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  1. Article ; Online: History of Thyroid Surgery in the Last Century.

    Orloff, Lisa A / Parangi, Sareh

    Thyroid : official journal of the American Thyroid Association

    2023  Volume 33, Issue 9, Page(s) 1029–1038

    Abstract: Before the 20th century, thyroid surgery was regarded as "horrid butchery" such that no honest and sensible surgeon would ever engage in it. Yet, by the mid-20th century, thyroidectomy had become a respected, life-saving, safe, and increasingly practiced ...

    Abstract Before the 20th century, thyroid surgery was regarded as "horrid butchery" such that no honest and sensible surgeon would ever engage in it. Yet, by the mid-20th century, thyroidectomy had become a respected, life-saving, safe, and increasingly practiced operation. From Kocher to Wells and onward into the 21st century, the evolution of thyroid surgery has continued, enhanced by the integration of endocrinology, genetics, immunology, physiology, technology, training, and multidisciplinary care. The ability to personalize and optimize the care of thyroid disorders has been progressively achieved through shared insights and discoveries, highlights of which are described herein.
    MeSH term(s) Humans ; Thyroid Gland/surgery ; Thyroidectomy ; Endocrinology ; Surgeons
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1086044-7
    ISSN 1557-9077 ; 1050-7256
    ISSN (online) 1557-9077
    ISSN 1050-7256
    DOI 10.1089/thy.2022.0629
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  2. Article ; Online: Editorial: Translaryngeal vocal cord ultrasound: Ready for prime time.

    Parangi, Sareh

    Surgery

    2016  Volume 159, Issue 1, Page(s) 67–69

    MeSH term(s) Female ; Humans ; Laryngoscopy ; Larynx/diagnostic imaging ; Male ; Thyroidectomy/adverse effects ; Ultrasonography ; Vocal Cord Paralysis/diagnostic imaging ; Vocal Cord Paralysis/prevention & control ; Vocal Cords/diagnostic imaging
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2015.10.014
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  3. Article ; Online: This Barbie is a surgeon.

    Griggs, Cornelia / McKinley, Sophia / Rangel, Erika / Parangi, Sareh

    BMJ (Clinical research ed.)

    2023  Volume 383, Page(s) 2781

    MeSH term(s) Humans ; Body Image ; Surgeons
    Language English
    Publishing date 2023-12-18
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p2781
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  4. Article ; Online: A Call for Multidisciplinary Consensus Guidelines for the Management of Tertiary Hyperparathyroidism.

    Parangi, Sareh / Gartland, Rajshri M

    Annals of surgery

    2020  Volume 273, Issue 3, Page(s) e123

    MeSH term(s) Consensus ; Humans ; Hyperparathyroidism/therapy ; Parathyroidectomy
    Language English
    Publishing date 2020-12-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000004694
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  5. Article ; Online: Single-cell analysis reveals context-dependent, cell-level selection of mtDNA.

    Kotrys, Anna V / Durham, Timothy J / Guo, Xiaoyan A / Vantaku, Venkata R / Parangi, Sareh / Mootha, Vamsi K

    Nature

    2024  Volume 629, Issue 8011, Page(s) 458–466

    Abstract: Heteroplasmy occurs when wild-type and mutant mitochondrial DNA (mtDNA) molecules co-exist in single ... ...

    Abstract Heteroplasmy occurs when wild-type and mutant mitochondrial DNA (mtDNA) molecules co-exist in single cells
    MeSH term(s) Animals ; Female ; Humans ; Mice ; Cell Division/genetics ; Cell Line ; Cell Lineage/genetics ; DNA, Mitochondrial/genetics ; Gene Editing ; Genetic Fitness ; Heteroplasmy/genetics ; Mitochondria/genetics ; Mutation ; Selection, Genetic ; Single-Cell Analysis/methods
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07332-0
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  6. Article ; Online: Deciphering albumin-directed drug delivery by imaging.

