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Article ; Online: Label-Free and Colorimetric Detection of Influenza A Virus via Receptor-Mediated Viral Fusion with Plasmonic Vesicles.

Moon, Yesol / Lee, Sojeong / Kim, Jinyoung / Park, Geunseon / Park, Chaewon / Lim, Jong-Woo / Yeom, Minjoo / Song, Daesub / Haam, Seungjoo

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 20, Issue 4, Page(s) e2305748

Abstract: The rapid transmission and numerous re-emerging human influenza virus variants that spread via the respiratory system have led to severe global damage, emphasizing the need for detection tools that can recognize active and intact virions with infectivity. ...

Abstract	The rapid transmission and numerous re-emerging human influenza virus variants that spread via the respiratory system have led to severe global damage, emphasizing the need for detection tools that can recognize active and intact virions with infectivity. Here, this work presents a plasmonic vesicle-mediated fusogenic immunoassay (PVFIA) comprising gold nanoparticle (GNP) encapsulating fusogenic polymeric vesicles (plasmonic vesicles; PVs) for the label-free and colorimetric detection of influenza A virus (IAV). The PVFIA combines two sequential assays: a biochip-based immunoassay for target-specific capture and a PV-induced fusion assay for color change upon the IAV-PV fusion complex formation. The PVFIA demonstrates excellent specificity in capturing the target IAV, while the fusion conditions and GNP induce a significant color change, enabling visual detection. The integration of two consecutive assays results in a low detection limit (10
MeSH term(s)	Humans ; Influenza A virus ; Colorimetry/methods ; Gold ; Reproducibility of Results ; Metal Nanoparticles
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2023-09-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202305748
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Article: Cell-mimetic biosensors to detect avian influenza virus via viral fusion

Park, Geunseon / Lim, Jong-Woo / Park, Chaewon / Yeom, Minjoo / Lee, Sojeong / Lyoo, Kwang-Soo / Song, Daesub / Haam, Seungjoo

Biosensors & bioelectronics. 2022 Sept. 15, v. 212

2022

Abstract: Avian influenza virus (AIV) causes acute infectious diseases in poultry, critically impacting food supply. Highly pathogenic avian influenza viruses (HPAIVs), in particular, cause morbidity and mortality, resulting in significant economic losses in the ... ...

Abstract	Avian influenza virus (AIV) causes acute infectious diseases in poultry, critically impacting food supply. Highly pathogenic avian influenza viruses (HPAIVs), in particular, cause morbidity and mortality, resulting in significant economic losses in the poultry industry. To prevent the spread of HPAIVs, detection at early stages is critical to implement effective countermeasures such as quarantine and isolation. Through a viral fusion mechanism, cell-mimetic nanoparticles (CMPs), developed in the current study, can rapidly detect HPAIV and low pathogenic AIV (LPAIV). The CMPs comprise polymeric nanoparticles, which are constructed using sialic acid and fluorescence resonance energy transfer (FRET) dye pairs that expose the FRET off signal in response to LPAIV and HPAIV, after activation by enzymatic cleavage in the endosomal environment. The CMPs detect a wide variety of LPAIVs and HPAIVs in biological environments. Additionally, the cross-reactivity of CMPs is determined by testing their function with different viral species. Therefore, these findings demonstrate the significant potential of the proposed strategy for mimicking viral infection in vitro and using them as a highly effective diagnostic assay to rapidly detect LPAIV and HPAIV, preventing economic losses associated with viral outbreaks.
Keywords	Influenza A virus ; avian influenza ; biosensors ; cross reaction ; dyes ; energy transfer ; fluorescence ; food availability ; morbidity ; mortality ; polymers ; poultry ; poultry industry ; quarantine ; sialic acid
Language	English
Dates of publication	2022-0915
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2022.114407
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Self-Assembled Nanostructures Presenting Repetitive Arrays of Subunit Antigens for Enhanced Immune Response.

Park, Geunseon / Na, Woonsung / Lim, Jong-Woo / Park, Chaewon / Lee, Sojeong / Yeom, Minjoo / Ga, Eulhae / Hwang, Jaehyun / Moon, Suyun / Jeong, Dae Gwin / Jeong, Hyoung Hwa / Song, Daesub / Haam, Seungjoo

ACS nano

2024 Volume 18, Issue 6, Page(s) 4847–4861

Abstract: Infectious diseases pose persistent threats to public health, demanding advanced vaccine technologies. Nanomaterial-based delivery systems offer promising solutions to enhance immunogenicity while minimizing reactogenicity. We introduce a self-assembled ... ...

