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  1. AU="Park, Jinny"
  2. AU="Hill, Benjamin D"
  3. AU=Huang Chunfa
  4. AU="Skonieczny, Paul"
  5. AU="LIVINGSTON, M S"
  6. AU="Lidia Gonzalez-Quereda"
  7. AU="Korkmaz, Asli"
  8. AU="Patel, Mrinal"
  9. AU="Louis Chauvel"
  10. AU="Jampen, Laurent"
  11. AU="Tan, Jiacheng"
  12. AU="Weiss, Jonathan D"

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  1. Artikel ; Online: Can we more efficiently save patients with vitamin K-dependent coagulopathy caused by superwarfarin intoxication?

    Park, Jinny

    The Korean journal of internal medicine

    2014  Band 29, Heft 4, Seite(n) 430–433

    Mesh-Begriff(e) 4-Hydroxycoumarins/poisoning ; Anticoagulants/poisoning ; Blood Coagulation/drug effects ; Female ; Humans ; Male ; Rodenticides/poisoning ; Vitamin K/blood ; Vitamin K Deficiency Bleeding/chemically induced
    Chemische Substanzen 4-Hydroxycoumarins ; Anticoagulants ; Rodenticides ; Vitamin K (12001-79-5) ; bromfenacoum (A25P3CP5S7)
    Sprache Englisch
    Erscheinungsdatum 2014-06-27
    Erscheinungsland Korea (South)
    Dokumenttyp Editorial ; Comment
    ZDB-ID 639023-7
    ISSN 2005-6648 ; 1226-3303
    ISSN (online) 2005-6648
    ISSN 1226-3303
    DOI 10.3904/kjim.2014.29.4.430
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Unsaturated Fatty Acids Complex Regulates Inflammatory Cytokine Production through the Hyaluronic Acid Pathway.

    Kim, Gi-Beum / Seo, Kwansung / Youn, Jong-Ung / Kwon, Il Keun / Park, Jinny / Park, Kwang-Hyun / Kim, Jong-Suk

    Molecules (Basel, Switzerland)

    2023  Band 28, Heft 8

    Abstract: In this study, we aimed to develop natural and/or functional materials with antioxidant and anti-inflammatory effects. We obtained extracts from natural plants through an oil and hot-water extraction process and prepared an extract composite of an ... ...

    Abstract In this study, we aimed to develop natural and/or functional materials with antioxidant and anti-inflammatory effects. We obtained extracts from natural plants through an oil and hot-water extraction process and prepared an extract composite of an effective unsaturated fatty acid complex (EUFOC). Furthermore, the antioxidant effect of the extract complex was evaluated, and the anti-inflammatory effect was explored by assessing its inhibitory effect on nitric oxide production through its HA-promoting effect. We conducted a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay to evaluate the cell viability of the EUFOC, and the results showed that EUFOC was not cytotoxic at the test concentrations. In addition, it showed no endogenous cytotoxicity in HaCaT (human keratinocyte) cells. The EUFOC showed excellent 1,1-diphenyl-2-picrylhydrazyl- and superoxide-scavenging abilities. Moreover, it exerted an inhibitory effect on NO production at concentrations that did not inhibit cell viability. The secretion of all the cytokines was increased by lipopolysaccharide (LPS) treatment; however, this was inhibited by the EUFOC in a concentration-dependent manner. In addition, hyaluronic acid content was markedly increased by the EUFOC in a dose-dependent manner. These results suggest that the EUFOC has excellent anti-inflammatory and antioxidant properties, and hence, it can be used as a functional material in various fields.
    Mesh-Begriff(e) Humans ; Antioxidants/pharmacology ; Hyaluronic Acid ; Plant Extracts/pharmacology ; Nitric Oxide/metabolism ; Anti-Inflammatory Agents/pharmacology ; Cytokines
    Chemische Substanzen Antioxidants ; Hyaluronic Acid (9004-61-9) ; Plant Extracts ; Nitric Oxide (31C4KY9ESH) ; Anti-Inflammatory Agents ; Cytokines
    Sprache Englisch
    Erscheinungsdatum 2023-04-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28083554
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Differences in Clinical Outcomes Between Hydroxyurea-Resistant and -Intolerant Polycythemia Vera Patients.

