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  1. Article ; Online: Lifelong cell-cell interactions in the testis: A driver for male fertility. Summary of the XXVth North American Testis Workshop.

    Papadopoulos, Vassilios

    Andrology

    2020  Volume 8, Issue 4, Page(s) 818–819

    MeSH term(s) Animals ; Cell Communication ; Fertility ; Humans ; Infertility, Male/metabolism ; Infertility, Male/physiopathology ; Male ; Testis
    Language English
    Publishing date 2020-04-27
    Publishing country England
    Document type Congress ; Editorial ; Introductory Journal Article
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.12833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Leydig cell aging: Molecular mechanisms and treatments.

    Papadopoulos, V / Zirkin, B R

    Vitamins and hormones

    2021  Volume 115, Page(s) 585–609

    Abstract: Late-onset hypogonadism, resulting from deficiency in serum testosterone (T), affects the health and quality of life of millions of aging men. T is synthesized by Leydig cells (LCs) in response to luteinizing hormone (LH). LH binds LC plasma membrane ... ...

    Abstract Late-onset hypogonadism, resulting from deficiency in serum testosterone (T), affects the health and quality of life of millions of aging men. T is synthesized by Leydig cells (LCs) in response to luteinizing hormone (LH). LH binds LC plasma membrane receptors, inducing the formation of a supramolecular complex of cytosolic and mitochondrial proteins, the Steroidogenic InteracTomE (SITE). SITE proteins are involved in targeting cholesterol to CYP11A1 in the mitochondria, the first enzyme of the steroidogenic cascade. Cholesterol translocation is the rate-determining step in T formation. With aging, LC defects occur that include changes in SITE, an increasingly oxidative intracellular environment, and reduced androgen formation and serum T levels. T replacement therapy (TRT) will restore T levels, but reported side effects make it desirable to develop additional strategies for increasing T. One approach is to target LC protein-protein interactions and thus increase T production by the hypofunctional Leydig cells themselves.
    MeSH term(s) Animals ; Cellular Senescence/physiology ; Leydig Cells/metabolism ; Luteinizing Hormone/metabolism ; Male ; Quality of Life ; Testosterone/metabolism
    Chemical Substances Testosterone (3XMK78S47O) ; Luteinizing Hormone (9002-67-9)
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 201161-x
    ISSN 2162-2620 ; 0083-6729
    ISSN (online) 2162-2620
    ISSN 0083-6729
    DOI 10.1016/bs.vh.2020.12.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cops5 in Peritubular Myoid Cells Influences Reproductive Development and Hormone Production.

    Garza, Samuel / Papadopoulos, Vassilios

    Endocrinology

    2023  Volume 164, Issue 7

    MeSH term(s) Mice ; Animals ; Male ; Testis/cytology ; Seminiferous Tubules ; Hormones ; Myocytes, Smooth Muscle ; Homeostasis
    Chemical Substances Hormones
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqad092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Conference proceedings: Adaptive effects of Ginkgo biloba extract (EGb 761)

    Papadopoulos, V.

    proceedings of the International Symposium [on Adaptive Effects of Ginkgo Biloba Extract (EGb 761)], Ottrott, France, October 25-26, 1996

    (Advances in Ginkgo biloba extract research ; 6)

    1997  

    Event/congress International Symposium on Adaptive Effects of Ginkgo Biloba Extract (EGb 761) (1996, Ottrott)
    Author's details ed. by V Papadopoulos
    Series title Advances in Ginkgo biloba extract research ; 6
    Collection
    Language English
    Size XIV, 151 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT008746012
    ISBN 2-84299-010-2 ; 978-2-84299-010-7
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Role of Constitutive STAR in Mitochondrial Structure and Function in MA-10 Leydig Cells.

    Galano, Melanie / Papadopoulos, Vassilios

    Endocrinology

    2022  Volume 163, Issue 8

    Abstract: The steroidogenic acute regulatory protein (STAR; STARD1) is critical for the transport of cholesterol into the mitochondria for hormone-induced steroidogenesis. Steroidogenic cells express STAR under control conditions (constitutive STAR). On hormonal ... ...

    Abstract The steroidogenic acute regulatory protein (STAR; STARD1) is critical for the transport of cholesterol into the mitochondria for hormone-induced steroidogenesis. Steroidogenic cells express STAR under control conditions (constitutive STAR). On hormonal stimulation, STAR localizes to the outer mitochondrial membrane (OMM) where it facilitates cholesterol transport and where it is processed to its mature form. Here, we show that knockout of Star in MA-10 mouse tumor Leydig cells (STARKO1) causes defects in mitochondrial structure and function under basal conditions. We also show that overexpression of Star in STARKO1 cells exacerbates, rather than recovers, mitochondrial structure and function, which further disrupts the processing of STAR at the OMM. Our findings suggest that constitutive STAR is necessary for proper mitochondrial structure and function and that mitochondrial dysfunction leads to defective STAR processing at the OMM.
    MeSH term(s) Animals ; Biological Transport ; Cholesterol/metabolism ; Leydig Cells/metabolism ; Male ; Mice ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Phosphoproteins/metabolism
    Chemical Substances Phosphoproteins ; steroidogenic acute regulatory protein ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqac091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Testosterone recovery therapy targeting dysfunctional Leydig cells.

