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Article ; Online: Bond-Breaking Efficiency of High-Energy Ions in Ultrathin Polymer Films.

Thomaz, R / Louette, P / Hoff, G / Müller, S / Pireaux, J J / Trautmann, C / Papaléo, R M

2018 Volume 121, Issue 6, Page(s) 66101

Abstract: Thin films of poly(methyl methacrylate) and poly(vinyl chloride) of different thickness are used to investigate the effect of spatial confinement on the efficiency of bond breaking induced by 2 MeV H^{+} and 2.1 GeV Bi ions. Effective cross sections for ... ...

Abstract	Thin films of poly(methyl methacrylate) and poly(vinyl chloride) of different thickness are used to investigate the effect of spatial confinement on the efficiency of bond breaking induced by 2 MeV H^{+} and 2.1 GeV Bi ions. Effective cross sections for oxygen and chlorine loss are extracted for films down to a thickness of about 5 nm and are compared to theoretical estimations based on radial energy density profiles simulated with geant-dna. The cross sections are to a large extent thickness independent, indicating that bond breaking is dominated by short-range processes. This is in contrast to the strongly reduced efficiencies found recently for cratering induced by high-energy ions in similar ultrathin polymer films [Phys. Rev. Lett. 114, 118302 (2015)PRLTAO0031-900710.1103/PhysRevLett.114.118302].
Language	English
Publishing date	2018-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.121.066101
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Article: Left ventricular free wall rupture during coronary intervention after acute myocardial infarction: report of two cases exhibiting fatal pseudocomplications.

Papaleo, R / Depowski, P L / Dincer, A D / Houghton, J L

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

1999 Volume 47, Issue 1, Page(s) 67–72

Abstract: Two cases of left ventricular free wall rupture occurring in temporal relation to interventional coronary procedures are presented as autopsy-verified pseudocomplications. The possible impact of pseudocomplications on operator-specific registry data and ... ...

Abstract	Two cases of left ventricular free wall rupture occurring in temporal relation to interventional coronary procedures are presented as autopsy-verified pseudocomplications. The possible impact of pseudocomplications on operator-specific registry data and credentialing is briefly discussed.
MeSH term(s)	Aged ; Aged, 80 and over ; Angioplasty, Balloon, Coronary/adverse effects ; Coronary Angiography ; Coronary Disease/therapy ; Fatal Outcome ; Female ; Humans ; Male ; Middle Aged ; Ventricular Septal Rupture/diagnostic imaging ; Ventricular Septal Rupture/etiology
Language	English
Publishing date	1999-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/(SICI)1522-726X(199905)47:1<67::AID-CCD16>3.0.CO;2-0
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Article ; Online: Design and optimization of biocompatible polycaprolactone/poly (l-lactic-co-glycolic acid) scaffolds with and without microgrooves for tissue engineering applications.

Alvim Valente, Cristhiane / Cesar Chagastelles, Pedro / Fontana Nicoletti, Natália / Ramos Garcez, Giovanna / Sgarioni, Bruna / Herrmann, Fábio / Pesenatto, Gustavo / Goldani, Eduardo / Zanini, Mara Lise / Campos, Maria Martha / Meurer Papaléo, Ricardo / Braga da Silva, Jefferson / de Souza Basso, Nara Regina

Journal of biomedical materials research. Part A

2018 Volume 106, Issue 6, Page(s) 1522–1534

Abstract: This study investigated the effects of smooth and microgrooved membrane blends, with different polycaprolactone (PCL)/ poly(lactic-co-glycolic acid) (PLGA) ratios on the viability, proliferation, and adhesion of different mammalian cell types. The ... ...

