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  1. Article ; Online: Reply.

    Paquette, Ian M

    Diseases of the colon and rectum

    2022  Volume 65, Issue 6, Page(s) e663

    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000002465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply.

    Paquette, Ian M

    Diseases of the colon and rectum

    2022  Volume 65, Issue 9, Page(s) e918

    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000002508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adding Versus Omitting: When New Clinical Information Appears After Updating Clinical Practice Guidelines.

    Paquette, Ian M

    Diseases of the colon and rectum

    2022  Volume 65, Issue 4, Page(s) 464–465

    MeSH term(s) Digestive System Surgical Procedures ; Evidence-Based Medicine/standards ; Humans ; Neoadjuvant Therapy ; Rectal Neoplasms ; Rectum
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000002399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply.

    Paquette, Ian M

    Diseases of the colon and rectum

    2022  Volume 66, Issue 4, Page(s) e175

    Language English
    Publishing date 2022-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000002699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Transition to Surgical Practice: The Early Years.

    Paquette, Ian M

    Clinics in colon and rectal surgery

    2019  Volume 32, Issue 6, Page(s) 457–460

    Abstract: The transition from years of surgical training to independent surgical practice is a time to enjoy the well-earned achievement of completion of training. The early years of clinical practice bring about many challenges to the young surgeon. These include ...

    Abstract The transition from years of surgical training to independent surgical practice is a time to enjoy the well-earned achievement of completion of training. The early years of clinical practice bring about many challenges to the young surgeon. These include transitioning to a more independent role in the operating room, running an office and understanding the business aspects of medicine, building clinical networks to sustain a clinical practice, and building a professional and academic reputation. This article will discuss aspects that are unique to the early career surgeon. Where possible, I will use the available literature to augment the discussion, whereas, in other areas, I will offer my thoughts from personal experience on the topic.
    Language English
    Publishing date 2019-08-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2048635-2
    ISSN 1531-0043
    ISSN 1531-0043
    DOI 10.1055/s-0039-1693420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Expert Commentary on the Prevention and Management of Colostomy Complications: Retraction and Stenosis.

    Paquette, Ian M

    Diseases of the colon and rectum

    2018  Volume 61, Issue 12, Page(s) 1348–1349

    MeSH term(s) Anal Canal ; Colostomy ; Constriction, Pathologic ; Humans ; Rectum
    Language English
    Publishing date 2018-12-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000001247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Systematic Review of Neoadjuvant Immunotherapy for Mismatch Repair Deficient Locally Advanced Colon Cancer: An Emerging Strategy.

    Loria, Anthony / Ammann, Allison M / Olowokure, Olugbenga O / Paquette, Ian M / Justiniano, Carla F

    Diseases of the colon and rectum

    2024  

    Abstract: Background: In April 2023, the National Comprehensive Cancer Network endorsed neoadjuvant immunotherapy for select patients with non-metastatic mismatch repair deficient colon cancer. Approximately 15% of incident colon cancers are mismatch repair ... ...

    Abstract Background: In April 2023, the National Comprehensive Cancer Network endorsed neoadjuvant immunotherapy for select patients with non-metastatic mismatch repair deficient colon cancer. Approximately 15% of incident colon cancers are mismatch repair deficient, resulting in a distinct molecular subtype with high microsatellite instability that is responsive to immune checkpoint inhibition.
    Objective: To describe the existing evidence supporting neoadjuvant immunotherapy for mismatch repair deficient, microsatellite unstable non-metastatic colon cancer.
    Data sources: A medical librarian performed PubMed, Embase, and Web of Science searches most recently on April 24, 2023. The PubMed search was re-run on September 26, 2023, to identify any additional studies published during the interim from April to September 2023.
    Study selection: Two authors screened titles and abstracts in the published studies. The inclusion criteria were (1) English-language; (2) adults with primary cancer of the colon; (3) non-metastatic disease; (4) neoadjuvant immunotherapy; (5) reporting on 10 or more cases.
    Intervention: Neoadjuvant immunotherapy.
    Main outcome measures: Safety (Grade 3+ treatment related adverse events) and efficacy (complete pathologic responses).
    Results: From 7,691 studies identified, 6,370 were screened, and 8 included. Various agents, dosing regimens, and treatment durations were employed, with durations of immunotherapy ranging from 1-16 cycles. Complete R0 resections were consistently achieved in 98%-100% of resections. Of patients who received neoadjuvant immunotherapy and underwent resection, 50%-91% had ypT0N0 pathology. The safety profiles were generally favorable, with Grade 1-2 treatment-related adverse events (mostly immune-related) during immunotherapy reported in 22.2%-70% of patients. Postoperative complications following neoadjuvant immunotherapy were reassuring, with no severe complications reported.
    Limitations: Small number of heterogeneous and uncontrolled studies precluding a meta-analysis.
    Conclusions: Neoadjuvant immune checkpoint inhibition is associated with high rates of pathologic complete responses in locally advanced colon cancer. The literature is limited, particularly for postoperative outcomes, and more studies are needed to understand the safety and positioning of these regimens in the neoadjuvant context.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000003263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Transition to Surgical Practice: The Early Years

