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Article: Silent Myocardial Ischemia: From Pathophysiology to Diagnosis and Treatment.

Theofilis, Panagiotis / Antonopoulos, Alexios S / Sagris, Marios / Papanikolaou, Aggelos / Oikonomou, Evangelos / Tsioufis, Konstantinos / Tousoulis, Dimitris

Biomedicines

2024 Volume 12, Issue 2

Abstract: Silent myocardial ischemia (SMI), characterized by a lack of overt symptoms despite an inadequate blood supply to the myocardium, remains a challenging entity in cardiovascular medicine. The pathogenesis involves intricate interactions of vascular, ... ...

Abstract	Silent myocardial ischemia (SMI), characterized by a lack of overt symptoms despite an inadequate blood supply to the myocardium, remains a challenging entity in cardiovascular medicine. The pathogenesis involves intricate interactions of vascular, neurohormonal, and metabolic factors, contributing to perfusion deficits without the characteristic chest pain. Understanding these mechanisms is pivotal for recognizing diverse clinical presentations and designing targeted interventions. Diagnostic strategies for SMI have evolved from traditional electrocardiography to advanced imaging modalities, including stress echocardiography, single-photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance imaging (MRI). Treating SMI is a matter of ongoing debate, as the available evidence on the role of invasive versus medical management is controversial. This comprehensive review synthesizes current knowledge of silent myocardial ischemia, addressing its pathophysiology, diagnostic modalities, and therapeutic interventions.
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020259
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Article: Intravascular Imaging in Ultra-Low or Zero-Contrast Percutaneous Coronary Interventions: The Time Is Now?

Dimitriadis, Kyriakos / Pyrpyris, Nikolaos / Papanikolaou, Aggelos / Beneki, Eirini / Tsioufis, Panagiotis / Antonopoulos, Alexios / Fragoulis, Christos / Tatakis, Fotis / Koutsopoulos, Georgios / Aznaouridis, Konstantinos / Aggeli, Konstantina / Tsioufis, Konstantinos

Journal of clinical medicine

2023 Volume 12, Issue 23

Abstract: Ultra-low contrast percutaneous coronary interventions (ULPCIs) are a novel field of interventional cardiology, aiming to reduce the risk of contrast-induced nephropathy (CIN), which is a well-described adverse event after angiography. CIN is a well- ... ...

Abstract	Ultra-low contrast percutaneous coronary interventions (ULPCIs) are a novel field of interventional cardiology, aiming to reduce the risk of contrast-induced nephropathy (CIN), which is a well-described adverse event after angiography. CIN is a well-described adverse event following PCI, especially in high-risk patients, i.e., patients with an already deteriorating renal function or chronic kidney disease, as well as patients of advanced age or requiring an increased amount of contrast during their intervention. Among the techniques described for ULPCI procedures, intravascular imaging guidance seems a promising option, as it allows lesion recognition and characterization, stent implantation, and PCI optimization. Intravascular ultrasound (IVUS) is the modality most commonly used, as it does not require contrast injection, contrary to optical coherence tomography (OCT). Several clinical trials, assessing IVUS in the context of ULPCI, have shown that it can be safely used in this setting while offering a substantial reduction in contrast media volume, as well as renal adverse outcomes. This review aims to describe the need for ULPCI and technical considerations regarding the use of intravascular imaging in this setting, as well as analyze the available evidence from clinical trials regarding the safety and efficacy of IVUS-ULPCI, in order to provide a comprehensive summary for practicing physicians.
Language	English
Publishing date	2023-12-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12237499
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Article ; Online: Antiplatelet and Antithrombotic Therapy After Patent Foramen Oval and Atrial Septal Defect Closure.

Drakopoulou, Maria / Soulaidopoulos, Stergios / Stathogiannis, Konstantinos / Oikonomou, Georgios / Papanikolaou, Aggelos / Toutouzas, Konstantinos / Tousoulis, Dimitrios

Current pharmaceutical design

2020 Volume 26, Issue 23, Page(s) 2769–2779

Abstract: Pathologies of the atrial septum include different interatrial communications varying from patent foramen ovale (PFO) to actual defects. Atrial septal defects (ASDs) may be localized within the fossa ovalis such as the secundum type ASD or outside the ... ...

