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  1. AU="Paresce, Erberto"
  2. AU=Theerthakarai R
  3. AU="Glenson S. France"
  4. AU=Cai Yi
  5. AU="Elbasiouny, Sherif M"
  6. AU=Bhandarkar Deepraj S
  7. AU="Stefano Masiero"
  8. AU=Zhang Jin-Ying
  9. AU="Cho, Yun-Ho"
  10. AU=Chatr-aryamontri Andrew
  11. AU="Thompson, Kristin"
  12. AU="Horiguchi, Kumiko"
  13. AU="Wagner, Franz F"
  14. AU="Mishra, Vandana"
  15. AU=Zucker Irving H
  16. AU=Dang Vinh T
  17. AU="Andrea Benedetti"
  18. AU="Xu, Jiyu"
  19. AU="Dawson, Holli E"
  20. AU="Dominy, Katherine M"
  21. AU="Maunik Chapala"
  22. AU="Luksic, Ivica"
  23. AU="Mastronardi, Luciano"
  24. AU="Md Farijul Islam"
  25. AU="Quansah, Gabriel W"
  26. AU="Keane, Stephen"
  27. AU="Marsela, Enklajd"
  28. AU="Tate, Amanda W"
  29. AU="Solodov, E P"
  30. AU="Cheng-Fang Yen"

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  1. Artikel ; Online: Use of ultrasound-assisted arthroscopy in rheumatology: an experience in 11 patients with different rheumatic diseases.

    Paresce, Erberto / De Lucia, Orazio / Bruschi, Eleonora / Giacomelli, Luca / Epis, Oscar Massimiliano

    Expert opinion on medical diagnostics

    2013  Band 7, Heft 4, Seite(n) 309–312

    Abstract: The 'real time' capability of ultrasound (US) allows dynamic assessment of joint and tendon movements, which can often aid in the detection of structural abnormalities. The simultaneous use of arthroscopy (AS) and US is therefore a logical progression. ... ...

    Abstract The 'real time' capability of ultrasound (US) allows dynamic assessment of joint and tendon movements, which can often aid in the detection of structural abnormalities. The simultaneous use of arthroscopy (AS) and US is therefore a logical progression. Here the results of a series of 11 patients with different rheumatic diseases in whom a combined use of US and AS was adopted are reported.
    Mesh-Begriff(e) Adult ; Arthroscopy ; Female ; Humans ; Male ; Middle Aged ; Rheumatic Diseases/diagnostic imaging ; Rheumatic Diseases/surgery ; Surgery, Computer-Assisted ; Ultrasonography
    Sprache Englisch
    Erscheinungsdatum 2013-07
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 2393880-8
    ISSN 1753-0067 ; 1753-0059
    ISSN (online) 1753-0067
    ISSN 1753-0059
    DOI 10.1517/17530059.2013.794136
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Unilateral sacroiliitis associated with systemic isotretinoin treatment.

    Barbareschi, Mauro / Paresce, Erberto / Chiaratti, Anna / Ferla Lodigiani, Alessandra / Clerici, Giovanna / Greppi, Franco

    International journal of dermatology

    2010  Band 49, Heft 3, Seite(n) 331–333

    Abstract: Background: Acne fulminans is the most severe form of inflammatory acne characterized by the acute onset of inflammatory nodules and plaques, most commonly on the chest and the back. The lesions undergo rapid suppuration, leaving ragged hemorrhagic ... ...

