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Article: Lobar pulmonary perfusion quantification with dual-energy CT angiography: Interlobar variability and relationship with regional clot burden in pulmonary embolism.

Lee, Hye Ju / Wanderley, Mark / Rubin, Vivian Cardinal da Silva / Rodrigues, Ana Clara Tude / Diniz, Amanda Rocha / Parga, Jose Rodrigues / Amato, Marcelo Britto Passos

European journal of radiology open

2022 Volume 9, Page(s) 100428

Abstract: Purpose: Semi-automated lobar segmentation tools enable an anatomical assessment of regional pulmonary perfusion with Dual-Energy CTA (DE-CTA). We aimed to quantify lobar pulmonary perfusion with DE-CTA, analyze the perfusion distribution among the ... ...

Abstract	Purpose: Semi-automated lobar segmentation tools enable an anatomical assessment of regional pulmonary perfusion with Dual-Energy CTA (DE-CTA). We aimed to quantify lobar pulmonary perfusion with DE-CTA, analyze the perfusion distribution among the pulmonary lobes in subjects without cardiopulmonary diseases and assess the correlation between lobar perfusion and regional endoluminal clots in patients with acute pulmonary embolism (PE). Methods: We evaluated 151 consecutive subjects with suspected PE and without cardiopulmonary comorbidities. DE-CTA derived perfused blood volume (PBV) of each pulmonary lobe was measured applying a semi-automated lobar segmentation technique. In patients with PE, blood clot location was assessed, and CT-based vascular obstruction index of each lobe (CTOI Results: Among patients without PE (103/151, 68.2%), median lobar PBV was 13.7% (IQR 10.2-18.0%); the right middle lobe presented lower PBV when compared to all the other lobes ( Conclusion: Pulmonary perfusion was heterogeneously distributed along the pulmonary lobes in patients without cardiopulmonary diseases. In patients with PE, the lobes with high vascular obstruction score (CTOI
Language	English
Publishing date	2022-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2810314-2
ISSN	2352-0477
ISSN	2352-0477
DOI	10.1016/j.ejro.2022.100428
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Article ; Online: Quantitative analysis of pulmonary perfusion with dual-energy CT angiography: comparison of two quantification methods in patients with pulmonary embolism.

Lee, Hye Ju / Wanderley, Mark / da Silva Rubin, Vivian Cardinal / Alcala, Glasiele Cristina / Costa, Eduardo Leite Vieira / Parga, Jose Rodrigues / Amato, Marcelo Britto Passos

The international journal of cardiovascular imaging

2022 Volume 39, Issue 4, Page(s) 853–862

Abstract: The study aimed to evaluate a quantification method of pulmonary perfusion with Dual-Energy CT Angiography (DE-CTA) normalized by lung density in the prediction of outcome in acute pulmonary embolism (PE). In this prospective study with CTA scans ... ...

Abstract	The study aimed to evaluate a quantification method of pulmonary perfusion with Dual-Energy CT Angiography (DE-CTA) normalized by lung density in the prediction of outcome in acute pulmonary embolism (PE). In this prospective study with CTA scans acquired with different breathing protocols, two perfusion parameters were calculated: %PBV (relative value of PBV, expressed per unit volume) and PBVm (PBV normalized by lung density, expressed per unit mass). DE-CTA parameters were correlated with simplified pulmonary embolism severity index (sPESI) and with outcome groups, alone and in combinationwith tomographic right-to-left ventricular ratios (RV/LV). PBVm showed significant correlation with sPESI. PBVm presented higher accuracy than %PBV In the prediction of ICU admission or death in patients with PE, with the best performance when combined with RV/LV volumetric ratio.
MeSH term(s)	Humans ; Computed Tomography Angiography ; Tomography, X-Ray Computed/methods ; Prospective Studies ; Predictive Value of Tests ; Pulmonary Embolism/diagnostic imaging ; Lung/diagnostic imaging ; Perfusion
Language	English
Publishing date	2022-12-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2055311-0
ISSN	1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
ISSN (online)	1875-8312 ; 1573-0743
ISSN	1569-5794 ; 0167-9899
DOI	10.1007/s10554-022-02781-y
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Zs.A 2104: Show issues

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Article ; Online: Stent evaluation by coronary computed tomography angiography: a comparison between Iopamidol-370 and Ioversol-320 hypo-osmolar iodine concentration contrasts.

