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  1. Article ; Online: Curvas ROC: características generales y su uso en la práctica clínica.

    Roy-García, Ivonne Analí / Paredes-Manjarrez, Carlos / Moreno-Palacios, Jorge / Rivas-Ruiz, Rodolfo / Flores-Pulido, Andrey Arturo

    Revista medica del Instituto Mexicano del Seguro Social

    2023  Volume 61, Issue Suppl 3, Page(s) S497–S502

    Abstract: The use of diagnostic tests to determine the presence or absence of a disease is essential in clinical practice. The results of a diagnostic test may correspond to numerical estimates that require quantitative reference parameters to be transferred to a ... ...

    Title translation ROC curves: general characteristics and their usefulness in clinical practice.
    Abstract The use of diagnostic tests to determine the presence or absence of a disease is essential in clinical practice. The results of a diagnostic test may correspond to numerical estimates that require quantitative reference parameters to be transferred to a dichotomous interpretation as normal or abnormal and thus implement actions for the care of a condition or disease. For example, in the diagnosis of anemia it is necessary to define a cut-off point for the hemoglobin variable and create two categories that distinguish the presence or absence of anemia. The method used for this process is the preparation of diagnostic performance curves, better known by their acronym in English as ROC (Receiver Operating Characteristic). The ROC curve is also useful as a prognostic marker, since it allows defining the cut-off point of a quantitative variable that is associated with greater mortality or risk of complications. They have been used in different prognostic markers in COVID-19, such as the neutrophil/lymphocyte ratio and D-dimer, in which cut-off points associated with mortality and/or risk of mechanical ventilation were identified. The ROC curve is used to evaluate the diagnostic performance of a test in isolation, but it can also be used to compare the performance of two or more diagnostic tests and define which one is more accurate. This article describes the basic concepts for the use and interpretation of the ROC curve, the interpretation of an area under the curve (AUC) and the comparison of two or more diagnostic tests.
    MeSH term(s) Humans ; ROC Curve ; Lymphocytes ; Anemia
    Language Spanish
    Publishing date 2023-10-02
    Publishing country Mexico
    Document type English Abstract ; Journal Article
    ZDB-ID 732133-8
    ISSN 2448-5667 ; 0443-5117 ; 0484-7849
    ISSN (online) 2448-5667
    ISSN 0443-5117 ; 0484-7849
    DOI 10.5281/zenodo.8319791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Lung Ultrasound Elastography by SWE2D and "Fibrosis-like" Computed Tomography Signs after COVID-19 Pneumonia: A Follow-Up Study.

    Paredes-Manjarrez, Carlos / Avelar-Garnica, Francisco J / Balderas-Chairéz, Andres Tlacaelel / Arellano-Sotelo, Jorge / Córdova-Ramírez, Ricardo / Espinosa-Poblano, Eliseo / González-Ruíz, Alejandro / Anda-Garay, Juan Carlos / Miguel-Puga, José Adan / Jáuregui-Renaud, Kathrine

    Journal of clinical medicine

    2023  Volume 12, Issue 24

    Abstract: The aim of this study was to assess the shear wave velocity by LUS elastography (SWE2D) for the evaluation of superficial lung stiffness after COVID-19 pneumonia, according to "fibrosis-like" signs found by Computed Tomography (CT), considering the ... ...

    Abstract The aim of this study was to assess the shear wave velocity by LUS elastography (SWE2D) for the evaluation of superficial lung stiffness after COVID-19 pneumonia, according to "fibrosis-like" signs found by Computed Tomography (CT), considering the respiratory function. Seventy-nine adults participated in the study 42 to 353 days from symptom onset. Paired evaluations (SWE2D and CT) were performed along with the assessment of arterial blood gases and spirometry, three times with 100 days in between. During the follow-up and within each evaluation, the SWE2D velocity changed over time (MANOVA,
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12247515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Respuesta a "Comentario al artículo: “Correlación entre ultrasonografía y radiografía portátil de tórax en pacientes con COVID-19”".

    Avelar-Garnica, Francisco José / Reyes-Olhagaray, Fernando Bernardo / Paredes-Manjarrez, Carlos / Arellano-Sotelo, Jorge / Luis-Jarquín, Viridiana Monserrat / Miguel-Puga, José Adán / Jáuregui-Renaud, Kathrine

    Revista medica del Instituto Mexicano del Seguro Social

    2023  Volume 61, Issue 6, Page(s) 720

    Abstract: Science, through scientific research, is an activity that generates new ideas. However, for the construction of new knowledge it is necessary to confront ideas with peers in the scientific world; which is exercised through scientific communication. ...

