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Article ; Online: Thrombosis in Pregnant Women with Hemolytic Anemia.

Papadakis, Emmanouil / Brenner, Benjamin

2022 Volume 49, Issue 4, Page(s) 364–370

Abstract: Hemolytic anemias are a group of uncommon disorders affecting both genders, frequently occurring at the reproductive age. While a link between hemolysis and hypercoagulability has been suggested based on the elucidation of certain involved ... ...

Abstract	Hemolytic anemias are a group of uncommon disorders affecting both genders, frequently occurring at the reproductive age. While a link between hemolysis and hypercoagulability has been suggested based on the elucidation of certain involved pathophysiological mechanisms, the extent of thrombotic risk in pregnant women with hemolytic anemia remains debatable. Due to the paucity of pregnancy-related data, risk assessment of gestations in women with hemolytic anemia is complicated. This review will highlight the latest advances in the diagnosis and management of these challenging disorders in pregnancy.
MeSH term(s)	Female ; Humans ; Male ; Pregnancy ; Pregnant Women ; Anemia, Hemolytic/diagnosis ; Anemia, Hemolytic/complications ; Thrombosis/complications ; Thrombophilia/complications ; Hemolysis
Language	English
Publishing date	2022-11-21
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0042-1758819
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between Ranolazine, Ischemic Preconditioning, and Cardioprotection in Patients Undergoing Scheduled Percutaneous Coronary Intervention.

Kourtis, Konstantinos / Bourazana, Angeliki / Xanthopoulos, Andrew / Skoularigkis, Spyridon / Papadakis, Emmanouil / Patsilinakos, Sotirios / Skoularigis, John

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 1

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Humans ; Ranolazine/pharmacology ; Ranolazine/therapeutic use ; Percutaneous Coronary Intervention ; Prospective Studies ; Troponin I ; Ischemic Preconditioning
Chemical Substances	Ranolazine (A6IEZ5M406) ; Troponin I
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60010166
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Article ; Online: Assessment-based management of placenta-mediated pregnancy complications: Pragmatism until a precision medicine approach evolves.

Brenner, Benjamin / Papadakis, Emmanouil / Greer, Ian A / Gris, Jean-Christophe

British journal of haematology

2023 Volume 202, Issue 1, Page(s) 18–30

Abstract: The management of pregnant women with thrombophilia and a history of gestational vascular complications remains debatable. Treatment of the latter is often based on clinical outcome rather than disease mechanism. While the use of venous thromboembolism ... ...

Abstract	The management of pregnant women with thrombophilia and a history of gestational vascular complications remains debatable. Treatment of the latter is often based on clinical outcome rather than disease mechanism. While the use of venous thromboembolism prophylaxis in pregnancy is recommended for those at increased risk, the ability of anticoagulant and/or antiplatelet agents to lower the risk of placenta-mediated complications in this clinical setting remains controversial. The available guidelines are inconsistent in some situations, which reflects the limited evidence base. This review critically discusses risk assessment models (RAMs) and management strategies of women with thrombophilia and pregnancy complications, using clinical vignettes. RAMs, taking into account obstetric and thrombotic history as well as thrombophilia status, could drive a precision medicine approach, based on disease mechanism, and guide individual therapeutic interventions in high-risk clinical settings.
MeSH term(s)	Female ; Pregnancy ; Humans ; Precision Medicine ; Placenta ; Pregnancy Complications/drug therapy ; Thrombophilia/etiology ; Thrombophilia/complications ; Anticoagulants/therapeutic use ; Pregnancy Complications, Hematologic/drug therapy ; Risk Factors
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18856
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Article: Thrombosis in Pregnant Women with Hemolytic Anemia

Papadakis, Emmanouil / Brenner, Benjamin

Seminars in Thrombosis and Hemostasis

(Maternal and Neonatal Hemostasis)

2022 Volume 49, Issue 04, Page(s) 364–370

Series title	Maternal and Neonatal Hemostasis
Abstract	Hemolytic anemias are a group of uncommon disorders affecting both genders, frequently occurring at the reproductive age. While a link between hemolysis and hypercoagulability has been suggested based on the elucidation of certain involved pathophysiological mechanisms, the extent of thrombotic risk in pregnant women with hemolytic anemia remains debatable. Due to the paucity of pregnancy-related data, risk assessment of gestations in women with hemolytic anemia is complicated. This review will highlight the latest advances in the diagnosis and management of these challenging disorders in pregnancy.
Keywords	hemolytic anemias ; pregnancy ; venous thromboembolism
Language	English
Publishing date	2022-11-21
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0042-1758819
Database	Thieme publisher's database

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Article: Aggressiveness and Patulin Production in

Ntasiou, Panagiota / Samaras, Anastasios / Papadakis, Emmanouil-Nikolaos / Menkissoglu-Spiroudi, Urania / Karaoglanidis, George S

Plants (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Penicillium ... ...

