Article ; Online: Cost of illness of stage IV non-small cell lung cancer (NSCLC) positive for programmed cell death ligand 1 (PD-L1) in the US.
Expert review of pharmacoeconomics & outcomes research
2022 , Page(s) 1–7
Abstract: Background: Non-small cell lung cancer (NSCLC) positive for programmed cell death ligand 1 (PD-L1) may be eligible for targeted immunotherapies. Literature does not currently estimate direct costs associated with this population. We aimed to identify ... ...
| Abstract | Background: Non-small cell lung cancer (NSCLC) positive for programmed cell death ligand 1 (PD-L1) may be eligible for targeted immunotherapies. Literature does not currently estimate direct costs associated with this population. We aimed to identify the total direct costs associated with PD-L1 positive stage IV NSCLC treated with immunotherapy. Methods: Using progression-free survival, overall survival, treatment-related serious adverse events leading to hospitalization, and end-of-life resource use, we estimated costs for one year of treatment in this incidence-based study. Data were obtained from online databases, guideline recommendations, clinical trials, and proprietary market share data. We summed the costs of PD-L1 immunohistochemistry (IHC) tests, drugs, hospitalizations, and deaths associated with treatment, estimating the overall cost-of-illness for stage IV NSCLC in the United States in 2021. Results: An estimated 22,711 patients in the US had stage IV NSCLC treated with PD-L1 immunotherapy in 2021. Total 2021 costs were estimated at $3.01 billion. Drugs (including immunotherapy, second-line chemotherapy, and other oncology drugs) accounted for nearly 97% ($2.91 billion) of the total. Conclusions: PD-L1 positive stage IV NSCLC treatment is a costly condition with annual direct medical costs of $3.01 billion. The primary cost driver was immunotherapy, making up 74.6% of the total cost. |
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| Language | English | |||||
| Publishing date | 2022-11-01 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2208481-2 | |||||
| ISSN | 1744-8379 ; 1473-7167 | |||||
| ISSN (online) | 1744-8379 | |||||
| ISSN | 1473-7167 | |||||
| DOI | 10.1080/14737167.2023.2140141 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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