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Article: Multiple non-syndromic basal cell carcinoma with the chest as primary site and lung metastases: A rare case.

Roditis, Konstantinos / Metaxas, George / Neofotistou, Ourania / Papaparaskeva, Kleo / Koutsoumbi, Aikaterini / Louis, Konstantinos

Dermatology reports

2021 Volume 13, Issue 2, Page(s) 9106

Abstract: Basal cell carcinoma (BCC) is the most commonly diagnosed cancer in humans, usually affecting elderly Caucasian men and skin regions mostly exposed to the sun, that rarely metastasizes. We report an unusual and aggressive case of multiple, non-syndromic ... ...

Abstract	Basal cell carcinoma (BCC) is the most commonly diagnosed cancer in humans, usually affecting elderly Caucasian men and skin regions mostly exposed to the sun, that rarely metastasizes. We report an unusual and aggressive case of multiple, non-syndromic metastatic BCC with an uncommon primary site in the chest and pulmonary metastases, treated successfully with surgery and vismodegib. A 51-year-old woman presented with a large pigmentary lesion of the chest, close to the sternum. She had the lesion for > 25 years and lately noticed multiple facial lesions. The diagnosis of multiple BCC was suspected and a punch biopsy of the primary lesion was performed. Diagnosis was confirmed by immunohistochemistry (BerEp4+, EMA- phenotype). After excision, staging with a thorax computed tomography scan revealed metastatic micro-nodules in the left lung, confirmed histologically after video-assisted thoracic surgical biopsy. Adjuvant chemotherapy with vismodegib was proposed and administered. At 30 days follow-up, thorax computed tomography scan was unaltered and her facial lesions showed significant regression. Although prognosis remains poor, early diagnosis and prompt management complimented by novel biological agents, like vismodegib, targeting disease pathogenesis, seems to bring promising results.
Language	English
Publishing date	2021-08-05
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2568735-9
ISSN	2036-7406 ; 2036-7392
ISSN (online)	2036-7406
ISSN	2036-7392
DOI	10.4081/dr.2021.9106
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Article: Innovations in macroscopic evaluation of pancreatic specimens and radiologic correlation.

Triantopoulou, Charikleia / Papaparaskeva, Kleo / Agalianos, Christos / Dervenis, Christos

European journal of radiology open

2016 Volume 3, Page(s) 49–59

Abstract: The purpose of this study was to evaluate the feasibility of a novel dissection technique of surgical specimens in different cases of pancreatic tumors and provide a radiologic pathologic correlation. In our hospital, that is a referral center for ... ...

Abstract	The purpose of this study was to evaluate the feasibility of a novel dissection technique of surgical specimens in different cases of pancreatic tumors and provide a radiologic pathologic correlation. In our hospital, that is a referral center for pancreatic diseases, the macroscopic evaluation of the pancreatectomy specimens is performed by the pathologists using the axial slicing technique (instead of the traditional procedure with longitudinal opening of the main pancreatic and/or common bile duct and slicing along the plane defined by both ducts). The specimen is sliced in an axial plane that is perpendicular to the longitudinal axis of the descending duodenum. The procedure results in a large number of thin slices (3-4 mm). This plane is identical to that of CT or MRI and correlation between pathology and imaging is straightforward. We studied 70 cases of suspected different solid and cystic pancreatic tumors and we correlated the tumor size and location, the structure-consistency (areas of necrosis-hemorrhage-fibrosis-inflammation), the degree of vessels' infiltration, the size of pancreatic and common bile duct and the distance from resection margins. Missed findings by imaging or pitfalls were recorded and we tried to explain all discrepancies between radiology evaluation and the histopathological findings. Radiologic-pathologic correlation is extremely important, adding crucial information on imaging limitations and enabling quality assessment of surgical specimens. The deep knowledge of different pancreatic tumors' consistency and way of extension helps to improve radiologists' diagnostic accuracy and minimize the radiological-surgical mismatching, preventing patients from unnecessary surgery.
Language	English
Publishing date	2016-03-11
Publishing country	England
Document type	Journal Article
ISSN	2352-0477
ISSN	2352-0477
DOI	10.1016/j.ejro.2016.02.001
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Article ; Online: Positive para-aortic lymph nodes following pancreatectomy for pancreatic cancer. Systematic review and meta-analysis of impact on short term survival and association with clinicopathologic features.

