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  1. Book ; Online: Machine Learning and Its Application to Reacting Flows

    Swaminathan, Nedunchezhian / Parente, Alessandro

    ML and Combustion

    (Lecture Notes in Energy ; 44)

    2023  

    Author's details edited by Nedunchezhian Swaminathan, Alessandro Parente
    Series title Lecture Notes in Energy ; 44
    Keywords Cogeneration of electric power and heat ; Fossil fuels ; Thermodynamics ; Heat engineering ; Heat transfer ; Mass transfer ; Machine learning
    Subject code 621.312132
    Language English
    Size 1 Online-Ressource (XI, 346 p. 127 illus., 98 illus. in color)
    Edition 1st ed. 2023
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT021711814
    ISBN 978-3-031-16248-0 ; 9783031162473 ; 9783031162497 ; 9783031162503 ; 3-031-16248-X ; 3031162471 ; 3031162498 ; 3031162501
    DOI 10.1007/978-3-031-16248-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Machine Learning and Its Application to Reacting Flows

    Swaminathan, Nedunchezhian / Parente, Alessandro

    ML and Combustion

    (Lecture Notes in Energy)

    2023  

    Series title Lecture Notes in Energy
    Keywords Fossil fuel technologies ; Engineering thermodynamics ; Machine learning ; Thermodynamics & heat ; Machine Learning ; Combustion Simulations ; Combustion Modelling ; Big Data Analysis ; Dimensionality reduction ; Reduced-order modelling ; Neural Networks ; Turbulent Combustion ; Physics-based modelling ; Data-driven modelling ; Deep learning ; Thermoacoustics and its modelling ; Reactive molecular dynamics ; Simulations of reacting flows
    Language English
    Size 1 electronic resource (346 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English
    HBZ-ID HT030380220
    ISBN 9783031162480 ; 303116248X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Data-driven models and digital twins for sustainable combustion technologies.

    Parente, Alessandro / Swaminathan, Nedunchezhian

    iScience

    2024  Volume 27, Issue 4, Page(s) 109349

    Abstract: We highlight the critical role of data in developing sustainable combustion technologies for industries requiring high-density and localized energy sources. Combustion systems are complex and difficult to predict, and high-fidelity simulations are out of ...

    Abstract We highlight the critical role of data in developing sustainable combustion technologies for industries requiring high-density and localized energy sources. Combustion systems are complex and difficult to predict, and high-fidelity simulations are out of reach for practical systems because of computational cost. Data-driven approaches and artificial intelligence offer promising solutions, enabling renewable synthetic fuels to meet decarbonization goals. We discuss open challenges associated with the availability and fidelity of data, physics-based numerical simulations, and machine learning, focusing on developing digital twins capable of mirroring the behavior of industrial combustion systems and continuously updating based on newly available information.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Assessment of advanced age candidates for liver transplantation warrants more caution.

    Parente, Alessandro / Ronca, Vincenzo

    World journal of transplantation

    2022  Volume 12, Issue 2, Page(s) 24–26

    Abstract: For patients with fulminant liver failure and end-stage liver disease, liver transplantation remains the only effective treatment. Over the years, as a result of the ageing population, the average age of liver transplant donors and recipients has ... ...

    Abstract For patients with fulminant liver failure and end-stage liver disease, liver transplantation remains the only effective treatment. Over the years, as a result of the ageing population, the average age of liver transplant donors and recipients has increased and currently about one quarter of patients receiving transplantation in the United States are above the age of 65. Recently, a study reported that patients aged 65 years or older had lower one-year survival compared to a younger cohort. Herein, we express our opinion about this interesting publication.
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article
    ISSN 2220-3230
    ISSN 2220-3230
    DOI 10.5500/wjt.v12.i2.24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Current evidence on the beneficial HOPE-effect based on systematic reviews and meta-analyses in liver transplantation.

    Parente, Alessandro / Dondossola, Daniele / Dutkowski, Philipp / Schlegel, Andrea

    Journal of hepatology

    2023  Volume 80, Issue 3, Page(s) e116–e119

    MeSH term(s) Liver Transplantation ; Evidence-Based Medicine
    Language English
    Publishing date 2023-11-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.10.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Improving reduced-order models through nonlinear decoding of projection-dependent outputs.

