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  1. AU="Park, I H"
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  1. Buch ; Online: Gamma-ray Bursts: 15 Years of GRB Afterglows

    Castro-Tirado, A.J. / Gorosabel, J. / Park, I.H.

    2012  

    Schlagwörter Physics ; gamma-ray bursts ; Universe energies
    Umfang 1 electronic resource (675 pages)
    Verlag EDP SCIENCES
    Dokumenttyp Buch ; Online
    Anmerkung French ; Open Access
    HBZ-ID HT021291899
    ISBN 9782759810024 ; 275981002X
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel ; Online: Abemaciclib plus a nonsteroidal aromatase inhibitor as initial therapy for HR+, HER2- advanced breast cancer: Final overall survival results of MONARCH 3.

    Goetz, M P / Toi, M / Huober, J / Sohn, J / Trédan, O / Park, I H / Campone, M / Chen, S-C / Manso, L M / Paluch-Shimon, S / Freedman, O C / O'Shaughnessy, J / Pivot, X / Tolaney, S M / Hurvitz, S / Llombart-Cussac, A / André, V / Saha, A / van Hal, G /
    Shahir, A / Iwata, H / Johnston, S R D

    Annals of oncology : official journal of the European Society for Medical Oncology

    2024  

    Abstract: Background: In MONARCH 2, the addition of abemaciclib to fulvestrant significantly improved both progression-free survival (PFS) and overall survival (OS) in patients with HR+, HER2- advanced breast cancer (ABC) with disease progression on prior ... ...

    Abstract Background: In MONARCH 2, the addition of abemaciclib to fulvestrant significantly improved both progression-free survival (PFS) and overall survival (OS) in patients with HR+, HER2- advanced breast cancer (ABC) with disease progression on prior endocrine therapy (ET). In MONARCH 3, the addition of abemaciclib to a nonsteroidal aromatase inhibitor (NSAI) as initial therapy for HR+, HER2- ABC significantly improved PFS. Here, we present the prespecified final OS results for MONARCH 3.
    Patients and methods: MONARCH 3 is a randomized, double-blind, phase 3 study of abemaciclib plus NSAI (anastrozole or letrozole) versus placebo plus NSAI in postmenopausal women with HR+, HER2- ABC without prior systemic therapy in the advanced setting. The primary objective was investigator-assessed PFS; OS was a gated secondary endpoint, and chemotherapy-free survival (CFS) was an exploratory endpoint.
    Results: A total of 493 women were randomized 2:1 to receive abemaciclib plus NSAI (n = 328) or placebo plus NSAI (n = 165). After a median follow-up of 8.1 years, there were 198 OS events (60.4%) in the abemaciclib arm and 116 (70.3%) in the placebo arm (hazard ratio, 0.804; 95% confidence interval [CI], 0.637-1.015; P = 0.0664, non-significant). Median OS was 66.8 versus 53.7 months for abemaciclib versus placebo. In the subgroup with visceral disease (sVD), there were 113 OS events (65.3%) in the abemaciclib arm and 65 (72.2%) in the placebo arm (hazard ratio, 0.758; 95% CI, 0.558-1.030; P = 0.0757, non-significant). Median OS was 63.7 months versus 48.8 months for abemaciclib versus placebo. The previously demonstrated PFS benefit was sustained, and CFS numerically improved with the addition of abemaciclib. No new safety signals were observed.
    Conclusion: Abemaciclib combined with an NSAI resulted in clinically meaningful improvement in median OS (ITT: 13.1 months; sVD: 14.9 months) in patients with HR+ HER2- ABC; however, statistical significance was not reached.
    Sprache Englisch
    Erscheinungsdatum 2024-05-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1016/j.annonc.2024.04.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: [A study on estimating health workers requirement (author's transl)].

    Park, I H

    Kajok kyehoek nonjip. Journal of family planning studies

    2002  Band 7, Seite(n) 149–162

    Mesh-Begriff(e) Delivery of Health Care ; Economics ; Family Planning Services ; Health ; Health Manpower ; Health Personnel ; Health Planning ; Health Services ; Korea ; Maternal-Child Health Centers ; Organization and Administration ; Primary Health Care
    Sprache Koreanisch
    Erscheinungsdatum 2002-06-27
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Design, fabrication and space suitability tests of wide field of view, ultra-compact, and high resolution telescope for space application.