Abstract	Infectious diseases pose persistent threats to public health, demanding advanced vaccine technologies. Nanomaterial-based delivery systems offer promising solutions to enhance immunogenicity while minimizing reactogenicity. We introduce a self-assembled vaccine (SAV) platform employing antigen-polymer conjugates designed to facilitate robust immune responses. The SAVs exhibit efficient cellular uptake by dendritic cells (DCs) and macrophages, which are crucial players in the innate immune system. The high-density antigen presentation of this SAV platform enhances the affinity for DCs through multivalent recognition, significantly augmenting humoral immunity. SAV induced high levels of immunoglobulin G (IgG), IgG1, and IgG2a, suggesting that mature DCs efficiently induced B cell activation through multivalent antigen recognition. Universality was confirmed by applying it to respiratory viruses, showcasing its potential as a versatile vaccine platform. Furthermore, we have also demonstrated strong protection against influenza A virus infection with SAV containing hemagglutinin, which is used in influenza A virus subunit vaccines. The efficacy and adaptability of this nanostructured vaccine present potential utility in combating infectious diseases.
MeSH term(s)	Humans ; Influenza Vaccines ; Antigens ; Immunity, Humoral ; Immunoglobulin G ; Influenza A virus ; Nanostructures ; Communicable Diseases ; Antibodies, Viral ; Adjuvants, Immunologic
Chemical Substances	Influenza Vaccines ; Antigens ; Immunoglobulin G ; Antibodies, Viral ; Adjuvants, Immunologic
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c09672
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Article: Application of Nanomaterials as an Advanced Strategy for the Diagnosis, Prevention, and Treatment of Viral Diseases.

Lim, Jong-Woo / Ahn, Yu-Rim / Park, Geunseon / Kim, Hyun-Ouk / Haam, Seungjoo

Pharmaceutics

2021 Volume 13, Issue 10

Abstract: The coronavirus disease (COVID-19) pandemic poses serious global health concerns with the continued emergence of new variants. The periodic outbreak of novel emerging and re-emerging infectious pathogens has elevated concerns and challenges for the ... ...

Abstract	The coronavirus disease (COVID-19) pandemic poses serious global health concerns with the continued emergence of new variants. The periodic outbreak of novel emerging and re-emerging infectious pathogens has elevated concerns and challenges for the future. To develop mitigation strategies against infectious diseases, nano-based approaches are being increasingly applied in diagnostic systems, prophylactic vaccines, and therapeutics. This review presents the properties of various nanoplatforms and discusses their role in the development of sensors, vectors, delivery agents, intrinsic immunostimulants, and viral inhibitors. Advanced nanomedical applications for infectious diseases have been highlighted. Moreover, physicochemical properties that confer physiological advantages and contribute to the control and inhibition of infectious diseases have been discussed. Safety concerns limit the commercial production and clinical use of these technologies in humans; however, overcoming these limitations may enable the use of nanomaterials to resolve current infection control issues via application of nanomaterials as a platform for the diagnosis, prevention, and treatment of viral diseases.
Language	English
Publishing date	2021-09-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13101570
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Article ; Online: Cell-mimetic biosensors to detect avian influenza virus via viral fusion.

Park, Geunseon / Lim, Jong-Woo / Park, Chaewon / Yeom, Minjoo / Lee, Sojeong / Lyoo, Kwang-Soo / Song, Daesub / Haam, Seungjoo