Garcia, Annelisa Moura / Assunção-Jr, Antonildes N / Dantas-Jr, Roberto Nery / Parga, Jose Rodrigues / Ganem, Fernando

The British journal of radiology

2020 Volume 93, Issue 1115, Page(s) 20200078

Abstract: Objective: Qualitative and quantitative image analysis between Iopamidol-370 and Ioversol-320 in stents´ evaluation by coronary computed tomography angiography (CTA).: Methods: Sixty-five patients with low-risk stable angina undergoing stent follow- ... ...

Abstract	Objective: Qualitative and quantitative image analysis between Iopamidol-370 and Ioversol-320 in stents´ evaluation by coronary computed tomography angiography (CTA). Methods: Sixty-five patients with low-risk stable angina undergoing stent follow-up with coronary CTA were assigned to Iopamidol I-370 ( Results: Image quality was similar between groups, with no significant difference (Likert score 4.48 ± 0.75 Conclusions: There was no significant difference between Iopamidol-370 mgI ml
MeSH term(s)	Angina, Stable/diagnostic imaging ; Angina, Stable/therapy ; Artifacts ; Cardiac Complexes, Premature ; Computed Tomography Angiography/adverse effects ; Computed Tomography Angiography/methods ; Computed Tomography Angiography/standards ; Contrast Media ; Coronary Angiography/adverse effects ; Coronary Angiography/methods ; Coronary Angiography/standards ; Double-Blind Method ; Female ; Heart Rate ; Humans ; Iopamidol ; Male ; Middle Aged ; Multivariate Analysis ; Prohibitins ; Prospective Studies ; Stents/statistics & numerical data ; Triiodobenzoic Acids
Chemical Substances	Contrast Media ; PHB protein, human ; Prohibitins ; Triiodobenzoic Acids ; Iopamidol (JR13W81H44) ; ioversol (N3RIB7X24K)
Language	English
Publishing date	2020-08-20
Publishing country	England
Document type	Comparative Study ; Equivalence Trial ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20200078
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Article: [No title information]

Amato, Alexandre Campos Moraes / Parga, José Rodrigues / Stolf, Noedir Antônio Groppo

Jornal vascular brasileiro

2018 Volume 17, Issue 1, Page(s) 19–25

Title translation	Desenvolvimento de modelo clínico para predição da possibilidade de identificação da artéria de Adamkiewicz por angiotomografia.
Language	Portuguese
Publishing date	2018-06-13
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2571403-X
ISSN	1677-7301 ; 1677-5449
ISSN (online)	1677-7301
ISSN	1677-5449
DOI	10.1590/1677-5449.006317
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Article ; Online: Rare association of endomyocardial fibrosis and Chagas heart disease.

Hotta, Viviane Tiemi / Ianni, Bárbara Maria / Assunção, Antonildes Nascimento / Parga, José Rodrigues / Mady, Charles

European heart journal cardiovascular Imaging

2016 Volume 18, Issue 3, Page(s) 378–379

MeSH term(s)	Chagas Cardiomyopathy/complications ; Chagas Cardiomyopathy/diagnostic imaging ; Echocardiography, Three-Dimensional/methods ; Electrocardiography/methods ; Endomyocardial Fibrosis/complications ; Endomyocardial Fibrosis/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging, Cine/methods ; Middle Aged ; Multimodal Imaging/methods ; Rare Diseases ; Severity of Illness Index
Language	English
Publishing date	2016-10-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jew214
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Article: Clinical evaluation of left ventricular function and morphology using an accelerated k-t sensitivity encoding method in cardiovascular magnetic resonance.

Assuncao-Jr, Antonildes Nascimento / Dantas-Jr, Roberto Nery / do Val, Renata Margarida / Gianotto, Priscilla / Marin, Angela Dos Santos / Golden, Mark / Gutierrez, Marco Antonio / Parga, Jose Rodrigues / Nomura, Cesar Higa

Insights into imaging

2019 Volume 10, Issue 1, Page(s) 62

Abstract: Objectives: To provide clinical validation of a recent 2D SENSE-based accelerated cardiovascular magnetic resonance (CMR) sequence (accelerated k-t SENSE), investigating whether this technique accurately quantifies left ventricle (LV) volumes, function, ...