Abstract	This study investigated the effects of smooth and microgrooved membrane blends, with different polycaprolactone (PCL)/ poly(lactic-co-glycolic acid) (PLGA) ratios on the viability, proliferation, and adhesion of different mammalian cell types. The polymer matrices with and without microgrooves, obtained by solvent casting, were characterized by field-emission scanning electron microscopy, atomic force microscopy, contact angle and Young's modulus. Blend characterization showed an increase in roughness and stiffness of membranes with 30% PLGA, without any effect on the contact angle value. Pure PCL significantly decreased the viability of Vero, HaCaT, RAW 264.7, and human fetal lung and gingival fibroblast cells, whereas addition of increasing concentrations of PLGA led to a reduced cytotoxicity. Increased proliferation rates were observed for all cell lines. Fibroblasts adhered efficiently to smooth membranes of the PCL70/PLGA30 blend and pure PLGA, compared to pure PCL and silicone. Microgrooved membranes promoted similar cell adhesion for all groups. Microstructured membranes (15 and 20-μm wide grooves) promoted suitable orientation of fibroblasts in both PCL70/PLGA30 and pure PLGA, as compared to pure PCL. Neuronal cells of the dorsal root ganglion exhibited an oriented adhesion to all the tested microgrooved membranes. Data suggest a satisfactory safety profile for the microgrooved PCL70/PLGA30 blend, pointing out this polymer combination as a promising biomaterial for peripheral nerve regeneration when cell orientation is required. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1522-1534, 2018.
MeSH term(s)	Animals ; Biocompatible Materials/chemistry ; Cell Adhesion ; Cell Line ; Cells, Cultured ; Cercopithecus aethiops ; Elastic Modulus ; Humans ; Male ; Mice ; Polyesters/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; RAW 264.7 Cells ; Rats, Wistar ; Surface Properties ; Tissue Engineering ; Tissue Scaffolds/chemistry ; Vero Cells
Chemical Substances	Biocompatible Materials ; Polyesters ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; polycaprolactone (24980-41-4)
Language	English
Publishing date	2018-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099989-6
ISSN	1552-4965 ; 1549-3296 ; 0021-9304
ISSN (online)	1552-4965
ISSN	1549-3296 ; 0021-9304
DOI	10.1002/jbm.a.36355
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Article ; Online: Ion crater healing and variable temperature ellipsometry as complementary probes for the glass transition in thin polymer films.

Grohens, Y / Papaléo, R M / Hamon, L

The European physical journal. E, Soft matter

2003 Volume 12 Suppl 1, Page(s) S81–5

Abstract: Poly(methyl methacrylate) (PMMA) thin films of various tacticity and thickness were bombarded at grazing angles by 20 MeV Au ions at different temperatures. The shape of the tracks was investigated by scanning force microscopy (SFM) after annealing for ... ...

Abstract	Poly(methyl methacrylate) (PMMA) thin films of various tacticity and thickness were bombarded at grazing angles by 20 MeV Au ions at different temperatures. The shape of the tracks was investigated by scanning force microscopy (SFM) after annealing for various time at different temperatures and constant quenching rate. The thickness dependent glass transition temperature, T(g)(h), was estimated from the temperature of relaxation of ion-caused nanodeformations in the films. T(g)(h) obtained from the thermal healing of the holes and hillocks is found in good agreement with the one determined by variable temperature ellipsometry for PMMA film thickness of 80 nm and corresponds to the T(g) of each bulk PMMA stereoisomer. Below this thickness, some significant divergences are observed between the T(g) measured by the two techniques. We propose that the healing of ion crater hillock and the kink in the thermal expansion arise from the different nature of chains motions which are perturbed to different extents according to the main polymer chain preferential orientation in the thin film. This can be tentatively interpreted by a so-called "anisotropic" character of the glass transition.
Language	English
Publishing date	2003-11
Publishing country	France
Document type	Journal Article
ZDB-ID	2004003-9
ISSN	1292-895X ; 1292-8941
ISSN (online)	1292-895X
ISSN	1292-8941
DOI	10.1140/epjed/e2003-01-020-6
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Article ; Online: Confinement effects of ion tracks in ultrathin polymer films.

Papaléo, R M / Thomaz, R / Gutierres, L I / de Menezes, V M / Severin, D / Trautmann, C / Tramontina, D / Bringa, E M / Grande, P L

Physical review letters

2015 Volume 114, Issue 11, Page(s) 118302

Abstract: We show direct experimental evidence that radiation effects produced by single MeV heavy ions on a polymer surface are weakened when the length of the ion track in the material is confined into layers of a few tens of nanometers. Deviation from the bulk ( ...