    Abstract Background: Acne fulminans is the most severe form of inflammatory acne characterized by the acute onset of inflammatory nodules and plaques, most commonly on the chest and the back. The lesions undergo rapid suppuration, leaving ragged hemorrhagic ulcers. Typically, it affects adolescent males with a history of mild to moderate acne. The affected patients often have constitutional symptoms such as fever, malaise, arthralgias, and myalgias. Leukocytosis is commonly associated. Sacroiliitis is reported in 21% of acne fulminans patients in association with arthritis and in a few cases it is reported during isotretinoin treatment, suggesting the drug triggering.
    Conclusion: We report a case of a young male patient in whom the induction of acne fulminans by systemic isotretinoin was associated with unilateral sacroiliitis.
    Mesh-Begriff(e) Acne Vulgaris/chemically induced ; Acne Vulgaris/diagnosis ; Acne Vulgaris/drug therapy ; Adolescent ; Anti-Inflammatory Agents/therapeutic use ; Arthritis/chemically induced ; Arthritis/diagnostic imaging ; Arthritis/drug therapy ; Humans ; Isotretinoin/adverse effects ; Isotretinoin/therapeutic use ; Male ; Physical Therapy Modalities ; Radiography ; Sacroiliac Joint
    Chemische Substanzen Anti-Inflammatory Agents ; Isotretinoin (EH28UP18IF)
    Sprache Englisch
    Erscheinungsdatum 2010-03
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/j.1365-4632.2009.04334.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis.

    Schwager, Kathrin / Kaspar, Manuela / Bootz, Frank / Marcolongo, Roberto / Paresce, Erberto / Neri, Dario / Trachsel, Eveline

    Arthritis research & therapy

    2009  Band 11, Heft 5, Seite(n) R142

    Abstract: Introduction: In this article, we present a comparative immunohistochemical evaluation of four clinical-stage antibodies (L19, F16, G11 and F8) directed against splice isoforms of fibronectin and of tenascin-C for their ability to stain synovial tissue ... ...

    Abstract Introduction: In this article, we present a comparative immunohistochemical evaluation of four clinical-stage antibodies (L19, F16, G11 and F8) directed against splice isoforms of fibronectin and of tenascin-C for their ability to stain synovial tissue alterations in rheumatoid arthritis patients. Furthermore we have evaluated the therapeutic potential of the most promising antibody, F8, fused to the anti-inflammatory cytokine interleukin (IL) 10.
    Methods: F8-IL10 was produced and purified to homogeneity in CHO cells and shown to comprise biological active antibody and cytokine moieties by binding assays on recombinant antigen and by MC/9 cell proliferation assays. We have also characterized the ability of F8-IL10 to inhibit arthritis progression in the collagen-induced arthritis mouse model.
    Results: The human antibody F8, specific to the extra-domain A of fibronectin, exhibited the strongest and most homogenous staining pattern in synovial biopsies and was thus selected for the development of a fully human fusion protein with IL10 (F8-IL10, also named DEKAVIL). Following radioiodination, F8-IL10 was able to selectively target arthritic lesions and tumor neo-vascular structures in mice, as evidenced by autoradiographic analysis and quantitative biodistribution studies. The subcutaneous administration route led to equivalent targeting results when compared with intravenous administration and was thus selected for the clinical development of the product. F8-IL10 potently inhibited progression of established arthritis in the collagen-induced mouse model when tested alone and in combination with methotrexate. In preparation for clinical trials in patients with rheumatoid arthritis, F8-IL10 was studied in rodents and in cynomolgus monkeys, revealing an excellent safety profile at doses tenfold higher than the planned starting dose for clinical phase I trials.
    Conclusions: Following the encouraging preclinical results presented in this paper, clinical trials with F8-IL10 will now elucidate the therapeutic potential of this product and whether the targeted delivery of IL10 potentiates the anti-arthritic action of the cytokine in rheumatoid arthritis patients.
    Mesh-Begriff(e) Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal, Humanized ; Antibody Specificity ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/pathology ; Autoantibodies/blood ; Autoantibodies/immunology ; CHO Cells ; Cricetinae ; Cricetulus ; Cytokines/blood ; Cytokines/immunology ; Drug Delivery Systems ; Female ; Fluorescent Antibody Technique ; Humans ; Immunohistochemistry ; Immunosuppressive Agents/pharmacology ; Immunotherapy/methods ; Interleukin-10/administration & dosage ; Interleukin-10/adverse effects ; Interleukin-10/immunology ; Macaca fascicularis ; Male ; Methotrexate/pharmacology ; Mice ; Mice, Inbred DBA ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/adverse effects ; Recombinant Fusion Proteins/immunology ; Synovial Membrane/immunology ; Synovial Membrane/metabolism
    Chemische Substanzen Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Autoantibodies ; Cytokines ; F8 monoclonal antibody ; Immunosuppressive Agents ; Recombinant Fusion Proteins ; Interleukin-10 (130068-27-8) ; Methotrexate (YL5FZ2Y5U1)
    Sprache Englisch
    Erscheinungsdatum 2009-09-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/ar2814
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Use of antibodies recognizing cyclic citrullinated peptide in the differential diagnosis of joint involvement in systemic sclerosis.