    Hu, Huiyu / Quintana, Jeremy / Weissleder, Ralph / Parangi, Sareh / Miller, Miles

    Advanced drug delivery reviews

    2022  Volume 185, Page(s) 114237

    Abstract: Albumin is the most abundant plasma protein, exhibits extended circulating half-life, and its properties have long been exploited for diagnostics and therapies. Many drugs intrinsically bind albumin or have been designed to do so, yet questions remain ... ...

    Abstract Albumin is the most abundant plasma protein, exhibits extended circulating half-life, and its properties have long been exploited for diagnostics and therapies. Many drugs intrinsically bind albumin or have been designed to do so, yet questions remain about true rate limiting factors that govern albumin-based transport and their pharmacological impacts, particularly in advanced solid cancers. Imaging techniques have been central to quantifying - at a molecular and single-cell level - the impact of mechanisms such as phagocytic immune cell signaling, FcRn-mediated recycling, oncogene-driven macropinocytosis, and albumin-drug interactions on spatial albumin deposition and related pharmacology. Macroscopic imaging of albumin-binding probes quantifies vessel structure, permeability, and supports efficiently targeted molecular imaging. Albumin-based imaging in patients and animal disease models thus offers a strategy to understand mechanisms, guide drug development and personalize treatments.
    MeSH term(s) Albumins ; Animals ; Drug Delivery Systems ; Humans ; Molecular Imaging ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy
    Chemical Substances Albumins
    Language English
    Publishing date 2022-03-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2022.114237
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    Zs.A 2241: Show issues Location:
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  7. Article ; Online: h-Index and Academic Rank by Gender Among Breast Surgery Fellowship Faculty.

    Radford, Diane M / Parangi, Sareh / Tu, Chao / Silver, Julie K

    Journal of women's health (2002)

    2021  Volume 31, Issue 1, Page(s) 110–116

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Breast Neoplasms/surgery ; Cross-Sectional Studies ; Faculty, Medical ; Fellowships and Scholarships ; Female ; Humans ; Male ; Retrospective Studies ; United States
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1139774-3
    ISSN 1931-843X ; 1059-7115 ; 1540-9996
    ISSN (online) 1931-843X
    ISSN 1059-7115 ; 1540-9996
    DOI 10.1089/jwh.2020.8579
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    Zs.A 3584: Show issues Location:
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  8. Article ; Online: Implementation of a New Surgeon Onboarding Program in an Academic-affiliated Community Hospital.

    Etheridge, James C / Goldstone, Robert N / Harrington, Bryanne / Calcaterra, Michael J / Tomczyk, Eleanor G / Parangi, Sareh / Haas, Susan

    Annals of surgery

    2023  Volume 278, Issue 6, Page(s) e1156–e1158

    Abstract: Best practices in onboarding are well-established, but surgeons frequently receive suboptimal introductions to new practice settings. At the same time, increasing regionalization of surgical programs and strategic alignments between academic and ... ...

    Abstract Best practices in onboarding are well-established, but surgeons frequently receive suboptimal introductions to new practice settings. At the same time, increasing regionalization of surgical programs and strategic alignments between academic and community hospitals have increased the demand for surgeons to practice at multiple sites with variable resources and institutional cultures. In response to this growing problem, we developed and implemented a surgeon onboarding program in an academic-affiliated community hospital. This pilot demonstrated excellent process adherence, user satisfaction, and significant improvements in preparedness to practice. We therefore conclude that robust onboarding is feasible and can be readily implemented by a local team to promote safe transitions in practice settings for surgeons.
    MeSH term(s) Humans ; Hospitals, Community ; Surgeons
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006034
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  9. Article ; Online: Do Resident Coaching Programs Benefit their Coaches? Impact of a Professional Development Coaching Program on The Coaches.

    Merrill, Andrea L / Stein, Sharon L / Chu, Jacqueline T / Sarode, Anuja L / McKinley, Sophia K / Parangi, Sareh / Donelan, Karen / Palamara, Kerri

    World journal of surgery

    2023  Volume 47, Issue 7, Page(s) 1609–1616

    Abstract: Background: Coaching has been shown to decrease physician burnout; however, coachee outcomes have been the focus. We report the impact of coaching on women-identifying surgeons who participated as coaches in a 9-month virtual program.: Methods: A ... ...