Abstract	Pathologies of the atrial septum include different interatrial communications varying from patent foramen ovale (PFO) to actual defects. Atrial septal defects (ASDs) may be localized within the fossa ovalis such as the secundum type ASD or outside the region of fossa ovalis, such as the ostium primum defect and sinus venosus defect. Over the last decades, the percutaneous closure of interatrial shunts has become a feasible and safe method. During these procedures, the delicate balance between thrombotic risk, device sealing process and bleeding risk is crucial. In this review, we sought to describe current available data on the antiplatelet and antithrombotic management of patients after percutaneous ASD or PFO closure.
MeSH term(s)	Cardiac Catheterization ; Fibrinolytic Agents ; Foramen Ovale, Patent/drug therapy ; Foramen Ovale, Patent/surgery ; Humans ; Treatment Outcome
Chemical Substances	Fibrinolytic Agents
Language	English
Publishing date	2020-04-26
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1385272824999200427083838
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Article ; Online: Interventional management of mitral regurgitation and sleep disordered breathing: "Catching two birds with one stone".

Dimitriadis, Kyriakos / Stathakopoulou, Christina / Pyrpyris, Nikolaos / Beneki, Eirini / Adamopoulou, Elena / Soulaidopoulos, Stergios / Leontsinis, Ioannis / Kasiakogias, Alexandros / Papanikolaou, Aggelos / Tsioufis, Panagiotis / Aznaouridis, Konstantinos / Tsiachris, Dimitris / Aggeli, Konstantina / Tsioufis, Konstantinos

Sleep medicine

2023 Volume 113, Page(s) 157–164

Abstract: Sleep disordered breathing (SDB), mostly constituting of obstructive and central sleep apnea (OSA and CSA, respectively), is highly prevalent in the general population, and even more among patients with cardiovascular disease, heart failure (HF) and ... ...

Abstract	Sleep disordered breathing (SDB), mostly constituting of obstructive and central sleep apnea (OSA and CSA, respectively), is highly prevalent in the general population, and even more among patients with cardiovascular disease, heart failure (HF) and valvular heart disease, such as mitral regurgitation (MR). The coexistence of HF, MR and SDB is associated with worse cardiovascular outcomes and increased morbidity and mortality. Pulmonary congestion, as a result of MR, can exaggerate and worsen the clinical status and symptoms of SDB, while OSA and CSA, through various mechanisms that impair left ventricular dynamics, can promote left ventricular remodelling, mitral annulus dilatation and consequently MR. Regarding treatment, positive airway pressure devices used to ameliorate symptoms in SDB also seem to result in a reduction of MR severity, MR jet fraction and an improvement of left ventricular ejection fraction. However, surgical and transcatheter interventions for MR, and especially transcatheter edge to edge mitral valve repair (TEER), seem to also have a positive effect on SDB, by reducing OSA and CSA-related severity indexes and improving symptom control. The purpose of this review is to provide a comprehensive analysis of the common pathophysiology between SDB and MR, as well as to discuss the available evidence regarding the effect of SDB treatment on MR and the effect of mitral valve surgery or transcatheter repair on both OSA and CSA.
MeSH term(s)	Humans ; Mitral Valve Insufficiency/complications ; Mitral Valve Insufficiency/surgery ; Stroke Volume ; Ventricular Function, Left ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/therapy ; Sleep Apnea Syndromes/diagnosis ; Heart Failure ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy
Language	English
Publishing date	2023-11-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2023.11.019
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Zs.A 5315: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: In vivo correlation between morphological characteristics of coronary plaques and functional characteristics of carotid arteries in acute coronary syndrome.

Synetos, Andreas / Bounas, Pavlos / Karanasos, Antonis / Latsios, George / Drakopoulou, Maria / Papanikolaou, Aggelos / Olympios, Christoforos / Trantalis, George / Tsioufis, Konstantinos / Toutouzas, Konstantinos

American journal of cardiovascular disease

2021 Volume 11, Issue 3, Page(s) 360–367

Abstract: Background: Carotid artery temperature heterogeneity (ΔΤ) measured by microwave radiometry (MWR) has been associated with future cardiovascular events including acute coronary syndromes. The vulnerable plaques of the coronary arterial tree, that can be ... ...

