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  1. AU="Papathemelis, Thomas"
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  3. AU="Eefje Belt-van Zoen"
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  1. Book ; Thesis: Nicht-invasive kreislaufphysiologische Untersuchungen an zeitentsprechend Gewachsenen und wachstumsverzögerten menschlichen Feten

    Papathemelis, Thomas

    2009  

    Author's details vorgelegt von Thomas Papathemelis
    Language German
    Size 65 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Diss., 2009
    HBZ-ID HT015978855
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Crossed fused renal ectopia during paraaortic lymphadenectomy for cervical cancer.

    Tsaousidis, Georgios / Zitzelsberger, Ute / Papathemelis, Thomas

    Journal of minimally invasive gynecology

    2023  Volume 30, Issue 7, Page(s) 525–526

    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/surgery ; Lymph Node Excision/adverse effects ; Kidney Diseases/surgery ; Kidney/surgery
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2186934-0
    ISSN 1553-4669 ; 1553-4650
    ISSN (online) 1553-4669
    ISSN 1553-4650
    DOI 10.1016/j.jmig.2023.03.011
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  3. Article ; Online: Risk factors and temporal patterns of recurrences in patients with vulvar cancer: implications for follow-up intervals and duration

    Röhrmoser, Katharina / Ignatov, Atanas / Gerken, Michael / Ortmann, Olaf / Klinkhammer-Schalke, Monika / Papathemelis, Thomas

    J Cancer Res Clin Oncol. 2023 Feb., v. 149, no. 2, p. 803-810

    2023  , Page(s) 803–810

    Abstract: BACKGROUND: To date, information on risk factors and temporal patterns of recurrences in patients with vulvar cancer is sparse. Conclusive data for an optimal surveillance strategy are lacking. METHODS: This multicenter, retrospective population-based ... ...

    Abstract BACKGROUND: To date, information on risk factors and temporal patterns of recurrences in patients with vulvar cancer is sparse. Conclusive data for an optimal surveillance strategy are lacking. METHODS: This multicenter, retrospective population-based register study included 1412 patients who have been treated from 2000 to 2017 for vulvar cancer in the German districts of Upper Palatinate, Lower Bavaria, and Saxony-Anhalt. Kaplan–Meier method, and univariate and multivariate Cox regression were employed to evaluate prognostic factors and temporal course of overall survival, cumulative recurrence, and recurrence-free survival rates. RESULTS: After exclusion, the final study cohort comprised 829 patients. Most recurrences occurred within the first 3 years after diagnosis. Notably, a significant subset of patients were recurrent even after 5 years. The cumulative recurrence rate from all relapses was 18.6% 1 year after primary diagnosis. The recurrence rate increased to 34.7% after 3, to 41.8% after 5, and to 56.6% after 10 years post-diagnosis. The risk of relapse was significantly increased in patients over 70 years of age (hazard ratio (HR) = 2.7; p < 0.001; 95% CI 1.6–4.4), and in patients with positive nodal status N1 (HR = 2.0; p = 0.019; 95% CI 1.1–3.5) and N2/3 (HR = 2.2; p = 0.033; 95% CI 1.1–4.4). CONCLUSION: Our study provides compelling evidence that follow-up care should be carried out for longer than 5 years, especially for high-risk patients.
    Keywords hazard ratio ; monitoring ; regression analysis ; relapse ; risk ; Germany
    Language English
    Dates of publication 2023-02
    Size p. 803-810
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-022-03954-x
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  4. Article ; Online: Assessment of breast cancer primary tumor material in a 3D in vivo model.

    Kohl, Cynthia / Aung, Thiha / Haerteis, Silke / Papathemelis, Thomas

    Clinical hemorheology and microcirculation

    2021  Volume 79, Issue 1, Page(s) 157–166

    Abstract: Background: Breast cancer is the most common malignant tumor in women and highly heterogeneous with a variety of different molecular subtypes. The analysis of the individual tumor biology is necessary to develop a specific and individualized treatment ... ...

