LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 40

Search options

  1. Article ; Online: Bidirectional thermo-regulating hydrogel composite for autonomic thermal homeostasis.

    Park, Gyeongsuk / Park, Hyunmin / Seo, Junyong / Yang, Jun Chang / Kim, Min / Lee, Bong Jae / Park, Steve

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3049

    Abstract: Thermal homeostasis is an essential physiological function for preserving the optimal state of complex organs within the human body. Inspired by this function, here, we introduce an autonomous thermal homeostatic hydrogel that includes infrared wave ... ...

    Abstract Thermal homeostasis is an essential physiological function for preserving the optimal state of complex organs within the human body. Inspired by this function, here, we introduce an autonomous thermal homeostatic hydrogel that includes infrared wave reflecting and absorbing materials for improved heat trapping at low temperatures, and a porous structure for enhanced evaporative cooling at high temperatures. Moreover, an optimized auxetic pattern was designed as a heat valve to further amplify heat release at high temperatures. This homeostatic hydrogel provides effective bidirectional thermoregulation with deviations of 5.04 °C ± 0.55 °C and 5.85 °C ± 0.46 °C from the normal body temperature of 36.5 °C, when the external temperatures are 5 °C and 50 °C, respectively. The autonomous thermoregulatory characteristics of our hydrogel may provide a simple solution to people suffering from autonomic nervous system disorders and soft robotics that are susceptible to sudden temperature fluctuations.
    MeSH term(s) Humans ; Hydrogels ; Body Temperature Regulation/physiology ; Hot Temperature ; Cold Temperature
    Chemical Substances Hydrogels
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38779-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Anticancer Activity and Underlying Mechanism of Phytochemicals against Multiple Myeloma.

    Kang, Beomku / Park, Hyunmin / Kim, Bonglee

    International journal of molecular sciences

    2019  Volume 20, Issue 9

    Abstract: Multiple myeloma (MM)-a common hematologic malignancy of plasma cells-accounts for substantial mortality and morbidity rates. Due to the advent of novel therapies such as immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and monoclonal ... ...

    Abstract Multiple myeloma (MM)-a common hematologic malignancy of plasma cells-accounts for substantial mortality and morbidity rates. Due to the advent of novel therapies such as immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and monoclonal antibodies (mAbs), response rates were increased and free survival and overall survival have been elevated. However, adverse events including toxicity, neuropathy or continuous relapse are still problems. Thus, development of novel drugs which have less side effects and more effective is needed. This review aims to recapitulate the pharmacologic anti-MM mechanisms of various phytochemicals, elucidating their molecular targets. Keywords related to MM and natural products were searched in PUBMED/MEDLINE. Phytochemicals have been reported to display a variety of anti-MM activities, including apoptosis, cell cycle arrest, antiangiogenesis, and miRNA modulation. Some phytochemicals sensitize the conventional therapies such as dexamethasone. Also, there are clinical trials with phytochemicals such as agaricus, curcumin, and Neovastat regarding MM treatment. Taken together, this review elucidated and categorized the evidences that natural products and their bioactive compounds could be potent drugs in treating MM.
    MeSH term(s) Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/pathology ; Neovascularization, Pathologic/drug therapy ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use
    Chemical Substances Antineoplastic Agents, Phytogenic ; Phytochemicals
    Language English
    Publishing date 2019-05-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20092302
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Self-Mixed Biphasic Liquid Metal Composite with Ultra-High Stretchability and Strain-Insensitivity for Neuromorphic Circuits.

    Lee, Do Hoon / Lim, Taesu / Pyeon, Jeongsu / Park, Hyunmin / Lee, Sang-Won / Lee, Seungkyu / Kim, Wonsik / Kim, Min / Lee, Jeong-Chan / Kim, Do-Wan / Han, Seungmin / Kim, Hyoungsoo / Park, Steve / Choi, Yang-Kyu

    Advanced materials (Deerfield Beach, Fla.)

    2024  Volume 36, Issue 16, Page(s) e2310956

    Abstract: Neuromorphic circuits that can function under extreme deformations are important for various data-driven wearable and robotic applications. Herein, biphasic liquid metal particle (BMP) with unprecedented stretchability and strain-insensitivity (ΔR/ ... ...

    Abstract Neuromorphic circuits that can function under extreme deformations are important for various data-driven wearable and robotic applications. Herein, biphasic liquid metal particle (BMP) with unprecedented stretchability and strain-insensitivity (ΔR/R
    Language English
    Publishing date 2024-01-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202310956
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Ultrathin Mixed Ionic-Electronic Conducting Interlayer via the Solution Shearing Technique for High-Performance Lithium-Sulfur Batteries.