Abstract	Objectives: To provide clinical validation of a recent 2D SENSE-based accelerated cardiovascular magnetic resonance (CMR) sequence (accelerated k-t SENSE), investigating whether this technique accurately quantifies left ventricle (LV) volumes, function, and mass as compared to 2D cine steady-state free precession (2D-SSFP). Methods: Healthy volunteers (n = 16) and consecutive heart failure patients (n = 26) were scanned using a 1.5 T MRI system. Two LV short axis (SA) stacks were acquired: (1) accelerated k-t SENSE (5-6 breath-holds; temporal/spatial resolution: 37 ms/1.82 × 1.87 mm; acceleration factor = 4) and (2) standard 2D-SSFP (10-12 breath-holds; temporal/spatial resolution: 49 ms/1.67 × 1.87 mm, parallel imaging). Ascending aorta phase-contrast was performed on all volunteers as a reference to compare LV stroke volumes (LVSV) and validate the sequences. An image quality score for SA images was used, with lower scores indicating better quality (from 0 to 18). Results: There was a high agreement between accelerated k-t SENSE and 2D-SSFP for LV measurements: bias (limits of agreement) of 2.4% (- 5.4% to 10.1%), 6.9 mL/m Conclusion: The accelerated k-t SENSE CMR sequence is clinically feasible and accurately quantifies LV volumes, function, and mass, with short acquisition time and good image quality.
Language	English
Publishing date	2019-06-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1186/s13244-019-0750-6
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Article ; Online: Myocardial perfusion in patients with suspected coronary artery disease: comparison between 320-MDCT and rubidium-82 PET.

Dantas, Roberto Nery / Assuncao, Antonildes Nascimento / Marques, Ismar Aguiar / Fahel, Mateus Guimaraes / Nomura, Cesar Higa / Avila, Luiz Francisco Rodrigues / Giorgi, Maria Clementina Pinto / Soares, Jose / Meneghetti, Jose Claudio / Parga, Jose Rodrigues

European radiology

2018 Volume 28, Issue 6, Page(s) 2665–2674

Abstract: Objectives: Despite advances in non-invasive myocardial perfusion imaging (MPI) evaluation, computed tomography (CT) multiphase MPI protocols have not yet been compared with the highly accurate rubidium-82 positron emission tomography (: Methods: ... ...

Abstract	Objectives: Despite advances in non-invasive myocardial perfusion imaging (MPI) evaluation, computed tomography (CT) multiphase MPI protocols have not yet been compared with the highly accurate rubidium-82 positron emission tomography ( Methods: Forty-four patients referred for MPI evaluation were prospectively enrolled and underwent dipyridamole stress Results: There was high agreement for recognizing summed stress scores ≥ 4 (kappa 0.77, 95% CI 0.55-0.98, p < 0.001) and moderate for detecting SDS ≥ 2 (kappa 0.51, 95% CI 0.23-0.80, p < 0.001). In a per segment analysis, agreement was high for the presence of perfusion defects during stress and rest (kappa 0.75 and 0.82, respectively) and was moderate for impairment severity (kappa 0.58 and 0.65, respectively). The 320-CT protocol was safe, with low radiation burden (9.3 ± 2.4 mSv). Conclusions: There was a significant agreement between dipyridamole stress 320-CT MPI and Key points: • Rubidium-82 PET and 320-MDCT can perform MPI studies for CAD investigation. • There is high agreement between rubidium-82 PET and 320-MDCT for MPI assessment. • Multiphase CT perfusion protocols are feasible and with low radiation. • Multiphase CT perfusion protocols can identify image artefacts.
MeSH term(s)	Computed Tomography Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Vessels/diagnostic imaging ; Dipyridamole/pharmacology ; Female ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography ; Myocardial Perfusion Imaging/methods ; Positron-Emission Tomography/methods ; Prospective Studies ; Radiopharmaceuticals ; Rubidium Radioisotopes ; Software ; Tomography, Emission-Computed, Single-Photon/methods ; Vasodilator Agents/pharmacology
Chemical Substances	Radiopharmaceuticals ; Rubidium Radioisotopes ; Vasodilator Agents ; Dipyridamole (64ALC7F90C) ; Rubidium-82 (9K730EL8KU)
Language	English
Publishing date	2018-01-19
Publishing country	Germany
Document type	Evaluation Study ; Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-017-5257-2
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Article ; Online: Radiation dose reduction by adjusting bolus tracking parameters in a 320-detector row scanner.