    Lee, Sung-Eun / Hong, Junshik / Bang, Soo-Mee / Park, Jinny / Choi, Chul Won / Bae, Sung Hwa / Kim, Min Kyoung / Yoon, Seug Yun / Kim, Sung-Yong

    Journal of Korean medical science

    2024  Band 39, Heft 3, Seite(n) e24

    Abstract: Background: Previous studies have suggested that patients with polycythemia vera (PV) who exhibit hydroxyurea-resistance (HU-R) and -intolerance (HU-I) may have distinct characteristics and clinical outcomes. However, to date, no studies have reported a ...

    Abstract Background: Previous studies have suggested that patients with polycythemia vera (PV) who exhibit hydroxyurea-resistance (HU-R) and -intolerance (HU-I) may have distinct characteristics and clinical outcomes. However, to date, no studies have reported a comparison between these two groups or assessed prognostic factors in these patients.
    Methods: The objective of this study was to evaluate clinical outcomes and identify prognostic factors among PV patients with HU-R or HU-I. We conducted a review of PV patients who received frontline treatment with HU from nine centers and identified 90 patients with HU-R or HU-I.
    Results: The cumulative incidence of thrombosis after 7 years of HU-R/I was 21.4%, and the incidence of disease progression was 22.5%. Comparing the HU-R and HU-I groups, the HU-R group had a significantly higher rate of disease progression (36.7% vs. 0.56%,
    Conclusion: These findings suggest that patients with HU-R face a higher risk of hematological transformation, but have a comparable risk of thrombosis to patients with HU intolerance. These distinctions should guide decisions on second-line treatment options and clinical trials involving these patients.
    Mesh-Begriff(e) Humans ; Disease Progression ; Heart Disease Risk Factors ; Hydroxyurea/pharmacology ; Polycythemia Vera/drug therapy ; Thrombosis/epidemiology ; Retrospective Studies
    Chemische Substanzen Hydroxyurea (X6Q56QN5QC)
    Sprache Englisch
    Erscheinungsdatum 2024-01-22
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2024.39.e24
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Low-dose abdominopelvic computed tomography in patients with lymphoma: An image quality and radiation dose reduction study.

    Yoon, Sungjin / Yoo, Kwai Han / Park, So Hyun / Kim, Hawk / Lee, Jae Hoon / Park, Jinny / Park, Seong Ho / Kim, Hwa Jung

    PloS one

    2022  Band 17, Heft 8, Seite(n) e0272356

    Abstract: This study aimed to evaluate image quality, the detection rate of enlarged lymph nodes, and radiation dose exposure of ultralow-dose and low-dose abdominopelvic computed tomography (CT) in patients with lymphoma. Patients with lymphoma who underwent ... ...

    Abstract This study aimed to evaluate image quality, the detection rate of enlarged lymph nodes, and radiation dose exposure of ultralow-dose and low-dose abdominopelvic computed tomography (CT) in patients with lymphoma. Patients with lymphoma who underwent abdominopelvic CT using dual-source scanner were retrospectively recruited from a single center. CT images were obtained at 90 kVp dual-source mode reformatted in three data sets using the advanced modelled iterative reconstruction algorithm: 100% (standard-dose CT), 66.7% (low-dose CT), and 33.3% (ultralow-dose CT). Two radiologists analyzed subjective image quality and detection of abdominal enlarged lymph nodes on ultralow-dose, low-dose, and standard-dose CT blindly and independently. The results were compared with reference standards. Three readers (two radiologists and one hematologist) reviewed overall image quality and spleen size. In total, 128 consecutive CT scans (77 complete response, 44 partial response, 6 progressive disease, and 1 initial evaluation) from 86 patients (64 B-cell lymphoma, 14 T/NK-cell lymphoma, and 8 Hodgkin's lymphoma cases) were assessed. The enlarged lymph node-based detection rates for two readers were 97.0% (96/99) and 94.0% (93/99) on standard-dose CT, 97.0% (96/99) and 94.0% (93/99) on low-dose CT, and 94.0% (93/99) and 89.9% (89/99) on ultralow-dose CT. Overall image quality was 3.8 ± 0.5, 3.9 ± 0.5, and 4.1 ± 0.5 on ultralow-dose CT; 4.7 ± 0.4, 4.6 ± 0.5, and 4.8 ± 0.3 on low-dose CT; and 4.8 ± 0.4, 4.7 ± 0.4, and 4.9 ± 0.2 on standard-dose CT, according to two radiologists and one hematologist, respectively. Intraclass correlation coefficients of spleen size were 0.90 (95% confidence interval [CI], 0.87-0.93), 0.91 (95% CI, 0.88-0.93), and 0.91 (95% CI, 0.88-0.93) on ultralow-dose, low-dose, and standard-dose CT, respectively. Mean effective radiation doses of standard-dose, low-dose, and ultralow-dose CT were 5.7 ±1.8 mSv, 3.8 ± 1.2 mSv, and 1.9 ± 0.6 mSv, respectively. Our findings suggest that ultralow-dose and low-dose CT, even with radiation doses reduced by 66.7% and 33.3%, respectively, maintained adequate image quality. These imaging modalities may be employed for follow-up lymphoma evaluation in consideration of the long surveillance periods.
    Mesh-Begriff(e) Drug Tapering ; Humans ; Lymphoma/diagnostic imaging ; Radiation Dosage ; Radiographic Image Interpretation, Computer-Assisted/methods ; Retrospective Studies ; Tomography, X-Ray Computed/methods
    Sprache Englisch
    Erscheinungsdatum 2022-08-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0272356
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Fisetin Inhibits UVA-Induced Expression of MMP-1 and MMP-3 through the NOX/ROS/MAPK Pathway in Human Dermal Fibroblasts and Human Epidermal Keratinocytes.