    Son, Donghyeok / Park, Hyunmin / Lim, Won-Gwang / Baek, Seunghyeok / Kang, Seok Hun / Lee, Jeong-Chan / Maiyalagan, Thandavarayan / Lee, Young-Gi / Park, Steve / Lee, Jinwoo

    ACS nano

    2023  Volume 17, Issue 24, Page(s) 25507–25518

    Abstract: The commercialization of lithium-sulfur (Li-S) batteries has been hampered by diverse challenges, including the shuttle phenomenon and low electrical/ionic conductivity of lithium sulfide and sulfur. To address these issues, extensive research has been ... ...

    Abstract The commercialization of lithium-sulfur (Li-S) batteries has been hampered by diverse challenges, including the shuttle phenomenon and low electrical/ionic conductivity of lithium sulfide and sulfur. To address these issues, extensive research has been devoted to developing multifunctional interlayers. However, interlayers capable of simultaneously suppressing the polysulfide (PS) shuttle and ensuring stable electrical and ionic conductivity are relatively uncommon. Moreover, the use of thick and heavy interlayers results in an unavoidable decline in the energy density of Li-S batteries. We developed an ultrathin (750 nm), lightweight (0.182 mg cm
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c09333
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Testing for a Debt-Threshold Effect on Output Growth.

    Lee, Sokbae / Park, Hyunmin / Seo, Myung Hwan / Shin, Youngki

    Fiscal studies

    2017  Volume 38, Issue 4, Page(s) 701–717

    Abstract: Using the Reinhart-Rogoff dataset, we find a debt threshold not around 90 per cent but around 30 per cent, above which the median real gross domestic product (GDP) growth falls abruptly. Our work is the first to formally test for threshold effects in the ...

    Abstract Using the Reinhart-Rogoff dataset, we find a debt threshold not around 90 per cent but around 30 per cent, above which the median real gross domestic product (GDP) growth falls abruptly. Our work is the first to formally test for threshold effects in the relationship between public debt and median real GDP growth. The null hypothesis of no threshold effect is rejected at the 5 per cent significance level for most cases. While we find no evidence of a threshold around 90 per cent, our findings from the post-war sample suggest that the debt threshold for economic growth may exist around a relatively small debt-to-GDP ratio of 30 per cent. Furthermore, countries with debt-to-GDP ratios above 30 per cent have GDP growth that is 1 percentage point lower at the median.
    Language English
    Publishing date 2017-08-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044782-6
    ISSN 1475-5890 ; 0143-5671
    ISSN (online) 1475-5890
    ISSN 0143-5671
    DOI 10.1111/1475-5890.12134
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Large-Area Synthesis of Ultrathin, Flexible, and Transparent Conductive Metal-Organic Framework Thin Films via a Microfluidic-Based Solution Shearing Process.

    Lee, Taehoon / Kim, Jin-Oh / Park, Chungseong / Kim, Hanul / Kim, Min / Park, Hyunmin / Kim, Ikjin / Ko, Jaehyun / Pak, Kyusoon / Choi, Siyoung Q / Kim, Il-Doo / Park, Steve

    Advanced materials (Deerfield Beach, Fla.)

    2022  Volume 34, Issue 12, Page(s) e2107696

    Abstract: Iminosemiquinone-linker-based conductive metal-organic frameworks (c-MOFs) have attracted much attention as next-generation electronic materials due to their high electrical conductivity combined with high porosity. However, the utility of such c-MOFs in ...

    Abstract Iminosemiquinone-linker-based conductive metal-organic frameworks (c-MOFs) have attracted much attention as next-generation electronic materials due to their high electrical conductivity combined with high porosity. However, the utility of such c-MOFs in high-performance devices has been limited to date by the lack of high-quality MOF thin-film processing. Herein, a technique known as the microfluidic-assisted solution shearing combined with post-synthetic rapid crystallization (MASS-PRC) process is introduced to generate a high-quality, flexible, and transparent thin-film of Ni
    Language English
    Publishing date 2022-02-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202107696
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Online: A contribution to the Reinhart and Rogoff debate: not 90 percent but maybe 30 percent

    Lee, Sokbae / Park, Hyunmin / Seo, Myung Hwan / Shin, Youngki

    (Cemmap working paper / Centre for Microdata Methods and Practice ; 39/14)

    2014  

    Abstract: Using the Reinhart-Rogoff dataset, we find a debt threshold not around 90 percent but around 30 percent above which the median real GDP growth falls abruptly. Our work is the first to formally test for threshold effects in the relationship between public ...

