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Article ; Online: Giant Left Main Aneurysm Excluded by Percutaneous Approach.

Paolucci, Luca / Scarpelli, Mario / Maselli, Daniele / Briguori, Carlo

2023 Volume 16, Issue 15, Page(s) 1935–1936

MeSH term(s)	Humans ; Aneurysm/surgery
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2023.06.008
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Article ; Online: Systematic review and meta-analysis of randomized and nonrandomized studies on fractional flow reserve-guided revascularization.

Mangiacapra, Fabio / Paolucci, Luca / Johnson, Nils P / Viscusi, Michele Mattia / Ussia, Gian Paolo / Grigioni, Francesco / De Bruyne, Bernard / Barbato, Emanuele

Revista espanola de cardiologia (English ed.)

2024

Abstract: Introduction and objectives: Several studies have investigated the effectiveness of fractional flow reserve (FFR) guidance in improving clinical outcomes after myocardial revascularization, yielding conflicting results. The aim of this study was to ... ...

Abstract	Introduction and objectives: Several studies have investigated the effectiveness of fractional flow reserve (FFR) guidance in improving clinical outcomes after myocardial revascularization, yielding conflicting results. The aim of this study was to compare clinical outcomes in patients with coronary artery disease following FFR-guided or angiography-guided revascularization. Methods: Both randomized controlled trials (RCTs) and nonrandomized intervention studies were included. Coprimary endpoints were all-cause death, myocardial infarction, and major adverse cardiovascular events (MACE). The study is registered with PROSPERO (CRD42022344765). Results: A total of 30 studies enrolling 393 588 patients were included. FFR-guided revascularization was associated with significantly lower rates of all-cause death (OR, 0.63; 95%CI, 0.53-0.73), myocardial infarction (OR, 0.70; 95%CI, 0.59-0.84), and MACE (OR, 0.77; 95%CI, 0.70-0.85). When only RCTs were considered, no significant difference between the 2 strategies was observed for any endpoints. However, the use of FFR was associated with reduced rates of revascularizations and treated lesions. Metaregression suggested that the higher the rate of revascularized patients the lower the benefit of FFR guidance on MACE reduction compared with angiography guidance (P=.012). Similarly, higher rates of patients with acute coronary syndromes were associated with a lower benefit of FFR-guided revascularization (P=.039). Conclusions: FFR-guided revascularization was associated with lower rates of all-cause death, myocardial infarction and MACE compared with angiographic guidance, with RCTs and nonrandomized intervention studies yielding conflicting data. The benefits of FFR-guidance seem to be less evident in studies with high revascularization rates and with a high prevalence of patients with acute coronary syndrome.
Language	Spanish
Publishing date	2024-03-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2592481-3
ISSN	1885-5857 ; 1885-5857
ISSN (online)	1885-5857
ISSN	1885-5857
DOI	10.1016/j.rec.2024.02.010
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Article ; Online: New Guideline-Directed Treatments for Heart Failure: Navigating Through the Multiple Turns of Everyday Clinical Practice.

Paolucci, Luca / Grigioni, Francesco / Cammalleri, Valeria / Ussia, Gian Paolo / Enriquez-Sarano, Maurice

JACC. Case reports

2022 Volume 4, Issue 1, Page(s) 75–78

Abstract: The new European guidelines for the treatment and management of heart failure (HF) introduce several new recommendations. The revised HF definition has abolished the term "mid-range," introducing the new concept of "mildly reduced" ejection fraction (EF), ...

Abstract	The new European guidelines for the treatment and management of heart failure (HF) introduce several new recommendations. The revised HF definition has abolished the term "mid-range," introducing the new concept of "mildly reduced" ejection fraction (EF), which now deserves consideration for therapies previously confined to reduced EF (HF with reduced EF). Following the introduction of sodium-glucose cotransporter 2 inhibitors, physicians should now combine up to 4 different drugs to improve HF with reduced EF prognosis, leading to new issues regarding tolerance and adherence to therapy. Transcatheter treatments of mitral and tricuspid regurgitation are progressively gaining increasing consideration among nonpharmacological strategies. Dedicated therapies for HF with preserved EF are still lacking. These are only some of the most relevant changes provided by European guidelines on HF that are addressed in the present editorial, taking into account the most updated American recommendations.
Language	English
Publishing date	2022-01-05
Publishing country	Netherlands
Document type	Editorial
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2021.11.006
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Article ; Online: Myelomatous meningitis diagnosed by cerebrospinal fluid cytology examination.