    Title translation Answer to "Comment on article: "Correlation between ultrasonography and thorax portable radiography in patients with COVID-19"".
    Abstract Science, through scientific research, is an activity that generates new ideas. However, for the construction of new knowledge it is necessary to confront ideas with peers in the scientific world; which is exercised through scientific communication.
    MeSH term(s) Humans ; COVID-19 ; Thorax/diagnostic imaging ; Radiography ; Ultrasonography
    Language Spanish
    Publishing date 2023-11-06
    Publishing country Mexico
    Document type English Abstract ; Journal Article ; Letter
    ZDB-ID 732133-8
    ISSN 2448-5667 ; 0443-5117 ; 0484-7849
    ISSN (online) 2448-5667
    ISSN 0443-5117 ; 0484-7849
    DOI 10.5281/zenodo.10064262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Shear-wave elastography as a tool in the assessment of thyroid nodules.

    Paredes-Manjarrez, Carlos / Arreola-Cháidez, Demetrio / Magdalena-Buitrago, Andrés / Ferreira-Hermosillo, Aldo / Avelar-Garnica, José F / Arreola-Rosales, Rocío

    Gaceta medica de Mexico

    2021  Volume 157, Issue 1, Page(s) 18–23

    Abstract: Introduction: Shear-wave elastography (SWE) has been shown to be predictive of malignancy in thyroid nodules.: Objective: To determine, by SWE, the stiffness cutoff point with the highest specificity and sensitivity to detect thyroid nodules that ... ...

    Title translation Elastografía por ondas de corte como herramienta en la evaluación de los nódulos tiroideos.
    Abstract Introduction: Shear-wave elastography (SWE) has been shown to be predictive of malignancy in thyroid nodules.
    Objective: To determine, by SWE, the stiffness cutoff point with the highest specificity and sensitivity to detect thyroid nodules that require surgery.
    Methods: Cross-sectional study of ultrasonographically-evaluated patients for thyroid nodules over a period of three years; the TI-RADS classification system was used, and nodule stiffness was determined by SWE. Histopathological specimens were classified using the Bethesda system, and the stiffness cutoff point with the highest specificity and sensitivity was obtained using ROC curves.
    Results: Forty-one percent of the nodules were classified as TI-RADS 5, and 59 %, as TI-RADS 1-4. In TI-RADS 5 nodules, median stiffness of those in Bethesda system IV-VI categories was 35.9 kPa; in nodules with TI-RADS 1-4, 21.6 kPa. In TI-RADS 5 nodules, a cutoff point > 32.5 kPa had a specificity of 75 % and sensitivity of 57 % to detect those requiring surgery; in TI-RADS 1 to 4 nodules, a cutoff point of 21.5 kPa had a specificity of 63 % and sensitivity of 51 %.
    Conclusion: SWE-determined stiffness is useful to detect nodules that require surgical evaluation.
    MeSH term(s) Aged ; Biopsy, Fine-Needle/methods ; Cross-Sectional Studies ; Elasticity Imaging Techniques/methods ; Female ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/pathology ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology
    Language English
    Publishing date 2021-07-07
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 425456-9
    ISSN 0016-3813
    ISSN 0016-3813
    DOI 10.24875/GMM.M21000531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correlación entre ultrasonografía y radiografía portátil de tórax en pacientes con COVID-19.

    Avelar-Garnica, Francisco José / Reyes-Olhagaray, Fernando Bernardo / Paredes-Manjarrez, Carlos / Arellano-Sotelo, Jorge / Luis-Jarquín, Viridiana Monserrat / Miguel-Puga, José Adán / Jáuregui-Renaud, Kathrine

    Revista medica del Instituto Mexicano del Seguro Social

    2022  Volume 60, Issue 1, Page(s) 44–51

    Abstract: Background: During the COVID-19 pandemic, portable chest radiography (portable CRx) and lung ultrasonography (LUS) have been widely used to follow up hospitalized patients. Yet, it is scarce the information about the relation between the signs observed ... ...