    Jang, Hye-Yeon / Kim, Gi-Beum / Kim, Jeong-Mi / Kang, Sang Yull / Youn, Hyun-Jo / Park, Jinny / Ro, Su Yeon / Chung, Eun-Yong / Park, Kwang-Hyun / Kim, Jong-Suk

    International journal of molecular sciences

    2023  Band 24, Heft 24

    Abstract: Fisetin is a flavonoid found in plants and has been reported to be effective in various human diseases. However, the effective mechanisms of ultraviolet-A (UVA)-mediated skin damage are not yet clear. In this study, we investigated the protective ... ...

    Abstract Fisetin is a flavonoid found in plants and has been reported to be effective in various human diseases. However, the effective mechanisms of ultraviolet-A (UVA)-mediated skin damage are not yet clear. In this study, we investigated the protective mechanisms of fisetin regarding UVA-induced human dermal fibroblasts (HDFs) and human epidermal keratinocytes (HEKs) damages. Fisetin showed a cytoprotective effect against UVA irradiation and suppressed matrix metalloproteinases (MMPs), MMP-1, and MMP-3 expression. In addition, fisetin was rescued, which decreased mRNA levels of pro-inflammatory cytokines, reactive oxygen species production, and the downregulation of MAPK/AP-1 related protein and NADPH oxidase (NOX) mRNA levels. Furthermore, UVA-induced MMP-1 and MMP-3 were effectively inhibited by siRNAs to NOX 1 to 5 in HDFs and HEKs. These results indicate that fisetin suppresses UVA-induced damage through the NOX/ROS/MAPK pathway in HDFs and HEKs.
    Mesh-Begriff(e) Humans ; Reactive Oxygen Species/metabolism ; Matrix Metalloproteinase 1/metabolism ; Matrix Metalloproteinase 3/genetics ; Matrix Metalloproteinase 3/metabolism ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Cells, Cultured ; Skin/metabolism ; Keratinocytes/metabolism ; Fibroblasts/metabolism ; RNA, Messenger/metabolism ; Ultraviolet Rays/adverse effects
    Chemische Substanzen Reactive Oxygen Species ; fisetin (OO2ABO9578) ; Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; NADPH Oxidases (EC 1.6.3.-) ; RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2023-12-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242417358
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Effect of

    Park, Hyunkyung / Kim, Hyeong-Joon / Sohn, Sang-Kyun / Baik, Yoonsuk / Kim, Dongho / Lee, Sung-Yeoun / Kong, Jee Hyun / Kim, Hawk / Shin, Dong-Yeop / Ahn, Jae-Sook / Park, Jinny / Park, Seonyang / Kim, Inho

    Therapeutic advances in hematology

    2023  Band 14, Seite(n) 20406207231205637

    Abstract: Background: Droplet digital polymerase chain reaction (ddPCR) is an exact method of measurement.: Objectives: We conducted this study to identify the prognostic factors for successful treatment-free remission in patients with chronic-phase chronic ... ...

