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Article ; Online: Thalidomide, the story goes on.

Papaseit, Esther / Farré, Magí / Garcia-Algar, Óscar

2023 Volume 98, Issue 6, Page(s) 490–491

MeSH term(s)	Thalidomide/adverse effects
Chemical Substances	Thalidomide (4Z8R6ORS6L)
Language	English
Publishing date	2023-05-08
Publishing country	Spain
Document type	Letter
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpede.2023.03.007
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Article ; Online: La nueva moda de consumo de algunos inhalantes: riesgos y alerta por la falsa inocuidad.

Cárdenas-Quesada, Jose / Pérez-Mañá, Clara / Papaseit, Esther / Farré, Magí

Medicina clinica

2023 Volume 161, Issue 12, Page(s) 543–546

Title translation	The new trend of some inhalant use: Risks and warnings of false harmlessness.
Language	Spanish
Publishing date	2023-07-28
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2023.07.001
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Article ; Online: Metabolic profile of N-ethylhexedrone, N-ethylpentedrone, and 4-chloromethcathinone in urine samples by UHPLC-QTOF-HRMS.

Massano, Marta / Nuñez-Montero, Melani / Papaseit, Esther / Hladun, Olga / Pérez-Maña, Clara / Ventura, Mireia / Marchei, Emilia / Alladio, Eugenio / Gerace, Enrico / Pichini, Simona / Farrè, Magi / Salomone, Alberto

Journal of pharmaceutical and biomedical analysis

2024 Volume 241, Page(s) 115994

Abstract: Forensic laboratories are constantly required to identify new drugs and their metabolites. N-ethylhexedrone (NEH, HEXEN), N-Ethylpentedrone (NEP), and 4-Chloromethcathinone (4-CMC, clephedrone) are synthetic substances structurally related to natural ... ...

Abstract	Forensic laboratories are constantly required to identify new drugs and their metabolites. N-ethylhexedrone (NEH, HEXEN), N-Ethylpentedrone (NEP), and 4-Chloromethcathinone (4-CMC, clephedrone) are synthetic substances structurally related to natural cathinone, alkaloid present in the leaves of the Catha edulis (Khat) plant. These synthetic cathinones (SC) are members of the heterogenous family of new psychoactive substances (NPS) that raised major concerns in scientific and forensic communities over the past years due to their widespread consumption. In this context, we investigated their metabolic profile using of UHPLC-QTOF-HRMS to elucidate the distribution of the parent drug and its metabolites in urine samples over time. Initially, both male and female volunteers were divided into three groups and eight subjects of each group were administered intranasally or orally with one SC (20-40 mg of NEH or NEP intranasal, 100-150 mg of 4-CMC oral). Urine samples were collected at 0-2 and 2-4 or 2-5 h. Urine (50 μL) was diluted 1:2 with acetonitrile/methanol (95:5) and injected into the UHPLC-QTOF-HRMS. Phase-I and phase-II metabolites were identified on the basis of fragmentation patterns and exact masses. Several phase-I and glucuronide-phase-II metabolites were identified in urine samples. Keto group reduction, hydroxylation and dealkylation were the common metabolic pathways identified for all cathinones and the presence of NEH-glucuronide, NEP-glucuronide and 4-CMC-glucuronide was also relevant. Significant is the slower metabolite formation for 4-CMC, which was detected at high concentrations in its original form even 5 h after administration, due to its long half-life and low intrinsic clearance compared to the other SCs. UHPLC-QTOF-HRMS demonstrated a considerable capability to semi-quantify the three synthetic cathinones and identify the target metabolites with high reliability. The introduction of new target compounds improves the efficiency of toxicological screening analysis on real samples and extends the window of detection of the SCs in biological matrices.
MeSH term(s)	Humans ; Chromatography, High Pressure Liquid ; Synthetic Cathinone ; Reproducibility of Results ; Glucuronides ; Metabolome ; Methylamines ; Propiophenones
Chemical Substances	clephedrone (PTAYYYZMMT) ; Synthetic Cathinone ; Glucuronides ; Methylamines ; Propiophenones
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.115994
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Article ; Online: UHPLC-HRMS and GC-MS Screening of a Selection of Synthetic Cannabinoids and Metabolites in Urine of Consumers.

