LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: A 3D-printed blood-brain barrier model with tunable topology and cell-matrix interactions.

    Paone, Louis S / Benmassaoud, Mohammed Mehdi / Curran, Aidan / Vega, Sebastián L / Galie, Peter A

    Biofabrication

    2023  Volume 16, Issue 1

    Abstract: Recent developments in digital light processing (DLP) can advance the structural and biochemical complexity of ... ...

    Abstract Recent developments in digital light processing (DLP) can advance the structural and biochemical complexity of perfusable
    MeSH term(s) Blood-Brain Barrier/metabolism ; Endothelial Cells ; Peptides/chemistry ; Hydrogels/chemistry ; Printing, Three-Dimensional ; Oligopeptides
    Chemical Substances Peptides ; Hydrogels ; Oligopeptides
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2500944-8
    ISSN 1758-5090 ; 1758-5082
    ISSN (online) 1758-5090
    ISSN 1758-5082
    DOI 10.1088/1758-5090/ad0260
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Effects of Drag-Reducing Polymers on Hemodynamics and Whole Blood-Endothelial Interactions in 3D-Printed Vascular Topologies.

    Paone, Louis S / Szkolnicki, Matthew / DeOre, Brandon J / Tran, Kiet A / Goldman, Noah / Andrews, Allison M / Ramirez, Servio H / Galie, Peter A

    ACS applied materials & interfaces

    2024  Volume 16, Issue 12, Page(s) 14457–14466

    Abstract: Most in vitro models use culture medium to apply fluid shear stress to endothelial cells, which does not capture the interaction between blood and endothelial cells. Here, we describe a new system to characterize whole blood flow through a 3D-printed, ... ...

    Abstract Most in vitro models use culture medium to apply fluid shear stress to endothelial cells, which does not capture the interaction between blood and endothelial cells. Here, we describe a new system to characterize whole blood flow through a 3D-printed, endothelialized vascular topology that induces flow separation at a bifurcation. Drag-reducing polymers, which have been previously studied as a potential therapy to reduce the pressure drop across the vascular bed, are evaluated for their effect on mitigating the disturbed flow. Polymer concentrations of 1000 ppm prevented recirculation and disturbed flow at the wall. Proteomic analysis of plasma collected from whole blood recirculated through the vascularized channel with and without drag-reducing polymers provides insight into the effects of flow regimes on levels of proteins indicative of the endothelial-blood interaction. The results indicate that blood flow alters proteins associated with coagulation, inflammation, and other processes. Overall, these proof-of-concept experiments demonstrate the importance of using whole blood flow to study the endothelial response to perfusion.
    MeSH term(s) Polymers/pharmacology ; Endothelial Cells ; Proteomics ; Hemodynamics/physiology ; Printing, Three-Dimensional ; Stress, Mechanical
    Chemical Substances Polymers
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c17099
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Matching mechanical heterogeneity of the native spinal cord augments axon infiltration in 3D-printed scaffolds.

    Tran, Kiet A / DeOre, Brandon J / Ikejiani, David / Means, Kristen / Paone, Louis S / De Marchi, Laura / Suprewicz, Łukasz / Koziol, Katarina / Bouyer, Julien / Byfield, Fitzroy J / Jin, Ying / Georges, Penelope / Fischer, Itzhak / Janmey, Paul A / Galie, Peter A

    Biomaterials

    2023  Volume 295, Page(s) 122061

    Abstract: Scaffolds delivered to injured spinal cords to stimulate axon connectivity often match the anisotropy of native tissue using guidance cues along the rostral-caudal axis, but current approaches do not mimic the heterogeneity of host tissue mechanics. ... ...

    Abstract Scaffolds delivered to injured spinal cords to stimulate axon connectivity often match the anisotropy of native tissue using guidance cues along the rostral-caudal axis, but current approaches do not mimic the heterogeneity of host tissue mechanics. Although white and gray matter have different mechanical properties, it remains unclear whether tissue mechanics also vary along the length of the cord. Mechanical testing performed in this study indicates that bulk spinal cord mechanics do differ along anatomical level and that these differences are caused by variations in the ratio of white and gray matter. These results suggest that scaffolds recreating the heterogeneity of spinal cord tissue mechanics must account for the disparity between gray and white matter. Digital light processing (DLP) provides a means to mimic spinal cord topology, but has previously been limited to printing homogeneous mechanical properties. We describe a means to modify DLP to print scaffolds that mimic spinal cord mechanical heterogeneity caused by variation in the ratio of white and gray matter, which improves axon infiltration compared to controls exhibiting homogeneous mechanical properties. These results demonstrate that scaffolds matching the mechanical heterogeneity of white and gray matter improve the effectiveness of biomaterials transplanted within the injured spinal cord.
    MeSH term(s) Humans ; Spinal Cord Injuries ; Spinal Cord ; Axons ; Biocompatible Materials ; Printing, Three-Dimensional ; Tissue Scaffolds
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2023-02-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2023.122061
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top