Abstract	Penicillium expansum
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12061398
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Article ; Online: Five-year morbidity and mortality of patients with ischemia with non-obstructive coronary artery disease and myocardial single-photon emission computed tomography perfusion defects.

Lampas, Evangelos / Syrmali, Kiriaki / Nikitas, Georgios / Papadakis, Emmanouil C / Patsilinakos, Sotirios P

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

2023 Volume 42, Issue 6, Page(s) 519–524

Abstract: Introduction: Patients with angina and a positive single-photon emission computed tomography (SPECT) scan for reversible ischemia, with no or non-obstructive coronary artery disease (CAD) on invasive coronary angiography (ICA), represent a frequent ... ...

Abstract	Introduction: Patients with angina and a positive single-photon emission computed tomography (SPECT) scan for reversible ischemia, with no or non-obstructive coronary artery disease (CAD) on invasive coronary angiography (ICA), represent a frequent clinical problem and predicting prognosis is challenging. Methods: This was a retrospective single-center study on patients who underwent elective ICA with angina and a positive SPECT with no or non-obstructive CAD over a seven-year period. Cardiovascular morbidity, mortality, and major adverse cardiac events were assessed during a follow-up of at least three years after ICA, with the aid of a telephone questionnaire. Results: Data on all patients who underwent ICA in our hospital over a period of seven years (between January 1, 2011 and December 31, 2017) were analyzed. A total of 569 patients fulfilled the pre-specified criteria. In the telephone survey, 285 (50.1%) were successfully contacted and agreed to participate. Mean age was 67.6 (SD 8.8) years (35.4% female) and mean follow-up was 5.53 years (SD 1.85). Mortality was 1.7% (four patients, from non-cardiac causes), 1.7% underwent revascularization, 31 (10.9%) were hospitalized for cardiac reasons and 10.9% reported symptoms of heart failure (no patients with NYHA class>II). Twenty-one had arrhythmic events and only two had mild anginal symptoms. It was also noteworthy that mortality in the uncontacted group (12 out of 284, 4.2%), derived from public social security records, did not differ significantly from the contacted group. Conclusions: Patients with angina, a positive SPECT for reversible ischemia and no or non-obstructive CAD on ICA have excellent long-term cardiovascular prognosis for at least five years.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnostic imaging ; Retrospective Studies ; Coronary Angiography ; Prospective Studies ; Tomography, Emission-Computed, Single-Photon/methods ; Ischemia ; Perfusion ; Myocardial Perfusion Imaging/methods
Language	Portuguese
Publishing date	2023-03-07
Publishing country	Portugal
Document type	Journal Article
ZDB-ID	632718-7
ISSN	2174-2030 ; 0870-2551 ; 0304-4750
ISSN (online)	2174-2030
ISSN	0870-2551 ; 0304-4750
DOI	10.1016/j.repc.2022.07.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genetic Assessment, Propagation and Chemical Analysis of Flowers of Rosa damascena Mill. Genotypes Cultivated in Greece

Ziogou, Fotios-Theoharis / Kotoula, Aikaterini-Angeliki / Hatzilazarou, Stefanos / Papadakis, Emmanouil-Nikolaos / Avramis, Panos-George / Economou, Athanasios / Kostas, Stefanos

Horticulturae. 2023 Aug. 20, v. 9, no. 8

2023

Abstract: Rosa damascena Mill. is commercially the most important rose species used to produce essential oils. The plants of this species, cultivated in the district of Western Macedonia (Greece) for rose oil production, originated from indigenous genotypes but ... ...