    Abstract Background: Coaching has been shown to decrease physician burnout; however, coachee outcomes have been the focus. We report the impact of coaching on women-identifying surgeons who participated as coaches in a 9-month virtual program.
    Methods: A coaching program was implemented in the Association of Women Surgeons (AWS) to determine the effects of coaching on well-being and burnout from 2018 to 2020. AWS members volunteered and completed training in professional development coaching. Pre- and post-study measures were assessed, and bivariate analysis performed based on burnout and professional fulfillment score.
    Results: Seventy-five coaches participated; 57 completed both pre- and post-study surveys. There were no significant changes in burnout or professional fulfillment including the Positive Emotion, Engagement, Relationship, Meaning, and Accomplishment scale, hardiness, self-valuation, coping, gratitude, or intolerance of uncertainty scores from baseline to post-survey. On bivariate analysis, hardiness was associated with lower burnout throughout the duration of the program. Coaches with lower burnout at the end of the program met with their coachee more frequently than coaches with higher burnout [mean (SD) 3.95(2.16) versus 2.35(2.13) p = 0.0099].
    Discussion: Burnout and professional fulfillment demonstrated no change in women surgeons who participated as professional development coaches. Those with lower burnout and higher professional fulfillment at the end of the program were found to have higher hardiness, which may be worth future investigation.
    Conclusions: Acquisition of coaching skills did not directly improve well-being in faculty who participated in a resident coaching program. Future studies would benefit from control groups and exploration of qualitative benefits of coaching.
    MeSH term(s) Humans ; Female ; Mentoring ; Surgeons/education ; Surveys and Questionnaires ; Burnout, Professional/prevention & control ; Personal Satisfaction
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-023-06957-y
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  10. Article ; Online: Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids.

    Jung, Youngsook Lucy / Zhao, Wenping / Li, Ian / Jain, Dhawal / Epstein, Charles B / Bernstein, Bradley E / Parangi, Sareh / Sherwood, Richard / Robinson-Cohen, Cassianne / Hsu, Yi-Hsiang / Park, Peter J / Mannstadt, Michael

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2106

    Abstract: In all terrestrial vertebrates, the parathyroid glands are critical regulators of calcium homeostasis and the sole source of parathyroid hormone (PTH). Hyperparathyroidism and hypoparathyroidism are clinically important disorders affecting multiple ... ...

    Abstract In all terrestrial vertebrates, the parathyroid glands are critical regulators of calcium homeostasis and the sole source of parathyroid hormone (PTH). Hyperparathyroidism and hypoparathyroidism are clinically important disorders affecting multiple organs. However, our knowledge regarding regulatory mechanisms governing the parathyroids has remained limited. Here, we present the comprehensive maps of the chromatin landscape of the human parathyroid glands, identifying active regulatory elements and chromatin interactions. These data allow us to define regulatory circuits and previously unidentified genes that play crucial roles in parathyroid biology. We experimentally validate candidate parathyroid-specific enhancers and demonstrate their integration with GWAS SNPs for parathyroid-related diseases and traits. For instance, we observe reduced activity of a parathyroid-specific enhancer of the Calcium Sensing Receptor gene, which contains a risk allele associated with higher PTH levels compared to the wildtype allele. Our datasets provide a valuable resource for unraveling the mechanisms governing parathyroid gland regulation in health and disease.
    MeSH term(s) Animals ; Humans ; Calcium/metabolism ; Parathyroid Glands/metabolism ; Parathyroid Hormone/genetics ; Parathyroid Hormone/metabolism ; Chromatin/genetics ; Epigenesis, Genetic
    Chemical Substances Calcium (SY7Q814VUP) ; Parathyroid Hormone ; Chromatin
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46181-3
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