Article ; Online: Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein.
The Journal of infectious diseases
2018 Volume 219, Issue 3, Page(s) 415–419
Abstract: Ebola virus infection causes severe disease in humans and represents a global health threat. Candidates for immunotherapeutics and vaccines have shown promise in clinical trials, although they are ineffective against other members of the Ebolavirus genus ...
Abstract | Ebola virus infection causes severe disease in humans and represents a global health threat. Candidates for immunotherapeutics and vaccines have shown promise in clinical trials, although they are ineffective against other members of the Ebolavirus genus that also cause periodic, lethal outbreaks. In this study, we present a crystal structure of a pan-ebolavirus antibody, 6D6, as well as single-particle electron microscopy reconstructions of 6D6 in complex with Ebola and Bundibugyo virus glycoproteins. 6D6 binds to the conserved glycoprotein fusion peptide, implicating it as a site of immune vulnerability that could be exploited to reliably elicit a pan-ebolavirus neutralizing antibody response. |
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MeSH term(s) | Antibodies, Neutralizing/immunology ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Cross Reactions/immunology ; Ebolavirus/immunology ; Glycoproteins/chemistry ; Glycoproteins/immunology ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/virology ; Immunotherapy, Active ; Membrane Glycoproteins/immunology ; Models, Molecular ; Peptides ; Viral Fusion Proteins/chemistry ; Viral Fusion Proteins/immunology |
Chemical Substances | Antibodies, Neutralizing ; Antibodies, Viral ; Glycoproteins ; Membrane Glycoproteins ; Peptides ; Viral Fusion Proteins |
Language | English |
Publishing date | 2018-09-03 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. |
ZDB-ID | 3019-3 |
ISSN | 1537-6613 ; 0022-1899 |
ISSN (online) | 1537-6613 |
ISSN | 0022-1899 |
DOI | 10.1093/infdis/jiy532 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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