    Garza, Samuel / Papadopoulos, Vassilios

    Andrology

    2022  Volume 11, Issue 5, Page(s) 816–825

    Abstract: Reduced serum testosterone affects millions of men across the world and has been linked to several comorbidities, metabolic dysfunctions, and quality of life changes. The standard treatment for testosterone deficiency remains testosterone replacement ... ...

    Abstract Reduced serum testosterone affects millions of men across the world and has been linked to several comorbidities, metabolic dysfunctions, and quality of life changes. The standard treatment for testosterone deficiency remains testosterone replacement therapy. However, limitations on its use and the risk of significant adverse effects make alternative therapeutics desirable. Studies on the mechanisms regulating and synthesizing testosterone formation in testicular Leydig cells demonstrate numerous endogenous targets that could increase testosterone biosynthesis, which could alleviate reduced testosterone effects. Testosterone biosynthesis is facilitated by a conglomerate of cytosolic and mitochondrial proteins that facilitate cholesterol translocation into the mitochondria, the rate-limiting step in steroidogenesis. An effective therapeutic approach would be required to increase endogenous testosterone formation by enhancing steroidogenesis in Leydig cells. Numerous ligands for steroidogenic proteins have been developed, which increase steroid hormone formation. However, off-target effects on neurosteroid and adrenal steroid formation may limit their clinical use. First-in-class biologics, such as voltage-dependent anion channel peptides and transplantation of induced human Leydig-like cells offer advances in the development of specific strategies that could be used to enhance endogenous steroid formation in hormone deficient patients.
    MeSH term(s) Male ; Humans ; Leydig Cells/metabolism ; Testosterone ; Quality of Life ; Testis/metabolism ; Cholesterol/metabolism
    Chemical Substances Testosterone (3XMK78S47O) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-10-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In vitro

    Garza, Samuel / Sottas, Chantal / Gukasyan, Hovhannes J / Papadopoulos, Vassilios

    Frontiers in toxicology

    2024  Volume 6, Page(s) 1357857

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3080
    ISSN (online) 2673-3080
    DOI 10.3389/ftox.2024.1357857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Conference proceedings: Ein Pilotprojekt gegen die Periodenarmut – kostenfreie Menstruationsartikel zur Stärkung der sozialen und gesundheitlichen Chancengleichheit.

    Constantin, S. / Borgmann, W. M. / Rübenkönig, F. / Sörensen, C. / Papadopoulos, V.

    Das Gesundheitswesen

    2024  Volume 86, Issue S 02

    Event/congress Der Öffentliche Gesundheitsdienst - Rückenwind für Gesundheit! 73. Wissenschaftlicher Kongress | BVÖGD e.V., BZÖG e.V., DGÖG e.V., Hamburg, 2024-04-24
    Language German
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
    DOI 10.1055/s-0044-1781888
    Database Thieme publisher's database

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  9. Article: Translocator protein in the rise and fall of central nervous system neurons.

    Cheung, Garett / Lin, Yiqi Christina / Papadopoulos, Vassilios

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1210205

    Abstract: Translocator protein (TSPO), a 18 kDa protein found in the outer mitochondrial membrane, has historically been associated with the transport of cholesterol in highly steroidogenic tissues though it is found in all cells throughout the mammalian body. ... ...

    Abstract Translocator protein (TSPO), a 18 kDa protein found in the outer mitochondrial membrane, has historically been associated with the transport of cholesterol in highly steroidogenic tissues though it is found in all cells throughout the mammalian body. TSPO has also been associated with molecular transport, oxidative stress, apoptosis, and energy metabolism. TSPO levels are typically low in the central nervous system (CNS), but a significant upregulation is observed in activated microglia during neuroinflammation. However, there are also a few specific regions that have been reported to have higher TSPO levels than the rest of the brain under normal conditions. These include the dentate gyrus of the hippocampus, the olfactory bulb, the subventricular zone, the choroid plexus, and the cerebellum. These areas are also all associated with adult neurogenesis, yet there is no explanation of TSPO's function in these cells. Current studies have investigated the role of TSPO in microglia during neuron degeneration, but TSPO's role in the rest of the neuron lifecycle remains to be elucidated. This review aims to discuss the known functions of TSPO and its potential role in the lifecycle of neurons within the CNS.
    Language English
    Publishing date 2023-06-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1210205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: ATAD3A: A Key Regulator of Mitochondria-Associated Diseases.

    Chen, Liting / Li, Yuchang / Zambidis, Alexander / Papadopoulos, Vassilios

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Mitochondrial membrane protein ATAD3A is a member of the AAA-domain-containing ATPases superfamily. It is important for the maintenance of mitochondrial DNA, structure, and function. In recent years, an increasing number ... ...

    Abstract Mitochondrial membrane protein ATAD3A is a member of the AAA-domain-containing ATPases superfamily. It is important for the maintenance of mitochondrial DNA, structure, and function. In recent years, an increasing number of
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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