    Zdybał, Kamila / Parente, Alessandro / Sutherland, James C

    Patterns (New York, N.Y.)

    2023  Volume 4, Issue 11, Page(s) 100859

    Abstract: A fundamental hindrance to building data-driven reduced-order models (ROMs) is the poor topological quality of a low-dimensional data projection. This includes behavior such as overlapping, twisting, or large curvatures or uneven data density that can ... ...

    Abstract A fundamental hindrance to building data-driven reduced-order models (ROMs) is the poor topological quality of a low-dimensional data projection. This includes behavior such as overlapping, twisting, or large curvatures or uneven data density that can generate nonuniqueness and steep gradients in quantities of interest (QoIs). Here, we employ an encoder-decoder neural network architecture for dimensionality reduction. We find that nonlinear decoding of projection-dependent QoIs, when embedded in a dimensionality reduction technique, promotes improved low-dimensional representations of complex multiscale and multiphysics datasets. When data projection (encoding) is affected by forcing accurate nonlinear reconstruction of the QoIs (decoding), we minimize nonuniqueness and gradients in representing QoIs on a projection. This in turn leads to enhanced predictive accuracy of a ROM. Our findings are relevant to a variety of disciplines that develop data-driven ROMs of dynamical systems such as reacting flows, plasma physics, atmospheric physics, or computational neuroscience.
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3899
    ISSN (online) 2666-3899
    DOI 10.1016/j.patter.2023.100859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Endothelial Cells and Mitochondria: Two Key Players in Liver Transplantation.

    Parente, Alessandro / Flores Carvalho, Mauricio / Schlegel, Andrea

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Building the inner layer of our blood vessels, the endothelium forms an important line communicating with deeper parenchymal cells in our organs. Previously considered passive, endothelial cells are increasingly recognized as key players in intercellular ...

    Abstract Building the inner layer of our blood vessels, the endothelium forms an important line communicating with deeper parenchymal cells in our organs. Previously considered passive, endothelial cells are increasingly recognized as key players in intercellular crosstalk, vascular homeostasis, and blood fluidity. Comparable to other cells, their metabolic function strongly depends on mitochondrial health, and the response to flow changes observed in endothelial cells is linked to their mitochondrial metabolism. Despite the direct impact of new dynamic preservation concepts in organ transplantation, the impact of different perfusion conditions on sinusoidal endothelial cells is not yet explored well enough. This article therefore describes the key role of liver sinusoidal endothelial cells (LSECs) together with their mitochondrial function in the context of liver transplantation. The currently available ex situ machine perfusion strategies are described with their effect on LSEC health. Specific perfusion conditions, including perfusion pressure, duration, and perfusate oxygenation are critically discussed considering the metabolic function and integrity of liver endothelial cells and their mitochondria.
    MeSH term(s) Liver Transplantation ; Endothelial Cells/metabolism ; Liver/metabolism ; Hepatocytes/metabolism ; Mitochondria ; Perfusion ; Organ Preservation
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Efficiency of machine perfusion in pediatric liver transplantation.

    Parente, Alessandro / Kasahara, Mureo / De Meijer, Vincent E / Hashimoto, Koji / Schlegel, Andrea

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2024  

    Abstract: Liver transplantation is the only lifesaving procedure for children with end-stage liver disease. The field is however heterogenic with various graft types, recipient age and weight and underlying diseases. Despite recently improved overall outcomes and ... ...