    Tumarina, M / Ryazanskiy, M / Jeong, S / Hong, G / Vedenkin, N / Park, I H / Milov, A

    Optics express

    2018  Band 26, Heft 3, Seite(n) 2390–2399

    Abstract: We report on the design, manufacture, and testing of an ultra-compact telescope for 16 unit (16U) CubeSats for Earth and space observation. This telescope provides 1 arcsec resolution at a 2.9 degree field of view. Dimensions are optimized to 230 × 230 × ...

    Abstract We report on the design, manufacture, and testing of an ultra-compact telescope for 16 unit (16U) CubeSats for Earth and space observation. This telescope provides 1 arcsec resolution at a 2.9 degree field of view. Dimensions are optimized to 230 × 230 × 330mm
    Sprache Englisch
    Erscheinungsdatum 2018-02-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.26.002390
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Electromyographic power spectrum of jaw muscles during clenching in unilateral temporomandibular joint osteoarthritis patients.

    Park, I H / McCall, W D / Chung, J W

    Journal of oral rehabilitation

    2012  Band 39, Heft 9, Seite(n) 659–667

    Abstract: The relationship between temporomandibular joints (TMJ) osteoarthritis and masticatory muscle disorders is poorly understood. The data are sparse, the results are conflicting, and electromyographic (EMG) power spectrum analysis has not been used. The ... ...

    Abstract The relationship between temporomandibular joints (TMJ) osteoarthritis and masticatory muscle disorders is poorly understood. The data are sparse, the results are conflicting, and electromyographic (EMG) power spectrum analysis has not been used. The aims of this study were to compare the differences in EMG power spectrum during, and pressure pain thresholds (PPTs) before and after, sustained clenching in patients with unilateral TMJ osteoarthritis and healthy control subjects. Nineteen patients with unilateral TMJ osteoarthritis without masticatory muscle pain and 20 control subjects were evaluated. We measured EMG amplitudes at maximum voluntary contraction, median frequency from the EMG power spectrum during sustained clenching at 70% and PPTs before and after the clenching in both temporalis and masseter muscles. There were no significant differences in PPT decrease between muscles or between groups during sustained clenching. There were no significant differences in maximum voluntary contraction EMG activity ratios of affected to unaffected sides between groups, or of masseter to temporalis muscles between affected and unaffected side of patients with TMJ osteoarthritis. Median frequencies decreased from the beginning to the end of the sustained clench, and the interaction between group and clench was significant: the median frequency decrease was larger in the osteoarthritis group. Our results suggested that masticatory muscles of patients with unilateral TMJ osteoarthritis are more easily fatigued during sustained clenching than normal subjects.
    Mesh-Begriff(e) Adult ; Case-Control Studies ; Cross-Sectional Studies ; Electromyography/methods ; Female ; Humans ; Male ; Masseter Muscle/physiology ; Muscle Contraction/physiology ; Muscle Fatigue/physiology ; Osteoarthritis/diagnostic imaging ; Osteoarthritis/physiopathology ; Pain Measurement ; Radiography ; Temporal Muscle/physiology ; Temporomandibular Joint Dysfunction Syndrome/diagnostic imaging ; Temporomandibular Joint Dysfunction Syndrome/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2012-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 187079-8
    ISSN 1365-2842 ; 0305-182X
    ISSN (online) 1365-2842
    ISSN 0305-182X
    DOI 10.1111/j.1365-2842.2012.02322.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 991: Hefte anzeigen Standort:
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  6. Artikel ; Online: A case of erythema multiforme followed by herpes zoster.

    Park, I H / Kang, J N / Seol, J E / Sung, H S / Kim, H

    Infection

    2014  Band 42, Heft 4, Seite(n) 799–800

    Mesh-Begriff(e) Erythema Multiforme/complications ; Erythema Multiforme/diagnosis ; Herpes Zoster/diagnosis ; Herpes Zoster/pathology ; Humans ; Male ; Middle Aged
    Sprache Englisch
    Erscheinungsdatum 2014-04-24
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-014-0623-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Report 7

    Park, I. H / Kim, S

    A new look at the Korean fertility transition: its impact on women. Report on a pilot study. [Draft], [by] Lee, Hyun-Song; Kong, Sae-Kwon; Cho, Hyoung; Lee, Dong-Won; Kim, Mun-Cho; Choi Eun-Jung; Byun, Wha-Soon; Lim, Hyun-Chin; Lee, Mijeong; and Park, Insook H

    Korean women's attitudes toward politics

    1998  

    Abstract: This paper describes levels of participation of Korean women in activities associated with existing democratization policies and programs. This study uses secondary data as well as information obtained from focus group discussions of younger and older ... ...