    Abstract Background: Droplet digital polymerase chain reaction (ddPCR) is an exact method of measurement.
    Objectives: We conducted this study to identify the prognostic factors for successful treatment-free remission in patients with chronic-phase chronic myeloid leukemia who discontinued tyrosine kinase inhibitors (TKIs). We also aimed to validate ddPCR for predicting molecular relapse.
    Design: This is a prospective, multicenter study.
    Methods: We enrolled patients treated with TKIs for at least 3 years with a confirmed sustained deep molecular response (DMR) for at least 1 year. TKI was re-administered in patients who experienced the loss of major molecular response (MMR).
    Results: A total of 66 patients from five institutions in South Korea were enrolled. During a median follow-up period of 16.5 months, 29/66 (43.9%) patients experienced molecular relapse; the probability of molecular relapse-free survival (RFS) at 6 or 12 months after TKI discontinuation was 65.6% or 57.8%, respectively, with most molecular relapses occurring within the first 7 months. All patients who lost MMR were re-treated with TKI, and all re-achieved MMR at a median of 2.8 months. E14a2 transcript type (
    Conclusion: Our data suggest that transcript type and
    Sprache Englisch
    Erscheinungsdatum 2023-11-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2585183-4
    ISSN 2040-6215 ; 2040-6207
    ISSN (online) 2040-6215
    ISSN 2040-6207
    DOI 10.1177/20406207231205637
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Differences in the Cytotoxic Effects of Multi-Walled Carbon Nanotubes on Two- and Three-Dimensionally Cultured Human Neural Precursor Cells and Rat Brain Slices.

    Kim, Myeong Jin / Yoo, Chan-Jong / Kim, Yong-Jung / Lee, Uhn / Park, Jinny / Choi, Dae Han / Yoo, Young-Mi

    Journal of nanoscience and nanotechnology

    2021  Band 21, Heft 9, Seite(n) 4596–4604

    Mesh-Begriff(e) Brain ; Cell Survival ; Humans ; Nanotubes, Carbon/toxicity ; Neural Stem Cells ; Rats ; Animals
    Chemische Substanzen Nanotubes, Carbon
    Sprache Englisch
    Erscheinungsdatum 2021-02-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1533-4899
    ISSN (online) 1533-4899
    DOI 10.1166/jnn.2021.19360
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Dose-Dependent Cytotoxicity of Gold Nanoparticles on Human Neural Progenitor Cells and Rat Brain.

    Yoo, Chan-Jong / Lee, Uhn / Kim, Yong-Jung / Park, Jinny / Yoo, Young-Mi

    Journal of nanoscience and nanotechnology

    2019  Band 19, Heft 9, Seite(n) 5441–5447

    Abstract: Gold nanoparticles (GNPs) are utilized as diagnostic and therapeutic tools to detect and treat human disease. Researchers in the field of nanotoxicity are working to determine the physicochemical properties of nanoparticles that lead to toxicity in an ... ...

    Abstract Gold nanoparticles (GNPs) are utilized as diagnostic and therapeutic tools to detect and treat human disease. Researchers in the field of nanotoxicity are working to determine the physicochemical properties of nanoparticles that lead to toxicity in an effort to establish safe design rules. In this study, we performed the MTT and terminal transferase dUTP nick end labeling (TUNEL) assays to verify the cytotoxicity of GNPs on rat brain tissue and human neural progenitor cells (NPCs). As results, we observed that GNPs induced apoptosis in NPCs. NPCs were markedly damaged following the administration of 200 μM and 2 mM GNPs, whereas 2 μM GNPs showed slightly increased damage relative to that of the control. In addition, TUNEL-positive cells were densely distributed at regions surrounding the GNP injection site in the brain 7 days after the GNPs injection. During long-term GNPs exposure, TUNEL-positive cells were rarely observed in the cerebral cortex. In this study, we observed that apoptosis increased in proportion to GNP concentrations in the brain and in cultivated NPCs. These result suggest that large GNPs (<100 nm) are toxic and that the cytotoxicity increased as the concentration of GNPs increased in NPCs or in the brain.
    Mesh-Begriff(e) Animals ; Brain ; Gold/toxicity ; Humans ; Metal Nanoparticles/toxicity ; Neural Stem Cells ; Particle Size ; Rats
    Chemische Substanzen Gold (7440-57-5)
    Sprache Englisch
    Erscheinungsdatum 2019-04-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1533-4880
    ISSN 1533-4880
    DOI 10.1166/jnn.2019.16547
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Modifiable Factors Associated with the Completion of Advance Treatment Directives in Hematologic Malignancy: A Patient-Caregiver Dyadic Analysis.