    Abstract Liver transplantation is the only lifesaving procedure for children with end-stage liver disease. The field is however heterogenic with various graft types, recipient age and weight and underlying diseases. Despite recently improved overall outcomes and the expanded use of living donors, waiting list mortality remains unacceptable particularly in small children and infants. Based on the known negative effect of elevated donor age, higher body mass index, and prolonged cold ischemia time, the number of available donors for pediatric recipients is limited. Machine perfusion has regained significant interest in the adult liver transplant population during the last decade. Ten randomized controlled trials are published with an overall advantage of machine perfusion techniques over cold storage regarding post-operative outcomes, including graft survival. The concept of hypothermic oxygenated perfusion (HOPE) was the first and only perfusion technique used for pediatric liver transplantation today. In 2018 the first pediatric candidate received a full-size graft donated after circulatory death with cold storage and HOPE, followed by a few split liver transplants after HOPE with an overall limited case number until today. One series of split procedures during HOPE was recently presented by colleagues from France with excellent results, reduced complications, and better graft survival. Such early experience paves the way for a more systematic use of machine perfusion techniques for different graft types for pediatric recipients. Clinical reports of pediatric liver transplants with other perfusion techniques are awaited. Strong collaborative efforts are needed to explore the effect of perfusion techniques in this vulnerable population impacting not only the immediate posttransplant outcome, but the development and success of an entire life.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1097/LVT.0000000000000381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4702: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Routine utilization of machine perfusion in liver transplantation: Ready for prime time?

    Parente, Alessandro / Sun, Keyue / Dutkowski, Philipp / Shapiro, Am James / Schlegel, Andrea

    World journal of gastroenterology

    2024  Volume 30, Issue 11, Page(s) 1488–1493

    Abstract: The last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest ...

    Abstract The last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver preservation. Robust evidence from numerous randomized controlled trials has been pooled by meta-analyses, providing the highest available evidence on the protective effect of machine perfusion (MP) over static cold storage in liver transplantation (LT). Based on a protective effect with less complications and improved graft survival, the field has seen a paradigm shift in organ preservation. This editorial focuses on the role of MP in LT and how it could become the new "gold standard". Strong collaborative efforts are needed to explore its effects on long-term outcomes.
    MeSH term(s) Humans ; Blood Coagulation Tests ; Cryopreservation ; Graft Survival ; Liver Transplantation/adverse effects ; Perfusion
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v30.i11.1488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Association between Hepatocellular Carcinoma Recurrence and Graft Size in Living Donor Liver Transplantation: A Systematic Review.

    Parente, Alessandro / Cho, Hwui-Dong / Kim, Ki-Hun / Schlegel, Andrea

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: The aim of this work was to assess the association between graft-to-recipient weight ratio (GRWR) in adult-to-adult living donor liver transplantation (LDLT) and hepatocellular carcinoma (HCC) recurrence. A search of the MEDLINE and EMBASE databases was ... ...

    Abstract The aim of this work was to assess the association between graft-to-recipient weight ratio (GRWR) in adult-to-adult living donor liver transplantation (LDLT) and hepatocellular carcinoma (HCC) recurrence. A search of the MEDLINE and EMBASE databases was performed until December 2022 for studies comparing different GRWRs in the prognosis of HCC recipients in LDLT. Data were pooled to evaluate 1- and 3-year survival rates. We identified three studies, including a total of 782 patients (168 GRWR < 0.8 vs. 614 GRWR ≥ 0.8%). The pooled overall survival was 85% and 77% at one year and 90% and 83% at three years for GRWR < 0.8 and GRWR ≥ 0.8, respectively. The largest series found that, in patients within Milan criteria, the GRWR was not associated with lower oncological outcomes. However, patients with HCC outside the Milan criteria with a GRWR < 0.8% had lower survival and higher tumor recurrence rates. The GRWR < 0.8% appears to be associated with lower survival rates in HCC recipients, particularly for candidates with tumors outside established HCC criteria. Although the data are scarce, the results of this study suggest that considering the individual GRWR not only as risk factor for small-for-size-syndrome but also as contributor to HCC recurrence in patients undergoing LDLT would be beneficial. Novel perfusion technologies and pharmacological interventions may contribute to improving outcomes.
    MeSH term(s) Adult ; Humans ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/etiology ; Liver Transplantation/methods ; Living Donors ; Liver Neoplasms/surgery ; Liver Neoplasms/etiology ; Risk Factors ; Retrospective Studies ; Treatment Outcome ; Liver
    Language English
    Publishing date 2023-03-25
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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