    Abstract Background: Breast cancer is the most common malignant tumor in women and highly heterogeneous with a variety of different molecular subtypes. The analysis of the individual tumor biology is necessary to develop a specific and individualized treatment plan for every patient. The chick chorioallantoic membrane (CAM) model, a 3D-in-vivo-tumor-model, could potentially provide a methodology that facilitates the gain of additional information regarding the tumor biology as well as the testing of the tumor's individual sensitivity to different therapies.
    Objective: The objective was to establish the grafting of different breast cancer primaries onto the CAM for tumor profiling and the investigation of different parameters.
    Methods: Breast cancer primary tissue of different patients was grafted onto the CAM. Subsequently, 3D volume and perfusion measurements were performed during the engraftment period. Histological analyses of the tumors were carried out after the engraftment period.
    Results: The grafting of the breast cancer primaries onto the CAM was successful. The tumors remained partially vital and displayed angiogenic development on the CAM.
    Conclusions: Breast cancer primary material can be grafted onto the CAM and we observed visible and measurable changes of perfusion over time.
    MeSH term(s) Animals ; Breast Neoplasms ; Chickens ; Chorioallantoic Membrane ; Female ; Humans
    Language English
    Publishing date 2021-09-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-219113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The 3D in vivo chorioallantoic membrane model and its role in breast cancer research.

    Kohl, Cynthia / Aung, Thiha / Haerteis, Silke / Ignatov, Atanas / Ortmann, Olaf / Papathemelis, Thomas

    Journal of cancer research and clinical oncology

    2022  Volume 148, Issue 5, Page(s) 1033–1043

    Abstract: Purpose: We aimed to evaluate the role of the chorioallantoic membrane model (CAM) in breast cancer research.: Methods: The following is an overview of the use of the CAM in the field of breast cancer research based on a PubMed literature query.: ... ...

    Abstract Purpose: We aimed to evaluate the role of the chorioallantoic membrane model (CAM) in breast cancer research.
    Methods: The following is an overview of the use of the CAM in the field of breast cancer research based on a PubMed literature query.
    Results: The CAM is a 3D in vivo model that can be used for the analysis of tumor growth, biology and angiogenesis of primary tumor tissue or tumor cell lines. The CAM model has been used in breast cancer research for drug testing, migration assays and the evaluation of vascularization, amongst others. The CAM model is a valuable method that offers a better imitation of the physiological phenomena compared to 2D or 3D in vitro models.
    Conclusion: The CAM model has primarily and successfully been utilized for the assessment of the tumor biology of established breast cancer cell lines. Further, the CAM model is a promising method to analyze patient derived primary tumor material and could be used as a "patient-specific 3D-tumor-therapy-model" for the cost-efficient evaluation of anti-cancer drugs to find the optimal treatment for breast cancer patients.
    MeSH term(s) Animals ; Antineoplastic Agents/therapeutic use ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Chorioallantoic Membrane/metabolism ; Chorioallantoic Membrane/pathology ; Female ; Humans ; Neovascularization, Pathologic/pathology
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-02-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-022-03936-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Risk factors and temporal patterns of recurrences in patients with vulvar cancer: implications for follow-up intervals and duration.

    Röhrmoser, Katharina / Ignatov, Atanas / Gerken, Michael / Ortmann, Olaf / Klinkhammer-Schalke, Monika / Papathemelis, Thomas

    Journal of cancer research and clinical oncology

    2022  Volume 149, Issue 2, Page(s) 803–810

    Abstract: Background: To date, information on risk factors and temporal patterns of recurrences in patients with vulvar cancer is sparse. Conclusive data for an optimal surveillance strategy are lacking.: Methods: This multicenter, retrospective population- ... ...

    Abstract Background: To date, information on risk factors and temporal patterns of recurrences in patients with vulvar cancer is sparse. Conclusive data for an optimal surveillance strategy are lacking.
    Methods: This multicenter, retrospective population-based register study included 1412 patients who have been treated from 2000 to 2017 for vulvar cancer in the German districts of Upper Palatinate, Lower Bavaria, and Saxony-Anhalt. Kaplan-Meier method, and univariate and multivariate Cox regression were employed to evaluate prognostic factors and temporal course of overall survival, cumulative recurrence, and recurrence-free survival rates.
    Results: After exclusion, the final study cohort comprised 829 patients. Most recurrences occurred within the first 3 years after diagnosis. Notably, a significant subset of patients were recurrent even after 5 years. The cumulative recurrence rate from all relapses was 18.6% 1 year after primary diagnosis. The recurrence rate increased to 34.7% after 3, to 41.8% after 5, and to 56.6% after 10 years post-diagnosis. The risk of relapse was significantly increased in patients over 70 years of age (hazard ratio (HR) = 2.7; p < 0.001; 95% CI 1.6-4.4), and in patients with positive nodal status N1 (HR = 2.0; p = 0.019; 95% CI 1.1-3.5) and N2/3 (HR = 2.2; p = 0.033; 95% CI 1.1-4.4).
    Conclusion: Our study provides compelling evidence that follow-up care should be carried out for longer than 5 years, especially for high-risk patients.
    MeSH term(s) Female ; Humans ; Aged ; Aged, 80 and over ; Retrospective Studies ; Follow-Up Studies ; Vulvar Neoplasms/therapy ; Neoplasm Recurrence, Local/epidemiology ; Risk Factors
    Language English
    Publishing date 2022-02-18
    Publishing country Germany
    Document type Multicenter Study ; Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-022-03954-x
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  7. Article ; Online: Survival Advantage of Lymphadenectomy in Patients with Ovarian Cancer.