    Verfasserangabe I.H. Park, S. Kim
    Abstract This paper describes levels of participation of Korean women in activities associated with existing democratization policies and programs. This study uses secondary data as well as information obtained from focus group discussions of younger and older generations that center on turbulent economic and political issues. The study revealed that younger women were politically inactive, showed less interests in politics, and are involved less in social activities. This generation was preoccupied with home management and child raising and spends its leisure time with friends and relatives. On the contrary, the older generation, being freed from the burden of educating their children, showed greater interest in social activities such as fund raising, as well as in political events related to the presidential election. Focus group discussions conducted after the presidential election of Korea revealed that young women acquired a sudden interest in politics, including political campaigns, presidential candidates, and party policies. This was due to the realization that the presidential election and vote affect their daily lives.
    Mesh-Begriff(e) Attitude ; Politics ; Research ; Women ; Behavior ; Developing Countries ; Economics ; Psychology
    Schlagwörter Asia ; Far East ; Korea ; Eastern Asia ; Attitude ; Political Factors ; Summary Report ; Women In Development ; Economic Development ; Economic Factors ; Psychological Factors
    Sprache Englisch
    Umfang p. 116-137.
    Dokumenttyp Artikel
    Anmerkung 1998 Jun. ; Draft.
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  8. Artikel: Effects of a 1:1 inspiratory to expiratory ratio on respiratory mechanics and oxygenation during one-lung ventilation in the lateral decubitus position.

    Kim, S H / Choi, Y S / Lee, J G / Park, I H / Oh, Y J

    Anaesthesia and intensive care

    2012  Band 40, Heft 6, Seite(n) 1016–1022

    Abstract: Prolonged inspiratory to expiratory (I:E) ratio ventilation may have both positive and negative effects on respiratory mechanics and oxygenation during one-lung ventilation (OLV), but definitive information is currently lacking. We therefore compared the ...

    Abstract Prolonged inspiratory to expiratory (I:E) ratio ventilation may have both positive and negative effects on respiratory mechanics and oxygenation during one-lung ventilation (OLV), but definitive information is currently lacking. We therefore compared the effects of volume-controlled ventilation with I:E ratios of 1:1 and 1:2 on respiratory mechanics and oxygenation during OLV. Fifty-six patients undergoing thoracoscopic lobectomy were randomly assigned volume-controlled ventilation with an I:E ratio of 1:1 (group 1:1, n=28) or 1:2 (group 1:2, n=28) during OLV. Arterial and central venous blood gas analyses and respiratory variables were recorded 15 minutes into two-lung ventilation, at 30 and 60 minutes during OLV, and 15 minutes after two-lung ventilation was re-initiated. Peak and plateau airway pressures in cmH2O [standard deviation] during OLV were significantly lower in group 1:1 than in group 1:2 (P <0.01) (19 [3] and 23 [4]; 16 [3] and 19 [5], respectively). The arterial to end-tidal carbon dioxide tension difference was significantly lower in group 1:1 than in group 1:2 (P <0.01), (0.5 [0.3] and 1.1 [0.5]). There were no significant differences in PaO2 during OLV between the two groups (OLV30, P=0.856; OLV60, P=0.473). In summary, volume-controlled ventilation with an I:E ratio of 1:1 reduced peak and plateau airway pressures improved dynamic compliance and efficiency of alveolar ventilation, but it did not improve arterial oxygenation in a substantial manner. Furthermore, the associated increase in mean airway pressure might have reduced cardiac output, resulting in a lower central venous oxygen saturation.
    Mesh-Begriff(e) Adult ; Aged ; Blood Gas Analysis ; Carbon Dioxide/metabolism ; Cardiac Output ; Female ; Humans ; Male ; Middle Aged ; Oxygen Consumption ; Posture ; Respiration, Artificial/methods ; Respiratory Mechanics/physiology ; Thoracoscopy/methods ; Time Factors
    Chemische Substanzen Carbon Dioxide (142M471B3J)
    Sprache Englisch
    Erscheinungsdatum 2012-11-21
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 187524-3
    ISSN 1448-0271 ; 0310-057X
    ISSN (online) 1448-0271
    ISSN 0310-057X
    DOI 10.1177/0310057X1204000613
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1017: Hefte anzeigen Standort:
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  9. Artikel ; Online: Human neural stem cells overexpressing glial cell line-derived neurotrophic factor in experimental cerebral hemorrhage.

