Raffaella / Raimondi, Francesco / Del Porro, Leonardo / Guazzo, Raffaella / Mancini, Virginia / Granai, Massimo / Jim Rocca, Bruno / Lopez, Cristina / Bens, Susanne / Onyango, Noel / Nyagol, Joshua / Abinya, Nicholas / Navari, Mohsen / Ndede, Isaac / Patel, Kirkita / Paolo Piccaluga, Pier / Bob, Roshanak / de Santi, Maria Margherita /
    Russell, Robert B / Lazzi, Stefano / Siebert, Reiner / Stein, Harald / Leoncini, Lorenzo

    Blood cancer journal

    2019  Volume 9, Issue 12, Page(s) 91

    Abstract: MYC is the most altered oncogene in human cancer, and belongs to a large family of genes, including MYCN and MYCL. Recently, while assessing the degree of correlation between MYC gene rearrangement and MYC protein expression in aggressive B-cell ... ...

    Abstract MYC is the most altered oncogene in human cancer, and belongs to a large family of genes, including MYCN and MYCL. Recently, while assessing the degree of correlation between MYC gene rearrangement and MYC protein expression in aggressive B-cell lymphomas, we observed few Burkitt lymphoma (BL) cases lacking MYC protein expression despite the translocation involving the MYC gene. Therefore, in the present study we aimed to better characterize such cases. Our results identified two sub-groups of MYC protein negative BL: one lacking detectable MYC protein expression but presenting MYCN mRNA and protein expression; the second characterized by the lack of both MYC and MYCN proteins but showing MYC mRNA. Interestingly, the two sub-groups presented a different pattern of SNVs affecting MYC gene family members that may induce the switch from MYC to MYCN. Particulary, MYCN-expressing cases show MYCN SNVs at interaction interface that stabilize the protein associated with loss-of-function of MYC. This finding highlights MYCN as a reliable diagnostic marker in such cases. Nevertheless, due to the overlapping clinic, morphology and immunohistochemistry (apart for MYC versus MYCN protein expression) of both sub-groups, the described cases represent bona fide BL according to the current criteria of the World Health Organization.
    MeSH term(s) Adolescent ; Adult ; Aged ; Burkitt Lymphoma/epidemiology ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/metabolism ; Burkitt Lymphoma/pathology ; Child ; Female ; Gene Expression Regulation, Neoplastic ; Genes, Switch ; Genes, myc ; Genomics/methods ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; Immunophenotyping ; Male ; Middle Aged ; Models, Molecular ; Mutation ; Protein Conformation ; RNA, Messenger/genetics ; Structure-Activity Relationship ; Translocation, Genetic ; Young Adult
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2019-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-019-0252-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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