Biosensors & bioelectronics

2022 Volume 212, Page(s) 114407

Abstract	Avian influenza virus (AIV) causes acute infectious diseases in poultry, critically impacting food supply. Highly pathogenic avian influenza viruses (HPAIVs), in particular, cause morbidity and mortality, resulting in significant economic losses in the poultry industry. To prevent the spread of HPAIVs, detection at early stages is critical to implement effective countermeasures such as quarantine and isolation. Through a viral fusion mechanism, cell-mimetic nanoparticles (CMPs), developed in the current study, can rapidly detect HPAIV and low pathogenic AIV (LPAIV). The CMPs comprise polymeric nanoparticles, which are constructed using sialic acid and fluorescence resonance energy transfer (FRET) dye pairs that expose the FRET off signal in response to LPAIV and HPAIV, after activation by enzymatic cleavage in the endosomal environment. The CMPs detect a wide variety of LPAIVs and HPAIVs in biological environments. Additionally, the cross-reactivity of CMPs is determined by testing their function with different viral species. Therefore, these findings demonstrate the significant potential of the proposed strategy for mimicking viral infection in vitro and using them as a highly effective diagnostic assay to rapidly detect LPAIV and HPAIV, preventing economic losses associated with viral outbreaks.
MeSH term(s)	Animals ; Biosensing Techniques ; Chickens ; Influenza A virus ; Influenza in Birds/diagnosis ; Poultry
Language	English
Publishing date	2022-05-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2022.114407
Database	MEDical Literature Analysis and Retrieval System OnLINE

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In stock of ZB MED Cologne/Königswinter

Zs.A 2275: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Rapid detection of influenza A (H1N1) virus by conductive polymer-based nanoparticle via optical response to virus-specific binding.

Park, Geunseon / Kim, Hyun-Ouk / Lim, Jong-Woo / Park, Chaewon / Yeom, Minjoo / Song, Daesub / Haam, Seungjoo

Nano research

2021 Volume 15, Issue 3, Page(s) 2254–2262

Abstract: A recurrent pandemic with unpredictable viral nature has implied the need for a rapid diagnostic technology to facilitate timely and appropriate countermeasures against viral infections. In this study, conductive polymer-based nanoparticles have been ... ...

Abstract	A recurrent pandemic with unpredictable viral nature has implied the need for a rapid diagnostic technology to facilitate timely and appropriate countermeasures against viral infections. In this study, conductive polymer-based nanoparticles have been developed as a tool for rapid diagnosis of influenza A (H1N1) virus. The distinctive property of a conductive polymer that transduces stimulus to respond, enabled immediate optical signal processing for the specific recognition of H1N1 virus. Conductive poly(aniline-co-pyrrole)-encapsulated polymeric vesicles, functionalized with peptides, were fabricated for the specific recognition of H1N1 virus. The low solubility of conductive polymers was successfully improved by employing vesicles consisting of amphiphilic copolymers, facilitating the viral titer-dependent production of the optical response. The optical response of the detection system to the binding event with H1N1, a mechanical stimulation, was extensively analyzed and provided concordant information on viral titers of H1N1 virus in 15 min. The specificity toward the H1N1 virus was experimentally demonstrated via a negative optical response against the control group, H3N2. Therefore, the designed system that transduces the optical response to the target-specific binding can be a rapid tool for the diagnosis of H1N1. Electronic supplementary material: Supplementary material (Table S1 and Figs. S1-S8) is available in the online version of this article at 10.1007/s12274-021-3772-6.
Language	English
Publishing date	2021-09-21
Publishing country	China
Document type	Journal Article
ZDB-ID	2442216-2
ISSN	1998-0000 ; 1998-0124
ISSN (online)	1998-0000
ISSN	1998-0124
DOI	10.1007/s12274-021-3772-6
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Article: Kinetic stability modulation of polymeric nanoparticles for enhanced detection of influenza virus via penetration of viral fusion peptides

Park, Chaewon / Lim, Jong-Woo / Park, Geunseon / Kim, Hyun-Ouk / Lee, Sojeong / Kwon, Yuri H. / Kim, Seong-Eun / Yeom, Minjoo / Na, Woonsung / Song, Daesub / Kim, Eunjung / Haam, Seungjoo

Journal of materials chemistry B. 2021 Dec. 8, v. 9, no. 47

2021

Abstract: Specific interactions between viruses and host cells provide essential insights into material science-based strategies to combat emerging viral diseases. pH-triggered viral fusion is ubiquitous to multiple viral families and is important for ... ...