Pellegrini, Manuela / Marchei, Emilia / Papaseit, Esther / Farré, Magí / Zaami, Simona

Medicina (Kaunas, Lithuania)

2020 Volume 56, Issue 8

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Gas Chromatography-Mass Spectrometry/methods ; Humans ; Illicit Drugs/urine ; Indoles/urine ; Naphthalenes/urine ; Reproducibility of Results
Chemical Substances	(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone ; 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone ; Illicit Drugs ; Indoles ; Naphthalenes ; (4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone (44147RI31X)
Language	English
Publishing date	2020-08-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina56080408
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Article: Antidepressant Drugs and COVID-19: A Review of Basic and Clinical Evidence.

Mas, Marta / García-Vicente, Juan Antonio / Estrada-Gelonch, Anaïs / Pérez-Mañá, Clara / Papaseit, Esther / Torrens, Marta / Farré, Magí

Journal of clinical medicine

2022 Volume 11, Issue 14

Abstract: The COVID-19 pandemic has encouraged the repurposing of existing drugs as a shorter development strategy in order to support clinicians with this difficult therapeutic dilemma. There is evidence to support the theory that some antidepressants can reduce ... ...

Abstract	The COVID-19 pandemic has encouraged the repurposing of existing drugs as a shorter development strategy in order to support clinicians with this difficult therapeutic dilemma. There is evidence to support the theory that some antidepressants can reduce concentrations of different cytokines in humans and animals and, recently, the antiviral activity of some antidepressants against SARS-CoV-2 has been reported. The aims of this narrative review are to evaluate the possible role of antidepressants in the treatment of COVID-19 infection and the possible benefits and risks of patients taking antidepressants for mental disorders and COVID-19 infection. A review was performed to analyse the current literature to identify the role of antidepressant medication in the treatment of COVID-19 patients. The electronic search was completed in MEDLINE and MedRxiv/BioRxiv for published literature and in ClinicalTrials.gov for ongoing clinical trials. The results show some evidence from preclinical data and observational studies about the possible efficacy of some specific antidepressants for treating COVID-19 infection. In addition, two published phase II studies testing fluvoxamine showed positive results for clinical deterioration and hospitalization rate versus a placebo. Seven ongoing clinical trials testing fluvoxamine, fluoxetine, and tramadol (as per its anti-inflammatory and antidepressant effect) are still in the early phases. Although the available evidence is limited, the sum of the antiviral and anti-inflammatory preclinical studies and the results from several observational studies and two phase II clinical trials provide the basis for ongoing clinical trials evaluating the possible use of antidepressants for COVID-19 infection in humans. Further investigations will be needed to support the possible use of antidepressants for this application.
Language	English
Publishing date	2022-07-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11144038
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Article ; Online: Reversible taste and smell dysfunction associated with sodium valproate and quetiapine in bipolar depression: a case report.

Alvarez, Pilar / Papaseit, Esther / Pérez, Víctor / Bulbena, Antoni / Farré, Magí

Actas espanolas de psiquiatria

2019 Volume 47, Issue 1, Page(s) 33–36

MeSH term(s)	Antimanic Agents/administration & dosage ; Antimanic Agents/adverse effects ; Antimanic Agents/therapeutic use ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Drug Therapy, Combination/adverse effects ; Humans ; Male ; Middle Aged ; Olfaction Disorders/chemically induced ; Quetiapine Fumarate/administration & dosage ; Quetiapine Fumarate/adverse effects ; Quetiapine Fumarate/therapeutic use ; Taste Disorders/chemically induced ; Valproic Acid/administration & dosage ; Valproic Acid/adverse effects ; Valproic Acid/therapeutic use
Chemical Substances	Antimanic Agents ; Antipsychotic Agents ; Quetiapine Fumarate (2S3PL1B6UJ) ; Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2019-01-01
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	1480971-0
ISSN	1578-2735 ; 1575-071X ; 1139-9287
ISSN (online)	1578-2735
ISSN	1575-071X ; 1139-9287
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Article ; Online: GC-MS/MS Determination of Synthetic Cathinones: 4-chloromethcathinone, N-ethyl Pentedrone, and N-ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study.