Agalianos, Christos / Gouvas, Nikolaos / Papaparaskeva, Kleo / Dervenis, Christos

HPB : the official journal of the International Hepato Pancreato Biliary Association

2016 Volume 18, Issue 8, Page(s) 633–641

Abstract: Background: The relation between para-aortic lymph nodes (PALN) involvement and pancreatic ductal adenocarcinoma (PDAC) survival, along with the optimal handling of this particular lymph node station remain unclear. A systematic review and meta-analysis ...

Abstract	Background: The relation between para-aortic lymph nodes (PALN) involvement and pancreatic ductal adenocarcinoma (PDAC) survival, along with the optimal handling of this particular lymph node station remain unclear. A systematic review and meta-analysis was performed to assess this. Methods: A search of Medline, Embase, Ovid and Cochrane databases was performed until July 2015 to identify studies reporting on the relation of PALN involvement and PDAC outcomes and a meta-analysis was performed following data extraction. Results: Ten retrospective studies and two prospective non randomized studies (2467 patients) were included. Patients with positive PALN had worse one (p < 0.00001) and two year (p < 0.00001) survival when compared with patients with negative PALN. Even when comparing only patients with positive lymph nodes (N1), patients with PALN involvement presented with a significant lower one (p = 0.03) and two (p = 0.002) year survival. PALN involvement was associated with an increased possibility of positive margin (R1) resection (p < 0.00001), stations' 12, 14 and 17 malignant infiltration (p < 0.00001), but not with tumour stage (p = 0.78). Discussion: Involvement of PALN is associated with decreased survival in pancreatic cancer patients. However, existence of long term survivors among this subgroup of patients should be further evaluated, in order to identify factors associated with their favourable prognosis.
Language	English
Publishing date	2016-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2016.04.007
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Article: Donor's site evaluation after restoration with autografts or synthetic plugs in rabbits.

Intzoglou, Konstantinos S / Mastrokalos, Dimitrios S / Korres, Dimitrios S / Papaparaskeva, Kleo / Koulalis, Dimitrios / Babis, George C

World journal of orthopedics

2014 Volume 5, Issue 4, Page(s) 550–556

Abstract: Aim: To investigate donor site's area histological and immunohistochemical knee cartilage appearances after resurfacing iatrogenic defects with biosynthetic plugs orautografts.: Methods: Thirty New Zealand White rabbits were used in this study. A ... ...

Abstract	Aim: To investigate donor site's area histological and immunohistochemical knee cartilage appearances after resurfacing iatrogenic defects with biosynthetic plugs orautografts. Methods: Thirty New Zealand White rabbits were used in this study. A full-thickness cylindrical defect of 4.5 mm (diameter) × 7 mm (depth) was created with a hand drill in the femoral groove of every animal. In Group A (n = 10) the defect of the donor site was repaired with a biosynthetic osteochondral plug, in Group B (n = 10) with an osteochondral autograft, while in Group C (control group of 10) rabbits were left untreated. Results: Twenty-four weeks postoperatively, smooth articular cartilage was found macroscopically in some trocleas' surfaces; in all others, an articular surface with discontinuities was observed. Twenty-eight out of 30 animals were found with predominantly viable chondrocytes leaving the remaining two -which were found only in the control group- with partially viable chondrocytes. However, histology revealed many statistical differences between the groups as far as the International Cartilage Repair Society (ICRS) categories are concerned. Immunofluoresence also revealed the presence of collagen II in all specimens of Group B, whereas in Group A collagen II was found in less specimens. In Group C collagen IIwas not found. Conclusion: The matrix, cell distribution, subchondral bone and cartilage mineralization ICRS categories showed statistically differences between the three groups. Group A was second, while group B received the best scores; the control group got the worst ICRS scores in these categories. So, the donor site area, when repairing osteochondral lesions with autografting systems, is better amended with osteochondral autograft rather than bone graft substitute implant.
Language	English
Publishing date	2014-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649712-8
ISSN	2218-5836
ISSN	2218-5836
DOI	10.5312/wjo.v5.i4.550
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Article ; Online: Pigmented villonodular synovitis of the distal tibiofibular joint: a case report.