Abstract	We show direct experimental evidence that radiation effects produced by single MeV heavy ions on a polymer surface are weakened when the length of the ion track in the material is confined into layers of a few tens of nanometers. Deviation from the bulk (thick film) behavior of ion-induced craters starts at a critical thickness as large as ∼40 nm, due to suppression of long-range additive effects of excited atoms along the track. Good agreement was found between the experimental results, molecular dynamic simulations, and an analytical model.
MeSH term(s)	Heavy Ions ; Models, Chemical ; Molecular Dynamics Simulation ; Polymethyl Methacrylate/chemistry
Chemical Substances	Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2015-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.114.118302
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Article ; Online: Prediction of nodal metastasis and prognosis of breast cancer by ANN-based assessment of tumour size and p53, Ki-67 and steroid receptor expression.

Mojarad, Shirin / Venturini, Barbara / Fulgenzi, Patrizia / Papaleo, Renata / Brisigotti, Massimo / Monti, Franco / Canuti, Debora / Ravaioli, Alberto / Woo, Lok / Dlay, Satnam / Sherbet, Gajanan V

Anticancer research

2013 Volume 33, Issue 9, Page(s) 3925–3933

Abstract: Background: Tumour stage and the appropriate course of treatment in patients with breast cancer are primarily characterized by the state of metastasis in the axillary lymph nodes. In recent years, substantial research has focused on the prediction of ... ...

Abstract	Background: Tumour stage and the appropriate course of treatment in patients with breast cancer are primarily characterized by the state of metastasis in the axillary lymph nodes. In recent years, substantial research has focused on the prediction of lymph node status based on various pathological and molecular markers in order to obviate the necessity to carry out axillary dissection. In the present study, artificial neural network (ANN) is employed as the analysis platform to examine the prognostic significance of a group of well-established prognostic markers for breast cancer outcome prediction in terms of nodal status. Furthermore, we investigated existing interactions between these markers. Patients and methods: The data set contained 66 patient records, where 5 pathological and molecular markers including tumour size, oestrogen receptor status (ER), progesterone receptor status (PR), Ki-67 and p53 expression had been assessed for each patient. The spread of metastasis to the axillary lymph nodes was clinically diagnosed and patients were accordingly categorized into node-positive and node-negative groups. The aforementioned markers were analyzed using a probabilistic neural network (PNN) for nodal status prediction which was considered as the network output. Furthermore, the interactions between these markers were evaluated using different marker combinations as the network input for finding the best marker arrangement for nodal predication. Results: The best prediction accuracy was obtained by a 3-marker combination including tumour size, PR and p53 with 71% accuracy for nodal prediction. Leaving out ER and PR from the full marker set showed approximately the same variations in the results, which is an indication of the direct correlation of these two markers. Furthermore, tumour size was proved to be the most significant individual marker for predicting nodal metastasis. However, when used in combination with Ki-67 the prediction results drop significantly. Conclusion: The results presented here indicate that molecular and pathological markers can provide useful information for early-stage prognosis. However, the interactions between these markers must be considered in order to achieve accurate and reliable prediction.
MeSH term(s)	Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Humans ; Ki-67 Antigen/metabolism ; Lymphatic Metastasis ; Prognosis ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Biomarkers, Tumor ; Ki-67 Antigen ; Receptors, Estrogen ; Receptors, Progesterone ; Tumor Suppressor Protein p53
Language	English
Publishing date	2013-09
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
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Article: Direct evidence for projectile charge-state dependent crater formation due to fast ions.

Papaléo, R M / Silva, M R / Leal, R / Grande, P L / Roth, M / Schattat, B / Schiwietz, G

Physical review letters

2008 Volume 101, Issue 16, Page(s) 167601

Abstract: We report on craters formed by individual 3 MeV/u Au (q(ini)+) ions of selected incident charge states q_(ini) penetrating thin layers of poly(methyl methacrylate). Holes and raised regions are formed around the region of the impact, with sizes that ... ...

Abstract	We report on craters formed by individual 3 MeV/u Au (q(ini)+) ions of selected incident charge states q_(ini) penetrating thin layers of poly(methyl methacrylate). Holes and raised regions are formed around the region of the impact, with sizes that depend strongly and differently on q_(ini). Variation of q_(ini) of the film thickness and of the angle of incidence allows us to extract information about the depth of origin contributing to different crater features.
Language	English
Publishing date	2008-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.101.167601
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Article: ICARUS at the Fermilab Short-Baseline Neutrino program: initial operation.