Abstract	Specific interactions between viruses and host cells provide essential insights into material science-based strategies to combat emerging viral diseases. pH-triggered viral fusion is ubiquitous to multiple viral families and is important for understanding the viral infection cycle. Inspired by this process, virus detection has been achieved using nanomaterials with host-mimetic membranes, enabling interactions with amphiphilic hemagglutinin fusion peptides of viruses. Most research has been on designing functional nanoparticles with fusogenic capability for virus detection, and there has been little exploitation of the kinetic stability to alter the ability of nanoparticles to interact with viral membranes and improve their sensing performance. In this study, a homogeneous fluorescent assay using self-assembled polymeric nanoparticles (PNPs) with tunable responsiveness to external stimuli is developed for rapid and straightforward detection of an activated influenza A virus. Dissociation of PNPs induced by virus insertion can be readily controlled by varying the fraction of hydrophilic segments in copolymers constituting PNPs, giving rise to fluorescence signals within 30 min and detection of various influenza viruses, including H9N2, CA04(H1N1), H4N6, and H6N8. Therefore, the designs demonstrated in this study propose underlying approaches for utilizing engineered PNPs through modulation of their kinetic stability for direct and sensitive identification of infectious viruses.
Keywords	Influenza A virus ; composite polymers ; fluorescence ; hemagglutinins ; hydrophilicity ; influenza ; peptides ; viruses
Language	English
Dates of publication	2021-1208
Size	p. 9658-9669.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb01847g
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Kinetic stability modulation of polymeric nanoparticles for enhanced detection of influenza virus

Park, Chaewon / Lim, Jong-Woo / Park, Geunseon / Kim, Hyun-Ouk / Lee, Sojeong / Kwon, Yuri H / Kim, Seong-Eun / Yeom, Minjoo / Na, Woonsung / Song, Daesub / Kim, Eunjung / Haam, Seungjoo

Journal of materials chemistry. B

2021 Volume 9, Issue 47, Page(s) 9658–9669

Abstract	Specific interactions between viruses and host cells provide essential insights into material science-based strategies to combat emerging viral diseases. pH-triggered viral fusion is ubiquitous to multiple viral families and is important for understanding the viral infection cycle. Inspired by this process, virus detection has been achieved using nanomaterials with host-mimetic membranes, enabling interactions with amphiphilic hemagglutinin fusion peptides of viruses. Most research has been on designing functional nanoparticles with fusogenic capability for virus detection, and there has been little exploitation of the kinetic stability to alter the ability of nanoparticles to interact with viral membranes and improve their sensing performance. In this study, a homogeneous fluorescent assay using self-assembled polymeric nanoparticles (PNPs) with tunable responsiveness to external stimuli is developed for rapid and straightforward detection of an activated influenza A virus. Dissociation of PNPs induced by virus insertion can be readily controlled by varying the fraction of hydrophilic segments in copolymers constituting PNPs, giving rise to fluorescence signals within 30 min and detection of various influenza viruses, including H9N2, CA04(H1N1), H4N6, and H6N8. Therefore, the designs demonstrated in this study propose underlying approaches for utilizing engineered PNPs through modulation of their kinetic stability for direct and sensitive identification of infectious viruses.
MeSH term(s)	Animals ; Carbocyanines/chemistry ; Chickens ; Eggs/virology ; Fluorescence Resonance Energy Transfer/methods ; Fluorescent Dyes/chemistry ; Influenza A virus/isolation & purification ; Influenza A virus/metabolism ; Limit of Detection ; Membrane Fusion/drug effects ; Membranes, Artificial ; Nanoparticles/chemistry ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/metabolism ; Polyethylene Glycols/chemical synthesis ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/metabolism ; Viral Fusion Proteins/metabolism
Chemical Substances	Carbocyanines ; Fluorescent Dyes ; Membranes, Artificial ; Peptides ; Viral Fusion Proteins ; polyleucine (25248-98-0) ; Polyethylene Glycols (3WJQ0SDW1A) ; 3,3'-dioctadecylindocarbocyanine (40957-95-7) ; 3,3'-dioctadecyloxacarbocyanine (68006-80-4)
Language	English
Publishing date	2021-12-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb01847g
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Article ; Online: Advanced Nanomaterials for Preparedness Against (Re-)Emerging Viral Diseases.

Kim, Eunjung / Lim, Eun-Kyung / Park, Geunseon / Park, Chaewon / Lim, Jong-Woo / Lee, Hyo / Na, Woonsung / Yeom, Minjoo / Kim, Jinyoung / Song, Daesub / Haam, Seungjoo

Advanced materials (Deerfield Beach, Fla.)