    Ingegnoli, Francesca / Galbiati, Valentina / Zeni, Silvana / Meani, Laura / Zahalkova, Lenka / Lubatti, Chiara / Soldi, Amedeo / Paresce, Erberto / Murgo, Antonella / Crapanzano, Calogero / Fantini, Flavio

    Clinical rheumatology

    2006  Band 26, Heft 4, Seite(n) 510–514

    Abstract: Objective: To determine the prevalence of anti-cyclic citrullinated peptide (CCP) antibodies in systemic sclerosis (SSc) and to assess any association between the presence of anti-CCP, radiographic features, and clinical manifestations.: Materials and ...

    Abstract Objective: To determine the prevalence of anti-cyclic citrullinated peptide (CCP) antibodies in systemic sclerosis (SSc) and to assess any association between the presence of anti-CCP, radiographic features, and clinical manifestations.
    Materials and methods: Anti-CCP antibodies and rheumatoid factor (RF) were tested in serum samples from 75 patients with SSc (64 women and 11 men), with a mean age of 59.4 years (range 24-85) with either diffuse (dcSSc) and limited (lcSSc) cutaneous involvement. As a control group, 22 age- and sex-matched healthy controls (HCs) were examined. Standard radiographs of the hands and wrists were examined in each patient.
    Results: The presence of anti-CCP was found in sera of 10.6% (8/75) patients with SSc (lcSSc 3 of 44, 6.8%; dcSSc 5 of 31, 16.1%). None of the HCs was positive for anti-CCP. The positivity of RF was observed in 19 of 75 (25.3%) SSc patients (lcSSc 10 of 44, 22.7%; dcSSc 9 of 31, 29%). Statistically significant association was found between anti-CCP positivity and the presence of arthritis (p<0.0001) and marginal erosions (p=0.001).
    Conclusion: Our data show that joint involvement is a common presenting feature of SSc. In this report, we show that anti-CCP antibodies can be detected also in patients with SSc, but they are generally less commonly present than in adults with rheumatoid arthritis (RA). Thus, the finding of high titers of anti-CCP antibodies may help to define the diagnosis of overlap syndrome SSc/RA and facilitate diagnosis and appropriate treatment.
    Mesh-Begriff(e) Aged ; Arthralgia/complications ; Arthritis/blood ; Arthritis/complications ; Autoantibodies/blood ; Diagnosis, Differential ; Female ; Hand/diagnostic imaging ; Humans ; Male ; Matched-Pair Analysis ; Middle Aged ; Peptides, Cyclic/immunology ; Radiography ; Scleroderma, Diffuse/blood ; Scleroderma, Diffuse/complications ; Scleroderma, Diffuse/diagnostic imaging ; Scleroderma, Limited/blood ; Scleroderma, Limited/complications ; Scleroderma, Limited/diagnostic imaging ; Sensitivity and Specificity ; Wrist/diagnostic imaging
    Chemische Substanzen Autoantibodies ; Peptides, Cyclic ; cyclic citrullinated peptide
    Sprache Englisch
    Erscheinungsdatum 2006-05-03
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 604755-5
    ISSN 0770-3198
    ISSN 0770-3198
    DOI 10.1007/s10067-006-0313-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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