Abratenko, P / Aduszkiewicz, A / Akbar, F / Pons, M Artero / Asaadi, J / Aslin, M / Babicz, M / Badgett, W F / Bagby, L F / Baibussinov, B / Behera, B / Bellini, V / Beltramello, O / Benocci, R / Berger, J / Berkman, S / Bertolucci, S / Bertoni, R / Betancourt, M /

Bettini, M / Biagi, S / Biery, K / Bitter, O / Bonesini, M / Boone, T / Bottino, B / Braggiotti, A / Brailsford, D / Bremer, J / Brice, S J / Brio, V / Brizzolari, C / Brown, J / Budd, H S / Calaon, F / Campani, A / Carber, D / Carneiro, M / Terrazas, I Caro / Carranza, H / Casazza, D / Castellani, L / Castro, A / Centro, S / Cerati, G / Chalifour, M / Chambouvet, P / Chatterjee, A / Cherdack, D / Cherubini, S / Chithirasreemadam, N / Cicerchia, M / Cicero, V / Coan, T / Cocco, A G / Convery, M R / Copello, S / Cristaldo, E / Dange, A A / de Icaza Astiz, I / De Roeck, A / Di Domizio, S / Di Noto, L / Di Stefano, C / Di Ferdinando, D / Diwan, M / Dolan, S / Domine, L / Donati, S / Doubnik, R / Drielsma, F / Dyer, J / Dytman, S / Fabre, C / Fabris, F / Falcone, A / Farnese, C / Fava, A / Ferguson, H / Ferrari, A / Ferraro, F / Gallice, N / Garcia, F G / Geynisman, M / Giarin, M / Gibin, D / Gigli, S G / Gioiosa, A / Gu, W / Guerzoni, M / Guglielmi, A / Gurung, G / Hahn, S / Hardin, K / Hausner, H / Heggestuen, A / Hilgenberg, C / Hogan, M / Howard, B / Howell, R / Hrivnak, J / Iliescu, M / Ingratta, G / James, C / Jang, W / Jung, M / Jwa, Y-J / Kashur, L / Ketchum, W / Kim, J S / Koh, D-H / Kose, U / Larkin, J / Laurenti, G / Lukhanin, G / Marchini, S / Marshall, C M / Martynenko, S / Mauri, N / Mazzacane, A / McFarland, K S / Méndez, D P / Menegolli, A / Meng, G / Miranda, O G / Mladenov, D / Mogan, A / Moggi, N / Montagna, E / Montanari, C / Montanari, A / Mooney, M / Moreno-Granados, G / Mueller, J / Naples, D / Nebot-Guinot, M / Nessi, M / Nichols, T / Nicoletto, M / Norris, B / Palestini, S / Pallavicini, M / Paolone, V / Papaleo, R / Pasqualini, L / Patrizii, L / Peghin, R / Petrillo, G / Petta, C / Pia, V / Pietropaolo, F / Poirot, J / Poppi, F / Pozzato, M / Prata, M C / Prosser, A / Putnam, G / Qian, X / Rampazzo, G / Rappoldi, A / Raselli, G L / Rechenmacher, R / Resnati, F / Ricci, A M / Riccobene, G / Rice, L / Richards, E / Rigamonti, A / Rosenberg, M / Rossella, M / Rubbia, C / Sala, P / Sapienza, P / Savage, G / Scaramelli, A / Scarpelli, A / Schmitz, D / Schukraft, A / Sergiampietri, F / Sirri, G / Smedley, J S / Soha, A K / Spanu, M / Stanco, L / Stewart, J / Suarez, N B / Sutera, C / Tanaka, H A / Tenti, M / Terao, K / Terranova, F / Togo, V / Torretta, D / Torti, M / Tortorici, F / Tosi, N / Tsai, Y-T / Tufanli, S / Turcato, M / Usher, T / Varanini, F / Ventura, S / Vercellati, F / Vicenzi, M / Vignoli, C / Viren, B / Warner, D / Williams, Z / Wilson, R J / Wilson, P / Wolfs, J / Wongjirad, T / Wood, A / Worcester, E / Worcester, M / Wospakrik, M / Yu, H / Yu, J / Zani, A / Zatti, P G / Zennamo, J / Zettlemoyer, J C / Zhang, C / Zucchelli, S / Zuckerbrot, M