Abstract	Rosa damascena Mill. is commercially the most important rose species used to produce essential oils. The plants of this species, cultivated in the district of Western Macedonia (Greece) for rose oil production, originated from indigenous genotypes but also nurseries abroad, mainly from Bulgaria. The present study investigated the genetic relationship between nine genotypes of R. damascena from Greece, one genotype from Turkey, three genotypes from Bulgaria and three genotypes from France using the molecular markers ISSR and SCoT. Also, the rooting ability of shoot cuttings from these nine genotypes was investigated by applying 2 g/L of the rooting regulator K-IBA. In addition, petals were chemically analyzed using GC-MS and LC-MS to identify the compounds that are the main components of the rose oil. The nine rose genotypes of R. damascena, cultivated in Greece, one from Turkey and one of the three genotypes from Bulgaria were clustered in one clade in the dendrogram. The other two genotypes from Bulgaria were clustered in a separate clade that demonstrated the existence of genetic diversity among the three Bulgarian genotypes, while the French genotypes were clustered in a third clade. The shoot cuttings rooted relatively easily (55–70%) with the application of K-IBA, without any significant differences among the nine genotypes. Large variation was observed among the nine genotypes in the main volatile compounds of the flower petal extracts, which are related to rose oil components. For these compounds, the concentrations in μg/g of the fresh petal weight were 2-phenylethylalcohol (1148.35–2777.19), nerol (27.45–64.93), citronellol (88.45–206.59), geraniol (69.12–170.99) and nonadecane (209.27–533.15). Of the non-volatile compounds, gallic acid was the most abundant phenolic acid in the petal extracts of the nine genotypes (0.28–0.82 μg/g), while for the flavonoids, quercetin and kaempferol variations of 0.35–1.17 μg/g and 0.26–2.13 μg/g were recorded, respectively.
Keywords	Rosa damascena ; chemical analysis ; citronellol ; corolla ; gallic acid ; genetic relationships ; genetic variation ; genotype ; geraniol ; kaempferol ; nerol ; oils ; quercetin ; Bulgaria ; France ; Greece
Language	English
Dates of publication	2023-0820
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2813983-5
ISSN	2311-7524
ISSN	2311-7524
DOI	10.3390/horticulturae9080946
Database	NAL-Catalogue (AGRICOLA)

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Article: Conventional vs. organic vineyards: Black Aspergilli population structure, mycotoxigenic capacity and mycotoxin contamination assessment in wines, using a new Q-TOF MS-MS detection method

Testempasis, Stefanos I. / Kamou, Nathalie N. / Papadakis, Emmanouil-Nikolaos / Menkissoglu-Spiroudi, Urania / Karaoglanidis, George S.

Food control. 2022 June, v. 136

2022

Abstract: Aspergillus bunch rot, caused by several mycotoxigenic species of Black Aspergilli section Nigri is one of the most severe diseases of grapevine, while mycotoxin contaminated products may pose a risk to the consumers health. During a 2-year (2018–2019) ... ...

Abstract	Aspergillus bunch rot, caused by several mycotoxigenic species of Black Aspergilli section Nigri is one of the most severe diseases of grapevine, while mycotoxin contaminated products may pose a risk to the consumers health. During a 2-year (2018–2019) survey, the impact of conventional and organic farming systems on Black Aspergilli population structure in Greek vineyards was thoroughly investigated. In total, 300 isolates of Aspergillus spp. were selected and identified by amplicon sequencing of the ITS-region, β-tubulin and calmodulin genes. Four different Aspergillus section Nigri species (A. tubingensis, A. uvarum, A. carbonarius and A. niger) were identified as the casual agents of the disease. During both sampling years, higher frequencies of A. tubingensis and A. uvarum were found in the organic and conventional vineyards, respectively. In vitro production of ochratoxin A (OTA) and fumonisin B₂, B₃ and B₄ (FB₂, FB₃, and FB₄) was evaluated in two selective media. The analysis revealed a low frequency of mycotoxigenic isolates, while, most of these isolates originated from conventional vineyards. As expected, A. carbonarious was identified as the main OTA producer (0.01–9.2 μg/g), whereas A. niger was the leading producer of FBs. In total, 74 wine samples originating from either organic or conventional vineyards of the same region, were analyzed using a new Quadrupole Time-of-Flight Mass Spectrometry (QTOF MS-MS) analytical method developed to detect and quantify Alternariol (AOH), Alternariol monomethyl ether (AME), and Citrinin (CIT) in addition to the aforementioned Aspergillus mycotoxins (OTA, FB₁, FB₂ FB₃), using a modified QuEChERS extraction protocol. Interestingly, a low frequency of mycotoxin-contaminated wines was detected. At the same time, fumonisins (FBs) were identified as the main mycotoxins in Greek wines. This is the first study deciphering the impact of conventional and organic farming systems on Aspergillus section Nigri species in Greek vineyards, suggesting that farming system may affect the species composition within the vineyard. Furthermore, evidence was provided for a higher risk of selection of Aspergillus strains with higher mycotoxigenic capacity in conventional vineyards, associated with higher risk of mycotoxin contamination in wines originating from these vineyards.
Keywords	Vitis ; calmodulin ; citrinin ; food safety ; mass spectrometry ; ochratoxin A ; population structure ; risk ; species diversity ; surveys ; vineyards ; wines
Language	English
Dates of publication	2022-06
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1027805-9
ISSN	0956-7135
ISSN	0956-7135
DOI	10.1016/j.foodcont.2022.108860
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Insights on the impact of deep eutectic solvents on the composition of the extracts from lemon (Citrus limon L.) peels analyzed by a novel RP-LC–QTOF-MS/MS method