    Ignatov, Atanas / Hassan, Sheref Salim / Ivros, Stylianos / Papathemelis, Thomas / Ignatova, Zoya / Eggemann, Holm

    Cancer investigation

    2022  Volume 40, Issue 7, Page(s) 621–628

    Abstract: We investigated the survival effect of lymphadenectomy in ovarian cancer. The five-year progression-free and overall survival in early-stage ovarian cancer were not affected. Preliminary, unadjusted analysis in advanced ovarian cancer suggested an ... ...

    Abstract We investigated the survival effect of lymphadenectomy in ovarian cancer. The five-year progression-free and overall survival in early-stage ovarian cancer were not affected. Preliminary, unadjusted analysis in advanced ovarian cancer suggested an improvement in survival. However, after adjusting for other factors, e.g. ECOG performance status and patients' age, this survival advantage vanished. Our analysis suggests that systemic pelvic and para-aortic lymphadenectomy was not associated with an improvement of the progression-free and overall survival of patients with optimally debulked ovarian cancer.
    MeSH term(s) Carcinoma, Ovarian Epithelial/surgery ; Female ; Humans ; Lymph Node Excision ; Neoplasm Staging ; Ovarian Neoplasms/pathology ; Pelvis/pathology ; Retrospective Studies
    Language English
    Publishing date 2022-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2022.2067558
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  8. Article ; Online: Guideline concordant therapy improves survival in high-grade endometrial cancer patients.

    Scharl, Sophia / Sprötge, Tim / Gerken, Michael / Scharl, Anton / Ortmann, Olaf / Kölbl, Oliver / Klinkhammer-Schalke, Monika / Papathemelis, Thomas

    Journal of cancer research and clinical oncology

    2022  Volume 149, Issue 8, Page(s) 4761–4769

    Abstract: Purpose: Data from randomized controlled trials in high-grade endometrial cancer are scarce due to its low prevalence. Therefore, guideline recommendations in this cancer subtype rely on relatively few randomized trials and data from retrospective ... ...

    Abstract Purpose: Data from randomized controlled trials in high-grade endometrial cancer are scarce due to its low prevalence. Therefore, guideline recommendations in this cancer subtype rely on relatively few randomized trials and data from retrospective studies. The aim of this study was to evaluate the benefits from guideline-concordant therapy in high-grade endometrial cancer in a real-world patient group.
    Methods: The effect of treatment according to German S3 guidelines and the former S2k guideline on overall survival (OS) and recurrence-free survival (RFS) was evaluated in a cohort of 293 high-grade endometrial cancer patients.
    Results: Treatment concordant with the S3 guideline significantly improved OS (HR 0.623, CI 0.420-0.923, p = 0.018) and RFS (HR 0.578, CI 0.387-0.863, p = 0.007). Treatment concordant with the S2k guideline did not result in a significantly higher OS (HR 0.783, CI 0.465-1.316, p = 0.335) or RFS (HR 0.741, CI 0.347-1.740, p = 0.242).
    Conclusion: Therapy according to the German S3 guideline improved OS and RFS in univariate as well as multivariate analysis in this cohort of high-grade endometrial cancer patients.
    MeSH term(s) Humans ; Female ; Retrospective Studies ; Endometrial Neoplasms/drug therapy ; Radiotherapy, Adjuvant ; Neoplasm Staging
    Language English
    Publishing date 2022-10-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-022-04318-1
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  9. Article: Treatment in Certified Breast Cancer Centers Improves Chances of Survival of Patients with Breast Cancer: Evidence Based on Health Care Data from the WiZen Study.

    Schoffer, Olaf / Wimberger, Pauline / Gerken, Michael / Bierbaum, Veronika / Bobeth, Christoph / Rößler, Martin / Dröge, Patrik / Ruhnke, Thomas / Günster, Christian / Kleihues-van Tol, Kees / Link, Theresa / Scharl, Anton / Inwald, Elisabeth C / Kast, Karin / Papathemelis, Thomas / Ortmann, Olaf / Klinkhammer-Schalke, Monika / Schmitt, Jochen

    Geburtshilfe und Frauenheilkunde

    2024  Volume 84, Issue 2, Page(s) 153–163

    Abstract: Introduction: Certified breast cancer centers offer specific quality standards in terms of their structure, diagnostic and treatment approaches with regards to breast surgery, drug-based cancer therapy, radiotherapy, and psychosocial support. Such ... ...