Abstract	Background: Carotid artery temperature heterogeneity (ΔΤ) measured by microwave radiometry (MWR) has been associated with future cardiovascular events including acute coronary syndromes. The vulnerable plaques of the coronary arterial tree, that can be ideally depicted by intracoronary imaging such as optical coherence tomography (OCT) have anatomical characteristics such as the thin fibrous cap (TCFA), that make them vulnerable to rupture. The scope of the study was to assess the implication of the carotid artery temperature heterogeneity on the culprit coronary plaque morphology in patients presenting with acute myocardial infarction. Methods: 34 patients presented with an acute myocardial infarction were enrolled in the study. All patients underwent percutaneous coronary intervention (PCI) and OCT for the evaluation of the anatomical characteristics of the culprit lesion. After the completion of the PCI all patients underwent carotid ultrasound and MWR of both carotid arteries and thermal heterogeneity of the carotid arteries was assessed. Blood samples were collected for high sensitivity C-reactive protein (CRP) analysis. Results: Thirty four patients, 21 with STEMI (61.76%) and 13 (38.23%) with NSTEMI, were included in the study. Patients with ruptured plaques had significantly increased hsCRP compared to patients that did not have a ruptured plaque (14.41±4.02 vs 9.9±2.5, P<0.005). Thermal heterogeneity, was significantly increased in ruptured plaques compared to no ruptured ones (1.01±0.31 vs 0.51±0.14°C, P=0.001), and in plaques with TCFA compared to those without a TCFA (0.82±0.37 vs 0.60±0.05°C, P=0.001). Diabetes mellitus, ΔΤ and hsCRP, were entered in the multivariate analysis, from which DM (OR 4.12; 95% CI 0.77-22.07; P=0.07) and ΔΤ (OR for 0.1°C increase 1.43; 95% CI 1.03-1.98; P=0.03) remained in the final analysis, and only ΔΤ was independently associated with the presence of the TCFA. Regarding plaque rupture, STEMI, hsCRP, and ΔT were entered in the multivariate analysis from which hsCRP (OR 1.51; 95% CI 0.99-2.28; P=0.051) and ΔΤ (OR for 0.1°C increase 3.40; 95% CI 1.29-8.96; P=0.013) remained in the final analysis with the ΔT being the only variable.
Language	English
Publishing date	2021-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2616844-3
ISSN	2160-200X
ISSN	2160-200X
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Article ; Online: CardioPulmonary Resuscitation in patients with suspected or confirmed Covid-19. A consensus of the Working group on CardioPulmonary Resuscitation of the Hellenic Society of Cardiology.

Latsios, George / Synetos, Andreas / Mastrokostopoulos, Antonios / Vogiatzi, Georgia / Bounas, Pavlos / Nikitas, Georgios / Papanikolaou, Aggelos / Parisis, Charalampos / Kanakakis, Ioannis / Goudevenos, John

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2020 Volume 62, Issue 1, Page(s) 24–28

Abstract: The unprecedented for modern medicine pandemic caused by the SARS-COV-2 virus ("coronavirus", Covid-19 disease) creates in turn new data on the management and survival of cardiac arrest victims, but mainly on the safety of CardioPulmonary Resuscitation ( ... ...

Abstract	The unprecedented for modern medicine pandemic caused by the SARS-COV-2 virus ("coronavirus", Covid-19 disease) creates in turn new data on the management and survival of cardiac arrest victims, but mainly on the safety of CardioPulmonary Resuscitation (CPR) providers. The Covid-19 pandemic resulted in losses of thousands of lives, and many more people were hospitalized in simple or in intensive care unit beds, both globally and locally in Greece. More specifically, in victims of cardiac arrest, both in- and out- of hospital, the increased mortality and high contagiousness of the SARS-CoV-2 virus posed new questions, of both medical and moral nature/ to CPR providers. What we all know in resuscitation, that we cannot harm the victim and therefore do the most/best we can, is no longer the everyday reality. What we need to know and incorporate into decision-making in the resuscitation process is the distribution of limited human and material resources, the potentially very poor outcome of patients with Covid-19 and cardiac arrest, and especially that a potential infection of health professionals can lead in the lack of health professionals in the near future. This review tries to incorporate the added skills and precautions for CPR providers in terms of both in- and out- hospital CPR.
MeSH term(s)	COVID-19/mortality ; COVID-19/prevention & control ; COVID-19/transmission ; Cardiopulmonary Resuscitation/ethics ; Cardiopulmonary Resuscitation/methods ; Cardiopulmonary Resuscitation/standards ; Heart Arrest/therapy ; Heart Arrest/virology ; Humans ; Occupational Exposure/prevention & control ; Occupational Health/ethics ; Occupational Health/standards ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-09-17
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2020.09.010
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Article ; Online: Retention of knowledge after basic training in cardiopulmonary resuscitation: a cumulative 3-year experience of certified ERC seminars of the Hellenic Society of Cardiology.