Bizzarro, Tommaso / De Marco, Giovanna / Romoli, Michele / Paolucci, Lina / Morigi, Federico / Longoni, Marco / Bartolini, Daniela

Cytopathology : official journal of the British Society for Clinical Cytology

2023 Volume 35, Issue 2, Page(s) 307–309

Abstract: Myelomatous meningitis diagnosed by CSF cytology. The combined use of cytology with immunocytochemistry can identify the presence of multiple myeloma cells in cerebrospinal fluid specimens. ...

Abstract	Myelomatous meningitis diagnosed by CSF cytology. The combined use of cytology with immunocytochemistry can identify the presence of multiple myeloma cells in cerebrospinal fluid specimens.
MeSH term(s)	Humans ; Multiple Myeloma/diagnosis ; Multiple Myeloma/pathology ; Meningitis/diagnosis ; Meningitis/cerebrospinal fluid ; Cytological Techniques ; Cytodiagnosis
Language	English
Publishing date	2023-10-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1034190-0
ISSN	1365-2303 ; 0956-5507 ; 1350-4037
ISSN (online)	1365-2303
ISSN	0956-5507 ; 1350-4037
DOI	10.1111/cyt.13326
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Zs.A 2926: Show issues

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Article ; Online: Contrast media volume reduction with the DyeVert

Paolucci, Luca / De Micco, Francesca / Bezzeccheri, Andrea / Scarpelli, Mario / Esposito, Giovanni / Airoldi, Flavio / Focaccio, Amelia / Briguori, Carlo

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2023 Volume 102, Issue 4, Page(s) 655–662

Abstract: Background: Contrast associated acute kidney injury (CA-AKI) can lead to an increased risk of adverse events. Contrast media (CM) volume reduction has been advocated as a pivotal strategy to prevent CA-AKI in stable patients undergoing percutaneous ... ...

Abstract	Background: Contrast associated acute kidney injury (CA-AKI) can lead to an increased risk of adverse events. Contrast media (CM) volume reduction has been advocated as a pivotal strategy to prevent CA-AKI in stable patients undergoing percutaneous coronary procedures. Aims: To compare the effectiveness of CM volume reduction with the DyeVert Methods: We prospectively collected data from 136 patients with stable coronary artery disease at high risk of CA-AKI treated with left ventricular end diastolic pressure (LVEDP)- guided hydration and undergoing interventions with the use of the DyeVert Results: Patients in the DyeVert group were treated with a significant lower CM volume (median: 47.5 vs. 84.0 mL, p < 0.001). The trend in creatinine increase was lower (p = 0.004) and the Δ of creatinine (0-48 h) showed a higher drop (-0.18 vs. -0.10 mg/dL, p = 0.036) in the DyeVert group. The risk of CA-AKI was significantly lower in DyeVert group compared to control group (5.1% vs. 16.8%; odds ratio 0.27, 95% confidence interval [0.12-0.61]). Conclusions: CM volume reduction with the DyeVert
MeSH term(s)	Humans ; Contrast Media/adverse effects ; Creatinine ; Treatment Outcome ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/diagnosis ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Coronary Artery Disease/chemically induced ; Percutaneous Coronary Intervention/adverse effects ; Risk Factors ; Coronary Angiography/adverse effects
Chemical Substances	Contrast Media ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30809
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Zs.A 1226: Show issues

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Article ; Online: In vivo

Silva Rocha Junior, Sérgio / Corrêa, Mayara G / Dias, Lucas A / Antunes de Lima, Marcos Paulo / Beier, Suzane L / Paolucci, Leopoldo / Alberto do Lago, Luiz / Las Casas, Estevam B / Faleiros, Rafael R

PeerJ

2024 Volume 12, Page(s) e16656

Abstract: The objective of this study was to test a composite of polyester resin and fiberglass in the form of an intramedullary nail for osteosynthesis of femoral fractures in calves. The methodology was established based on a previous study that used a bovine ... ...

Abstract	The objective of this study was to test a composite of polyester resin and fiberglass in the form of an intramedullary nail for osteosynthesis of femoral fractures in calves. The methodology was established based on a previous study that used a bovine femur finite element model to simulate fractures, which were then stabilized by the same nails as proposed in this study. General anesthesia was induced in six calves followed by fracture creation
MeSH term(s)	Animals ; Cattle ; Fracture Fixation, Intramedullary/methods ; Bone Nails/veterinary ; Polyesters ; Femoral Fractures/surgery ; Fracture Healing ; Femur/surgery ; Glass
Chemical Substances	fiberglass ; Polyesters
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.16656
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Article: Description of a change in teaching methods and comparison of quizzes versus midterms scores in a research methods course.