    Kim, JinShil / Park, Jinny / Lee, Mee Ok / Park, Eun Young / Heo, Seongkum / Shim, Jae Lan

    Journal of palliative medicine

    2019  Band 23, Heft 5, Seite(n) 611–618

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Advance Directives ; Caregivers ; Hematologic Neoplasms ; Hospice Care ; Humans ; Palliative Care
    Sprache Englisch
    Erscheinungsdatum 2019-12-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2019.0274
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: US and Dutch Perspectives on the Use of COVID-19 Clinical Prediction Models: Findings from a Qualitative Analysis.

    Basile, Melissa J / Helmrich, I R A Retel / Park, Jinny G / Polo, Jennifer / Rietjens, Judith A C / van Klaveren, David / Zanos, Theodoros P / Nelson, Jason / Lingsma, Hester F / Kent, David M / Alsma, Jelmer / Verdonschot, R J C G / Hajizadeh, Negin

    Medical decision making : an international journal of the Society for Medical Decision Making

    2023  Band 43, Heft 4, Seite(n) 445–460

    Abstract: Introduction: Clinical prediction models (CPMs) for coronavirus disease 2019 (COVID-19) may support clinical decision making, treatment, and communication. However, attitudes about using CPMs for COVID-19 decision making are unknown.: Methods: Online ...

    Abstract Introduction: Clinical prediction models (CPMs) for coronavirus disease 2019 (COVID-19) may support clinical decision making, treatment, and communication. However, attitudes about using CPMs for COVID-19 decision making are unknown.
    Methods: Online focus groups and interviews were conducted among health care providers, survivors of COVID-19, and surrogates (i.e., loved ones/surrogate decision makers) in the United States and the Netherlands. Semistructured questions explored experiences about clinical decision making in COVID-19 care and facilitators and barriers for implementing CPMs.
    Results: In the United States, we conducted 4 online focus groups with 1) providers and 2) surrogates and survivors of COVID-19 between January 2021 and July 2021. In the Netherlands, we conducted 3 focus groups and 4 individual interviews with 1) providers and 2) surrogates and survivors of COVID-19 between May 2021 and July 2021. Providers expressed concern about CPM validity and the belief that patients may interpret CPM predictions as absolute. They described CPMs as potentially useful for resource allocation, triaging, education, and research. Several surrogates and people who had COVID-19 were not given prognostic estimates but believed this information would have supported and influenced their decision making. A limited number of participants felt the data would not have applied to them and that they or their loved ones may not have survived, as poor prognosis may have suggested withdrawal of treatment.
    Conclusions: Many providers had reservations about using CPMs for people with COVID-19 due to concerns about CPM validity and patient-level interpretation of the outcome predictions. However, several people who survived COVID-19 and their surrogates indicated that they would have found this information useful for decision making. Therefore, information provision may be needed to improve provider-level comfort and patient and surrogate understanding of CPMs.
    Highlights: While clinical prediction models (CPMs) may provide an objective means of assessing COVID-19 prognosis, provider concerns about CPM validity and the interpretation of CPM predictions may limit their clinical use.Providers felt that CPMs may be most useful for resource allocation, triage, research, or educational purposes for COVID-19.Several survivors of COVID-19 and their surrogates felt that CPMs would have been informative and may have aided them in making COVID-19 treatment decisions, while others felt the data would not have applied to them.
    Mesh-Begriff(e) Humans ; Decision Making ; COVID-19 Drug Treatment ; COVID-19 ; Prognosis
    Chemische Substanzen 4-chlorophenyl methyl sulfide (123-09-1)
    Sprache Englisch
    Erscheinungsdatum 2023-02-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604497-9
    ISSN 1552-681X ; 0272-989X
    ISSN (online) 1552-681X
    ISSN 0272-989X
    DOI 10.1177/0272989X231152852
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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