    Title translation Correlation between ultrasonography and thorax portable radiography in patients with COVID-19.
    Abstract Background: During the COVID-19 pandemic, portable chest radiography (portable CRx) and lung ultrasonography (LUS) have been widely used to follow up hospitalized patients. Yet, it is scarce the information about the relation between the signs observed by means of each method in patients with COVID-19.
    Objective: To assess the correlation between concurrent images acquired by LUS and portable CRx during the follow-up of hospitalized patients with COVID-19.
    Material and methods: We performed 113 LUS and 113 corresponding CRx during the follow-up of 44 patients (30 men/14 women, 30-85 years old) with COVID-19 (RT-qPCR). Images were stored in a picture communication system and were revised by two specialists of each imaging method independently. Statistical analysis was performed using Gamma correlation and t test (significance level of 0.05).
    Results: The most frequent LUS sign was confluent B lines, and it was related to the most frequent portable CRx signs (ground-glass opacities and consolidations). An inverse relationship was observed between A lines (gas in the lungs) and B7 lines (suggestive of interstitial edema). Confluent B lines also showed a strong inverse correlation with A lines (more frequent confluent B lines were related to low frequent A lines), a moderate inverse correlation with B7 lines, and a mild inverse correlation with B3 lines.
    Conclusion: During the follow-up of hospitalized patients with COVID-19, LUS and portable CRx may complement each other to provide information about lung damage.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnostic imaging ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Radiography ; SARS-CoV-2 ; Thorax ; Ultrasonography
    Language Spanish
    Publishing date 2022-02-01
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 732133-8
    ISSN 2448-5667 ; 0443-5117 ; 0484-7849
    ISSN (online) 2448-5667
    ISSN 0443-5117 ; 0484-7849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Risk factors associated with thyroid nodular disease in acromegalic patients: A case-cohort study in a tertiary center.

    Vargas-Ortega, Guadalupe / Romero-Gameros, Carlos Alfonso / Rendón-Macias, Mario Enrique / Balcázar-Hernández, Lourdes / Sosa-Eroza, Ernesto / Mercado, Moises / de Los Monteros-Sánchez, Ana L Espinosa / Pérez-Aguilar, Barbara / Paredes-Manjarrez, Carlos / Reyes-Olhagaray, Fernando Bernardo / Serrano-Ramírez, Diana Laura / la Cruz, Erick Vladimir Martínez-De / González-Virla, Baldomero

    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

    2021  Volume 60-61, Page(s) 101431

    Abstract: Introduction: Goiter is very common in patients with acromegaly; its development is correlated to the duration of the disease. Thyroid cells express the IGF-1 receptor and the TSH/IGF-1 interaction has been demonstrated to have a synergistic effect in ... ...

    Abstract Introduction: Goiter is very common in patients with acromegaly; its development is correlated to the duration of the disease. Thyroid cells express the IGF-1 receptor and the TSH/IGF-1 interaction has been demonstrated to have a synergistic effect in thyroid cell growth. There is a correlation between IGF-1 levels and the thyroid volume of patients with acromegaly. The aim of this study was to evaluate, in a retrospective case-cohort study of patients with acromegaly, the associated risk factors for thyroid nodules disease in this population.
    Methods: This was a case-cohort study matched by age, gender, and growth hormone at diagnosis. Cases consisted of acromegalic patients that developed thyroid nodules during the follow up, and controls consisted in acromegalic patients without thyroid nodules. A Cox proportional hazard estimation was carried out for measure the associated risk factors for thyroid nodules disease in acromegalic patients. A nodular thyroid disease-free survival analysis was estimated using the Kaplan-Meier analysis.
    Results: We recruited 49 cases and 56 controls. In a multivariate Cox proportional hazard analysis age and IGF-1 ≥ 2.2 x ULN were significantly related with the presence of thyroid nodules [HR of 2.21 (95% CI; 1.15-4.25, p = 0.01)]. Nodularity-free survival rates in patients who had an IGF-1 X ULN ≥ 2.2 was found to be lower in comparison to those who had IGF-1 X ULN < 2.2, according to a Kaplan-Meier survival analysis.
    Conclusions: Our findings support that exist more probability to develop thyroid nodular disease in patients with acromegaly that present IGF-1 X ULN ≥ 2.2, suggesting a possible direct effect between the time of exposure to the IGF-1 axis hyperactivity and the genesis of thyroid nodules.
    MeSH term(s) Acromegaly/complications ; Biomarkers/blood ; Case-Control Studies ; Female ; Follow-Up Studies ; Humans ; Insulin-Like Growth Factor I/analysis ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate ; Tertiary Care Centers/statistics & numerical data ; Thyroid Nodule/etiology ; Thyroid Nodule/metabolism ; Thyroid Nodule/pathology
    Chemical Substances Biomarkers ; IGF1 protein, human ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2021-10-12
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1436781-6
    ISSN 1532-2238 ; 1096-6374
    ISSN (online) 1532-2238
    ISSN 1096-6374
    DOI 10.1016/j.ghir.2021.101431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Elastography in the evaluation of thyroid nodules