Nuñez-Montero, Melani / Lombroni, Claudia / Maida, Nunzia La / Rotolo, Maria Concetta / Pichini, Simona / Papaseit, Esther / Hladun, Olga / Ventura, Mireia / Poyatos, Lourdes / Pérez-Mañá, Clara / Farré, Magí / Marchei, Emilia

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: This study presents a validated GC-MS/MS method for the detection and quantification of 4-chloromethcathinone or clephedrone (4-CMC), N-ethyl Pentedrone (NEP), and N-ethyl Hexedrone (NEH, also named HEXEN) in oral fluid and sweat and verifies its ... ...

Abstract	This study presents a validated GC-MS/MS method for the detection and quantification of 4-chloromethcathinone or clephedrone (4-CMC), N-ethyl Pentedrone (NEP), and N-ethyl Hexedrone (NEH, also named HEXEN) in oral fluid and sweat and verifies its feasibility in determining human oral fluid concentrations and pharmacokinetics following the administration of 100 mg of 4-CMC orally and 30 mg of NEP and NEH intranasally. A total of 48 oral fluid and 12 sweat samples were collected from six consumers. After the addition of 5 μL of methylone-d
MeSH term(s)	Humans ; Tandem Mass Spectrometry/methods ; Synthetic Cathinone ; Gas Chromatography-Mass Spectrometry/methods ; Pilot Projects ; Sweat
Chemical Substances	pentedrone (2ELU1B757Q) ; clephedrone (PTAYYYZMMT) ; ethyl acetate (76845O8NMZ) ; Synthetic Cathinone
Language	English
Publishing date	2023-05-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119387
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Article: Usefulness of Oral Fluid for Measurement of Methylone and Its Metabolites: Correlation with Plasma Drug Concentrations and the Effect of Oral Fluid pH.

Sprega, Giorgia / Di Giorgi, Alessandro / Poyatos, Lourdes / Papaseit, Esther / Pérez-Mañá, Clara / Tini, Anastasio / Pichini, Simona / Busardò, Francesco Paolo / Lo Faro, Alfredo Fabrizio / Farré, Magí

Metabolites

2023 Volume 13, Issue 4

Abstract: The aim of this study was to investigate methylone and its metabolites concentration in oral fluid following controlled increasing doses, focusing on the effect of oral fluid pH. Samples were obtained from a clinical trial where twelve healthy volunteers ...

Abstract	The aim of this study was to investigate methylone and its metabolites concentration in oral fluid following controlled increasing doses, focusing on the effect of oral fluid pH. Samples were obtained from a clinical trial where twelve healthy volunteers participated after ingestion of 50, 100, 150 and 200 mg of methylone. Concentration of methylone and its metabolites 4-hydroxy-3-methoxy-N-methylcathinone (HMMC) and 3,4-methylenedioxycathinone in oral fluid were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Pharmacokinetic parameters were estimated, and the oral fluid-to-plasma ratio (OF/P) at each time interval was calculated and correlated with the oral fluid pH using data from our previous study in plasma. Methylone was detected at all time intervals after each dose; MDC and HMMC were not detectable after the lowest dose. Oral fluid concentrations of methylone ranged between 88.3-503.8, 85.5-5002.3, 182.8-13,201.8 and 214.6-22,684.6 ng/mL following 50, 100, 150 and 200 mg doses, respectively, peaked between 1.5 and 2.0 h, and were followed by a progressive decrease. Oral fluid pH was demonstrated to be affected by methylone administration. Oral fluid is a valid alternative to plasma for methylone determination for clinical and toxicological studies, allowing for a simple, easy and non-invasive sample collection.
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13040468
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Article ; Online: Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans.