Matsumoto, Jacqueline Kioko Nishimura / Assuncao-Jr, Antonildes Nascimento / Dantas Junior, Roberto Nery / Araujo-Filho, Jose de Arimateia Batista / Andrade, Solange de Sousa / Nomura, Cesar Higa / Parga, Jose Rodrigues

Journal of cardiovascular computed tomography

2018 Volume 12, Issue 4, Page(s) 312–315

Abstract: Background: The importance of bolus tracking (BT) regarding total effective radiation dose (ERD) in the era of advanced coronary computed tomography angiography (CTA) has been ignored. We aimed to investigate whether adjusting BT parameters reduces ERD.! ...

Abstract	Background: The importance of bolus tracking (BT) regarding total effective radiation dose (ERD) in the era of advanced coronary computed tomography angiography (CTA) has been ignored. We aimed to investigate whether adjusting BT parameters reduces ERD. Methods: Adults consecutively referred to CTA (n = 289) in a 320 detector-row scanner were distributed into four BT protocols according to delay time and time between intermittent scans, as follows: A (n = 70, delay 10s, intermittent scans 1s); B (n = 79, delay 10s, intermittent scans 2s); C (n = 68, delay 15s, intermittent scans 1s); and D (n = 72, delay 15s, intermittent scans 2s). Image quality was assessed. Results: The overall ERD in BT and AP were 0.32 ± 0.14 mSv and 6.06 ± 0.66 mSv, respectively. ERD in BT was different among protocols (A:0.44 ± 0.14 mSv; B:0.32 ± 0.10 mSv; C:0.28 ± 0.14 mSv; D:0.23 ± 0.09 mSv; p < 0.001), with no loss in image quality. Adjusted for potential confounders (heart rate, tube current and acquisition window), protocol D provided the highest reduction in total ERD (β = -0.33, p = 0.004). Conclusion: Delaying initiation of BT images (and acquiring them less frequently) reduces radiation dose and does not impair image quality.
MeSH term(s)	Aged ; Computed Tomography Angiography/adverse effects ; Coronary Angiography/adverse effects ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Vessels/diagnostic imaging ; Female ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography/adverse effects ; Predictive Value of Tests ; Prospective Studies ; Radiation Dosage ; Radiation Exposure/adverse effects ; Radiation Exposure/prevention & control ; Radiographic Image Interpretation, Computer-Assisted ; Reproducibility of Results ; Risk Factors ; Time Factors
Language	English
Publishing date	2018-04-05
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2018.03.009
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Article ; Online: Dipyridamole stress myocardial perfusion by computed tomography in patients with left bundle branch block.

Cabeda, Estêvan Vieira / Falcão, Andréa Maria Gomes / Soares, José / Rochitte, Carlos Eduardo / Nomura, César Higa / Ávila, Luiz Francisco Rodrigues / Parga, José Rodrigues

Arquivos brasileiros de cardiologia

2015 Volume 105, Issue 6, Page(s) 614–624

Abstract: Background: Functional tests have limited accuracy for identifying myocardial ischemia in patients with left bundle branch block (LBBB).: Objective: To assess the diagnostic accuracy of dipyridamole-stress myocardial computed tomography perfusion ( ... ...

Abstract	Background: Functional tests have limited accuracy for identifying myocardial ischemia in patients with left bundle branch block (LBBB). Objective: To assess the diagnostic accuracy of dipyridamole-stress myocardial computed tomography perfusion (CTP) by 320-detector CT in patients with LBBB using invasive quantitative coronary angiography (QCA) (stenosis ≥ 70%) as reference; to investigate the advantage of adding CTP to coronary computed tomography angiography (CTA) and compare the results with those of single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy. Methods: Thirty patients with LBBB who had undergone SPECT for the investigation of coronary artery disease were referred for stress tomography. Independent examiners performed per-patient and per-coronary territory assessments. All patients gave written informed consent to participate in the study that was approved by the institution's ethics committee. Results: The patients' mean age was 62 ± 10 years. The mean dose of radiation for the tomography protocol was 9.3 ± 4.6 mSv. With regard to CTP, the per-patient values for sensitivity, specificity, positive and negative predictive values, and accuracy were 86%, 81%, 80%, 87%, and 83%, respectively (p = 0.001). The per-territory values were 63%, 86%, 65%, 84%, and 79%, respectively (p < 0.001). In both analyses, the addition of CTP to CTA achieved higher diagnostic accuracy for detecting myocardial ischemia than SPECT (p < 0.001). Conclusion: The use of the stress tomography protocol is feasible and has good diagnostic accuracy for assessing myocardial ischemia in patients with LBBB.
MeSH term(s)	Aged ; Bundle-Branch Block/diagnostic imaging ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Dipyridamole ; Female ; Humans ; Male ; Middle Aged ; Multidetector Computed Tomography/instrumentation ; Myocardial Perfusion Imaging/methods ; Prospective Studies ; Radiation Exposure ; Reproducibility of Results ; Risk Factors ; Sensitivity and Specificity ; Time Factors ; Tomography, Emission-Computed, Single-Photon/methods ; Vasodilator Agents
Chemical Substances	Vasodilator Agents ; Dipyridamole (64ALC7F90C)
Language	Portuguese
Publishing date	2015-12
Publishing country	Brazil
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.5935/abc.20150117
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Article ; Online: Exercise-induced decrease in myocardial high-energy phosphate metabolites in patients with Chagas heart disease.