Sullivan, Stephanie G B / Hoiriis, Kathryn T / Paolucci, Lucia

The Journal of chiropractic education

2018 Volume 32, Issue 2, Page(s) 84–89

Abstract: Objective:: We describe a change in teaching method from extended face-to-face instruction to a blended classroom environment in a research methods course and compare student scores following a change in assessment from mid-term examination to weekly ... ...

Abstract	Objective:: We describe a change in teaching method from extended face-to-face instruction to a blended classroom environment in a research methods course and compare student scores following a change in assessment from mid-term examination to weekly quizzes. Methods:: The course traditionally had been taught using a weekly 2-hour lecture for each academic term. A change in teaching methods was designed to include 20 minutes of lecture followed by 30 minutes of topic-specific in-class group discussions. The students then continued group work for an additional hour at an alternative location of their choice, such as the library, café, student study areas, or at home. Student homework/reading assignments were given as topics for weekly group discussions. In addition, the midterm examinations were replaced with weekly quizzes. Using t-test and analysis of variance, scores for four student cohorts in two successive academic terms were compared using identical multiple-choice questions from the midterms and quizzes for two topics. Student verbal feedback was elicited at the end of each term. Results:: Quiz scores showed significant improvement over midterm scores for the more challenging statistics multiple-choice questions ( t[371] = -2.21, p = .03, d = 0.23) with no significant improvement in multiple-choice questions about the safety of human subjects ( t[374] = -.401, p = .69, d = 0.04). Student verbal feedback indicated higher satisfaction with the blended classroom and experiential learning style. Conclusion:: Assessment using quizzes in an early and often format, instead of a midterm examination, was associated with higher scores on identical questions. Students preferred the blended classroom environment with experiential learning exercises and weekly quizzes.
Language	English
Publishing date	2018-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2261817-X
ISSN	1042-5055
ISSN	1042-5055
DOI	10.7899/JCE-17-20
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Article ; Online: Intravenous volume expansion to prevent contrast-associated acute kidney injury.

Briguori, Carlo / Di Iorio, Antonietta / Riviezzo, Guido / Scafuri, Stefano / Focaccio, Amelia / Paolucci, Luca / Cavaliere, Valeria / Di Micco, Francesca / Mariano, Enrica / Celotto, Roberto / Valenti, Francesco / Sangiorgi, Giuseppe Massimo / Biondi-Zoccai, Giuseppe

The Journal of invasive cardiology

2023 Volume 35, Issue 11

Abstract: Objectives: Several volume expansion protocols have been proposed to prevent contrast-associated acute kidney injury (CA-AKI). The aim of our study was to seek the ideal intravenous volume expansion to prevent CA-AKI in patients with chronic kidney ... ...

Abstract	Objectives: Several volume expansion protocols have been proposed to prevent contrast-associated acute kidney injury (CA-AKI). The aim of our study was to seek the ideal intravenous volume expansion to prevent CA-AKI in patients with chronic kidney disease (CKD) undergoing invasive cardiovascular procedures. Methods: We analyzed 1927 CKD patients enrolled in 6 studies that took place from September 15, 2000 to June 6, 2019. Four volume expansion regiments were included: (1) conventional group (n=625); (2) bicarbonate group (n=255); (3) left ventricular end-diastolic pressure-guided group (n=355); and (4) urine flow rate-guided group (n=500). Results: CA-AKI (serum creatinine increase ≥0.3 mg/dL at 48 hours) occurred in 224 (11%) patients. In patients with CA-AKI, volume expansion was lower (2090 ± 1382 mL vs 2551 ± 1716 mL; P less than .001) and acute pulmonary edema occurred more often (3.5% vs 0.29%; P less than .001). By ROC curve analysis, an absolute volume expansion greater than or equal to 1430 mL (AUC = 0.70) and a volume expansion to contrast media volume ratio greater than or equal to 17 (AUC = 0.57) were the best thresholds for freedom from CA-AKI. Conclusions: In our comprehensive pooled analysis, an absolute volume expansion greater than or equal to 1430 mL and a volume expansion to contrast media volume ratio greater than or equal to 17 are the best dichotomous thresholds for CA-AKI prevention. These cutoffs should be formally tested in a dedicated trial as a pragmatic means to prevent CA-AKI.
MeSH term(s)	Humans ; Contrast Media/adverse effects ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/prevention & control ; Renal Insufficiency, Chronic ; Risk Factors ; Creatinine
Chemical Substances	Contrast Media ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
DOI	10.25270/jic/23.00187
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Zs.A 3701: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 272: Show issues
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Article ; Online: Effects of ticagrelor and prasugrel on coronary microcirculation in elective percutaneous coronary intervention.