    Paredes-Manjarrez, Carlos / Magdalena-Buitrago, Andrés / Meza-Hernández, Gamaliel / Camacho-Zarco, Eduardo / Avelar-Garnica, Francisco José / Tanus-Hajj, Janet / Guerrero-Rivera, Susana

    Revista medica del Instituto Mexicano del Seguro Social

    2018  Volume 55, Issue Suppl 4, Page(s) S402–S407

    Title translation Elastografía en la evaluación de nódulos tiroideos
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Elasticity Imaging Techniques ; Female ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology
    Language Spanish
    Publishing date 2018-05-30
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 732133-8
    ISSN 2448-5667 ; 0443-5117 ; 0484-7849
    ISSN (online) 2448-5667
    ISSN 0443-5117 ; 0484-7849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Double-task exercise programmes to strengthen cognitive and vascular health in older adults at risk of cognitive decline: protocol for a randomised clinical trial.

    Sánchez-Arenas, Rosalinda / Doubova, Svetlana V / Bernabe-Garcia, Mariela / Gregory, Michel A / Mejía-Alonso, Laura Alejandra / Orihuela-Rodríguez, Oscar / Paredes-Manjarrez, Carlos / Colín-Martínez, Tania / Mujica-Morales, Irene / Grijalva-Otero, Israel / Basurto-Acevedo, Lourdes / Manuel-Apolinar, Leticia / Cuadros-Moreno, Juan / Bernal-Diaz, Arcelia / Shigematsu, Ryosuke

    BMJ open

    2020  Volume 10, Issue 12, Page(s) e039723

    Abstract: Introduction: Cognitive and physical declines are frequent causes of disability among older adults (OAs) in Mexico that imposes significant burden on the health system and OAs' families. Programmes to prevent or delay OAs' cognitive and physical decline ...

    Abstract Introduction: Cognitive and physical declines are frequent causes of disability among older adults (OAs) in Mexico that imposes significant burden on the health system and OAs' families. Programmes to prevent or delay OAs' cognitive and physical decline are scarce.
    Methods and analysis: A double-blind randomised clinical trial will be conducted. The study will aim to evaluate two 24-week double-task (aerobic and cognitive) square-stepping exercise programmes for OAs at risk of cognitive decline-one programme with and another without caregiver participation-and to compare these with an aerobic-balance-stretching exercise programme (control group). 300 OAs (100 per group) affiliated with the Mexican Institute of Social Security (IMSS) between 60 and 65 years of age with self-reported cognitive concerns will participate. They will be stratified by education level and randomly allocated to the groups. The intervention will last 24 weeks, and the effect of each programme will be evaluated 12, 24 and 52 weeks after the intervention. Participants' demographic and clinical characteristics will be collected at baseline. The outcomes will include: (1) general cognitive function; (2) specific cognitive functions; (3) dual-task gait; (4) blood pressure; (5) carotid intima-media thickness; (6) OAs' health-related quality of life; and (7) caregiver burden. The effects of the interventions on each outcome variable will be examined using a repeated-measures analysis of variance (ANOVA), with study groups as the between-subjects variable and time as the within-subject variable.
    Ethics and dissemination: The study was approved by the IMSS Ethics and Research Committees (registration number: 2018-785-095). All participants will sign a consent form prior to their participation. The study results will be disseminated to the IMSS authorities, healthcare providers and the research community.
    Trial registration number: ClinicalTrials.gov (NCT04068376).
    MeSH term(s) Aged ; Carotid Intima-Media Thickness ; Cognition ; Cognitive Dysfunction/prevention & control ; Double-Blind Method ; Exercise ; Exercise Therapy ; Humans ; Mexico ; Quality of Life
    Language English
    Publishing date 2020-12-30
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-039723
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