Mavrogenis, Andreas F / Papaparaskeva, Kleo T / Galanakos, Spyros / Papagelopoulos, Panayiotis J

Clinics in podiatric medicine and surgery

2011 Volume 28, Issue 3, Page(s) 589–597

Abstract: Pigmented villonodular synovitis (PVNS) is a proliferative disorder of the synovium. Monoarticular involvement is the more common process. This article presents a case of PVNS with rare location at the distal tibiofibular joint and discusses the current ... ...

Abstract	Pigmented villonodular synovitis (PVNS) is a proliferative disorder of the synovium. Monoarticular involvement is the more common process. This article presents a case of PVNS with rare location at the distal tibiofibular joint and discusses the current concepts of diagnosis and treatment of this disease.
MeSH term(s)	Adult ; Ankle Joint/pathology ; Ankle Joint/surgery ; Arthroscopy/methods ; Biopsy, Needle ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging/methods ; Male ; Rare Diseases ; Risk Assessment ; Severity of Illness Index ; Synovitis, Pigmented Villonodular/diagnosis ; Synovitis, Pigmented Villonodular/surgery ; Tomography, X-Ray Computed/methods ; Treatment Outcome
Language	English
Publishing date	2011-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1323674-x
ISSN	1558-2302 ; 0742-0668 ; 0891-8422
ISSN (online)	1558-2302
ISSN	0742-0668 ; 0891-8422
DOI	10.1016/j.cpm.2011.04.005
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Article ; Online: Extra-gastrointestinal stromal tumor of the omentum: a rare case report and review of the literature.

Fagkrezos, Dimitris / Touloumis, Zisis / Giannila, Maria / Penlidis, Charalampos / Papaparaskeva, Kleo / Triantopoulou, Charikleia

Rare tumors

2012 Volume 4, Issue 3, Page(s) e44

Abstract: Gastrointestinal stromal tumors (GIST) are uncommon mesenchymal spindle-cell or epithelioid neoplasms, located mainly with higher frequency in the stomach and small bowel. GISTs represent the majority of primary non-epithelial neoplasms of the digestive ... ...

Abstract	Gastrointestinal stromal tumors (GIST) are uncommon mesenchymal spindle-cell or epithelioid neoplasms, located mainly with higher frequency in the stomach and small bowel. GISTs represent the majority of primary non-epithelial neoplasms of the digestive tract, most frequently expressing the KIT protein a transmembrane tyrosine kinase receptor for stem cell factor. Extra-gastrointestinal stromal tumors tend to present In fewer than 5% of cases; they originate primarily from the mesentery, omentum or peritoneum. Furthermore, these extra-gastrointestinal tumors (EGIST) tend to be more common in patients over the age of 50 years. EGISTs are neoplasms with overlapping immunohistological features, occurring in the abdomen outside the gastrointestinal tract with no connection to the gastric or intestinal wall. We describe here a rare case of EGIST of the lesser omentum and report the clinical, macroscopic, immunohistological and radiological features of an EGIST arising in the lesser omentum of a 63-year old man. Clinical course and the prognostic factors of such lesions will also be discussed. EGISTs in the lesser omentum can grow slowly and remain silent despite a large tumor size. In most cases, a pre-operative diagnosis is not possible, and the patient undergoes a surgical operation for the generic diagnosis of abdominal mass. During the intervention it is important to achieve a complete removal of the mass and to examine every possible adhesion to the gastrointestinal wall.
Language	English
Publishing date	2012-08-08
Publishing country	England
Document type	Case Reports
ZDB-ID	2514363-3
ISSN	2036-3613 ; 2036-3605
ISSN (online)	2036-3613
ISSN	2036-3605
DOI	10.4081/rt.2012.e44
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Article: Microsurgical muscle-splitting approach for extracanalicular lumbar disc herniation: an analysis of 28 consecutive cases.