Betim Paes Leme, Ana Maria / Salemi, Vera Maria Cury / Weiss, Robert G / Parga, Jose Rodrigues / Ianni, Bárbara Maria / Mady, Charles / Kalil-Filho, Roberto

Journal of cardiac failure

2013 Volume 19, Issue 7, Page(s) 454–460

Abstract: Background: The influence of exercise on cardiac metabolic response in patients with Chagas disease is incompletely understood.: Methods and results: Changes in cardiac energetic metabolism were investigated in Chagas disease patients before and ... ...

Abstract	Background: The influence of exercise on cardiac metabolic response in patients with Chagas disease is incompletely understood. Methods and results: Changes in cardiac energetic metabolism were investigated in Chagas disease patients before and during isometric handgrip exercise with (31)P magnetic resonance spectroscopy (MRS). Twenty-eight patients (10 with systolic dysfunction: group I; 10 with normal systolic function and electrocardiogram (ECG) abnormalities: group II; and 8 asymptomatic without ECG abnormalities: group III) and 8 healthy control subjects (group C) were evaluated by electrocardiogram, echocardiogram, functional tests for coronary artery disease, and image-selected localized cardiac (31)P-MRS. The myocardial phosphocreatine to [β-phosphate]adenosine triphosphate ratio (PCr/β-ATP) was measured at rest and during isometric handgrip exercise. Exercise testing or 99mTc-sestamibi scintigraphy were negative for myocardial ischemia in all individuals. At rest, cardiac PCr/β-ATP was decreased in all Chagas groups (1.23 ± 0.37) versus group C (1.88 ± 0.08; P < .001) and was lower in group I (0.89 ± 0.24) versus groups II (1.44 ± 0.23) and III (1.40 ± 0.37; P < .001). There was no stress-induced change in cardiac PCr/β-ATP (1.88 ± 0.08 at rest vs 1.89 ± 0.08 during exercise; P = NS) in group C. Mean cardiac PCr/β-ATP was 0.89 ± 0.24 and 0.56 ± 0.21 at rest and during exercise, respectively, in group I (37% decrease; P < .001). In group II, PCr/β-ATP was 1.44 ± 0.23 at rest and 0.97 ± 0.37 during exercise (33% decrease; P < .001). In group III, PCr/β-ATP was 1.40 ± 0.37 at rest and 0.60 ± 0.19 during exercise (57% decrease; P < .001). Conclusions: Myocardial high-energy phosphates are reduced at rest in Chagas heart disease patients, and the reduction is greater in patients with left ventricular dysfunction. Regardless of left ventricular function, Chagas patients exhibit an exercise-induced decline in cardiac high-energy phosphates consistent with myocardial ischemia, suggesting the possibility that this metabolic approach may offer a tool to probe new interventions in Chagas disease patients.
MeSH term(s)	Adult ; Chagas Cardiomyopathy/diagnosis ; Chagas Cardiomyopathy/metabolism ; Energy Metabolism/physiology ; Exercise/physiology ; Exercise Test/methods ; Female ; Hand Strength/physiology ; Humans ; Magnetic Resonance Spectroscopy/methods ; Male ; Middle Aged ; Myocardium/metabolism ; Phosphates/metabolism
Chemical Substances	Phosphates
Language	English
Publishing date	2013-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1281194-4
ISSN	1532-8414 ; 1071-9164
ISSN (online)	1532-8414
ISSN	1071-9164
DOI	10.1016/j.cardfail.2013.05.008
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