Kalogiouri, Natasa P. / Palaiologou, Eirini / Papadakis, Emmanouil Nikolaos / Makris, Dimitris P. / Biliaderis, Costas G. / Mourtzinos, Ioannis

Eur Food Res Technol. 2022 Dec., v. 248, no. 12 p.2913-2927

2022

Abstract: Extraction of polyphenolic compounds from lemon peels using deep eutectic solvents (DES) was investigated. A choline chloride-based DES paired with glycerol was used as the extraction solvent, alternative to conventional ones. Response surface ... ...

Abstract	Extraction of polyphenolic compounds from lemon peels using deep eutectic solvents (DES) was investigated. A choline chloride-based DES paired with glycerol was used as the extraction solvent, alternative to conventional ones. Response surface methodology (RSM) was employed to optimize the extraction parameters, namely, the water concentration (CW), the liquid to solid ratio (RL/S) and the duration of the extraction (t) in terms of total phenol content and radical scavenging activity; the conditions that can be recommended as optimum for the recovery of the phenolic compounds were 55% (w/v), 13 mL g⁻¹ and 36 min, respectively. The composition of the obtained extracts under optimum conditions was compared with extracts prepared in ethanol and water. A novel reversed phase ultra-pressure electrospray liquid chromatographic time-of-flight mass spectrometric method (RP-UPLC–ESI–QTOF-MS) was developed and validated for the determination of individual bioactive compounds in the extracts through target, suspect, and non-target screening. The developed RP-UPLC–ESI–QTOF-MS methodology was validated and presented adequately low limits of detection (LODs) and limits of quantification (LOQs) over the ranges 8.64 (quercetin)–30.4 μg L⁻¹ (p-coumaric acid), and 25.9 (quercetin)–91.2 μg L⁻¹ (p-coumaric acid), respectively. The RSD% of the within-day and between-day assays were lower than 3.2, and 9.8, respectively, demonstrating good method precision. Overall, 10 compounds were determined and quantified through target screening, as well as 4 suspect, and 9 non-target compounds were tentatively identified in the extracts by means of suspect and non-target screening, respectively.
Keywords	Citrus limon ; choline ; ethanol ; glycerol ; lemons ; liquid chromatography ; liquids ; mass spectrometry ; p-coumaric acid ; phenols ; quercetin ; response surface methodology ; solvents
Language	English
Dates of publication	2022-12
Size	p. 2913-2927.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1359456-4
ISSN	1431-4630 ; 1438-2377
ISSN	1431-4630 ; 1438-2377
DOI	10.1007/s00217-022-04100-0
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: RotaWire-induced coronary perforation and tamponade during rotational atherectomy.

Mantis, Christos / Kintis, Konstantinos / Papadakis, Emmanouil / Patsilinakos, Sotirios

Kardiologia polska

2018 Volume 76, Issue 3, Page(s) 676

MeSH term(s)	Atherectomy, Coronary/adverse effects ; Cardiac Tamponade/diagnostic imaging ; Cardiac Tamponade/etiology ; Cardiac Tamponade/surgery ; Coronary Angiography ; Coronary Artery Disease/surgery ; Heart Injuries/diagnostic imaging ; Heart Injuries/etiology ; Heart Injuries/surgery ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2018-03-26
Publishing country	Poland
Document type	Case Reports ; Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.5603/KP.2018.0067
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