    Author's details Sokbae Lee; Hyunmin Park; Myung Hwan Seo; Youngki Shin
    Series title Cemmap working paper / Centre for Microdata Methods and Practice ; 39/14
    Abstract Using the Reinhart-Rogoff dataset, we find a debt threshold not around 90 percent but around 30 percent above which the median real GDP growth falls abruptly. Our work is the first to formally test for threshold effects in the relationship between public debt and median real GDP growth. The null hypothesis of no threshold effect is rejected at the 5 percent significance level for most cases. While we find no evidence of a threshold around 90 percent, our findings suggest that the debt threshold for economic growth may exist around a relatively small debt-to-GDP ratio of 30 percent. Empirical results are more robust with the postwar sample than the long sample that goes before World War II.
    Keywords Government debt ; growth ; fiscal policy ; median regression ; testing
    Language English
    Size Online-Ressource (23 S.), graph. Darst.
    Publisher Centre for Microdata Methods and Practice
    Publishing place London
    Document type Book ; Online
    Database ECONomics Information System

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Implications of red Panax ginseng in oxidative stress associated chronic diseases

    Lee, Yoon-Mi / Yoon, Haelim / Park, Hyun-Min / Song, Byeng Chun / Yeum, Kyung-Jin

    Journal of Ginseng Research. 2017 Apr., v. 41, no. 2

    2017  

    Abstract: The steaming process of Panax ginseng has been reported to increase its major known bioactive components, ginsenosides, and, therefore, its biological properties as compared to regular Panax ginseng. Biological functions of red Panax ginseng attenuating ... ...

    Abstract The steaming process of Panax ginseng has been reported to increase its major known bioactive components, ginsenosides, and, therefore, its biological properties as compared to regular Panax ginseng. Biological functions of red Panax ginseng attenuating pro-oxidant environments associated with chronic diseases are of particular interest, since oxidative stress can be a key contributor to the pathogenesis of chronic diseases. Additionally, proper utilization of various biomarkers for evaluating antioxidant activities in natural products, such as ginseng, can also be important to providing validity to their activities. Thus, studies on the effects of red ginseng against various diseases as determined in cell lines, animal models, and humans were reviewed, along with applied biomarkers for verifying such effects. Limitations and future considerations of studying red ginseng were been discussed. Although further clinical studies are warranted, red ginseng appears to be beneficial for attenuating disease-associated symptoms via its antioxidant activities, as well as for preventing oxidative stress-associated chronic diseases.
    Keywords Panax ginseng ; antioxidants ; biomarkers ; ginsenosides ; oxidative stress ; pathogenesis ; research
    Language English
    Dates of publication 2017-04
    Size p. 113-119.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2765273-7
    ISSN 2093-4947 ; 1226-8453
    ISSN (online) 2093-4947
    ISSN 1226-8453
    DOI 10.1016/j.jgr.2016.03.003
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Testing for a debt-threshold effect on output growth

    Lee, Sokbae / Park, Hyunmin / Seo, Myung Hwan / Shin, Youngki

    Fiscal studies : the journal of the Institute for Fiscal Studies Vol. 38, No. 4 , p. 701-717

    2017  Volume 38, Issue 4, Page(s) 701–717

    Author's details Sokbae Lee, Hyunmin Park, Myung Hwan Seo and Youngki Shin
    Keywords Fiscal policy ; government debt ; growth ; median regression ; testing
    Language English
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Document type Article
    ZDB-ID 875401-9 ; 2044782-6
    ISSN 1475-5890 ; 0143-5671
    ISSN (online) 1475-5890
    ISSN 0143-5671
    Database ECONomics Information System

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: BK002 Induces miR-192-5p-Mediated Apoptosis in Castration-Resistant Prostate Cancer Cells

    Park, Moon Nyeo / Park, Hyunmin / Rahman, Md Ataur / Kim, Jeong Woo / Park, Se Sun / Cho, Yongmin / Choi, Jinwon / Son, So-Ri / Jang, Dae Sik / Shim, Bum-Sang / Kim, Sung-Hoon / Ko, Seong-Gyu / Cheon, Chunhoo / Kim, Bonglee

    Frontiers in oncology

    2022  Volume 12, Page(s) 791365

    Abstract: BK002 consists ... ...

    Abstract BK002 consists of
    Language English
    Publishing date 2022-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.791365
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top