The European physical journal. C, Particles and fields

2023 Volume 83, Issue 6, Page(s) 467

Abstract: The ICARUS collaboration employed the 760-ton T600 detector in a successful 3-year physics run at the underground LNGS laboratory, performing a sensitive search for LSND-like ... ...

Abstract	The ICARUS collaboration employed the 760-ton T600 detector in a successful 3-year physics run at the underground LNGS laboratory, performing a sensitive search for LSND-like anomalous
Language	English
Publishing date	2023-06-04
Publishing country	France
Document type	Journal Article
ZDB-ID	1459069-4
ISSN	1434-6052 ; 1434-6044
ISSN (online)	1434-6052
ISSN	1434-6044
DOI	10.1140/epjc/s10052-023-11610-y
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Article: Il ruolo della colposcopia nella diagnosi dell'infezione virale da HPV.

Scarpellini, M / Fulgenzi, P / Papaleo, R / Tononi, A / Monti, F / Ravaioli, A

Minerva ginecologica

1992 Volume 44, Issue 12, Page(s) 617–622

Abstract: Human papillomavirus (HPV) has been implicated as an important etiologic factor in cervical carcinoma. This study evaluates the efficacy of colposcopy in the detection of cervical lesions with koilocytosis features. Colposcopy, cervical smears and biopsy ...

Title translation	The role of colposcopy in the diagnosis of HPV infection.
Abstract	Human papillomavirus (HPV) has been implicated as an important etiologic factor in cervical carcinoma. This study evaluates the efficacy of colposcopy in the detection of cervical lesions with koilocytosis features. Colposcopy, cervical smears and biopsy specimens from 217 women seen in our department between January-December 1991 were examined. The colposcopy examination detected 77.5% of the viral presence the histological diagnosis detected 85% of HPV, but the cytologic smears showed only 52% of infection. The data suggests that colposcopy is a good examination to evidence koilocytosis infection.
MeSH term(s)	Adult ; Colposcopy ; Female ; Humans ; Middle Aged ; Papillomaviridae ; Tumor Virus Infections/diagnosis ; Tumor Virus Infections/microbiology ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/prevention & control
Language	Italian
Publishing date	1992-12
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	80159-8
ISSN	0026-4784 ; 0325-8793
ISSN	0026-4784 ; 0325-8793
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Article: Lo screening cervico-vaginale in alcune USL della Regione Emilia-Romagna.

Scarpellini, M / Tononi, A / Nicolini, M / Papaleo, R / Fulgenzi, P / Ravaioli, A

Minerva ginecologica

1992 Volume 44, Issue 9, Page(s) 467–471

Abstract: Some Local Sanitary Units (USL) of the Emilia-Romagna region were contacted to define cervical screening variables, such as adequacy of smear technique, data collection and evaluation, laboratory quality control modalities of invitations to screening. ... ...

Title translation	Cervico-vaginal screening in some Local Sanitary Units of the Emilia-Romagna region.
Abstract	Some Local Sanitary Units (USL) of the Emilia-Romagna region were contacted to define cervical screening variables, such as adequacy of smear technique, data collection and evaluation, laboratory quality control modalities of invitations to screening. Our data show there are a lot of deficiencies in the present management of the cervical program in Romagna. The most serious inadequacies concern data evaluation, follow-up, cytologic quality control, modalities of active invitations of women to screening. The survey has confirmed the need for launching organized programs of cervical screening to promote their efficacy of diagnosis and therapy.
MeSH term(s)	Adult ; Female ; Humans ; Italy/epidemiology ; Middle Aged ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology ; Vaginal Smears
Language	Italian
Publishing date	1992-09
Publishing country	Italy
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80159-8
ISSN	0026-4784 ; 0325-8793
ISSN	0026-4784 ; 0325-8793
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