    Lee, H J / Park, I H / Kim, H J / Kim, S U

    Gene therapy

    2009  Band 16, Heft 9, Seite(n) 1066–1076

    Abstract: Recent studies have reported that glial cell line-derived growth factor (GDNF) has neurotrophic effects on the central nervous system, and the neural stem cells (NSCs) engrafted in animal models of stroke survive and ameliorate the neurological deficits. ...

    Abstract Recent studies have reported that glial cell line-derived growth factor (GDNF) has neurotrophic effects on the central nervous system, and the neural stem cells (NSCs) engrafted in animal models of stroke survive and ameliorate the neurological deficits. In this study, a stable human NSC line overexpressing GDNF (F3.GDNF) was transplanted next to the intracerebral hemorrhage (ICH) lesion site and a possible therapeutic effect was investigated. F3.GDNF human NSC line was transplanted into the cortex overlying the striatal ICH lesion. ICH was induced in adult mice by the unilateral injection of bacterial collagenase into the striatum. The animals were evaluated for 8 weeks with rotarod and limb placement tests. Transplanted NSCs were detected by beta-gal immunostaining with double labeling of neurofilament, microtubule associated protein-2, glial fibrillary acidic protein or human nuclear matrix antigen (HuNuMA). F3.GDNF human NSCs produced a four times higher amount of GDNF over parental F3 cells in vitro, induced behavioral improvement in ICH mice after brain transplantation and two- to threefold increase in cell survival of transplanted NSCs at 2 and 8 weeks post-transplantation. In F3.GDNF-grafted ICH brain, a significant increase in the antiapoptotic protein and cell survival signal molecules, and a marked reduction in proapoptotic proteins were found as compared with control group. Brain transplantation of human NSCs overexpressing GDNF in ICH animals provided functional recovery in ICH animals, and survival and differentiation of grafted human NSCs. These results indicate that the F3.GDNF human NSCs should be of a great value as a cellular source for the cellular therapy in animal models of human neurological disorders including ICH.
    Mesh-Begriff(e) Animals ; Apoptosis ; Brain Tissue Transplantation/methods ; Cell Differentiation ; Cerebral Hemorrhage/metabolism ; Cerebral Hemorrhage/physiopathology ; Cerebral Hemorrhage/therapy ; Genetic Therapy/methods ; Genetic Vectors ; Glial Cell Line-Derived Neurotrophic Factor/genetics ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Graft Survival ; Humans ; Mice ; Mice, Inbred ICR ; Neurons/metabolism ; Neurons/transplantation ; Recovery of Function ; Retroviridae/genetics ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Stem Cell Transplantation/methods
    Chemische Substanzen Glial Cell Line-Derived Neurotrophic Factor
    Sprache Englisch
    Erscheinungsdatum 2009-09
    Erscheinungsland England
    Dokumenttyp Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1191036-7
    ISSN 1476-5462 ; 0969-7128
    ISSN (online) 1476-5462
    ISSN 0969-7128
    DOI 10.1038/gt.2009.51
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Effect of pre-treatments on dormancy of goldenrain-tree (Koelreuteria paniculata Laxm.) seeds

    Rehman, S / Park, I.H

    Journal of new seeds. 2000. v. 2 (4)

    2000  

    Schlagwörter Koelreuteria paniculata ; seeds ; seed dormancy ; seed treatment ; ornamental woody plants ; dormancy breaking ; imbibition ; gibberellic acid ; seed germination
    Sprache Englisch
    Umfang p. 29-36.
    Dokumenttyp Artikel
    ZDB-ID 2000188-5
    ISSN 1522-886X
    ISSN 1522-886X
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

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