    Paquette, Ian M.

    Clinics in Colon and Rectal Surgery

    (Surgeon Health)

    2019  Volume 32, Issue 06, Page(s) 457–460

    Abstract: The transition from years of surgical training to independent surgical practice is a time to enjoy the well-earned achievement of completion of training. The early years of clinical practice bring about many challenges to the young surgeon. These include ...

    Series title Surgeon Health
    Abstract The transition from years of surgical training to independent surgical practice is a time to enjoy the well-earned achievement of completion of training. The early years of clinical practice bring about many challenges to the young surgeon. These include transitioning to a more independent role in the operating room, running an office and understanding the business aspects of medicine, building clinical networks to sustain a clinical practice, and building a professional and academic reputation. This article will discuss aspects that are unique to the early career surgeon. Where possible, I will use the available literature to augment the discussion, whereas, in other areas, I will offer my thoughts from personal experience on the topic.
    Keywords early career ; transition ; surgical practice
    Language English
    Publishing date 2019-08-22
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2048635-2
    ISSN 1530-9681 ; 1531-0043
    ISSN (online) 1530-9681
    ISSN 1531-0043
    DOI 10.1055/s-0039-1693420
    Database Thieme publisher's database

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  9. Article ; Online: Conditional Survival: Changing the Frame of Reference in Anal Cancer Follow-up.

    Paquette, Ian M

    Diseases of the colon and rectum

    2016  Volume 59, Issue 4, Page(s) 251–252

    MeSH term(s) African Americans/statistics & numerical data ; Anus Neoplasms/mortality ; Carcinoma, Squamous Cell/mortality ; European Continental Ancestry Group/statistics & numerical data ; Female ; Humans ; Male
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000000556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Surveillance, Epidemiology, and End Results (SEER) and SEER-Medicare Databases: Use in Clinical Research for Improving Colorectal Cancer Outcomes.

    Daly, Meghan C / Paquette, Ian M

    Clinics in colon and rectal surgery

    2019  Volume 32, Issue 1, Page(s) 61–68

    Abstract: The Surveillance, Epidemiology, and End Results (SEER) program is a clinical database, funded by the National Cancer Institute (NCI), which was created to collect cancer incidence, prevalence, and survival data from U.S. cancer registries. By capturing ... ...

    Abstract The Surveillance, Epidemiology, and End Results (SEER) program is a clinical database, funded by the National Cancer Institute (NCI), which was created to collect cancer incidence, prevalence, and survival data from U.S. cancer registries. By capturing approximately 30% of the U.S. population, it serves as a powerful resource for researchers focused on understanding the natural history of colorectal cancer and improvement in patient care. The linked SEER-Medicare database is a robust database allowing investigators to perform studies focusing on health disparities, quality of care, and cost of treatment in oncologic disease. Since its infancy in the early 1970s, the database has been utilized for thousands of studies resulting in novel publications that have shaped our management of colorectal cancer among other malignancies.
    Language English
    Publishing date 2019-01-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2048635-2
    ISSN 1531-0043
    ISSN 1531-0043
    DOI 10.1055/s-0038-1673355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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