Latsios, George / Synetos, Andreas / Leopoulou, Marianna / Stamatopoulou, Evangelia / Vogiatzi, Georgia / Parisis, Charalambos / Papanikolaou, Aggelos / Kanakakis, John / Toutouzas, Konstantinos / Tousoulis, Dimitris / Tsioufis, Kostas

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2021 Volume 63, Page(s) 82–85

MeSH term(s)	Cardiology/education ; Cardiopulmonary Resuscitation ; Defibrillators ; Educational Measurement ; Humans ; Surveys and Questionnaires
Language	English
Publishing date	2021-04-09
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2021.04.001
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Article ; Online: Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors.

Chrysohoou, Christina / Kouvari, Matina / Lazaros, George / Varlas, John / Dimitriadis, Kyriakos / Zaromytidou, Marina / Masoura, Constantina / Skoumas, John / Kambaxis, Manolis / Galiatsatos, Nikos / Papanikolaou, Aggelos / Xydis, Panagiotis / Konstantinou, Konstantinos / Pitsavos, Christos / Tsioufis, Konstantinos / Stefanadis, Christodoulos

Nutrients

2020 Volume 12, Issue 11

Abstract: The sex-specific effect of skeletal muscle mass (SMM) index (SMI) on 4-year first fatal/non-fatal cardiovascular disease (CVD) event in free-of-disease individuals was examined. In 2009, ...

Abstract	The sex-specific effect of skeletal muscle mass (SMM) index (SMI) on 4-year first fatal/non-fatal cardiovascular disease (CVD) event in free-of-disease individuals was examined. In 2009,
MeSH term(s)	Aged ; Body Composition ; Body Mass Index ; Cardiovascular Diseases/epidemiology ; Female ; Greece/epidemiology ; Humans ; Insulin Resistance ; Male ; Middle Aged ; Muscle, Skeletal ; Obesity/epidemiology ; Proportional Hazards Models ; Prospective Studies ; Sex Factors ; Vascular Stiffness
Language	English
Publishing date	2020-10-27
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12113293
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Article ; Online: The impact of COVID-19 pandemic on adult cardiac surgery procedures.

Lazaros, George / Oikonomou, Evangelos / Theofilis, Panagiotis / Theodoropoulou, Alexandra / Triantafyllou, Konstantinos / Charitos, Christos / Charalambous, Georgios / Papanikolaou, Aggelos / Gastouniotis, Ioannis / Siasos, Gerasimos / Vlachopoulos, Charalambos / Tousoulis, Dimitris

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

2020 Volume 62, Issue 3, Page(s) 231–233

MeSH term(s)	Adult ; COVID-19 ; Cardiac Surgical Procedures/adverse effects ; Humans ; Pandemics ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-15
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2215027-4
ISSN	2241-5955 ; 1109-9666
ISSN (online)	2241-5955
ISSN	1109-9666
DOI	10.1016/j.hjc.2020.07.001
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Article: CardioPulmonary Resuscitation in patients with suspected or confirmed Covid-19. A consensus of the Working group on CardioPulmonary Resuscitation of the Hellenic Society of Cardiology

Hell. j. cardiol

Abstract	The unprecedented for modern medicine pandemic caused by the SARS-COV-2 virus ("coronavirus", Covid-19 disease) creates in turn new data on the management and survival of cardiac arrest victims, but mainly on the safety of CardioPulmonary Resuscitation (CPR) providers. The Covid-19 pandemic resulted in losses of thousands of lives, and many more people were hospitalized in simple or in intensive care unit beds, both globally and locally in Greece. More specifically, in victims of cardiac arrest, both in- and out- of hospital, the increased mortality and high contagiousness of the SARS-CoV-2 virus posed new questions, of both medical and moral nature/ to CPR providers. What we all know in resuscitation, that we cannot harm the victim and therefore do the most/best we can, is no longer the everyday reality. What we need to know and incorporate into decision-making in the resuscitation process is the distribution of limited human and material resources, the potentially very poor outcome of patients with Covid-19 and cardiac arrest, and especially that a potential infection of health professionals can lead in the lack of health professionals in the near future. This review tries to incorporate the added skills and precautions for CPR providers in terms of both in- and out- hospital CPR.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #773675
Database	COVID19

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