Birbilis, Theodossios / Koulalis, Dimitrios / Matis, Georgios / Theodoropoulou, Efthymia / Papaparaskeva, Kleo

Acta orthopaedica Belgica

2009 Volume 75, Issue 1, Page(s) 70–74

Abstract: Extracanalicular lumbar disc herniation (ELDH) is a specific clinical entity with compression of the nerve root in its extraforaminal course. The classical midline interlaminar approach is often difficult because the facet joint obviates a direct view of ...

Abstract	Extracanalicular lumbar disc herniation (ELDH) is a specific clinical entity with compression of the nerve root in its extraforaminal course. The classical midline interlaminar approach is often difficult because the facet joint obviates a direct view of the nerve, and a partial facetectomy is required. Consequently, the risk of instability or continued postoperative back pain is increased. The authors performed a microsurgical muscle-splitting approach in an attempt to obtain a direct view of the disc rupture without sacrificing the facet joint. Twenty-eight consecutive patients were operated upon with this surgical procedure. A retrospective study showed that 10 patients (35.7%) had an excellent, 13 (46.4%) a good, 4 (14.3%) a fair and one (3.6%) a poor result, according to the Macnab criteria. No serious postoperative complications were noted. This procedure is safe, effective and less invasive.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Intervertebral Disc Displacement/surgery ; Magnetic Resonance Imaging ; Male ; Microsurgery ; Middle Aged ; Muscle, Skeletal/surgery ; Orthopedic Procedures/methods ; Retrospective Studies ; Tomography, X-Ray Computed ; Treatment Outcome ; Zygapophyseal Joint/surgery
Language	English
Publishing date	2009-02
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	210367-9
ISSN	0001-6462 ; 1784-407X
ISSN	0001-6462 ; 1784-407X
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Article ; Online: Hemiepiphysiodeses for guided growth in children.

Dovris, Dimitrios / Mavrogenis, Andreas F / Christogiannis, Ioannis / Nomikos, George / Papaparaskeva, Kleo / Koulalis, Dimitrios / Papalois, Apostolos / Karameris, Andreas / Babis, George C

Journal of long-term effects of medical implants

2014 Volume 24, Issue 2-3, Page(s) 121–129

Abstract: Lower-extremity angular deformities are among the most common non-traumatic conditions in children being referred to pediatric orthopedists. Understanding of this abnormality and knowledge of current treatment is essential for pediatricians and primary ... ...

Abstract	Lower-extremity angular deformities are among the most common non-traumatic conditions in children being referred to pediatric orthopedists. Understanding of this abnormality and knowledge of current treatment is essential for pediatricians and primary caregivers. A development in the surgical management of these problems has improved the quality of care of affected children and adolescents. Traditionally, angular deformities are treated by means of osteotomy. In patients who are skeletally immature, this major intervention can be avoided by influencing or guiding the growth of the affected physis using hemiepiphysiodesis techniques. Recently, alternative surgical techniques and implants have been described for improved control of the guided growth.
MeSH term(s)	Adolescent ; Bone Development/physiology ; Child ; Epiphyses/growth & development ; Epiphyses/surgery ; Humans ; Knee Joint/abnormalities ; Knee Joint/surgery ; Orthopedic Fixation Devices ; Orthopedic Procedures/methods ; Patient Care Planning ; Postoperative Complications
Language	English
Publishing date	2014-09-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1073166-0
ISSN	1940-4379 ; 1050-6934
ISSN (online)	1940-4379
ISSN	1050-6934
DOI	10.1615/jlongtermeffmedimplants.2014008304
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Article ; Online: Pancreatic neuroendocrine tumors: current opinions on a rare, but potentially curable neoplasm.

Karakaxas, Dimitrios / Gazouli, Maria / Liakakos, Theodoros / Vaiopoulou, Anna / Apessou, Dimitra / Papaparaskeva, Kleo / Patapis, Pavlos / Dervenis, Christos

European journal of gastroenterology & hepatology

2014 Volume 26, Issue 8, Page(s) 826–835

Abstract: Pancreatic neuroendocrine tumors (PNETs) share a unique genetic identity, functional behavior, and clinical course. Compared with tumors of the exocrine pancreas, they are rare and show a different biologic behavior and prognosis. On the basis of data ... ...