Mangiacapra, Fabio / Colaiori, Iginio / Di Gioia, Giuseppe / Pellicano, Mariano / Heyse, Alex / Paolucci, Luca / Peace, Aaron / Bartunek, Jozef / de Bruyne, Bernard / Barbato, Emanuele

Heart (British Cardiac Society)

2023 Volume 110, Issue 2, Page(s) 115–121

Abstract: Objective: To compare the effects of ticagrelor and prasugrel on absolute coronary blood flow (Q) and microvascular resistance (R) in patients with stable coronary artery disease (CAD) treated with elective percutaneous coronary intervention (PCI) ( ... ...

Abstract	Objective: To compare the effects of ticagrelor and prasugrel on absolute coronary blood flow (Q) and microvascular resistance (R) in patients with stable coronary artery disease (CAD) treated with elective percutaneous coronary intervention (PCI) (NCT05643586). Besides being at least as effective as prasugrel in inhibiting platelet aggregation, ticagrelor has been shown to have additional properties potentially affecting coronary microcirculation. Methods: We randomly assigned 50 patients to ticagrelor (180 mg) or prasugrel (60 mg) at least 12 hours before intervention. Continuous thermodilution was used to measure Q and R before and after PCI. Platelet reactivity was measured before PCI. Troponin I was measured before, 8 and 24 hours after PCI. Results: At baseline, fractional flow reserve, Q and R were similar in two study groups. Patients in the ticagrelor group showed higher post-PCI Q (242±49 vs 205±53 mL/min, p=0.015) and lower R values (311 (263, 366) vs 362 (319, 382) mm Hg/L/min, p=0.032). Platelet reactivity showed a negative correlation with periprocedural variation of Q values (r=-0.582, p<0.001) and a positive correlation with periprocedural variation of R values (r=0.645, p<0.001). The periprocedural increase in high-sensitivity troponin I was significantly lower in the ticagrelor compared with the prasugrel group (5 (4, 9) ng/mL vs 14 (10, 24) ng/mL, p<0.001). Conclusions: In patients with stable CAD undergoing PCI, pretreatment with a loading dose of ticagrelor compared with prasugrel improves post-procedural coronary flow and microvascular function and seems to reduce the related myocardial injury.
MeSH term(s)	Humans ; Acute Coronary Syndrome/drug therapy ; Coronary Artery Disease/surgery ; Coronary Artery Disease/drug therapy ; Fractional Flow Reserve, Myocardial ; Microcirculation ; Percutaneous Coronary Intervention/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Aggregation Inhibitors/pharmacology ; Prasugrel Hydrochloride/therapeutic use ; Purinergic P2Y Receptor Antagonists/therapeutic use ; Purinergic P2Y Receptor Antagonists/pharmacology ; Ticagrelor/therapeutic use ; Treatment Outcome ; Troponin I
Chemical Substances	Platelet Aggregation Inhibitors ; Prasugrel Hydrochloride (G89JQ59I13) ; Purinergic P2Y Receptor Antagonists ; Ticagrelor (GLH0314RVC) ; Troponin I
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2022-321868
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Zs.MO 112: Show issues

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Article: Acute coronary syndromes and multivessel coronary artery disease.

Zimbardo, Giuseppe / Cialdella, Pio / Di Fusco, Paolo / Donahue, Michael Edward / D'Aquino, Umberto Maria Lombardi / Paolucci, Luca / Sergi, Sonia Cristina / Talarico, Giovanni Paolo / Calò, Leonardo

European heart journal supplements : journal of the European Society of Cardiology

2023 Volume 25, Issue Suppl C, Page(s) C74–C78

Abstract: Patients with acute coronary syndromes (ACS) and multivessel coronary artery disease are frequently encountered during clinical practice and those patients are at higher risk of subsequent acute cardiovascular events. In patients presenting with both ST- ... ...

Abstract	Patients with acute coronary syndromes (ACS) and multivessel coronary artery disease are frequently encountered during clinical practice and those patients are at higher risk of subsequent acute cardiovascular events. In patients presenting with both ST-segment elevation myocardial infarction and non-ST-segment elevation acute coronary syndromes, complete revascularization is associated with decreased risk of major adverse cardiovascular events. Nevertheless, the optimal timing of the intervention and treatment modality are still in discussions. Furthermore, non-culprit lesions assessment based on stenosis severity, either on visual or on functional evaluation, may not provide information about vulnerable plaques prone to thrombosis. Therefore, insights from intracoronary imaging could further identify high-risk plaque and patients at higher risk of future adverse events. This article aims to provide an overview of current guideline recommendations, envisioning future perspectives for the treatment of patients with ACS and multivessel disease.
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1463769-8
ISSN	1554-2815 ; 1520-765X
ISSN (online)	1554-2815
ISSN	1520-765X
DOI	10.1093/eurheartjsupp/suad010
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