2021 Volume 33, Issue 47, Page(s) e2005927

Abstract: While the coronavirus disease (COVID-19) accounts for the current global pandemic, the emergence of other unknown pathogens, named "Disease X," remains a serious concern in the future. Emerging or re-emerging pathogens continue to pose significant ... ...

Abstract	While the coronavirus disease (COVID-19) accounts for the current global pandemic, the emergence of other unknown pathogens, named "Disease X," remains a serious concern in the future. Emerging or re-emerging pathogens continue to pose significant challenges to global public health. In response, the scientific community has been urged to create advanced platform technologies to meet the ever-increasing needs presented by these devastating diseases with pandemic potential. This review aims to bring new insights to allow for the application of advanced nanomaterials in future diagnostics, vaccines, and antiviral therapies, thereby addressing the challenges associated with the current preparedness strategies in clinical settings against viruses. The application of nanomaterials has advanced medicine and provided cutting-edge solutions for unmet needs. Herein, an overview of the currently available nanotechnologies is presented, highlighting the significant features that enable them to control infectious diseases, and identifying the challenges that remain to be addressed for the commercial production of nano-based products is presented. Finally, to conclude, the development of a nanomaterial-based system using a "One Health" approach is suggested. This strategy would require a transdisciplinary collaboration and communication between all stakeholders throughout the entire process spanning across research and development, as well as the preclinical, clinical, and manufacturing phases.
MeSH term(s)	Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19/diagnosis ; COVID-19/therapy ; Cell Membrane Permeability ; Drug Development ; Humans ; Nanostructures/chemistry ; Pandemics ; Reactive Oxygen Species/metabolism ; SARS-CoV-2/drug effects ; Surface Properties ; Theranostic Nanomedicine
Chemical Substances	Antiviral Agents ; Reactive Oxygen Species
Language	English
Publishing date	2021-02-15
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202005927
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Article: Cell-mimic polymersome-shielded islets for long-term immune protection of neonatal porcine islet-like cell clusters

Kim, Hyun-Ouk / Lee, Sang Hoon / Na, Woonsung / Lim, Jong-Woo / Park, Geunseon / Park, Chaewon / Lee, Hwunjae / Kang, Aram / Haam, Seungjoo / Choi, Inho / Kang, Jung-Taek / Song, Daesub

Journal of materials chemistry B. 2020 Mar. 25, v. 8, no. 12

2020

Abstract: Although islet cell transplantation has emerged as a promising treatment for type 1 diabetes, it remains an unmet clinical application due to the need for immunosuppression to prevent islet elimination and autoimmunity. To solve these problems, we ... ...

Abstract	Although islet cell transplantation has emerged as a promising treatment for type 1 diabetes, it remains an unmet clinical application due to the need for immunosuppression to prevent islet elimination and autoimmunity. To solve these problems, we developed novel nanoencapsulation of neonatal porcine islet-like cell clusters (NPCCs) with cell-mimic polymersomes (PSomes) based on PEG-b-PLA (poly(ethylene glycol)-b-poly(dl-lactic acid)). To accomplish this, we first formulated NHS-, NH2-, COOH-, and m(methoxy)-PSomes. This coating utilizes interactions involving NPCC surfaces and PSomes that have covalent bonds, electrostatic interactions, and hydrogen bonds. We extended the range of applicability by comparing the binding affinity of electrostatic attraction and hydrogen bonding, as well as covalent bonds. Our protocol can be used as an efficient hydrogen bonding method because it reduces cell membrane damage as well as the use of covalent bonding methods. We verified the selective permeability of NHS-, NH2-, COOH-, and m-PSome-shielded NPCCs. Furthermore, we showed that a novel nanoencapsulation did not affect insulin secretion from NPCCs. This study offers engineering advances in islet encapsulation technologies to be used for cell-based transplantation therapies.
Keywords	autoimmunity ; binding capacity ; cell membranes ; cell transplantation ; coatings ; electrostatic interactions ; encapsulation ; engineering ; hydrogen bonding ; immunosuppression ; insulin secretion ; insulin-dependent diabetes mellitus ; nanocapsules ; permeability ; polyethylene glycol ; swine
Language	English
Dates of publication	2020-0325
Size	p. 2476-2482.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/c9tb02270h
Database	NAL-Catalogue (AGRICOLA)

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