Abstract	Pancreatic neuroendocrine tumors (PNETs) share a unique genetic identity, functional behavior, and clinical course. Compared with tumors of the exocrine pancreas, they are rare and show a different biologic behavior and prognosis. On the basis of data from recent studies, all PNETs, outside of small insulinomas, should be considered potentially malignant and treated accordingly. Untreated tumors have a high possibility to grow locally into adjacent structures or spread to distant organs. Although surgical excision irrespective of tumor functioning or nonfunctioning state remains the cornerstone of therapy, providing the best disease-free and survival rates to date, the understanding of the genetic nature of the disease yields new 'targets' to consider in drug development. The aim of this review is to summarize all recent advances of genetic research and new drug development in terms of PNETs, especially their genetic identity and subsequent alterations leading to the development of near or total malignant activity, and the new medical treatment strategies of this potentially curable disease on the basis of therapeutical agents acting, where possible, at the genetic level.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/metabolism ; Genetic Predisposition to Disease ; Humans ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/genetics ; Neuroendocrine Tumors/therapy ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/therapy ; Prognosis
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor
Language	English
Publishing date	2014-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000000138
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Article ; Online: The effect of local use of nandrolone decanoate on rotator cuff repair in rabbits.

Papaspiliopoulos, Athanasios / Papaparaskeva, Kleo / Papadopoulou, Eleni / Feroussis, John / Papalois, Apostolos / Zoubos, Aristedes

Journal of investigative surgery : the official journal of the Academy of Surgical Research

2010 Volume 23, Issue 4, Page(s) 204–207

Abstract: Objective: There is still controversy about the effect of anabolic steroid on connective tissue. This study examines the hypothesis that the local use of nandrolone decanoate, an anabolic steroid on rotator cuff, facilitates the healing process when ... ...

Abstract	Objective: There is still controversy about the effect of anabolic steroid on connective tissue. This study examines the hypothesis that the local use of nandrolone decanoate, an anabolic steroid on rotator cuff, facilitates the healing process when used in combination with surgical repair. Methods: Forty-eight male rabbits were divided in four groups with anabolic steroids (Nandrolone Decanoate 10 mg/kg) and immobilization as variables. The groups were the following: first group, nonsteroid use-immobilization (NSI); second group, nonsteroid use-nonimmobilization (NSNI); third group, steroid use-immobilization (SI); fourth group steroid use-nonimmobilization (SNI). Every rabbit underwent a rotator cuff incision and reconstruction. Fifteen days later the tendons were sent for biomechanical and histological evaluation. Results: Groups that did not receive anabolic steroids showed better healing and more tendon strength in comparison to groups that received anabolic steroids. Microscopic examination of specimens from the groups without the use of anabolic steroid showed extensive fibroblastic activity whereas the specimens from those groups with anabolic steroid use showed focal fibroblastic reaction and inflammation. Immobilization provided better results in the groups with anabolic steroid use but it did not influence healing in groups without steroids. Conclusions: The effect of local nandrolone decanoate use on a rotator cuff tear is detrimental, acting as a healing inhibitor.
MeSH term(s)	Anabolic Agents/adverse effects ; Anabolic Agents/pharmacology ; Animals ; Biomechanical Phenomena ; Male ; Models, Animal ; Nandrolone/adverse effects ; Nandrolone/analogs & derivatives ; Nandrolone/pharmacology ; Nandrolone Decanoate ; Rabbits ; Recovery of Function/drug effects ; Restraint, Physical ; Rotator Cuff/surgery ; Tendons/drug effects ; Wound Healing/drug effects
Chemical Substances	Anabolic Agents ; Nandrolone (6PG9VR430D) ; Nandrolone Decanoate (H45187T098)
Language	English
Publishing date	2010-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	639444-9
ISSN	1521-0553 ; 0894-1939
ISSN (online)	1521-0553
ISSN	0894-1939
DOI	10.3109/08941939.2010.481007
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