Di Giorgi, Alessandro / Sprega, Giorgia / Poyatos, Lourdes / Papaseit, Esther / Pérez-Mañá, Clara / Di Trana, Annagiulia / Varì, Maria Rosaria / Busardò, Francesco Paolo / Pichini, Simona / Zaami, Simona / Lo Faro, Alfredo Fabrizio / Farré, Magí

International journal of molecular sciences

2023 Volume 24, Issue 8

Abstract: The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve healthy volunteers involved in a clinical trial. ... ...

Abstract	The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve healthy volunteers involved in a clinical trial. Methylone and its metabolites 4-hydroxy-3-methoxy-N-methylcathinone (HMMC) and 3,4-methylenedioxycathinone (MDC) were analyzed in sweat patches by liquid chromatography-tandem mass spectrometry. Methylone and MDC were detected in sweat at 2 h and reached their highest accumulation (C
MeSH term(s)	Humans ; Chromatography, Liquid/methods ; Mass Spectrometry ; Methamphetamine/metabolism ; Sweat/chemistry
Chemical Substances	Methamphetamine (44RAL3456C) ; methylone (L4I4B1R01F)
Language	English
Publishing date	2023-04-17
Publishing country	Switzerland
Document type	Clinical Study ; Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24087395
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Article ; Online: Development of enantioselective high-performance liquid chromatography-tandem mass spectrometry method for the quantitative determination of 3,4-methylenedioxy-methamphetamine (MDMA) and its phase-1 metabolites in human biological fluids.

Lo Faro, Alfredo Fabrizio / Sprega, Giorgia / Beradinelli, Diletta / Tini, Anstasio / Poyatos, Lourdes / Papaseit, Esther / Berretta, Paolo / Di Giorgi, Alessandro / Farre, Magì / Takaishvili, Nino / Farkas, Tivadar / Busardò, Francesco Paolo / Chankvetadze, Bezhan

Journal of pharmaceutical and biomedical analysis

2023 Volume 238, Page(s) 115768

Abstract: In the present study enantioselective high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were developed for the quantitative determination of 3,4-methylenedioxy-methamphetamine (MDMA) and its major phase-1 metabolites 4- ... ...

Abstract	In the present study enantioselective high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were developed for the quantitative determination of 3,4-methylenedioxy-methamphetamine (MDMA) and its major phase-1 metabolites 4-hydroxy-3-methoxyamphetamine (HMA), 4-hydroxy-3-methoxymethamphetamine (HMMA) and 3,4-methylenedioxyamphetamine (MDA) in human plasma, sweat, oral fluid (OF) and urine. The simultaneous separation of all these compounds and their respective enantioseparation was accomplished on two polysaccharide-based chiral columns. The Lux AMP column with a proprietary chiral selector enabled baseline separation of the enantiomers of MDMA, HMA and HMMA while MDA enantiomers could not be separated with this column under the experimental conditions used in this study. The Lux i-Amylose-3 column based on amylose tris(5-chloro-3-methylphenylcarbamate) as chiral selector baseline-separated the enantiomers of MDMA, HMMA and MDA while the enantiomers of HMA could not be separated. Thus, the various samples were analyzed by using both columns alternatively in combinations with acetonitrile containing 25% (v/v) 5 mM ammonium bicarbonate buffer at pH 11.0 as mobile phase. Analysis time was less than 4 min with the Lux AMP column and less than 6 min with the Lux i-Amylose-3 column. Both methods were validated and applied to the enantioselective determination of MDMA and its phase-I metabolites in human biological fluids, and enantioselective metabolism of MDMA was confirmed.
MeSH term(s)	Humans ; N-Methyl-3,4-methylenedioxyamphetamine/metabolism ; Chromatography, High Pressure Liquid ; Tandem Mass Spectrometry ; Chromatography, Liquid ; Stereoisomerism ; Amylose ; Methamphetamine ; 3,4-Methylenedioxyamphetamine
Chemical Substances	N-Methyl-3,4-methylenedioxyamphetamine (KE1SEN21RM) ; atrolactic acid (515-30-0) ; Amylose (9005-82-7) ; Methamphetamine (44RAL3456C) ; 3,4-Methylenedioxyamphetamine (4764-17-4)
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115768
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