    Abstract Introduction: Certified breast cancer centers offer specific quality standards in terms of their structure, diagnostic and treatment approaches with regards to breast surgery, drug-based cancer therapy, radiotherapy, and psychosocial support. Such centers aim to improve treatment outcomes of breast cancer patients. The question investigated here was whether patients with primary breast cancer have a longer overall survival if they are treated in a certified breast cancer center compared to treatment outside these centers.
    Methods: We used patient-specific data (demographics, diagnoses, treatments) obtained from data held by mandatory health insurance companies (
    Results: The sample population consisted of 143720 (GKV data) and 59780 (KKR data) patients with breast cancer, who were treated in 1010 hospitals across Germany (280 DKG-certified, 730 not DKG-certified). 63.5% (GKV data) and 66.7% (KKR data) of patients, respectively, were treated in DKG-certified breast cancer centers. Cox regression analysis for overall survival which included patient and hospital characteristics found a significantly lower mortality risk for patients treated in DKG-certified breast cancer centers (GKV data: HR = 0.77, 95% CI = 0.74-0.81; KKR data: HR = 0.88, 95% CI = 0.85-0.92). This result remained stable even after several sensitivity analyses including stratified estimates for subgroups of patients and hospitals. The effect was even more pronounced for recurrence-free survival (KKR data: HR = 0.78, 95% CI = 0.74-0.82).
    Conclusions: Patients who are treated by an interdisciplinary team in a DKG-certified breast cancer had clear and statistically significantly better survival rates. Certification is therefore an effective means of improving the quality of care, and more patients should be treated in certified breast cancer centers.
    Language English
    Publishing date 2024-01-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/a-1869-1772
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  10. Article ; Online: Treatment of endometrial cancer from 2000 to 2020 in Germany: a retrospective population based cohort study.

    Papathemelis, Thomas / Ortmann, Olaf / Kohl, Cynthia / Neuser, Petra / Tol, Kees Kleihues-van / Klinkhammer-Schalke, Monika / Ugocsai, Peter / Walter, Christina Barbara / Rottmann, Miriam / Real, Catherine / Justenhoven, Christina / Robers, Gabriele / Schneider, Constanze / Gerken, Michael / Sackmann, Andrea / Kim-Wanner, Soo-Zin

    Journal of cancer research and clinical oncology

    2024  Volume 150, Issue 5, Page(s) 279

    Abstract: Purpose: Endometrial cancer (EC) is one of the most common malignancies among women in western countries. This study aimed to assess data on patient treatment in Germany throughout two decades to evaluate the development and effect of surgery, radiation, ...

    Abstract Purpose: Endometrial cancer (EC) is one of the most common malignancies among women in western countries. This study aimed to assess data on patient treatment in Germany throughout two decades to evaluate the development and effect of surgery, radiation, and chemotherapy.
    Methods: This retrospective registry study included 34,349 EC patients diagnosed between 2000 and 2020. Patients were classified into five risk groups. Overall survival was analyzed by Kaplan-Meier method as well as univariable and multivariable Cox regression to evaluate risk factors and treatment options.
    Results: Over the study period, minimal invasive surgery was used more often compared to open surgery and was associated with better overall survival. Patients with advanced EC were more likely to receive multimodal therapy. Patients with intermediate risk EC had a good prognosis upon surgery, which further improved when radiotherapy was added. High-risk patients showed poorer prognosis but clearly benefited from additional radiotherapy. Survival of elderly high-risk patients with a non-endometrioid histology was improved when chemotherapy was added to surgery and radiotherapy.
    Conclusion: Our study includes a large analysis of data from German clinical cancer registries on the care of endometrial cancer during two decades. We observed an increase of minimal invasive surgery. There is evidence that minimal invasive surgery is not inferior to open surgery. Adjuvant radio- and chemotherapy further improves survival depending on risk group and age.
    MeSH term(s) Humans ; Female ; Endometrial Neoplasms/therapy ; Endometrial Neoplasms/epidemiology ; Endometrial Neoplasms/pathology ; Endometrial Neoplasms/mortality ; Retrospective Studies ; Germany/epidemiology ; Aged ; Middle Aged ; Registries ; Aged, 80 and over ; Combined Modality Therapy ; Adult ; Prognosis ; Survival Rate
    Language English
    Publishing date 2024-05-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-024-05772-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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